DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wb and lama4

DIOPT Version :9

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:NP_001034154.1 Gene:lama4 / 566796 ZFINID:ZDB-GENE-040724-213 Length:1871 Species:Danio rerio


Alignment Length:2705 Identity:562/2705 - (20%)
Similarity:897/2705 - (33%) Gaps:1070/2705 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   833 FKRIYENTSDHQILS---KCIPCPCNGHSNSCDLQSGNCGDCMHNTFGDRCERCQLGYYGNPLQG 894
            |..:|...:....||   .|:||.|.||::||:..:|.|.||..:|.||.||.|:..:....|..
Zfish    27 FNTVYRVCARGYFLSDQETCLPCNCKGHADSCEDITGICIDCRDHTLGDFCELCEDRFLPVFLPD 91

  Fly   895 TPNDCKRCACPLSEDSNNFSPSCQLKSYNYMDLNPQFELIEHAEYICTQCPEGYTGDHCQVCDDG 959
            ....|:.||||||.:||||:..|.                ...|::...|.:||.|.:|:.|..|
Zfish    92 GTFMCRPCACPLSLESNNFAAHCD----------------RRGEFLRCVCQDGYAGHYCERCAPG 140

  Fly   960 YFGNPRQPGSSCQRCDCAG--------GPCNVTTGECITCRGNTEGWHCERCKLGYWGD--PAVG 1014
            |:|||.:.|:||::|||.|        ..|:..||:|:.|.|:|.|.:||||..|::||  .|..
Zfish   141 YYGNPMELGNSCKKCDCNGNSDPNLIFNECHNVTGKCLNCWGDTAGDNCERCAPGFYGDAISAKD 205

  Fly  1015 CDPCHCHTEGSESGLCDSTDGQCLCKPRYAGQKCDECDVGYANVELRCPSCNCDPLGSLVQDRCD 1079
            |..|.|:..|:.|                                                  ||
Zfish   206 CQECQCNKCGTAS--------------------------------------------------CD 220

  Fly  1080 PHTGQCHCKEGVMGAKCHECQDGYFGMNAVAYRMDDLAALRQNSDSDDDEWELVPDTEDPNSEST 1144
            ..:|.||||.||.|..|..|:||:                                         
Zfish   221 DRSGVCHCKPGVTGQLCDRCEDGH----------------------------------------- 244

  Fly  1145 VACEECHCSSVGSLSSDCDKRTGQCACLANVTGRRCDKCRPGHWNLTAGEGCRDCRCDPHGSRGH 1209
                                 :|.|.|:                      |||.|.|.....|. 
Zfish   245 ---------------------SGFCTCM----------------------GCRRCECASAALRA- 265

  Fly  1210 ECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRCSACRSEGQVCDPHNGRCICPKFTRGLG 1274
            .|:|.|..|.|:.|.||::|..|..||:.:|..||::|. |..|.  ||.|.|.|: |:.::   
Zfish   266 TCHPLTHSCQCRPGAGGRYCERCLPGFWDYSPSGCRKCD-CPEEN--CDLHTGECL-PELSQ--- 323

  Fly  1275 CGQCVPGTWGWQARLGCRECECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFGYPECRR 1339
                                                                       ..||  
Zfish   324 -----------------------------------------------------------ISEC-- 327

  Fly  1340 CGCDAEGSFTQADGSIACDSNGQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGCTRCFCFGRSGEC 1404
                                           .:.||.|:                          
Zfish   328 -------------------------------NISCDACI-------------------------- 335

  Fly  1405 EQSDLSWGHIRMAESRNLSVQQIRPHSVPSSDYEYIVVVQMEGSSFHREDAEIQRMNDLSLVPKS 1469
                  |..|......|.::.|:|                                       .|
Zfish   336 ------WNLIGDIRQSNKTLDQVR---------------------------------------NS 355

  Fly  1470 TGNVSIGAYGQFYHPLYFQLPPQFYGDRTSSYGGFLYFTLITEGAHKPLERNILGQYPLVQLHAH 1534
            ..|:|.||..               .||                                     
Zfish   356 VLNISTGAAA---------------NDR------------------------------------- 368

  Fly  1535 SKLLLDFYEYEEFEYSLNVTHRVPLHESFWKYHHTSQAVDRNTLMAALQNIRHIFIRAFAFADFQ 1599
                |.:|.|        ..||:......|:.::...:.|.:.|....||   :......||: :
Zfish   369 ----LKYYNY--------TAHRLQAQFRGWRKNYAMMSGDTDVLEEETQN---LLTDMDQFAE-E 417

  Fly  1600 EVVLQNVHMDAAIYIKGSTNLIAKGVERCKCPKRFDGLSCQDPGRSFYRWRNTTIVES---VFIE 1661
            |..:||               :.|.|:             |:...|..|.:..|...|   |.||
Zfish   418 ENEVQN---------------LGKQVD-------------QETLNSSTRAKTLTANLSSLNVLIE 454

  Fly  1662 DLIGRAAPCHCNGRSSDCDRET-GVCQNCRGNTGGDHCHQCAEGFYGDPNSPHGCQACPCPETNR 1725
            |:|.              |.|. ||.|..                                    
Zfish   455 DMIR--------------DWELYGVYQEL------------------------------------ 469

  Fly  1726 NFARGCNVWDGEVSCVCKPGYTGRLCERCQAGYFGDPMRYPNTTCQPCNCHPDGIQTEGCDVETG 1790
                                               ||.                           
Zfish   470 -----------------------------------DPQ--------------------------- 472

  Fly  1791 RCYCREGVTGLKCDK-CQAERHHLVDNGCKICDNCTLLLLDYMELVGNKLRRGMHNMDLTGIPAP 1854
                      :|..| .:|||                 :|.:|    .||     |:      :|
Zfish   473 ----------VKLQKLAEAER-----------------ILGWM----RKL-----NL------SP 495

  Fly  1855 YRKLSEYESAYEKWNGRHWDFSQTKRRLQDYDSADILKLEAHAENLKFQSRKAVATIGKREFAIK 1919
            ...|:..||:         :..:..||::.:|                  |..:.|.|:    :.
Zfish   496 KEPLATDESS---------EAHELLRRVRSFD------------------RNLMTTQGR----LP 529

  Fly  1920 SMREDAVTQQHSVGLLRSEILQTLSDLHGYGKSAHYLSLPTALKQA-------RFYLQAIREHDQ 1977
            .|:|       .:|...|::||. .||....:.        |||||       :..||......|
Zfish   530 PMQE-------VLGRFTSKLLQA-QDLLSKAED--------ALKQAINKYKSNQLKLQRREAQQQ 578

  Fly  1978 MVQGIRSTNDCAWKHFYAMGNASDASFDESGRLEMLWRDLNQTNHRVVDMRLQVDRVQEVENEAE 2042
            .::.|:...|      ..:.||:..              |::.||.|:              |.|
Zfish   579 RLKDIQDGVD------QTIVNAAAV--------------LSEANHTVL--------------EVE 609

  Fly  2043 DVLEHVRNLSIRVGESHQELDELNQRISDHLDPGYLEQGEGLLRLTVQRQIMLNGHLNQLDGYRI 2107
            ||:.:||       |.|.|                                        :||.|:
Zfish   610 DVITNVR-------EQHAE----------------------------------------IDGARV 627

  Fly  2108 LLNTTLGVKTEQQREVRKHWLPKAEKHASHLLARSNEYARKFQPT-RNG-ARIAMLASSAHSNIT 2170
            ||..    :||:..:..:..:.:||.||..|...:.|.....:.: .|| .:.|:.|.:.:.||.
Zfish   628 LLER----RTEKISQSDRELVLRAEDHADQLQRHAEEPQHNLKGSDANGHVQKALNAFNVYDNIV 688

  Fly  2171 EAINDARLASILA---KERVYEA------QRTLYPSDGSSMIERAKHSLHRSKQLQQEALKQMHK 2226
            ::::||.:.|:.|   ..|.:.|      |..|..|..:.::..|. |||    .||    |..:
Zfish   689 KSVDDANITSLTALNISSRTHGAVDKLSSQLNLMRSQSAKVLNEAS-SLH----FQQ----QDSE 744

  Fly  2227 SNVLKDKLHRQEQQVEGIKSTIYDSGLRTNNISGQLQGLSDGSARRQAKDSLEM----ADRTGEQ 2287
            |.||.:|.:.:|                ||.       :.|||:::.||...|:    .|||.::
Zfish   745 SIVLDNKKYIEE----------------TNE-------MMDGSSKKIAKIITEINAIHTDRTPKR 786

  Fly  2288 MR-------------AE-LQKAKDMQKSIQ----NMRN-SFSNLEPDWEI-KLGMAQENISLTQT 2332
            ::             || |:|...:.|.::    ||:: ::|....|..: ..|.|.:::|....
Zfish   787 LQFTQEVAEGTLNRSAEVLEKVTPILKRVEQWDGNMKSEAYSAAAFDRTVLSAGEAVKDLSAIVP 851

  Fly  2333 NLRLANVSLSYLEQQAEKEQQVFEVWNNSMAQQLQQLRDQIAKARHAAEAIDVSLESLGPKCIRS 2397
            .|      ||.|....||:..      |::...:.::|..||:||..|:.:.||::..|...:..
Zfish   852 EL------LSKLRVVEEKKPV------NNVTTSIMKIRGLIAQARSVAKKVQVSMKFDGQSAVEV 904

  Fly  2398 YLPASYG-LSTSNKIRMSFAL-----SNHLESSPLIHLASSEGR--HITLELYKRRVRLVWNLGG 2454
            :...:.. |.|...|  ||.:     .:.:|...|::|...:|:  ::.|.:....:..|:.||.
Zfish   905 HPHTNLDELKTVTSI--SFYIRVDPDKDPIEDRFLLYLGDKQGKRDYMGLAIKNDNLVYVYKLGE 967

  Fly  2455 TTATVTHPMVVHTRDPKYDDAWYHVEANRTLNLGSLVVRRMNNYGE--LTPPNPVIITGSTDTEH 2517
            ....:  |:     ..|...:|..|       ...:.|.|:..:|:  ||.|       |.||..
Zfish   968 EEVEI--PL-----SSKPVSSWPPV-------FNFVKVERLGRHGKVFLTVP-------SQDTTA 1011

  Fly  2518 TRFYQSRSDRI---SLGGFASKDLQF-----TPGLNV--------VVHQVEVD---NKPLGLWNF 2563
            .:.:..:.:.:   :|.....||:.|     .||:.|        .|..:|::   |..:.|:||
Zfish  1012 EQKFIQKGEPVGTDTLFDLDPKDMVFIVGGVPPGVTVPPILSLAPFVGCIELETLNNDVISLYNF 1076

  Fly  2564 -------VTSEGSCGGSMVGAKESSASSTARHFNGLGYAQLMKTRPR-----PTRKNLFSVQMTF 2616
                   |.:...|....:...:|..:|..  |:|.|||.:.....|     .||   |.:::  
Zfish  1077 KQLHKMDVKASAPCPRHKLAFSQSRVTSYL--FDGTGYALVNNIERRGKIGVVTR---FDIEV-- 1134

  Fly  2617 RTLDENALLFLAVDDKNNRSVSVTLSRGRIMFRIDYG----------DESKLEINTTKKYNVG-- 2669
            ||:..|.:|||.|::.|  ...:.|..|.:....|:|          :.:||:||..:.:.|.  
Zfish  1135 RTVANNGILFLMVNETN--FFVLELKNGFLRLMYDFGFANGPVIIETNLAKLQINDARYHEVSVI 1197

  Fly  2670 --QWIKIEAAREFSAKRSTENGMLRVNNDRPISGAPTLPVNIHLLPDLSKTVYYLGGVP------ 2726
              ...||....:.|..:|.|      :..:|      ||.:     |:     |:||.|      
Zfish  1198 YHHSKKIILLVDRSHVKSFE------SEKKP------LPFS-----DI-----YIGGAPSRILQS 1240

  Fly  2727 -PGFTS--GTSKAPGADNPFLGCMKDVQVNGETYDPLESSSYYGVEPSCKN---MITKAGFSGNG 2785
             |..||  |..          ||:|..|...|.::.||.....|:...|..   |..||.|:|||
Zfish  1241 RPELTSLIGLK----------GCVKGFQFQKEDFNLLEEQGTIGISSGCPEESFMSHKAYFTGNG 1295

  Fly  2786 YLE-----LPSQSLRKRSNTALVFRTLQPDCLLLLAAYPPEILGDYDAKDIKGNFSISLVDGQLH 2845
            ||.     .|.||.    ...|.|:||||..||            :..:|....||:||.:|.:.
Zfish  1296 YLSSSDKISPFQSF----EGGLSFKTLQPSGLL------------FYHRDGSDEFSLSLENGAVV 1344

  Fly  2846 VWVNSGRSFIKMSSNSSQMNDGEFHVVHLIKTGRKLELMVDD-ELQEIRNLNGNPTVVSLPRDAG 2909
            :.....|    :.|.....:||..|.:....|.:|.|:::|| :.|:.:..:......:.|:   
Zfish  1345 LQAKGTR----VKSQKKHYSDGRSHFLVASVTNQKYEIVIDDKDKQDKKKPSSTSQSDNTPK--- 1402

  Fly  2910 GLYIGGAPPHESYTPLAPTFVNLEGAIRDVVFN--NRTINFNDALTFA-NVQIGRNGPLMGSLKG 2971
            ..|.||:        .:.:.:||.|.|.....:  :|.|...|...:: |||            .
Zfish  1403 AFYYGGS--------TSSSILNLTGCISYAYISRQDRDIEPEDFQRYSENVQ------------A 1447

  Fly  2972 GLYDVLLKTEP-------------------MIGKSFTASPEGCK----------RIGSY-----S 3002
            .|.|..::..|                   .:|:..:..|.|.|          ....|     .
Zfish  1448 SLQDCPIERPPSALLKDSRDSSRRSAGHSRKVGRDESGLPHGLKSNPLNIPEKEEASCYLSSRPR 1512

  Fly  3003 YEPNAFKFGDDIYS---YSQLKLPERHFWQRNFHLSFDFRSFYPNGML-YLSPGSKEKPKHYVAL 3063
            ..|:|..:|...:|   |:.:....:|  :.:|.||...||.:  |:: ||:..|.|   :.:||
Zfish  1513 ATPHANHYGGSAHSRHEYTGIASAIKH--ESHFSLSLKTRSAF--GLIFYLADASGE---NSMAL 1570

  Fly  3064 VLKDGQLVLVV-RGRRREELQLTAKLNDGEWHRVTISCHDRKVTMSVEIGR--TDQKTSAQMKLP 3125
            .|...:||... .|:.:..::...|.|||:||.:..       ..:..:||  .|..|..:.:.|
Zfish  1571 FLTHARLVFTFSSGQSQVRIRSKEKYNDGQWHDIIF-------IRAGNMGRMLIDGLTVLEDRAP 1628

  Fly  3126 KKIGASQL----LLVGGLPQSPVKVSSDLY-VRLEPFKGCLRRVSINNNTQDLARPGKHS-NVGQ 3184
            .: ..|.|    |.|||:|  |.:...::. ..:..|.||:|.:.:|..:...|   .|| .|..
Zfish  1629 GR-NTSLLVQDPLYVGGVP--PHQAMKNIQRTSVSSFTGCVRSLQLNGRSLTSA---SHSFGVTP 1687

  Fly  3185 CF--PTVERGSYFPGD-AYAIYKKNFNVGKYLDLETEFRTSELSGILLSV-SDPNGFPALSLELH 3245
            |:  |: |.|:||..: .|.:...:|:.|....:..|.|....||:||.| .:...:  |::.::
Zfish  1688 CYEGPS-EPGTYFAEEGGYVLLDDSFHFGSSFKMAMEVRPRVASGVLLHVFMEQKEY--LTVYIY 1749

  Fly  3246 NGNIIFSCDPGNGAPMRVESSLPTKYALCDNKWHNISALYDGEQIVLRIDQLPAVISVGNQGNAG 3310
            ...::...:  ||.........||: .:||..||.|:.:.||..:.|.:|.....: ||:..:|.
Zfish  1750 QSQVVVVVN--NGIAEFSTHVSPTQ-EICDGNWHKITVIRDGSVLQLDVDSEVNHV-VGSVSDAA 1810

  Fly  3311 KVQTRSPLYIGGLPESAPSGSLISRENFKGCIRHVSIRNE 3350
            : .:.||::|||.|:|..|.||:||..|.||:|.||: ||
Zfish  1811 Q-SSSSPVFIGGAPDSMLSHSLLSRRGFTGCMRSVSV-NE 1848

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 164..396 CDD:278484
EGF_Lam 401..450 CDD:238012
TNFRSF <407..507 CDD:304602
EGF_Lam 505..552 CDD:238012
Laminin_EGF 550..597 CDD:278482
Laminin_B 660..798 CDD:278481
EGF_Lam 851..900 CDD:238012 18/48 (38%)
Laminin_EGF <943..971 CDD:278482 12/27 (44%)
VSP 953..1414 CDD:146106 88/470 (19%)
Laminin_EGF 974..1018 CDD:278482 21/53 (40%)
EGF_Lam 1017..1065 CDD:238012 4/47 (9%)
Laminin_EGF 1065..>1105 CDD:278482 14/39 (36%)
EGF_Lam 1150..1197 CDD:238012 4/46 (9%)
Laminin_EGF 1199..1247 CDD:278482 18/47 (38%)
EGF_Lam 1247..1292 CDD:238012 9/44 (20%)
Laminin_EGF 1294..1342 CDD:278482 2/47 (4%)
Laminin_EGF 1340..1392 CDD:278482 3/51 (6%)
Laminin_B 1486..1611 CDD:278481 17/124 (14%)
EGF_Lam 1669..1716 CDD:238012 5/47 (11%)
Laminin_EGF 1718..1767 CDD:278482 2/48 (4%)
EGF_Lam 1772..1819 CDD:238012 5/47 (11%)
CrfC <1933..2267 CDD:223771 73/351 (21%)
Laminin_II 2277..2400 CDD:283628 32/146 (22%)
LamG 2399..>2492 CDD:304605 17/100 (17%)
Laminin_G_2 2616..2755 CDD:280389 38/161 (24%)
Laminin_G_2 2804..2944 CDD:280389 32/142 (23%)
Laminin_G_2 3038..3169 CDD:280389 37/139 (27%)
LamG 3192..3347 CDD:238058 47/156 (30%)
lama4NP_001034154.1 EGF_Lam 48..>84 CDD:238012 17/35 (49%)
Laminin_EGF 99..152 CDD:278482 24/68 (35%)
EGF_Lam 155..207 CDD:238012 20/51 (39%)
EGF_Lam 209..247 CDD:214543 18/149 (12%)
EGF_Lam 256..300 CDD:214543 16/44 (36%)
Laminin_I 351..611 CDD:283627 89/629 (14%)
SPEC 474..665 CDD:295325 66/354 (19%)
Laminin_II 790..919 CDD:283628 30/140 (21%)
LamG 893..1067 CDD:238058 37/196 (19%)
LamG 1104..1259 CDD:238058 47/195 (24%)
LamG 1289..1422 CDD:238058 42/163 (26%)
LamG 1535..1672 CDD:238058 40/153 (26%)
LamG 1696..1847 CDD:238058 48/158 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 64 1.000 Domainoid score I10135
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100395
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
54.670

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