Protein Alignment wb and lamb3

DIOPT Version :10

• Sequence 1: NP_723870.1
• Gene: wb / 43946
• FlyBaseID: FBgn0261563
• Length: 3375
• Species: Drosophila melanogaster
• Sequence 2: XP_073792955.1
• Gene: lamb3 / 572057
• ZFINID: ZDB-GENE-081104-69
• Length: 1161
• Species: Danio rerio
• Alignment Length: 1891
• Identity: 353/1891 - (18%)
• Similarity: 560/1891 - (29%)
• Gaps: 838/1891 - (44%)

  Fly   564 CSGVCQCKLNVEGSTCSECAPGYFDL---SAENAEGCTSCWCSGVSQTC--HSA-KLQTLAFETL 622
            ||....|:...       |.|...||   ..:|....::|...|....|  |.. |::....::.
Zfish    16 CSAQQDCRRGA-------CYPAMDDLLLGREQNLRASSTCGLMGSEVVCSPHGQWKMKCCPCDSR 73

  Fly   623 ND--WKITDIQR----------------VKPISIPVDAETNRLIFANELDEVEAIYWQASLGYLG 669
            |.  :....||.                |.|:::.:|        .|....:|.::    |.:.|
Zfish    74 NPAAYNAHTIQNVISSAGPNRWWQSKKDVNPVTLQLD--------LNGQYHLETVF----LSFKG 126

  Fly   670 --------NRLTSYGSRLQLVLSWDVIRGDRSGKPTTGPNVILVGKNGLKIAFGDESLDGLGINL 726
                    .|...||.      ||..:....:..|:|.|.|                    ..:.
Zfish   127 PRPDALIIERSRDYGR------SWQPVLYMATNCPSTFPRV--------------------STSF 165

  Fly   727 NVTLTEVGWYHVPPTVVDIKTRLRRTEGGDYHGESV---TRSQFLSVLVSLDAVLIRAAFHTDQG 788
            ..:..|...|.:|.|..|           .|..:.:   ...||..:.:..:..:..|:     |
Zfish   166 PRSFEETYCYTLPSTADD-----------PYKDQKIHFYPLRQFADINLPNEYKIEVAS-----G 214

  Fly   789 ETSLERAVIYSGGV-ELGGKSSSQVEQCLCPAGYTGLSCEGCAFGFKRIYENTSDHQILSKCIPC 852
            .|.|...:...|.| .|.|:..||                         |....:.:::..|.
Zfish   215 FTGLRVNLTQLGPVPSLPGRGLSQ-------------------------YYALREMKVIGSCF-- 252

  Fly   853 PCNGHSNSCDLQ------------SGNCGDCMHNTFGDRCERCQLGYYGNPLQ----GTPNDCKR 901
             |:||:|.| ||            .|.| :|.|||.|..|:||...|...|.:    |..:.|||
Zfish   253 -CHGHANRC-LQDTSNNYLPNTPVGGMC-ECQHNTAGVNCDRCDDFYNDLPWRPAESGNTHACKR 314

  Fly   902 CACPLSEDSNNFSPSCQLKSYNYMDLNPQFELIEHAEYICTQCPEGY--TGDHCQVCDDGYFGNP 964
            |.|      ||.|..|...                        ||.|  ||
Zfish   315 CEC------NNHSERCHFD------------------------PERYEATG-------------- 335

  Fly   965 RQPGSSCQRCDCAGGPCNVTTGECITCRGNTEGWHCERCKLGYWGDPAVGCDPCHCHTEGSESGL 1029
            |..|                 |.|..|..:|.|..||||:..|:.:|                 |
Zfish   336 RSSG-----------------GVCDACAHHTTGPQCERCERNYYPNP-----------------L 366

  Fly  1030 CDSTDGQCLCKPRYAGQKCDECDVGYANVELRCPSCNCDPLGSLVQDRCDPHTGQCHCKEGVMGA 1094
            .|.             :..|.|        ||   |.|||.||....:||..||.|.||:.|.|.
Zfish   367 SDM-------------RSADAC--------LR---CLCDPAGSENGGQCDAGTGVCVCKQNVEGE 407

  Fly  1095 KCHECQDGYFGMNAVAYRMDDLAALRQNSDSDDDEWELVPDTEDPNSESTVACEECHCSSVGSLS 1159
            :|..|:.|::.:||                                 .:.:.|.:|.||||||||
Zfish   408 RCDRCKAGFYNLNA---------------------------------NNPLGCSKCSCSSVGSLS 439

  Fly  1160 SDCDKRTGQCACLANVTGRRCDKCRPGHWNLTAGEGCRDCRCDPHGSRGHECNPWTGQCDCKIGV 1224
            ..|::.||||.|.:|:.|..||:|..|:||.|:..||:.|.|||..:|...|:..||||.|:.|.
Zfish   440 GVCNQLTGQCVCRSNMEGLSCDRCAAGYWNPTSPSGCQPCGCDPDNARSATCDQRTGQCQCRPGN 504

  Fly  1225 GGQHCNECTEGFFGFSTEGCQRCSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPGTWGWQARL 1289
            ||:.|:.|.:..:|                   ||                            .:
Zfish   505 GGRTCSGCPDNTYG-------------------DP----------------------------LI 522

  Fly  1290 GCRECECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFGYPECRRCGCDAEGSFTQADGS 1354
            |||.|:||.:|:  :.|....|.|:|:.|.:|.:||.|:.|:
Zfish   523 GCRRCDCDQLGT--EACDKRTGVCRCKPGVTGPRCDACSRGH----------------------- 562

  Fly  1355 IACDSNGQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGCTRCFCFGRSGECEQSDLSWGHIRMAES 1419
              |.|..|||.        |.:|.   |.:|:|                  ..||:      .:.
Zfish   563 --CASFPQCPA--------CPSCF---FSMSSQ------------------LQDLT------VDL 590

  Fly  1420 RNLSVQQIRPHSVPSS--DYEYIVVVQMEGSSFHREDAEIQRMNDLSLVPKSTGNV-----SIGA 1477
            ..|:.|.:.....|:|  ...:|..:|                ..|:|:.:|.|:.     ::..
Zfish   591 ERLTNQLLWSGGQPTSGNTSRWIQTLQ----------------QTLTLIQQSLGDTPESGRTVND 639

  Fly  1478 YGQFYHPLYFQLPPQFYGDRTSSYGGFLYFTLITEGAHKPLERNILGQYPLVQL-HAHSKLLLDF 1541
            ..|..:.|..|:.                 ||..:...:||:|::  :..|..| :..|.|.|||
Zfish   640 ALQKLNTLRSQMK-----------------TLRDDLPSQPLDRDL--ERSLDDLENLLSSLRLDF 685

  Fly  1542 YEYEEFEYSLNVTHRVPLHESFWKYHHTSQAVDRNTLMAALQNIRHIFIRAFAFADFQEVVLQNV 1606
                                 |.|.|..:...:.              |.|.||...|
Zfish   686 ---------------------FTKRHGINGGGES--------------INASAFVAIQ------- 708

  Fly  1607 HMDAAIYIKGSTNLIAKGVERCKCPKRFDGLSCQDPGRSFYRWRNTTIVESVFIEDLIGRAAPCH 1671
                                     :.||              ::|         |.|.||
Zfish   709 -------------------------RSFD--------------KST---------DAIKRA---- 721

  Fly  1672 CNGRSSDCDRETGVCQNCRGNTGGDHCHQCAEGFYGDPNSPHGCQACPCPETNRNFARGCNVWDG 1736
             |.......:..|:.:|            ...|.|.
Zfish   722 -NATEDTLKKSEGIREN------------ALSGLYD----------------------------- 744

  Fly  1737 EVSCVCKPGYTGRLCERCQAGYFGDPMRYPNTTCQPCNCHPDGIQTEGCDVETGRCYCREGVTGL 1801
                 .:||.|..| |:.:......|...| |..:.|.    |.:.|.|..|  ||      ||
Zfish   745 -----VQPGNTKDL-EKLKKDLATRPNLTP-TAVKVCG----GDRVEPCTPE--RC------TG- 789

  Fly  1802 KCDKCQAERHHLVDNGCKIC---DNCTLLLLDYMELVGNKLRRGMHNMDLTGIPAPYRKLSEYES 1863
              |.|.       .||...|   |||...|
Zfish   790 --DMCP-------PNGAPPCGAEDNCAGAL----------------------------------- 810

  Fly  1864 AYEKWNGRHWDFSQTKRRLQDYDSADILKLEAHAENLKFQSRKAVATIGKREFAIKSMREDAVTQ 1928
                        ....|..||.|     :::|..:.|..:..||.|.|.:.|.:...:|
Zfish   811 ------------PNANRAFQDAD-----EVKAKLQELNDKITKAAAQIQEAEDSANRVR------ 852

  Fly  1929 QHSVGLLRSEILQTLSDLHGYGKSAHYLSLPTALKQARFYLQAIREHDQMVQGIRSTNDCAWKHF 1993
             .|...|.::|.|..:|:.|            .||..:.::..:|:.
Zfish   853 -LSTDKLANQIKQARADVDG------------DLKDTKDFINTLRDF------------------ 886

  Fly  1994 YAMGNASDASFDESGRLEMLWRDLNQTNHRVVDMRLQVDRVQEVEN------EAEDVLEHVRNLS 2052
                 .||...|.           :|. .||.|..|:......|||      |.:|.::.|.:.|
Zfish   887 -----LSDPQSDP-----------DQV-QRVCDGVLEAQFPASVENLKKKLKEIQDAMKSVPDSS 934

  Fly  2053 IRVGESHQELDELNQRISDHLDP-----GYLEQGEGLLRLTVQRQIMLNGHLNQLDGYRILLNTT 2112
            ..:.:|..:|:|..|.:...::.     |..:..|.:|:...:.:       |.||..:..:|.:
Zfish   935 GALEDSRAQLEEAKQLLKRAINTRDAAFGIQQDAESILKTMDENE-------NILDDLKDKINQS 992

  Fly  2113 LGVKTEQQREVRKHWLPKAEKHASHLLARSNEYARKFQPTRNGARIAMLASSAHSNITEAINDAR 2177
            ..:....::::::                                           |.:|:..|.
Zfish   993 GTIAENVKKDIQQ-------------------------------------------IEDALTPAE 1014

  Fly  2178 LASILAKERVYEAQRTLYPSDGSSMIERAKHSLHRSKQLQQEALKQMHKSNVLKDKLHRQEQQVE 2242
            ...:...|.:.|.:         .:::..|..|...|.|..:|.||   :|:.:|:..|..:.:|
Zfish  1015 QGIVGIPELLDEMR---------PLLDSLKTDLPTGKTLANDAQKQ---ANLAQDEADRAAEDLE 1067

  Fly  2243 GIKSTIYDSGLRTNNISGQLQGLSDGSARRQAKDSLEMADRTGEQMRAELQKAKDMQKSIQNMRN 2307
            .:|                           ||.:.:::|.....|...:..:..::||..:::..
Zfish  1068 ELK---------------------------QALEQMKLAAAENTQAGEDSVRLLNLQKEAESLMT 1105

  Fly  2308 SFSNLEPDWEIKLGMAQENISLTQTNLRLANVSLSYLEQQAEKEQQVFEVWNNS-----MAQQLQ 2367
            ..|::     || .:..:.:|:                     :|:..::..||     :..|::
Zfish  1106 DTSDI-----IK-ALKDKEVSI---------------------QQRAADIEGNSTRLLGLDAQVE 1143

  Fly  2368 QLRDQI 2373
            :|||.|
Zfish  1144 KLRDDI 1149

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wb	NP_723870.1	Laminin_N	153..398	CDD:459653
		EGF_Lam	401..450	CDD:238012
		EGF_Lam	505..552	CDD:238012
		Laminin_EGF	550..597	CDD:395007	8/35 (23%)
		Laminin_B	660..813	CDD:459652	29/164 (18%)
		EGF_Lam	851..900	CDD:238012	20/64 (31%)
		Laminin_EGF	<943..971	CDD:395007	7/29 (24%)
		Laminin_EGF	974..1018	CDD:395007	11/43 (26%)
		EGF_Lam	1017..1065	CDD:238012	6/47 (13%)
		Laminin_EGF	1065..>1105	CDD:395007	18/39 (46%)
		EGF_Lam	1150..1197	CDD:238012	25/46 (54%)
		Laminin_EGF	1199..1247	CDD:395007	17/47 (36%)
		EGF_Lam	1247..1292	CDD:238012	3/44 (7%)
		Laminin_EGF	1294..1342	CDD:395007	14/47 (30%)
		Laminin_EGF	1340..1392	CDD:395007	10/51 (20%)
		Laminin_B	1486..1626	CDD:459652	21/140 (15%)
		EGF_Lam	1669..1716	CDD:238012	5/46 (11%)
		Laminin_EGF	1718..1767	CDD:395007	6/48 (13%)
		EGF_Lam	1772..1819	CDD:238012	13/46 (28%)
		YhaN	<1907..2141	CDD:443752	40/244 (16%)
		SMC_prok_B	<2123..>2390	CDD:274008	35/256 (14%)
		Laminin_II	2279..2400	CDD:368703	16/100 (16%)
		LamG	2399..>2492	CDD:473984
		LamG	2586..2753	CDD:238058
		Laminin_G_2	2804..2944	CDD:460494
		LamG	3018..3167	CDD:238058
		LamG	3192..3347	CDD:238058
lamb3	XP_073792955.1	None