Protein Alignment wb and cntnap5a

DIOPT Version :10

• Sequence 1: NP_723870.1
• Gene: wb / 43946
• FlyBaseID: FBgn0261563
• Length: 3375
• Species: Drosophila melanogaster
• Sequence 2: XP_009302955.1
• Gene: cntnap5a / 569185
• ZFINID: ZDB-GENE-081105-126
• Length: 1306
• Species: Danio rerio
• Alignment Length: 1139
• Identity: 232/1139 - (20%)
• Similarity: 403/1139 - (35%)
• Gaps: 322/1139 - (28%)

  Fly  2372 QIAKARHAAEAIDVSLESL--GPKC---------IRSYLPASYGLSTSNKIRMSFALSNHLESSP 2425
            |:.|:|  |.|:.::|.|:  ...|         :.|.||||           ||..|:|...|.
Zfish     2 QLPKSR--AFAVSLTLLSVLSSAMCGSQYSCDGSLSSLLPAS-----------SFQSSSHFSDSR 53

  Fly  2426 LIHLASSEGRHITLELYKRRVRLVWNLGGTTATVTHPMVVHTRDPKYDD--AWYHVEANRTLNLG 2488
            ..:.|         :|.||.....|:                  |::.|  .|..|:....:.:.
Zfish    54 AAYFA---------KLNKREGGGGWS------------------PEWMDRSPWLQVDLQDRMEVT 91

  Fly  2489 SLVVRRMNNYGELTPPNPVI-------------------ITGSTDTEHTRFYQ-SRSDRISLGGF 2533
            ::..:..::..:......::                   |.|:.:||....:: |.|.|
Zfish    92 AVATQGRHSSTDWVSAYMLLYSDTGRVWKQYMLEDSVGRIVGNVNTESVVHHKLSHSIR------ 150

  Fly  2534 ASKDLQFTP---------GLNVVVHQVEVDNKPLGLWNFVTSEGSCGGSMVGAKESSASSTARHF 2589
             ::.|:|.|         ||.|.|:                   .|......|.....||....|
Zfish   151 -TRFLRFVPLEWSPSGRVGLRVAVY-------------------GCAYRSYVADFDGRSSLLYRF 195

  Fly  2590 NGLGYAQLMKTRPRPTRKNLFSVQMTFRTLDENALLFLAVDDKNNRSVSVTLSRGRIMFRIDYGD 2654
            |         .:...|.|::.|::  |::.....:| |..:.:....:::.|.|||:...::. |
Zfish   196 N---------QKSMSTVKDVISLR--FKSRQAEGVL-LHGEGQRGDYITLELHRGRLALHLNL-D 247

  Fly  2655 ESKLEINTTKK-YNVG------QWIKIEAAR-----EFSAKRSTENGMLRVNNDRPISGAPTLPV 2707
            :|::..::.:. ..:|      .|..:...|     .|:..|.|::...:.:.|       :|.|
Zfish   248 DSRVRSSSARMVVTLGSLLDDLHWHSVLIERFNKQVNFTLDRHTQHFRTKGDGD-------SLEV 305

  Fly  2708 NIHLLPDLSKTVYYLGGVPPGFTSGTSKAPGADNPFL-----GCMKDVQVNGETYDPL------E 2761
            :..|         ..||:|         .||....|:     |||:::..||.....|      :
Zfish   306 DYEL---------SFGGIP---------LPGKPGTFIRRNFHGCMENLYYNGVNIIDLAKRRKPQ 352

  Fly  2762 SSSYYGVEPSCKN---MITKAGFSGNGYLELPSQS-LRKRSNTALVFRTLQPDCLLLLAAYPPEI 2822
            ..|...|..||..   :.|....|.:.:|.||:.: :.:..:..|.|||..||.|||
Zfish   353 IYSVGNVTFSCSEPQLVATTFQSSSSSFLSLPAPAPVLEGLSVRLQFRTWNPDGLLL-------- 409

  Fly  2823 LGDYDAKDIKGNFSISLVDGQ----LHVWVNSGR-------SFIKMS--SNSSQMNDGEFHVVHL 2874
                         |..|:..|    |.:.::|||       |.:|||  |...::|||.:|.|.|
Zfish   410 -------------SSPLISAQDSCYLILKISSGRLHLTHQTSALKMSEVSAGQRVNDGLWHSVSL 461

  Fly  2875 IKTGRKLELMVDDELQEIRNLNGNPTVVSLPRDAGGLYIGGAPPHESYTP-LAPTFVNLEGAIRD 2938
            ...|.::.:.:|:|.....:|......    :|.  .|.||.|..::.:. |.||.. .:|.:|.
Zfish   462 SARGLQMTMTLDNEPASSIHLKNYLEA----KDK--QYFGGCPVSQNDSSCLNPTMA-FQGCVRL 519

  Fly  2939 VVFNNRTINFNDALTFANVQIGRNGPLMGSLKGGLYDVLLKTEPMIGKSFTASPEGCKRI-GSYS 3002
            ::.||:.:   |.|:.....:|....|...| .|:.|..|       .:|......|.:. .|:|
Zfish   520 ILINNQPV---DLLSVQQGHLGSYNQLQFDL-CGIRDRCL-------YNFCEHGSRCSQTWSSFS 573

  Fly  3003 YEPNAFKFGDDIYSYSQLKLPERHFWQRNFHLSFDFRSFYPNGMLYLSP--------GSKEKPKH 3059
            .:.:...:.......|..:....|:  |....|..:.|..|:|...|.|        |:|
Zfish   574 CDCSGTGYSGATCHNSVYEASCEHY--RLAGSSSGYFSIDPDGSGPLDPIQVYCNITGNK----- 631

  Fly  3060 YVALVLKDGQLVLVVRGRRREEL------------QLTAKLNDGEWHRVTISCHDRK-------- 3104
            ...:|..:....:.|:|...::.            ||.|.|:..|.....||.|.||
Zfish   632 VWTVVRHNSSNPVRVQGSSLQKPHVEWFNYSSSSDQLKALLSLSEHCEQRISYHCRKSRLFNPWD 696

  Fly  3105 -VTMSVEIGRTDQKTSAQMKLPKKIGASQLLLVGGLPQSPVKVSSDL---YVRLEPFKGC-LRRV 3164
             ..:|..:.|..:|.:               ..||......:.|..|   ...:..|..| ..||
Zfish   697 GTPLSWWVDRRGEKRT---------------YWGGFQPGVQQCSCGLEESCADMNYFCNCDADRV 746

  Fly  3165 SINNNTQDLA----RPGKHSNVGQCFPTVERGSYFPG-----------DAYAIYK-------KNF 3207
            |..|:|..|:    .|.:...:|..:.......|..|           :|.:.|:       .:.
Zfish   747 SWENDTGVLSYKEHLPVREIVIGDTYRLGSEAMYVVGPLQCSGDKSLWNAVSFYQAASYLQFASL 811

  Fly  3208 NVGKYLDLETEFRTSELSGILLSVSDPNGFPALSLELHNGN-IIFSCDPGNG-APMRVESSLPTK 3270
            .....||:...|:|:..||:.|.....:.|  :.:||.:.. :.||.:.|:| ..:.|:|.:|
Zfish   812 QAELSLDVSFFFKTASPSGVFLENIGLHDF--IRVELSSPTAVTFSFNVGDGPVVLTVKSPVP-- 872

  Fly  3271 YALCDNKWHNISALYDGEQIVLRIDQLP-AVISVGNQGNAGKVQTRSPLYIGGLPESAPSGSLIS 3334
              |.|.:||.:.|..:.::..|::|||| .:|.....|:. ::|..:.|::|        |:...
Zfish   873 --LNDRQWHWVRAERNVKEACLQVDQLPLRIIETPPDGHL-RLQLGNQLFVG--------GTATR 926

  Fly  3335 RENFKGCIRHVSIRNERRDWIEMEDLRNVLLSEC 3368
            :..|.||||..::.....|..|...:...:.|.|
Zfish   927 QRGFLGCIRAFNMNGVNFDLEERAKVTPGVSSGC 960

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wb	NP_723870.1	Laminin_N	153..398	CDD:459653
		EGF_Lam	401..450	CDD:238012
		EGF_Lam	505..552	CDD:238012
		Laminin_EGF	550..597	CDD:395007
		Laminin_B	660..813	CDD:459652
		EGF_Lam	851..900	CDD:238012
		Laminin_EGF	<943..971	CDD:395007
		Laminin_EGF	974..1018	CDD:395007
		EGF_Lam	1017..1065	CDD:238012
		Laminin_EGF	1065..>1105	CDD:395007
		EGF_Lam	1150..1197	CDD:238012
		Laminin_EGF	1199..1247	CDD:395007
		EGF_Lam	1247..1292	CDD:238012
		Laminin_EGF	1294..1342	CDD:395007
		Laminin_EGF	1340..1392	CDD:395007
		Laminin_B	1486..1626	CDD:459652
		EGF_Lam	1669..1716	CDD:238012
		Laminin_EGF	1718..1767	CDD:395007
		EGF_Lam	1772..1819	CDD:238012
		YhaN	<1907..2141	CDD:443752
		SMC_prok_B	<2123..>2390	CDD:274008	6/17 (35%)
		Laminin_II	2279..2400	CDD:368703	9/38 (24%)
		LamG	2399..>2492	CDD:473984	18/94 (19%)
		LamG	2586..2753	CDD:238058	33/183 (18%)
		Laminin_G_2	2804..2944	CDD:460494	41/153 (27%)
		LamG	3018..3167	CDD:238058	36/181 (20%)
		LamG	3192..3347	CDD:238058	42/175 (24%)
cntnap5a	XP_009302955.1	FA58C	54..175	CDD:238014	23/173 (13%)
		LamG	182..338	CDD:238058	36/193 (19%)
		Laminin_G_2	399..525	CDD:460494	41/153 (27%)
		EGF	554..585	CDD:394967	5/37 (14%)
		GGGWT_bact	594..636	CDD:468872	10/48 (21%)
		COLFI	605..>689	CDD:470578	19/88 (22%)
		LamG	804..940	CDD:238058	38/150 (25%)
		Laminin_G_2	1048..1177	CDD:460494