DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wb and lamc2

DIOPT Version :9

Sequence 1:	NP_723870.1	Gene:	wb / 43946	FlyBaseID:	FBgn0261563	Length:	3375	Species:	Drosophila melanogaster
Sequence 2:	XP_003197932.2	Gene:	lamc2 / 567928	ZFINID:	ZDB-GENE-110222-3	Length:	1182	Species:	Danio rerio

Alignment Length:	695	Identity:	205/695 - (29%)
Similarity:	293/695 - (42%)	Gaps:	169/695 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   452 CQCYGHAESCTYDPFLDKGI-CQSCSNNTAGIECEFCEMGFYRELDAPLTDPCLPCSCNPARSTG 515
            |.|:|.|..|..|..   |: |.:|..||.|..||.|:.|:|.:...   |.|:||:||||.|.|
Zfish    73 CSCHGKARFCRADQL---GLYCLNCQGNTQGRHCESCKEGYYHQRAG---DNCVPCNCNPAGSQG 131

  Fly   516 GCQSDGGSCNCLEGFQGKNCEECAPG--YYGDDCK----RCECDERGSLGSTGSCSGVCQCKLNV 574
            ...|..|.|.|.:|..|..|:.|..|  ...:.|:    ||.....|.|
Zfish   132 PVCSSNGQCTCKQGIHGDKCDRCHDGSPVTANGCEPLRLRCWSRNNGRL---------------- 180

  Fly   575 EGSTCSECAPGYFDLSAENAEGCTSCWCSGVSQTCHSAKLQ-----TLAFET-LNDWKITDIQRV 633
                            ..|.|.|..|:|:|.|..|.||:..     |..||. ...|:....|.|
Zfish   181 ----------------TYNTEECLPCFCNGHSNVCSSAEGYSVYNITSPFENGPEGWRAATAQGV 229

  Fly   634 KPISIPVD-AETNRLIFANELD----EVEAIYWQASLGYLGNRLTSYGSRLQLVLSWDVIRGDRS 693
            .|..:... :.|::     :|:    |:..:|..|...|||||..|||..|...|..|  ||.|
Zfish   230 NPSQVQFRWSPTHK-----DLEVISKEILPVYLFAPATYLGNRALSYGQTLTFSLRLD--RGVR- 286

  Fly   694 GKPTTGPNVILVGKNGLKIAFGDESLDGLGINLNVTLTEVGWYHVPPTVVDIKTRLRRT-----E 753
             :|:|                .|..|:|.|:.::.:|.::      .|||....::..|     :
Zfish   287 -RPST----------------SDVVLEGAGLKVSASLGDL------RTVVPCGKKITYTFRLDEQ 328

  Fly   754 GGDYHGESVTRSQFLSVLVSLDAVLIRAAFHTDQGETSLERAVIYSGGVELG-GKSSSQVEQCLC 817
            .|......::.::|.::|.:|.|:.||..| .:.|...|:...:.|  .:|| |..:..||:|.|
Zfish   329 PGSKWKPQLSSAEFQTLLSNLTAIKIRGTF-GENGRGYLDDVSLVS--AKLGPGTPALWVEKCRC 390

  Fly   818 PAGYTGLSCEGCAFGFKRIYENTSDHQILSKCIPCPCNGHSNSCDLQSGNC--GDCMHNTFGDRC 880
            ||.|.|..||.||.||:|:.......   |.|:||.|.|  .:||.::|.|  .|.:.|     .
Zfish   391 PAEYDGHFCEHCATGFRRLIPGQGPR---SPCVPCSCQG--GACDPETGGCYSADEIPN-----L 445

  Fly   881 ERCQLGYYGNPLQGTPNDCKRCACPLSEDSNNFSPSCQLKSYNYMDLNPQFELIEHAEYICTQCP 945
            :.|..|||.|  :...|.|::|.|...:       ||      |:....|       |..||:||
Zfish   446 QMCPRGYYVN--RQLSNSCQKCPCREGD-------SC------YVIGGTQ-------EVTCTRCP 488

  Fly   946 EGYTGDHCQVCDDGYFGNP---RQPGSSCQRCDCAG-------GPCNVTTGECITCRGNTEGWHC 1000
            .|.||..|::||||::|:|   ..|...||.|.|.|       |.|:..||:|..|..::.|.:|
Zfish   489 RGTTGSRCEICDDGFYGDPLGEYGPRKQCQPCQCYGHVDQNAVGNCDRRTGQCRKCLNHSTGPNC 553

  Fly  1001 ERCKLGYWGD-PAVGCDPCHCHTEGSESGLCDSTDGQCLCKPRYAGQKCDECDVGYANVELRCPS 1064
            |.|:.||..: |...|..|:|:.:||.|..| |..|||.||..|.|.:|:|.         .|||
Zfish   554 EYCEAGYHHNYPTEPCQACNCNRQGSVSNSC-SDKGQCECKEGYDGLRCEES---------TCPS 608

  Fly  1065 CNCDPLGSLVQDRCDPHTGQCHCKEGVMGAKCHECQDGY--FGMN 1107
            | .:|:.|.::               |...:..|.:|.:  ||.|
Zfish   609 C-FNPVKSKIE---------------VYARQLQEMEDLFKGFGGN 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wb	NP_723870.1	Laminin_N	164..396	CDD:278484
		EGF_Lam	401..450	CDD:238012
		TNFRSF	<407..507	CDD:304602	20/55 (36%)
		EGF_Lam	505..552	CDD:238012	20/52 (38%)
		Laminin_EGF	550..597	CDD:278482	5/46 (11%)
		Laminin_B	660..798	CDD:278481	37/142 (26%)
		EGF_Lam	851..900	CDD:238012	16/50 (32%)
		Laminin_EGF	<943..971	CDD:278482	13/30 (43%)
		VSP	953..1414	CDD:146106	55/168 (33%)
		Laminin_EGF	974..1018	CDD:278482	17/51 (33%)
		EGF_Lam	1017..1065	CDD:238012	18/47 (38%)
		Laminin_EGF	1065..>1105	CDD:278482	6/41 (15%)
		EGF_Lam	1150..1197	CDD:238012
		Laminin_EGF	1199..1247	CDD:278482
		EGF_Lam	1247..1292	CDD:238012
		Laminin_EGF	1294..1342	CDD:278482
		Laminin_EGF	1340..1392	CDD:278482
		Laminin_B	1486..1611	CDD:278481
		EGF_Lam	1669..1716	CDD:238012
		Laminin_EGF	1718..1767	CDD:278482
		EGF_Lam	1772..1819	CDD:238012
		CrfC	<1933..2267	CDD:223771
		Laminin_II	2277..2400	CDD:283628
		LamG	2399..>2492	CDD:304605
		Laminin_G_2	2616..2755	CDD:280389
		Laminin_G_2	2804..2944	CDD:280389
		Laminin_G_2	3038..3169	CDD:280389
		LamG	3192..3347	CDD:238058
lamc2	XP_003197932.2	Laminin_EGF	73..122	CDD:278482	19/54 (35%)
		EGF_Lam	121..166	CDD:238012	17/44 (39%)
		Laminin_B	256..374	CDD:278481	38/146 (26%)
		Laminin_EGF	465..509	CDD:278482	21/63 (33%)
		EGF_Lam	519..570	CDD:238012	16/50 (32%)
		EGF_Lam	572..>603	CDD:214543	15/31 (48%)
		MCPsignal	647..868	CDD:278444
		V_Alix_like	648..943	CDD:187408
		TACC	783..944	CDD:282818
		LXG	817..1017	CDD:282581
		COG1340	889..1137	CDD:224259
		ApoLp-III_like	991..1141	CDD:304399
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910