Protein Alignment wb and cntnap5b

DIOPT Version :10

• Sequence 1: NP_723870.1
• Gene: wb / 43946
• FlyBaseID: FBgn0261563
• Length: 3375
• Species: Drosophila melanogaster
• Sequence 2: XP_009294485.1
• Gene: cntnap5b / 571891
• ZFINID: ZDB-GENE-070705-209
• Length: 1306
• Species: Danio rerio
• Alignment Length: 1106
• Identity: 238/1106 - (21%)
• Similarity: 386/1106 - (34%)
• Gaps: 308/1106 - (27%)

  Fly  2391 GPKCIRSYLPASYGLSTSNKIRMS--FALSNHLES----SPLIHLASSEGRHITLELYKR-RVRL 2448
            || .:.:..|.|:..|:|:....|  ||..|..:.    :|   ..:...|.:.::|.:| .|..
Zfish    34 GP-LVSALPPTSFQSSSSSSDSQSPYFAKLNRRDGGGGWAP---ERTDRLRWLQVDLQERVEVTA 94

  Fly  2449 VWNLG--GTTATVTHPMVVHTRDPKYDD---AWYHVEANRTLNLGSLVVRRMNNYGELTPPNPVI 2508
            |...|  |:...||..|::      |.|   ||..             .|:.:|.|.. |.|
Zfish    95 VATQGRFGSPDWVTSYMLL------YSDTGRAWKQ-------------FRQEDNIGTF-PGN--- 136

  Fly  2509 ITGSTDTEHTRFYQSRSDRISLGGFASKDLQFTPGLNVVVHQVEVDNKPLGLWNFVTSEGSCGGS 2573
             |.|....|.:...|...|.         |:|.|          :|..|.|..........|...
Zfish   137 -TNSDGVVHHKLSHSIRTRF---------LRFLP----------MDWSPGGWMGLRVEVYGCAYK 181

  Fly  2574 MVGAKESSASSTARHFNGLGYAQLMKTRPRPTRKNLFSVQMTFRTLDENALLFLAVDDKNNRS-- 2636
            ...|..:..||....||         .:...|.|::.|::  |::...:.:|   |..:..|.
Zfish   182 SDVADFNGRSSLLYRFN---------QKSTSTVKDVISLR--FKSQRADGVL---VHGEGQRGDY 232

  Fly  2637 VSVTLSRGRIMFRIDYGDESKLEINTTKKYNVG------QWIKIEAAR-----EFSAKRSTENGM 2690
            :::.|.:||:...|:..|......:......:|      .|..:...|     .|:..|.|::
Zfish   233 ITLELHKGRLALHINLDDAKTHPSSGHVSVFLGGLLDDQHWHSVLIERFNKQINFTVDRLTKH-- 295

  Fly  2691 LRVNNDRPISGAPTLPVNIHLLPDLSKTVYYL--GGVPPGFTSGTSKAPGADNPFL-----GCMK 2748
                            |....|.|..:..|.|  ||:|         .||....||     |||:
Zfish   296 ----------------VRTGGLDDSLEVDYELSFGGIP---------LPGKPGTFLRKNFHGCME 335

  Fly  2749 DVQVNGETYDPL------ESSSYYGVEPSCKN-MITKAGF--SGNGYLELPSQSLRKRSNTALVF 2804
            ::..||.....|      :..|...|..||.. ::..:.|  |.:.:|.||..|..:..:.:|.|
Zfish   336 NLYYNGVNIIDLAKRRKPQIYSVGNVSFSCSEPVLISSTFLSSSSSFLALPLDSAAETLSVSLQF 400

  Fly  2805 RTLQPDCLLLLAAYPPEILGDYDAKDIKGNFSISLVDGQLHVWVNSGRSFIKMSS--NSSQMNDG 2867
            ||...:.:||...     ||    ||.: ...:.||.|||.  ::..||.::.|.  ....::||
Zfish   401 RTWNREGMLLSVG-----LG----KDSE-KLLLLLVHGQLR--LSHHRSALQSSDIVIGQALSDG 453

  Fly  2868 EFHVVHLIKTGRKLELMVDDELQEIRNLNGNPTVVSLPRDAGGLYIGGAPPHESYTPLAPTFVNL 2932
            ::|.:.:...|.::.|.||||......:.    .|:||  ...|.|||.|...|........:..
Zfish   454 QWHTLSISIAGYQVSLAVDDEPPSTMQMK----EVALP--GKSLLIGGCPSVLSNQGCRNPTMAY 512

  Fly  2933 EGAIRDVVFNNRTINFNDALTFANVQIGRNGPLMGSLKGGLYDVLLKTEPMIGKSFTASPEGCKR 2997
            :|.:|.||.||:.||      |..||.|    |:|:.....:|:       .|......|..|:.
Zfish   513 QGCMRSVVINNKPIN------FYLVQQG----LLGNYSKLQFDI-------CGIRDRCLPNYCEH 560

  Fly  2998 IGSYSYEPNAFKFGDDIYSYSQLKLPERHFWQRNF-------------HLSFDFRSFYP------ 3043
                          |.:.|.|         |...|             |.|.    |.|
Zfish   561 --------------DGVCSQS---------WSTFFCDCSGTGYTGATCHNSI----FEPSCEAHR 598

  Fly  3044 -----NGMLYLSP-GSKEKPKHYVALVLKDGQLVLVVRGRRREELQLTAKLNDGEWHRVTISCHD 3102
                 :|...:.| ||.......|...:.|.::..||.......:::... :..:.|.:|.:...
Zfish   599 LTGSASGFFSIDPDGSGPLKSTVVYCNITDDKVWTVVNHNSTAMVRVQGS-SLQQPHVMTFNYST 662

  Fly  3103 RKVTMSVEIGRTDQKTSAQMKLPKKIGASQLL------------------------LVGGLPQSP 3143
            ....:...:||::......:.|.:|   |:|.                        .:.|:.|..
Zfish   663 SLEQLRTLVGRSEHCQQEVVYLCRK---SRLFNTWDGTPLSWWLDRAGERRTYWGGFLPGVQQCA 724

  Fly  3144 VKVSSDLYVRLEPFKGC-LRRVSINNNT----------------QDLARPGKHS--NVG--QCFP 3187
            ..:..:. :.:..|..| ..|.|..|:|                .|..|.|..:  .:|  .||
Zfish   725 CSLDENC-IDMNHFCNCDADRSSWENDTGILSYKEHLPVTEILVGDTNRSGSEAIYRIGSLHCF- 787

  Fly  3188 TVERGSYFPGDAYAIYKKNFNVGKYL-----------DLETEFRTSELSGILLSVSDPNGFPALS 3241
                |..|..:|.:.|:::    .||           |:...|:|:..||:.|.......|  :.
Zfish   788 ----GDRFLWNAASFYQES----SYLHFPTLQAELSVDISLYFKTTAPSGVFLENLGTKDF--IR 842

  Fly  3242 LELHNGNII-FSCDPGNG-APMRVESSLPTKYALCDNKWHNISALYDGEQIVLRIDQLP-AVISV 3303
            |||...::: |:.|.||| ..:.|:|.:|    |.|.:||.:.:..:..:..|::|||| ..:..
Zfish   843 LELSGPSVVTFTFDVGNGPVVLTVKSHVP----LNDKQWHYVRSERNVREASLQVDQLPLRFLEA 903

  Fly  3304 GNQGNAGKVQTRSPLYIGGLPESAPSGSLISRE-NFKGCIRHVSIRNERRDWIEMEDLRNVLLSE 3367
            .::|:. .:|..|.|:|||         ..||: .|.||||.::|.....|..|...:...:.|.
Zfish   904 PSEGHT-HLQLNSQLFIGG---------TASRQRGFLGCIRSLNINGMTLDLEERAKMTPGVSSG 958

  Fly  3368 C 3368
            |
Zfish   959 C 959

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wb	NP_723870.1	Laminin_N	153..398	CDD:459653
		EGF_Lam	401..450	CDD:238012
		EGF_Lam	505..552	CDD:238012
		Laminin_EGF	550..597	CDD:395007
		Laminin_B	660..813	CDD:459652
		EGF_Lam	851..900	CDD:238012
		Laminin_EGF	<943..971	CDD:395007
		Laminin_EGF	974..1018	CDD:395007
		EGF_Lam	1017..1065	CDD:238012
		Laminin_EGF	1065..>1105	CDD:395007
		EGF_Lam	1150..1197	CDD:238012
		Laminin_EGF	1199..1247	CDD:395007
		EGF_Lam	1247..1292	CDD:238012
		Laminin_EGF	1294..1342	CDD:395007
		Laminin_EGF	1340..1392	CDD:395007
		Laminin_B	1486..1626	CDD:459652
		EGF_Lam	1669..1716	CDD:238012
		Laminin_EGF	1718..1767	CDD:395007
		EGF_Lam	1772..1819	CDD:238012
		YhaN	<1907..2141	CDD:443752
		SMC_prok_B	<2123..>2390	CDD:274008
		Laminin_II	2279..2400	CDD:368703	2/8 (25%)
		LamG	2399..>2492	CDD:473984	23/104 (22%)
		LamG	2586..2753	CDD:238058	35/186 (19%)
		Laminin_G_2	2804..2944	CDD:460494	40/141 (28%)
		LamG	3018..3167	CDD:238058	29/198 (15%)
		LamG	3192..3347	CDD:238058	47/169 (28%)
cntnap5b	XP_009294485.1	FA58C	57..177	CDD:238014	34/165 (21%)
		LamG	209..342	CDD:214598	32/164 (20%)
		Laminin_G_2	400..524	CDD:460494	40/141 (28%)
		EGF	553..584	CDD:394967	7/53 (13%)
		GGGWT_bact	<601..635	CDD:468872	6/33 (18%)
		LamG	798..939	CDD:238058	44/160 (28%)
		EGF	963..996	CDD:394967
		LamG	1026..1175	CDD:238058