Protein Alignment wb and ush2a

DIOPT Version :10

• Sequence 1: NP_723870.1
• Gene: wb / 43946
• FlyBaseID: FBgn0261563
• Length: 3375
• Species: Drosophila melanogaster
• Sequence 2: XP_009291422.2
• Gene: ush2a / 568982
• ZFINID: ZDB-GENE-060503-794
• Length: 5243
• Species: Danio rerio
• Alignment Length: 3505
• Identity: 636/3505 - (18%)
• Similarity: 975/3505 - (27%)
• Gaps: 1693/3505 - (48%)

  Fly    15 LILLVTHCQAKRQRKRLRGFSTAKDLQ-DYSMPLNDNSTELQQNIVSWTGARIASSPDKKKKSPQ 78
            |:||||              .:.||:| .|.:......|....:|..|  |.:|
Zfish   189 LVLLVT--------------VSEKDIQIHYGIQSISMKTAGHISIGHW--AHLA----------- 226

  Fly    79 SSRRHKTKSGLIIESNIADSESM----LA-----IASSESVTKKKPPQRRRNGKLQKSGGGAGGG 134
             .:.|:|...|.:..|..|..::    ||     |.|..:|.    ..|..||..|..|
Zfish   227 -LQIHETSVSLFLNGNEEDGTALDTQTLAGLVDDITSDGAVW----IGRSSNGSNQFIG------ 280

  Fly   135 ALRLL------KT------EDVYSSSF------SGGLYPPLFNVVPRAQISVNATCGQNGAEE-- 179
              |:.      ||      |:||:..|      |..|.|...   ||....|...|..|.|.:
Zfish   281 --RMQDFRFYPKTLTNREIEEVYTGQFPHLHSQSTCLCPASH---PRVHPLVERYCIPNAANDTT 340

  Fly   180 YCKQVGAKPCGICNAHSSDRAKQRSIQSLISSGSGSGSGSGFEEGWWQS--PTLQ----GGRQFE 238
            :.|.:....    :||..|......|.:.                |..|  |:::    |
Zfish   341 HNKVLRLNQ----DAHPLDYINDNDIGTT----------------WISSIFPSIELLDKG----- 380

  Fly   239 YVTILLDLKQ-TFQIFSVWLKSANSPRPASWILEKSLDGINFEPWQ-------YFGLSDADCQRR 295
             :||.:||:. .:|:|.|.|:..|:...|..|..|::....::.||       |||:.|
Zfish   381 -ITITIDLENGQYQVFYVILQFLNAQPEAVRIQRKTVGSSEWKDWQFLAKNCSYFGMED------ 438

  Fly   296 WNLSGQNGKYVFQNDTEIICSTQFSKPGPLENGVLHASLL----KNRPGATD--QSPELMKFITT 354
                  ||  ...:...:.| .|.....|...|.:..|:|    ..|||..|  .|..|.:|:..
Zfish   439 ------NG--ALDSPDSVNC-LQLPSDIPYSRGNITFSMLTPEPNLRPGYNDFYNSAALQEFVRA 494

  Fly   355 RYIRIRLQGMHSTANQDNSLDWLLDSPSLEKHSFYSLSQLKVSARLDCNGHANRSHESPDDPLMQ 419
            .::||:|.|.:.|  ||.::.:        :|.:|::.::.:|.|.:|:|||:....|.......
Zfish   495 THVRIQLHGQYHT--QDATVPF--------RHRYYAVDEITISGRCECHGHADSCDTSVSPYRCA 549

  Fly   420 CICQHNTCGAQCEQCCPLFQDRPYQMGGE-----CEICQCYGHAESCTYDPFLDK---------- 469
            |:.:.:|.||.||:|.|||.|:|::.|.:     |..|||||||.||.|:..||.
Zfish   550 CLPESHTHGANCERCIPLFNDKPFRPGDQIQAFNCRPCQCYGHASSCHYNSSLDPHPGEHFRGGG 614

  Fly   470 GICQSCSNNTAGIECEFCEMGFYRELDAPLTDPCLPCSCNPARSTGGCQSDGGSCNCLEGFQGKN 534
            |:|..|::||.|..||.|...||||:.|.|
Zfish   615 GVCDDCTHNTTGRNCERCRSLFYREVGALL----------------------------------- 644

  Fly   535 CEECAPGYYGDDCKRCECDERGSLGSTGSC---SGVCQCKLNVEGSTCSECAPGYFDLSAENAEG 596
                   :..|.||.|||...|::.::..|   .|.|:||.:|.|..|::|..|::.|.:..|:|
Zfish   645 -------WATDVCKACECHSAGTINASLHCEPIGGQCKCKRHVSGRQCNQCQHGFYKLQSALADG 702

  Fly   597 CTSCWCSGVSQTCHSAKLQTLAFETLNDWKITDIQRVKPISIPVDAETNRLIFANELDEVEAIYW 661
            |.:|.|:
Zfish   703 CRACNCN---------------------------------------------------------- 709

  Fly   662 QASLGYLGNRLTSYGSRLQLVLSWDVIRGDRSGKPTTGPNVILVGKNGLKIAFGDESLDGLGINL 726
                                               |.|.
Zfish   710 -----------------------------------TAGT-------------------------- 713

  Fly   727 NVTLTEVGWYHVPPTVVDIKTRLRRTEGGDYHGESVTRSQFLSVLVSLDAVLIRAAFHTDQGETS 791
                       |.|.:                                       ..|.|.|
Zfish   714 -----------VQPDI---------------------------------------TCHQDSG--- 725

  Fly   792 LERAVIYSGGVELGGKSSSQVEQCLCPAGYTGLSCEGCAFGFKRIYENTSDHQILSKCIPCPCNG 856
                                  ||.|.|...||:|:.|.:|||.:                   .
Zfish   726 ----------------------QCQCKANVIGLTCDRCNYGFKFL-------------------N 749

  Fly   857 HSNSCDLQSGNCGDCMHNTFGDRCERCQLGYYGNPLQGTPNDCKRCACPLSEDSNNFSPSCQLKS 921
            |:|
Zfish   750 HTN-------------------------------------------------------------- 752

  Fly   922 YNYMDLNPQFELIEHAEYICTQCPEGYTGDHCQVCDDGYFGNPRQPGSSCQRCDCAGGPCNVTTG 986
                                   |:|
Zfish   753 -----------------------PDG--------------------------------------- 755

  Fly   987 ECITCRGNTEGWHCERCKLGYWGDPAVGCDPCHCHTEGSESGLCDSTDGQCLCKPRYAGQKCDEC 1051
                                                                             
Zfish   756 ----------------------------------------------------------------- 755

  Fly  1052 DVGYANVELRCPSCNCDPLGSLVQDRCDPHTGQCHCKEGVMGAKCHECQDGYFGMNAVAYRMDDL 1116
                      |.||.|||.|||.| .|:|.||||.||.||.|..|..|...::..|
Zfish   756 ----------CISCGCDPWGSLHQ-FCNPFTGQCECKAGVRGPLCDTCIPHFYSQN--------- 800

  Fly  1117 AALRQNSDSDDDEWELVPDTEDPNSESTVACEECHCSSVGSL-SSDCDKRTGQCACLANVTGRRC 1180
                                      |:..|..|:||..||: .:.||..||||.|..:..||||
Zfish   801 --------------------------SSGVCLPCNCSLNGSVPGTSCDAVTGQCKCKPHTEGRRC 839

  Fly  1181 DKCRPGHWNLTAGE--GCRDCRCDPHGSRGHE--CNPWTGQCDCKIGVGGQHCNECTEGFFGFS- 1240
            |.||.|:.:|....  ||..|:||..|:....  |:..||||.||..|....||.|:...:..|
Zfish   840 DVCRDGYHSLDRSNSLGCLPCQCDLRGTVNGSGVCDKTTGQCLCKNNVESLRCNRCSAHTYNLSS 904

  Fly  1241 ---TEGCQRCSACRSEG----QVCDPHNGRCICPKFTRGLGCGQCVPGTWGWQARLG-CRECECD 1297
               |.|||.| .|...|    .||||.:|:|||.....|..||.|.||.:..:|.|. |..|||.
Zfish   905 ANATHGCQPC-YCDHIGTVPATVCDPVSGQCICLPTRYGRDCGTCKPGFFLSEAGLSECEVCECH 968

  Fly  1298 HIGSIGQQCSTGDGQCQC-REGYSGRKCDTCAIGYFGY----PECRRCGCDAEGSFTQADGSIAC 1357
            .:|::||.|:...|||.| ....:|.:||.|...:||:    ..|..||||..|.|   :|:  |
Zfish   969 SVGAMGQVCAAHSGQCVCAHPSLTGHRCDQCQDLFFGFNPSVGRCEPCGCDPVGGF---NGT--C 1028

  Fly  1358 -DSNGQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGCTRCFCFGRSGECEQSDLSWGHIRMAESRN 1421
             ...|||.||..|.|.|||.|::....:...|..||::        :.:|.....|  |:..|..
Zfish  1029 HPQTGQCLCKPFVTGDKCDACVEGASFMDPNNYLGCSK--------DPQQQPPPLG--RVLNSTT 1083

  Fly  1422 LSVQQIRPHSVPSSDYEYIVVVQMEGSSFHREDAEIQRMNDLSLVPKSTGNVSIGAYGQFYHPLY 1486
            :.:....|.|..|:...|.:                  :.|..::..|...          ||.
Zfish  1084 IELSWRAPDSPNSNALMYTL------------------LRDTQIIHVSHSQ----------HPF- 1119

  Fly  1487 FQLPPQFYGDRTSSYGGFLYFTLITEGAHKPLERNILGQYPLVQLHAHSKLLLDFYEYEEFEYSL 1551
                            |.::|   .:.|..|                          |..:.|.|
Zfish  1120 ----------------GTMHF---IDTALSP--------------------------YTSYSYQL 1139

  Fly  1552 NVTHRVPLHESFWKYHHTSQAVDRNTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMDAAIYIKG 1616
             :|..:       :.:.:|..|...||.|..:.              :|:.|
Zfish  1140 -ITSNI-------RSNTSSSVVTLRTLSAVPEQ--------------EELQL------------- 1169

  Fly  1617 STNLIAKGVERCKCPKRFDGLSCQDPGRSFYRWRNTTIVESVFIEDLIGRAAPCHCNGRSSDCDR 1681
                                                         .|:|||.|   |..|.:
Zfish  1170 ---------------------------------------------TLVGRAKP---NSASFN--- 1183

  Fly  1682 ETGVCQNCRGNTGGDHCHQCAEGFYGDPNSPHGCQACPCPETNRNFARGCNVWDGEVSCVCKPGY 1746
                                                                |.
Zfish  1184 ----------------------------------------------------WT----------- 1185

  Fly  1747 TGRLCERCQAGYFGDPMRYPNTTCQPCNCHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQAERH 1811
                          :|:   |||..
Zfish  1186 --------------EPL---NTTGP---------------------------------------- 1193

  Fly  1812 HLVDNGCKICDNCTLLLLDYMELVGNKLRRGMHNMDLTGIPAPYRKLSEYESAYEKWNGRHWDFS 1876
                     .||.||..:                .||:|....|            :.|.
Zfish  1194 ---------IDNYTLSSI----------------QDLSGEKRIY------------YTGH----- 1216

  Fly  1877 QTKRRLQDYDSADILKLEAHAENLKFQSRKAVATIGKREFAIKSMREDAVTQQHSVGLLRSE--I 1939
            ||               ||.||.|:        ...:..|::|:..:.        |..|||  :
Zfish  1217 QT---------------EATAEELQ--------PFTRYNFSLKACTDG--------GCARSESLV 1250

  Fly  1940 LQTLSDLHGYGKSAHYLSLPTALKQARFYLQAIREHDQMVQGIRSTNDCAWKHFYAMGNASDASF 2004
            :||..                           |....|....|.:..
Zfish  1251 VQTAQ---------------------------IPPEQQPAPKITTLG------------------ 1270

  Fly  2005 DESGRLEMLWRDLNQTNHRVVDMRLQVDRVQEVENEAEDVLEHVRNLSIRVGESHQELDELNQRI 2069
              |.:|::.|......|..::...|.:                            |.|:||.:..
Zfish  1271 --SSQLKVDWEPPVLPNGIIIRYELFM----------------------------QLLNELQRNA 1305

  Fly  2070 SDHLDPGYLEQGEGLLRLTVQRQIMLNGHLNQLDGYRILLNTTLGVKTEQQREVRKHWLPKAEKH 2134
            |.:          |    |.||..:.:|.||.
Zfish  1306 SSY----------G----TEQRVFLSSGWLNP--------------------------------- 1323

  Fly  2135 ASHLLARSNEYARKFQPTRNGARIAMLASSAHSNITEAINDARLASILAKERVYEAQRTLYPSDG 2199
                           :|:         .|||:.|                        .|.|.:.
Zfish  1324 ---------------RPS---------LSSANEN------------------------ALTPPES 1340

  Fly  2200 SSMIERAK-HSLHRSKQLQQEALKQMHKSNVLKDKLHRQEQQVEGIKSTIYDSGLRTNNISGQLQ 2263
            :.::...: .|.:|.:.|                                      |.|::|.:
Zfish  1341 TVVVSNLQPFSTYRFRVL--------------------------------------TVNMAGSV- 1366

  Fly  2264 GLSDGSARRQAKDSLE-MADRTGEQMRAELQKAKDMQKSIQNMRNSFSNLEPDWE------IKLG 2321
             |||.:..|.|:...| ||.   .|:.|.                |.|:|...||      ::..
Zfish  1367 -LSDWAVGRTAEGVPEYMAP---PQVSAV----------------SSSSLRVSWETPRDKDVRGE 1411

  Fly  2322 MAQENISLTQTNLRLANVSLSYLEQQAEKEQQVFEVWNNSMAQQLQQLRDQIAKARHAAEAIDVS 2386
            :.:..::|.|                        |..:|..|..:      :.:..::..|.:.|
Zfish  1412 VTEYRVNLHQ------------------------EQMSNPYAPPI------VTQVLYSGSAQEHS 1446

  Fly  2387 LESLGPKCIRSYLPASYGLSTSNKIRMSFALSNHLESSPLIHLASSEGRHITLELYKRRVRLVWN 2451
            ..:.|.|....|   |:.::..|:       ...:.|||      :.||               .
Zfish  1447 YTAGGLKAYEEY---SFTVTVCNR-------QGCVSSSP------ASGR---------------T 1480

  Fly  2452 LGGTTATVTHPMVVHTRDPKYDDAWYHVEANRTLNLGSLVVRRMNNY----GELTPPNPVIITGS 2512
            |....|.:..|.:                  |.||:.:     ||.:    .||..|.|:
Zfish  1481 LPSAPAGLRAPGL------------------RPLNMTA-----MNVFWDAPAELNGPPPL----- 1517

  Fly  2513 TDTEHTRFYQSRSDRISLGGFASKDLQFTPGLNVVVHQVEVDNKPLGLWNFVTSEGSCGGSMVGA 2577
                   ::..|:| :||     .|.|                                |.::
Zfish  1518 -------YHVERTD-VSL-----SDAQ--------------------------------GQVI-- 1535

  Fly  2578 KESSASSTARHFNGLGYAQLMKTRPRPTRKNLFSVQMTFRTLDENALLFLAVD-DKNNRSVSVTL 2641
                   ..|.|.|.|:.: ..:...|...:...:|::|||..|..||..||. .:....|::.:
Zfish  1536 -------RGRRFTGSGFFR-FPSATLPVNADFTGLQLSFRTRAEEGLLLFAVSPGEQEEYVALQI 1592

  Fly  2642 SRGRIMFRIDYGDESKLEINTT----KKYNVGQWIKIEAAREFSAKRSTENGMLRVNND-----R 2697
            ..||..|..| ...|.:.::..    ::||..||..:.|.|:.:.      |.:.|:|.     .
Zfish  1593 HNGRPYFLFD-PQASAVALSPRNDGGRRYNDNQWHHLIATRKQAV------GTIIVDNQYSGSAS 1650

  Fly  2698 PISGAPTLPVNIHLLPDLSKTVYYLGGVPPGFT-----SGTSKAPGADNPFLGCMKDVQV----- 2752
            ..||:..:..|         |..::||:|..||     :|.:|.  ....|.||::||.|
Zfish  1651 ATSGSTIIGQN---------TGVFIGGIPENFTILRQDAGQAKL--VQQGFAGCLRDVLVQKSSG 1704

  Fly  2753 NGETYDPL--ESS--------SYYGVEPSCKNMITKAGFSGNGYLELPSQSLRKRS--NTALVFR 2805
            ..|.::||  ||:        |:.|.....:|   .|.|.|:|:|::..:.|...:  ..:..|:
Zfish  1705 TNEAWEPLDWESALETHETYESWEGCPAVSEN---GAYFLGHGFLKVKPEILTGGNYFEISFEFK 1766

  Fly  2806 TLQPDCLLLLAAYPPEILGDYDAKDIKGNFSISLVDG--------------QLHVWVNSGRSFIK 2856
            |.|.:.|||.|.       :.|.||    |.::.:.|              :|.|||  |.|:.
Zfish  1767 TDQLNALLLFAY-------NIDGKD----FILAELQGGVLFWVLRWGEQTVELSVWV--GLSYC- 1817

  Fly  2857 MSSNSSQMNDGEFHVVHLIKTGRKLELMVDDELQEIRNLNGNPTVVSLPRDAGGLYIGGAPPHES 2921
                     ||.::.:.::|.|......::|..::.|...|.|..:|.|     |||||.||..:
Zfish  1818 ---------DGGWNTLSVLKRGHLASAGLNDMYEQERKATGGPLTISSP-----LYIGGVPPGVT 1868

  Fly  2922 YTPLAPTFVNLEGAIRDVVFNNRTINFNDALTFANVQIGRNGPLMGSLKGGLYDVLLKTEPMIGK 2986
            :..|                |..:                   |:....|.:.||.|...|::..
Zfish  1869 HPAL----------------NKHS-------------------LLHGFGGCIRDVRLARGPVVSL 1898

  Fly  2987 SFTASP------EGCKRIGSYSYEPNAFKFGDDIYSYSQLKLPERHFWQRNFHLSFDFRSFYPNG 3045
            :..:|.      :||                                      ||.|
Zfish  1899 AAVSSSAVRVNLDGC--------------------------------------LSAD-------- 1917

  Fly  3046 MLYLSPGSKEKPKHYVALVLKDGQLVLVVRGRRREELQLTAKLNDGEWHRVTISCHDRKVTMSVE 3110
                           .::..:....:||..||.|....||.:......:||..|.....:....:
Zfish  1918 ---------------TSVNCRGNDSILVYTGRDRSAEDLTLQPFTEYLYRVMASGEGGWIGGPWQ 1967

  Fly  3111 IGRTDQKTSAQMKLPKKIGASQLLLVGGLPQSPVKVSSDLYVRLEP--FKGCLRRVSINNNTQDL 3173
            .||:.:.....:..|.::|:     |.|   |.|:||.:     ||  .:|.:.:..:...::|
Zfish  1968 RGRSRETVPQSVLPPSRVGS-----VNG---SSVEVSWE-----EPAEVRGVIEKYVLKAYSRD- 2018

  Fly  3174 ARPGKHSNVGQCFP-----TVERGSYFPGDAYAI--------------YKKNFNVGKYLDLETEF 3219
             || ..|.:...||     |.......|..:|:|              :...||..:....|...
Zfish  2019 -RP-SFSPISATFPHSQHLTGTLSGLAPFSSYSITLTACTQAGCSESPFATGFNTPQEAPEEVPP 2081

  Fly  3220 RTSELSGILLSV-----SDPNGFPALSLELHNGNIIFS--------CDPGNGAPMRVESSLPTKY 3271
            ..:......|||     ..|||.....:...|..:::.        .|.|...|.::..|..|:
Zfish  2082 PAAVSYPNALSVHWNHPPKPNGIITQYILYKNNTVLYRGNSTSFNITDVGVFTPHKLLLSACTE- 2145

  Fly  3272 ALCDNKWHNISALYDGEQIVLRIDQL------PAVISVGNQGNAGKVQTRSPLYIGGLPE 3325
            |.|.|          ..|:.|...||      |.:::| ....:..:|..:|:.:.||.|
Zfish  2146 AGCTN----------STQVTLFTGQLPPTYVEPPILTV-LDARSIHIQWAAPVEVNGLLE 2194

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wb	NP_723870.1	Laminin_N	153..398	CDD:459653	59/266 (22%)
		EGF_Lam	401..450	CDD:238012	18/53 (34%)
		EGF_Lam	505..552	CDD:238012	4/46 (9%)
		Laminin_EGF	550..597	CDD:395007	16/49 (33%)
		Laminin_B	660..813	CDD:459652	7/152 (5%)
		EGF_Lam	851..900	CDD:238012	2/48 (4%)
		Laminin_EGF	<943..971	CDD:395007	2/27 (7%)
		Laminin_EGF	974..1018	CDD:395007	0/43 (0%)
		EGF_Lam	1017..1065	CDD:238012	1/47 (2%)
		Laminin_EGF	1065..>1105	CDD:395007	21/39 (54%)
		EGF_Lam	1150..1197	CDD:238012	22/49 (45%)
		Laminin_EGF	1199..1247	CDD:395007	20/53 (38%)
		EGF_Lam	1247..1292	CDD:238012	19/49 (39%)
		Laminin_EGF	1294..1342	CDD:395007	19/52 (37%)
		Laminin_EGF	1340..1392	CDD:395007	20/52 (38%)
		Laminin_B	1486..1626	CDD:459652	15/139 (11%)
		EGF_Lam	1669..1716	CDD:238012	3/46 (7%)
		Laminin_EGF	1718..1767	CDD:395007	2/48 (4%)
		EGF_Lam	1772..1819	CDD:238012	0/46 (0%)
		YhaN	<1907..2141	CDD:443752	28/235 (12%)
		SMC_prok_B	<2123..>2390	CDD:274008	35/274 (13%)
		Laminin_II	2279..2400	CDD:368703	20/127 (16%)
		LamG	2399..>2492	CDD:473984	13/92 (14%)
		LamG	2586..2753	CDD:238058	46/186 (25%)
		Laminin_G_2	2804..2944	CDD:460494	37/153 (24%)
		LamG	3018..3167	CDD:238058	26/150 (17%)
		LamG	3192..3347	CDD:238058	32/167 (19%)
ush2a	XP_009291422.2	None