DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wb and si:ch211-241e1.3

DIOPT Version :9

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:XP_696031.6 Gene:si:ch211-241e1.3 / 567640 ZFINID:ZDB-GENE-030131-230 Length:1368 Species:Danio rerio


Alignment Length:1708 Identity:381/1708 - (22%)
Similarity:617/1708 - (36%) Gaps:518/1708 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  1567 HHTSQAVDRNTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMDAAIYIKGSTNLIAKGVERCKCP 1631
            |.:.|..:...:..|..|            |.|.|...::|                ..::.:.|
Zfish    64 HRSPQREEAEWIQRAQLN------------DAQRVQFPSLH----------------DTQQVQIP 100

  Fly  1632 KRFDGLSCQDPGRSFYRWRNTTIVESVFIEDLIGRAAPCHCNGRSSDCDRETGVCQNCRGNTGGD 1696
            ...||..| ..|....|            ..|..|..||.|||.|::|:..||.|.||..||.|.
Zfish   101 TLEDGQRC-PAGHYLDR------------SGLFPRCVPCSCNGHSNECEENTGRCLNCADNTAGQ 152

  Fly  1697 HCHQCAEGFYGDPNSPHGCQACPCPETNR--NFARGCNVWDGEVSCVCKPGYTGRLCERCQAGYF 1759
            .|..|.||||.. .:...|.|||||..|:  |||.||......:.||||.|:.|..||||.:||:
Zfish   153 RCELCKEGFYWS-EARRKCTACPCPLGNQDNNFAVGCTETQSRIQCVCKTGHAGERCERCASGYY 216

  Fly  1760 GDPMRYPNTTCQPCNCHPDGIQTEG--CDVETGRCYCREGVTGLKCDKCQAERHHLVDNGCKICD 1822
            |||:.| ...|:||.|       .|  ||.:||.|.     ..|:......|..      |:.||
Zfish   217 GDPLVY-GGGCRPCRC-------AGNLCDSKTGACR-----NSLELQDTNTEEQ------CEECD 262

  Fly  1823 NCTLLLLDYMELVGNKLRRGMHNMDLTGI-PAPYRKLSEYESAYEKWNGRHWDFSQTKRRLQDYD 1886
            ||...||:.:|.:..:|||.....|...: |:....|.:.|.|          .:.||..:..:.
Zfish   263 NCAQTLLNDLEKLEMELRRIKGQADFDSLRPSSKALLKQLEDA----------ITATKNLVNTFS 317

  Fly  1887 SA-------------DILKLEAHAENLKFQ-------SRKAVATIGKREFAIKSMREDAVTQQHS 1931
            .|             |::.|....::||.:       |:||:|.........|.:  |..||   
Zfish   318 FAVNSQMPKIVQLEQDVINLADDMDSLKEEVRKRSGDSQKALANAENSHQRAKDL--DTETQ--- 377

  Fly  1932 VGLLRS--EILQTLSDLHGYGKSAHYLSLPTALKQARFYLQAIREHDQMVQGIRSTNDCAWKHFY 1994
             .||..  |:|:.|.|....|.     |||:|     ...:.:.:.:.||:.:...:....|...
Zfish   378 -NLLTKIRELLKQLMDAKSDGS-----SLPSA-----DLAKLLEKSENMVKDMEKRSFTTQKDAA 431

  Fly  1995 AMGNASDASFDESGRLEMLWRDLNQTNHRVVDMRL-----QVDRVQEVENEAEDVLEHVRNLS-- 2052
            ....|....|.|..:..:...|.|:...:.||..|     ::..::::..:||::::..:||:  
Zfish   432 KKEQAEANKFLEDVKNIVKQCDQNEEASKRVDGLLSNYETKLKELEDLLKQAENMVKKAKNLNDV 496

  Fly  2053 ---------IRVGESHQELDELNQRISDHLDPGYLEQGEGLLRL-----TVQRQIMLNGHLNQLD 2103
                     .||.:..:|.|.:..:|.  |....|:..:.||::     |...|:..     ||:
Zfish   497 NAQGLKDILKRVNDLQRERDVVRDQIV--LATDQLKDTQDLLKMFNDGKTEYEQLAA-----QLN 554

  Fly  2104 GYRILLNTTLGVKTEQQREVRKHWLPKAEKHASHL--LARSNEYARKFQPTRNGARIAMLASSAH 2166
            |.:..|...|  :|..|...::..:.:||:||.::  ||:..:.|.:....|:|.:.|:....|:
Zfish   555 GAKTDLKKKL--QTVSQAAAKEKLVQQAEEHAENMYKLAKELQDAVQNVSGRSGVQDALSGIEAY 617

  Fly  2167 SNITEAINDARLASILAKERVYEAQRTLYPSD-----------GSSMIERAKHS----------L 2210
            .|||:|:|.|..|:..|||...:|...:...|           ||::::.||::          |
Zfish   618 KNITDAVNAAEEAAKKAKEAADKALNDVSQGDLINRAQDLKTNGSNLLKTAKNTAKDLKGATKDL 682

  Fly  2211 HRSKQLQQEALKQMHKSNVLKDKLHRQEQQVEGIK----STIYDSGLRTNNISGQLQGLSDGSAR 2271
            ...|...|:|.|   |...|:::|.:.:..::||:    :.|.|:..:|           ..:|.
Zfish   683 TEQKNRLQDAEK---KKKALEEELLKIQDGLKGIQRDDIAKIIDAAKKT-----------AAAAN 733

  Fly  2272 RQAKDSLEMADRTGEQMRAELQKAKDMQKSIQNMRNSFSNLEPDWEIKLGMAQENISLTQTNLRL 2336
            |...|:::..:    .::||::|. .:..::.||.|..:|::        |..:|:|.:..:|  
Zfish   734 RSTSDTMDQLN----DIKAEVKKI-SITPTVSNMDNVLNNVD--------MTVKNVSGSIPSL-- 783

  Fly  2337 ANVSLSYLEQQAEKEQQVFEVWNNSMAQQLQQLRDQIAKARHAAEAIDVSLESLGPKCIRSYLPA 2401
                   |::..|...|:  .:.|:::..:.::::.|.:||.||..:.|.               
Zfish   784 -------LDKIDELNNQI--NYGNNVSDNINKIKELIEQARDAANRVVVP--------------- 824

  Fly  2402 SYGLSTSNKIRMSFALSNHLESSPLIHLASSEGRHITLELYKRRVRLVWNLGGTTATVTHPMVVH 2466
                       |.|....|:|..|...||..                                  
Zfish   825 -----------MKFTGVGHVELRPPADLADM---------------------------------- 844

  Fly  2467 TRDPKYDDAWYHVEANRTLNLGSLVVRRMNNYGELTPPNPVIITGSTDTEHTRFYQSRSDRISLG 2531
                            |.....||.::|        |..|               .:|.|     
Zfish   845 ----------------RAFTALSLSLQR--------PEKP---------------PARGD----- 865

  Fly  2532 GFASKDLQFTPGLNVVVHQVEVDNKPLGLWNFVTSEGSCGGSMVGAKESSASSTARHFNGLGYAQ 2596
                         :.||.|.|.|     |:.....:.:..|..:|                    
Zfish   866 -------------DAVVQQDEDD-----LFVMYLGKKNASGDYIG-------------------- 892

  Fly  2597 LMKTRPRPTRKNL--FSVQMTFRTLDENALLFLAVDDKNNRSVSVTLSRGRIMF--RID-YGDES 2656
                  ...|||:  |..::..|..|..|             .::|.|...:.|  :|| |....
Zfish   893 ------MVLRKNVLHFIYKLNGREYDIEA-------------YNITESSSDLSFFDKIDLYRIYQ 938

  Fly  2657 KLEINTTKKYNVGQWIKIEAAREFSAKRSTENGMLRVNNDRPISGAPTLPVNIHLLPDLSKTVYY 2721
            ..|:..||:|.        :......:.....|.|..|             .:.|.||  ..|:|
Zfish   939 DAEVTYTKQYT--------SINPMPPQTKENKGDLTRN-------------LLDLQPD--DVVFY 980

  Fly  2722 LGGVPPGFTSGTSKAPGADNPFLGCMKDVQVNGE---TYDPLESSSYYGVEPSCKNMI----TKA 2779
            :||.|..||...|...|   .:.||::....|.:   .|: .:::....:|..||..|    |::
Zfish   981 VGGYPDNFTPPASLNYG---KYKGCIEFSTFNEKFLSLYN-FKNAVNINLETPCKRQIPLKSTES 1041

  Fly  2780 G-FSGNGYLELPSQSLRKRSNTALVFR--TLQPDCLLLLAAYPPEILGDYDAKDIKGNFSISLVD 2841
            . |.|:||.::..:  |..||..||.|  |...|.|||       .|||   ||....:|.||..
Zfish  1042 DYFEGSGYAKVLLE--RFPSNLQLVQRVETRAKDALLL-------YLGD---KDDDFYYSASLEG 1094

  Fly  2842 GQLHVWVNSGRSFIKMSSNSSQMNDGEFHVVHLIKTGRKLELMVDDELQEIRNLNGNPTV---VS 2903
            |.|.:......:.::...::.|........|.||...||          .:|.:.|...|   |:
Zfish  1095 GYLVLRGQEKDTILEPIRSNEQPVLSPGIDVRLILVNRK----------NLRVIIGTTEVKRDVN 1149

  Fly  2904 LPRDAGGLYIGGAPP--HESYTPLAPTFVNLEGAIRDVVFNNRTINFNDALTFANVQIGRNGPLM 2966
            :||.....||||.|.  .|.|....|.   |:..:::::.:|......:     .|.|||     
Zfish  1150 IPRKFLYYYIGGIPSILRERYNITVPA---LKACVKNILVSNVAPFIEE-----KVGIGR----- 1201

  Fly  2967 GSLKGGLYDVLLKTEPMIGKSFTASPEGCKRIGSYSYEPNAFKFGDDIYSYSQLKLPERHFWQRN 3031
                 |..|.||    |:.|:                     :||    |.|.|:.....|...:
Zfish  1202 -----GCSDELL----MVRKA---------------------EFG----SGSALEKLREDFKLDD 1232

  Fly  3032 FHLSFDFRSFYPNGMLYLSPGSKEKPKHYVALVLKDGQLVLVVRGRRREELQLTAKLNDGEWHRV 3096
            .:||..|||...:|:|.    ..:|..:::.|.|::|.:||...|.....   |.:..|||||.:
Zfish  1233 VNLSMGFRSTKSDGILM----ENQKNNNFIKLSLENGFVVLYFGGLIYTS---TKQYQDGEWHYL 1290

  Fly  3097 TISCHDRKVTMSVEIGRTDQKTSAQMKLPKKIGASQLLLVGGLPQSPVKVSSDLYVRLEPFKGC- 3160
            |.....:    |||: |.|::...|.            |.|...:   :.||::.:....::|| 
Zfish  1291 TAVAKGQ----SVEL-RVDEEDVGQR------------LTGIFRE---QYSSNVVLGKNTYEGCV 1335

  Fly  3161 ----LRRVSINNNTQDLA 3174
                |||.......:||:
Zfish  1336 SNLYLRRPGSPYRAEDLS 1353

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 164..396 CDD:278484
EGF_Lam 401..450 CDD:238012
TNFRSF <407..507 CDD:304602
EGF_Lam 505..552 CDD:238012
Laminin_EGF 550..597 CDD:278482
Laminin_B 660..798 CDD:278481
EGF_Lam 851..900 CDD:238012
Laminin_EGF <943..971 CDD:278482
VSP 953..1414 CDD:146106
Laminin_EGF 974..1018 CDD:278482
EGF_Lam 1017..1065 CDD:238012
Laminin_EGF 1065..>1105 CDD:278482
EGF_Lam 1150..1197 CDD:238012
Laminin_EGF 1199..1247 CDD:278482
EGF_Lam 1247..1292 CDD:238012
Laminin_EGF 1294..1342 CDD:278482
Laminin_EGF 1340..1392 CDD:278482
Laminin_B 1486..1611 CDD:278481 8/43 (19%)
EGF_Lam 1669..1716 CDD:238012 21/46 (46%)
Laminin_EGF 1718..1767 CDD:278482 26/50 (52%)
EGF_Lam 1772..1819 CDD:238012 11/48 (23%)
CrfC <1933..2267 CDD:223771 84/383 (22%)
Laminin_II 2277..2400 CDD:283628 21/122 (17%)
LamG 2399..>2492 CDD:304605 10/92 (11%)
Laminin_G_2 2616..2755 CDD:280389 31/141 (22%)
Laminin_G_2 2804..2944 CDD:280389 37/146 (25%)
Laminin_G_2 3038..3169 CDD:280389 34/135 (25%)
LamG 3192..3347 CDD:238058
si:ch211-241e1.3XP_696031.6 EGF_Lam 125..>162 CDD:238012 19/36 (53%)
TNFRSF 142..>263 CDD:328932 54/140 (39%)
Laminin_EGF <196..226 CDD:278482 16/30 (53%)
Laminin_I 293..541 CDD:310534 54/275 (20%)
OmpH 520..>599 CDD:332039 21/87 (24%)
Laminin_II 733..850 CDD:283628 31/216 (14%)
LamG 873..1011 CDD:214598 40/207 (19%)
LamG 1043..1186 CDD:238058 46/167 (28%)
LamG 1215..1340 CDD:238058 39/155 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 64 1.000 Domainoid score I10135
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100395
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.710

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