DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wb and USH2A

DIOPT Version :9

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:NP_996816.3 Gene:USH2A / 7399 HGNCID:12601 Length:5202 Species:Homo sapiens


Alignment Length:3145 Identity:550/3145 - (17%)
Similarity:866/3145 - (27%) Gaps:1509/3145 - (47%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 SPDKKKKSPQSSRRHKTKSGLII---ESNIADSESMLAIASSESVTKKKPPQRRRNGKLQKSGGG 130
            :|||....|.:   |...:..|.   :|..:...|...:||.......||.|:.....::|:..|
Human   110 TPDKNDLHPNA---HSNSASFIFGNHKSCFSSPPSPKLMASFTLAVWLKPEQQGVMCVIEKTVDG 171

  Fly   131 AGGGALRLLKTEDVYSSSFSGGLYPPL----------------------------FNVVPRAQIS 167
            .....|.:.:.|.::......||.||:                            .|.|.:....
Human   172 QIVFKLTISEKETMFYYRTVNGLQPPIKVMTLGRILVKKWIHLSVQVHQTKISFFINGVEKDHTP 236

  Fly   168 VNA---------------TCGQ--NGAEEY----------------------------------- 180
            .||               ..||  ||.|::                                   
Human   237 FNARTLSGSITDFASGTVQIGQSLNGLEQFVGRMQDFRLYQVALTNREILEVFSGDLLRLHAQSH 301

  Fly   181 CKQVGAKPCGICNAH-----------SSDRAKQRSIQSL------ISSGSGSGSGSGFEEGWWQS 228
            |:..|:.|    ..|           :.|.|..| :..|      :|..:.:..|:.     |.|
Human   302 CRCPGSHP----RVHPLAQRYCIPNDAGDTADNR-VSRLNPEAHPLSFVNDNDVGTS-----WVS 356

  Fly   229 PTLQGGRQF-EYVTILLDLKQ-TFQIFSVWLKSANSPRPAS-WILEKSLDGINFEPWQYFGLSDA 290
            .......|. :.|||.:||:. .:|:|.:.::.. ||:|.. .|..|..:.:::|.||||.    
Human   357 NVFTNITQLNQGVTISVDLENGQYQVFYIIIQFF-SPQPTEIRIQRKKENSLDWEDWQYFA---- 416

  Fly   291 DCQRRWNLSGQNGKYVFQNDTEIICSTQFSKPGPLENGVLHASLL----KNRPGATD--QSPELM 349
               |.....|.......:....:.| .|.|...|...|.:..|:|    ..|||..:  .:|.|.
Human   417 ---RNCGAFGMKNNGDLEKPDSVNC-LQLSNFTPYSRGNVTFSILTPGPNYRPGYNNFYNTPSLQ 477

  Fly   350 KFITTRYIRIRLQGMHSTANQDNSLDWLLDSPSLEKHSFYSLSQLKVSARLDCNGHANRSHESPD 414
            :|:....||....|.:.|.....:|          :|.:|::.::.:|.|..|:|||:.. ::..
Human   478 EFVKATQIRFHFHGQYYTTETAVNL----------RHRYYAVDEITISGRCQCHGHADNC-DTTS 531

  Fly   415 DPLMQCICQHN--TCGAQCEQCCPLFQDRPYQMGGE-----CEICQCYGHAESCTY----DPFLD 468
            .| .:|:|...  |.|..|::|.||:.|:|::.|.:     |:.|||..|::||.|    |||..
Human   532 QP-YRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPF 595

  Fly   469 K------GICQSCSNNTAGIECEFCEMGFYREL--DAPLTDPCLPCSCNPARSTGG---CQSDGG 522
            :      |:|..|.:||.|..||.|:..|:|::  |....|.|.||.|:...:..|   |...||
Human   596 EHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGG 660

  Fly   523 SCNCLEGFQGKNCEECAPGYYGDDCKRCECDERGSLGSTGSCSGVCQCKLNVEGSTCSECAPGYF 587
            .||                                            ||.:|.|..|::|..|::
Human   661 QCN--------------------------------------------CKRHVSGRQCNQCQNGFY 681

  Fly   588 DLSAENAEGCTSCWCSGVSQTCHSAKLQTLAFETLNDWKITDIQRVKPISIPVDAETNRLIFANE 652
            :|...:.:||:.|.|:                                                 
Human   682 NLQELDPDGCSPCNCN------------------------------------------------- 697

  Fly   653 LDEVEAIYWQASLGYLGNRLTSYGSRLQLVLSWDVIRGDRSGKPTTGPNVILVGKNGLKIAFGDE 717
                                                        |:|                  
Human   698 --------------------------------------------TSG------------------ 700

  Fly   718 SLDGLGINLNVTLTEVGWYHVPPTVVDIKTRLRRTEGGDYHGESVTRSQFLSVLVSLDAVLIRAA 782
            ::||                      ||                                    .
Human   701 TVDG----------------------DI------------------------------------T 707

  Fly   783 FHTDQGETSLERAVIYSGGVELGGKSSSQVEQCLCPAGYTGLSCEGCAFGFKRIYENTSDHQILS 847
            .|.:.|                         ||.|.|...||.|:.|.||||             
Human   708 CHQNSG-------------------------QCKCKANVIGLRCDHCNFGFK------------- 734

  Fly   848 KCIPCPCNGHSNSCDLQSGNCGDCMHNTFGDRCERCQLGYYGNPLQGTPNDCKRCACPLSEDSNN 912
                                                                             
Human   735 ----------------------------------------------------------------- 734

  Fly   913 FSPSCQLKSYNYMDLNPQFELIEHAEYICTQCPEGYTGDHCQVCDDGYFGNPRQPGSSCQRCDCA 977
                 .|:|:|                                                      
Human   735 -----FLRSFN------------------------------------------------------ 740

  Fly   978 GGPCNVTTGECITCRGNTEGWHCERCKLGYWGDPAVGCDPCHCHTEGSESGLCDSTDGQCLCKPR 1042
                                              .|||:||.|:..||.:..|:...|||.||..
Human   741 ----------------------------------DVGCEPCQCNLHGSVNKFCNPHSGQCECKKE 771

  Fly  1043 YAGQKCDECDVGYANVEL-RCPSCNCDPLGSLVQDRCDPHTGQCHCKEGVMGAKCHECQDGYFGM 1106
            ..|.:||.|...:..::: .|.:|:||..|||....|:..||||.||..|.|.:|::|.:|.|  
Human   772 AKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNF-- 834

  Fly  1107 NAVAYRMDDLAALRQNSDSDDDEWELVPDTEDPNSESTVACEECHCSSVGSLSSD--CDKRTGQC 1169
                       .||||                    ::..|..|:|...|:::..  |:|.||||
Human   835 -----------YLRQN--------------------NSFLCLPCNCDKTGTINGSLLCNKSTGQC 868

  Fly  1170 ACLANVTGRRCDKCRPGHWNLTAG--EGCRDCRCDPHGS-RGHECNPWTGQCDCKIGVGGQHCNE 1231
            .|...|||.||::|.|..:|||..  :.|:.|.||..|: .|..|:|.:|||.|.....|:.||:
Human   869 PCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQ 933

  Fly  1232 CTEGFFGFSTEGCQRCSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPGTWGWQARLGCRECEC 1296
            |..||:                   ..|.|.                          .||..|.|
Human   934 CQPGFY-------------------ISPGNA--------------------------TGCLPCSC 953

  Fly  1297 DHIGSIGQQCSTGDGQCQCRE-GYSGRKCDTCAIGYFGY-PE---CRRCGCDAEGSFTQADGSIA 1356
            ...|::...|::..|||.|:: ..:|::||.|...|||: |:   |:.|.|...|:..:....: 
Human   954 HTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLV- 1017

  Fly  1357 CDSNGQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGCTRCFCFGRSGECEQSDLSWGHIRMAESRN 1421
               .|||.||..|.|.|||.|:.|...|...|..||::                           
Human  1018 ---TGQCFCKQFVTGSKCDACVPSASHLDVNNLLGCSK--------------------------- 1052

  Fly  1422 LSVQQIRPHSVPSSDYEYIVVVQMEGSSFHREDAEIQRMNDLSLVPKSTGNVSIGAYGQFYHPLY 1486
            ...||..|..            |::.||          ..:||..|..:.|.         |.|.
Human  1053 TPFQQPPPRG------------QVQSSS----------AINLSWSPPDSPNA---------HWLT 1086

  Fly  1487 FQLPPQFYGDRTSSYGGFLYFTLITEGAHKPLERNILGQYPL-VQLHAHSKLLLDFYEYEEFEYS 1550
            :.|          ...||..:|  ||           .|||. :|....:.||    .|.::.|.
Human  1087 YSL----------LRDGFEIYT--TE-----------DQYPYSIQYFLDTDLL----PYTKYSYY 1124

  Fly  1551 LNVTHRVPLHESFWKYHHTSQAVDRNTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMDAAIYIK 1615
            :..|                                                  |||        
Human  1125 IETT--------------------------------------------------NVH-------- 1131

  Fly  1616 GSTNLIAKGVERCKCPKRFDGLSCQDPGRSFYRWRNTTIVESVFIEDLIGRAAPCHCNGRSSDCD 1680
            |||..:|                                                          
Human  1132 GSTRSVA---------------------------------------------------------- 1138

  Fly  1681 RETGVCQNCRGNTGGDHCHQCAEGFYGDPNSPHGCQACPCPETNRNFARGCNVWDGEVSCVCKPG 1745
                                                                     |:...|||
Human  1139 ---------------------------------------------------------VTYKTKPG 1146

  Fly  1746 YTGRLCERCQAGYFGDPMRYPNTTCQPCNCHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQAER 1810
            .                              |:|                               
Human  1147 V------------------------------PEG------------------------------- 1150

  Fly  1811 HHLVDNGCKICDNCTLLLLDYMELVGNKLRRGMHNMDLTGIPAPYRKLSEYESAYEKWNGRHWDF 1875
                        |.|   |.|:..:|:      .::.||     :..||......||:       
Human  1151 ------------NLT---LSYIIPIGS------DSVTLT-----WTTLSNQSGPIEKY------- 1182

  Fly  1876 SQTKRRLQDYDSADILK---LEAHAENLKFQSRKAVATI------GKREFAIKSMREDAVTQQHS 1931
                          ||.   |......:.::..:..|||      .|.:|::::...        
Human  1183 --------------ILSCAPLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQACTS-------- 1225

  Fly  1932 VGLLRSEILQTLSDLHGYGKSAHYLSLPTALKQARFYLQAIREHDQMVQGIRSTNDCAWKHFYAM 1996
                              |...|  |||                                     
Human  1226 ------------------GGCLH--SLP------------------------------------- 1233

  Fly  1997 GNASDASFDESGRLEMLWRDLNQTNHRVVDMRLQVDRVQEVENEAEDVLEHVRNLSIRVGESHQE 2061
                                :..|..:....||...::|::.:.                |.|.|
Human  1234 --------------------ITVTTAQAPPQRLSPPKMQKISST----------------ELHVE 1262

  Fly  2062 LDELNQRISDHLDPGYLEQGEGLLRLTVQRQIMLNGHLNQLDGYRILLNTTLGVKTEQQREVRKH 2126
                                                                             
Human  1263 ----------------------------------------------------------------- 1262

  Fly  2127 WLPKAEKHASHLLARSNEYARKFQPTRNGARIAMLASSAHSNITEAINDARLASILAKERVYEAQ 2191
            |.|.||.:.  ::.|...|.|:.:.|:                 |..::        :.||:::.
Human  1263 WSPPAELNG--IIIRYELYMRRLRSTK-----------------ETTSE--------ESRVFQSS 1300

  Fly  2192 RTLYPSDGSSMIERAKHSLHRSKQLQQEALKQMHKSNVLKDKLHRQEQQVEGIKS-TIYDSGLRT 2255
            ..|.|   .|.:|.|          .:.|||.......           :.|::. |.|:..:..
Human  1301 GWLSP---HSFVESA----------NENALKPPQTMTT-----------ITGLEPYTKYEFRVLA 1341

  Fly  2256 NNISGQLQGLSDGSARRQAKDSLEMADRTGEQMRAELQKAKDMQKSIQNMRNSFSNLEPDWEIKL 2320
            .|::|.:             .|..:::||||.....:     :..|:..: :|:| |...||   
Human  1342 VNMAGSV-------------SSAWVSERTGESAPVFM-----IPPSVFPL-SSYS-LNISWE--- 1383

  Fly  2321 GMAQENISLTQTNLRLANVSLSYLEQQAEKEQQVFEVWNNSMAQQLQQLRDQIAKARHAAEAIDV 2385
             ...:|:    |..::....::.|.:|:.::         |:.....||       .|.|::.::
Human  1384 -KPADNV----TRGKVVGYDINMLSEQSPQQ---------SIPMAFSQL-------LHTAKSQEL 1427

  Fly  2386 SLESLGPKCIRSY-----LPASYGLSTSNKIRMSFALSNHLESSPLIHLASSEGRHITLELYKRR 2445
            |....|.|..|.|     |..|.|..||                     ||..|:.:.....:.|
Human  1428 SYTVEGLKPYRIYEFTITLCNSVGCVTS---------------------ASGAGQTLAAAPAQLR 1471

  Fly  2446 VRLVWNLGGTTATVTHPMVVHTRDPKYDDAWYHVEANRTLNLGSLVVRRMNNYGELTPPNPVIIT 2510
            ..||..:..||        :|.|       |:..|                   ||..|:|:   
Human  1472 PPLVKGINSTT--------IHLR-------WFPPE-------------------ELNGPSPI--- 1499

  Fly  2511 GSTDTEHTRFYQSRSDRISLGGFASKDLQFTPGLNVVVHQVEVDNKPLGLWNFVTSEGSCGGSMV 2575
                      ||......||           |.|...:                         |.
Human  1500 ----------YQLERRESSL-----------PALMTTM-------------------------MK 1518

  Fly  2576 GAKESSASSTARHFNGLGYAQLMKTRPRPTRKNLFSVQMTFRT-LDENALLFLAVDDKNNRSVSV 2639
            |.:          |.|.||.: ..:...|...:...::.:||| :.|..::|.|.........::
Human  1519 GIR----------FIGNGYCK-FPSSTHPVNTDFTGIKASFRTKVPEGLIVFAASPGNQEEYFAL 1572

  Fly  2640 TLSRGRIMFRIDYGDESKLEINTT----KKYNVGQWIKIEAAREFSAKRSTENGMLRVNNDRPIS 2700
            .|.:||:.|..| ...|.:|:.||    |:|:.|:|.:|.|.|..:..:.|.:| :...:...::
Human  1573 QLKKGRLYFLFD-PQGSPVEVTTTNDHGKQYSDGKWHEIIAIRHQAFGQITLDG-IYTGSSAILN 1635

  Fly  2701 GAPTLPVNIHLLPDLSKTVYYLGGVPPGFTSGTSKAPGADNPFLGCMKDVQV-----NGETYDPL 2760
            |:..:..|         |..:|||:|..:|............|:||:|||..     ....::||
Human  1636 GSTVIGDN---------TGVFLGGLPRSYTILRKDPEIIQKGFVGCLKDVHFMKNYNPSAIWEPL 1691

  Fly  2761 ------ESSSYYGVEPSCKNMITK-AGFSGNGYLELPSQSLRKRSN--TALVFRTLQPDCLLLLA 2816
                  |..:.|.....|...:.: |.|.|.|:|||.........|  .:..|||.|.:.|||..
Human  1692 DWQSSEEQINVYNSWEGCPASLNEGAQFLGAGFLELHPYMFHGGMNFEISFKFRTDQLNGLLLFV 1756

  Fly  2817 AYPPEILGDYDAKDIKGNFSISLVDGQLHVWVNSGRSF--IKMSSNSSQMNDGEFHVVHLIKTGR 2879
                     |: ||.....::.|..|.|...:|:..:|  :.:....|..| |:::.|.:.|.|.
Human  1757 ---------YN-KDGPDFLAMELKSGILTFRLNTSLAFTQVDLLLGLSYCN-GKWNKVIIKKEGS 1810

  Fly  2880 KLELMVDDELQEIRNLNGNPTVVSLPRDAGGLYIGGAPPH--ESYTPLAPTFVNLE----GAIRD 2938
            .:...|:..::........|.||:.|     :|:||.|..  .||..|.     ||    |.::|
Human  1811 FISASVNGLMKHASESGDQPLVVNSP-----VYVGGIPQELLNSYQHLC-----LEQGFGGCMKD 1865

  Fly  2939 VVFNNRTINFNDALTFANVQIGRNGPLMGSLKGGLYDVLLKTEPMI------------GKSFTAS 2991
            |.|....:     :..|:|.       .|:::..| |..|.|:..:            ||..:..
Human  1866 VKFTRGAV-----VNLASVS-------SGAVRVNL-DGCLSTDSAVNCRGNDSILVYQGKEQSVY 1917

  Fly  2992 PEGCKRIGSYSYEPNAFKFGDDIYS 3016
            ..|.:....|.|...|...|..:||
Human  1918 EGGLQPFTEYLYRVIASHEGGSVYS 1942

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 164..396 CDD:278484 59/309 (19%)
EGF_Lam 401..450 CDD:238012 16/55 (29%)
TNFRSF <407..507 CDD:304602 38/118 (32%)
EGF_Lam 505..552 CDD:238012 9/49 (18%)
Laminin_EGF 550..597 CDD:278482 8/46 (17%)
Laminin_B 660..798 CDD:278481 8/137 (6%)
EGF_Lam 851..900 CDD:238012 0/48 (0%)
Laminin_EGF <943..971 CDD:278482 0/27 (0%)
VSP 953..1414 CDD:146106 121/471 (26%)
Laminin_EGF 974..1018 CDD:278482 3/43 (7%)
EGF_Lam 1017..1065 CDD:238012 16/48 (33%)
Laminin_EGF 1065..>1105 CDD:278482 18/39 (46%)
EGF_Lam 1150..1197 CDD:238012 20/50 (40%)
Laminin_EGF 1199..1247 CDD:278482 17/48 (35%)
EGF_Lam 1247..1292 CDD:238012 3/44 (7%)
Laminin_EGF 1294..1342 CDD:278482 18/52 (35%)
Laminin_EGF 1340..1392 CDD:278482 17/51 (33%)
Laminin_B 1486..1611 CDD:278481 18/125 (14%)
EGF_Lam 1669..1716 CDD:238012 0/46 (0%)
Laminin_EGF 1718..1767 CDD:278482 4/48 (8%)
EGF_Lam 1772..1819 CDD:238012 2/46 (4%)
CrfC <1933..2267 CDD:223771 36/334 (11%)
Laminin_II 2277..2400 CDD:283628 25/127 (20%)
LamG 2399..>2492 CDD:304605 17/92 (18%)
Laminin_G_2 2616..2755 CDD:280389 38/148 (26%)
Laminin_G_2 2804..2944 CDD:280389 39/147 (27%)
Laminin_G_2 3038..3169 CDD:280389
LamG 3192..3347 CDD:238058
USH2ANP_996816.3 LamGL 146..283 CDD:214722 22/136 (16%)
Laminin_N 291..516 CDD:413488 52/253 (21%)
EGF_Lam 517..565 CDD:238012 16/49 (33%)
EGF_Lam 574..639 CDD:238012 23/64 (36%)
Laminin_EGF 641..691 CDD:395007 16/93 (17%)
EGF_Lam 694..733 CDD:214543 19/232 (8%)
Laminin_EGF 747..795 CDD:395007 15/47 (32%)
EGF_Lam 794..844 CDD:238012 23/82 (28%)
EGF_Lam 847..897 CDD:214543 20/49 (41%)
EGF_Lam 900..948 CDD:238012 19/92 (21%)
EGF_Lam 950..1000 CDD:238012 16/49 (33%)
EGF_Lam 1001..>1037 CDD:238012 14/39 (36%)
fn3 1058..1132 CDD:394996 28/189 (15%)
fn3 1150..1227 CDD:394996 20/180 (11%)
FN3 1242..1357 CDD:238020 31/259 (12%)
FN3 1368..1451 CDD:214495 22/108 (20%)
LamG 1519..1678 CDD:238058 44/180 (24%)
LamG 1716..1868 CDD:238058 46/172 (27%)
FN3 1956..2051 CDD:238020
FN3 2241..2313 CDD:238020
FN3 2329..2428 CDD:238020
FN3 2432..2528 CDD:238020
FN3 2533..2619 CDD:238020
FN3 2621..2719 CDD:238020
FN3 2724..2799 CDD:238020
FN3 2818..2920 CDD:238020
FN3 2925..3015 CDD:238020
FN3 3026..>3087 CDD:238020
FN3 <3449..3494 CDD:238020
FN3 3503..3586 CDD:238020
FN3 3590..3676 CDD:238020
FN3 3680..3767 CDD:238020
fn3 3777..3856 CDD:394996
FN3 3866..3960 CDD:238020
FN3 3964..4057 CDD:238020
fn3 4161..4247 CDD:394996
FN3 4268..4351 CDD:238020
fn3 4357..4428 CDD:394996
FN3 4444..4516 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4518..4541
FN3 4529..4627 CDD:238020
FN3 4636..4730 CDD:238020
FN3 4826..4927 CDD:238020
PDZ-binding 5200..5202
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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