Protein Alignment wb and NTN4

DIOPT Version :10

• Sequence 1: NP_723870.1
• Gene: wb / 43946
• FlyBaseID: FBgn0261563
• Length: 3375
• Species: Drosophila melanogaster
• Sequence 2: NP_067052.2
• Gene: NTN4 / 59277
• HGNCID: 13658
• Length: 628
• Species: Homo sapiens
• Alignment Length: 617
• Identity: 165/617 - (26%)
• Similarity: 244/617 - (39%)
• Gaps: 141/617 - (22%)

  Fly   155 PPLFNVVPRAQISVNATCGQNGAEEY----------CKQVGAKPCGICNAHSSDRAKQRSIQSLI 209
            |.:.|:....::..:.|||||..|.|          |:|   ..|..|||.....|...|..
Human    36 PRMGNLALGRKLWADTTCGQNATELYCFYSENTDLTCRQ---PKCDKCNAAYPHLAHLPSAM--- 94

  Fly   210 SSGSGSGSGSGFEEGWWQSPTLQGGRQFEYVTILLDLKQTFQIFSVWLKSANSPRPASWILEKSL 274
                 :.|...|...||||     ........|.|||:..| .|:..:....|||||:.:|::|.
Human    95 -----ADSSFRFPRTWWQS-----AEDVHREKIQLDLEAEF-YFTHLIVMFKSPRPAAMVLDRSQ 148

  Fly   275 D-GINFEPWQYFGLSDADCQRRWNLSGQNGKYVFQNDTEIICSTQFSKPGPLENG-VLHASLLKN 337
            | |..::|::||.   .:|...:.|.....|      ...||::::|.|.|...| |:..:|...
Human   149 DFGKTWKPYKYFA---TNCSATFGLEDDVVK------KGAICTSKYSSPFPCTGGEVIFKALSPP 204

  Fly   338 RPGATDQSPELMKFITTRYIRIRLQGMHSTANQDNSLDWLLDSPSLEKHSFYSLSQLKVSARLDC 402
            .......|.::.:.:....:|::|....|...|.|.|:   :.|....|  |::....|.....|
Human   205 YDTENPYSAKVQEQLKITNLRVQLLKRQSCPCQRNDLN---EEPQHFTH--YAIYDFIVKGSCFC 264

  Fly   403 NGHAN--------RSHESPDDPLM---QCICQHNTCGAQCEQCCPLFQDRPYQMG-------GEC 449
            ||||:        |..::|....|   :|:|:|||.|:.|:.|.||:.|||::..       .||
Human   265 NGHADQCIPVHGFRPVKAPGTFHMVHGKCMCKHNTAGSHCQHCAPLYNDRPWEAADGKTGAPNEC 329

  Fly   450 EICQCYGHAESCTYDPFL-------DKGICQSCSNNTAGIECEFCEMGFYRELDAPLT--DPCLP 505
            ..|:|.|||::|.:|..:       ..|:|..|.:||.|..|:.|:.||||:|..|.:  |.|.|
Human   330 RTCKCNGHADTCHFDVNVWEASGNRSGGVCDDCQHNTEGQYCQRCKPGFYRDLRRPFSAPDACKP 394

  Fly   506 CSCN-------PARSTGGCQSDGGSCNCLEGFQGKNCEECAPGY--YGD-DCKRCECDERGSLGS 560
            |||:       ||.|...|....|.|.|..|..|:.|:.|..||  :|| .|:.|:|  .||...
Human   395 CSCHPVGSAVLPANSVTFCDPSNGDCPCKPGVAGRRCDRCMVGYWGFGDYGCRPCDC--AGSCDP 457

  Fly   561 -TGSC----------------------------------------SGVCQCKLNVEGSTCSECAP 584
             ||.|                                        ||.|:||....|:..:.|..
Human   458 ITGDCISSHTDIDWYHEVPDFRPVHNKSEPAWEWEDAQGFSALLHSGKCECKEQTLGNAKAFCGM 522

  Fly   585 GY-----FDLSAENAEGCTSCWCSGVSQTCHSAKLQTL-AFETLNDWKITDIQRVKPISIP---- 639
            .|     ..:.:.:.:|........:.:...|.||:.. ...||.....||.....||..|
Human   523 KYSYVLKIKILSAHDKGTHVEVNVKIKKVLKSTKLKIFRGKRTLYPESWTDRGCTCPILNPGLEY 587

  Fly   640 -----VDAETNRLIFANELDEVEAIYWQASLG 666
                 .|..|.:|| .|....|:  :|:.|||
Human   588 LVAGHEDIRTGKLI-VNMKSFVQ--HWKPSLG 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wb	NP_723870.1	Laminin_N	153..398	CDD:459653	63/254 (25%)
		EGF_Lam	401..450	CDD:238012	22/66 (33%)
		EGF_Lam	505..552	CDD:238012	21/56 (38%)
		Laminin_EGF	550..597	CDD:395007	15/92 (16%)
		Laminin_B	660..813	CDD:459652	4/7 (57%)
		EGF_Lam	851..900	CDD:238012
		Laminin_EGF	<943..971	CDD:395007
		Laminin_EGF	974..1018	CDD:395007
		EGF_Lam	1017..1065	CDD:238012
		Laminin_EGF	1065..>1105	CDD:395007
		EGF_Lam	1150..1197	CDD:238012
		Laminin_EGF	1199..1247	CDD:395007
		EGF_Lam	1247..1292	CDD:238012
		Laminin_EGF	1294..1342	CDD:395007
		Laminin_EGF	1340..1392	CDD:395007
		Laminin_B	1486..1626	CDD:459652
		EGF_Lam	1669..1716	CDD:238012
		Laminin_EGF	1718..1767	CDD:395007
		EGF_Lam	1772..1819	CDD:238012
		YhaN	<1907..2141	CDD:443752
		SMC_prok_B	<2123..>2390	CDD:274008
		Laminin_II	2279..2400	CDD:368703
		LamG	2399..>2492	CDD:473984
		LamG	2586..2753	CDD:238058
		Laminin_G_2	2804..2944	CDD:460494
		LamG	3018..3167	CDD:238058
		LamG	3192..3347	CDD:238058
NTN4	NP_067052.2	Laminin_N	34..260	CDD:459653	63/254 (25%)
		EGF_Lam	261..320	CDD:238012	21/58 (36%)
		Laminin_EGF	332..392	CDD:395007	22/59 (37%)
		EGF_Lam	395..446	CDD:214543	18/50 (36%)
		NTR_netrin-4_like	516..626	CDD:239633	23/104 (22%)