DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wb and lamc3

DIOPT Version :9

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:XP_687343.5 Gene:lamc3 / 558958 ZFINID:ZDB-GENE-060531-121 Length:1643 Species:Danio rerio


Alignment Length:2297 Identity:524/2297 - (22%)
Similarity:799/2297 - (34%) Gaps:800/2297 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 PPLFNVVPRAQISVNATCGQNGAEEYCKQVGA-KPCGICNAHSSDRAKQRSIQSLISSGSGSGSG 218
            |...|......:.|:..|| ...|:||.|.|: :.|..|:|..|:..:..:..:...:..     
Zfish    39 PKFENAAFNHSVMVSNMCG-IPPEDYCMQTGSTRSCHHCDAFDSELNRNATYLTDFHTDE----- 97

  Fly   219 SGFEEGWWQSPTLQGGRQF-EYVTILLDLKQTFQIFSVWLKSANSPRPASWILEKSLDGINFEPW 282
               |..||||.::..|.|: ..|.|.|.|.:.|:|..|.||...| ||.|:.:.|..|  ...||
Zfish    98 ---EPTWWQSQSMFYGVQYPNSVNITLHLGKAFEITYVRLKFYTS-RPESFAIYKRTD--ENGPW 156

  Fly   283 QYFGLSDADCQRRWNLSGQNGK-YVFQNDTE--IICSTQFSKPGPLENGVLHASLLKNRPGA--T 342
            |.:....|.|::.:   |::.| ::...|.|  .:|:.:||...||..|.:..|.|:.||.|  .
Zfish   157 QPYQYYSASCRKTY---GRDNKGFIRPGDNERTPLCTDEFSDISPLTGGNVAFSTLEGRPSAYNF 218

  Fly   343 DQSPELMKFITTRYIRIRLQGMHSTANQDNSLDWLLDSPSLEKHSFYSLSQLKVSARLDCNGHAN 407
            |||..|..::|...|.|.|..:::..:     ::..|:..|..: ||::|...|..|..|||||:
Zfish   219 DQSLVLQDWVTATDILISLDRLNTFGD-----EFFKDAKVLRSY-FYAISDFSVGGRCKCNGHAS 277

  Fly   408 RSHESPDDPLMQCICQHNTCGAQCEQCCPLFQDRPY-----QMGGECEICQCYGHAESCTYDPFL 467
            ....: ::....|:|:|||.|..|:.|.|.:||||:     ....||..|.|.|.|:.|.:|  :
Zfish   278 ECVVN-EEGRSVCVCEHNTAGVDCQLCAPFYQDRPWARATAHSANECVRCNCSGLADECVFD--V 339

  Fly   468 DK-------GICQSCSNNTAGIECEFCEMGFYRELDAPLTDPCLPCSCNPARSTG-GCQSDGGSC 524
            ::       |.|..|..||||..||.|...::|   :....||..|:||...|.. .|.:| |.|
Zfish   340 EQYRSTGQGGRCLGCRENTAGPHCEQCRENYFR---SSALQPCQNCNCNALGSVSLQCDAD-GVC 400

  Fly   525 NCLEGFQGKNCEECAPGYYG---DDCKRCECDERGSLGSTGSCSGVCQCKLNVEGSTCSECAPGY 586
            .|.....|..|:.|..|::.   ..|:.|:||||||:|...:..|.|.||.||||.:|:.|.||.
Zfish   401 VCWPSVSGVKCDICKSGFHSLGPGGCRLCDCDERGSVGVCSAEDGRCHCKANVEGQSCNRCKPGS 465

  Fly   587 FDLSAENAEGCTSCWCSGVSQTCHSAKLQTLAFET---LND---WKITDIQRVKPISIPVDAETN 645
            |:|..||.:||..|:|.|.|..|.|:...|..:.|   |.|   ||....:..:...|..:.|..
Zfish   466 FNLQLENPDGCNKCFCFGHSLACFSSNQYTPIYITSDFLEDPDGWKGVFSRAHEQSLIWKEGEVY 530

  Fly   646 RLIFANELDEVEAIYWQASLGYLGNRLTSYGSRLQLVLSWDVIRGDRSGKPTTGPNVILVGKNGL 710
            .|.:..|..     :::|...||||.|.|||..|.:..:.::        ....|..:.|...| 
Zfish   531 LLPYREENG-----FYKAPDKYLGNMLLSYGRTLSMSFTAEL--------EELLPRSVTVRLEG- 581

  Fly   711 KIAFGDESLDGLGINLNVTLTEVGWYHVPPTVVDIKTRLRRTEGGDYHGESVTRSQFLSVLVSLD 775
                     .|:.::.::...:..:..:..|.:: ...||.||  .:...||:..:||.:|.:|.
Zfish   582 ---------SGMSVSADLHTQQEPYSQLEKTPIN-SFSLRLTE--KHVNPSVSSFEFLRMLYNLT 634

  Fly   776 AVLIRAA----FHTDQGETSLERAV--IYSGGVELGGKSSSQVEQCLCPAGYTGLSCEGCAFGFK 834
            |:.|..|    :.:.....|||.||  .|...|.   ..:..||.|.||||:.|..|:.||.||.
Zfish   635 ALHISNAGGQNYTSQLSRVSLESAVQKAYHPDVL---PHALWVEVCSCPAGFAGQFCQLCAPGFT 696

  Fly   835 RIYENTSDHQILSKCIPCPCNGHSNSCDLQSGNCGDCMHNTFGDRCERCQLGYYGNPLQGTPNDC 899
            |   .|.|....|.|:||.||.| .:|..::|.|. |...|.|..||||:.|||||.|.|:|.||
Zfish   697 R---ETPDGGPFSPCVPCNCNQH-GTCHPETGVCA-CTDFTTGRHCERCEDGYYGNALTGSPGDC 756

  Fly   900 KRCACPLSEDSNNFSPSCQLKSYNYMDLNPQFELIEHAEYICTQCPEGYTGDHCQVCDDGYFGNP 964
            ..|.||                    |.....::.|..:.|||.||.|..|..|::|:||::|||
Zfish   757 LPCPCP--------------------DRTTCAQVPETGDVICTNCPTGQRGVRCELCEDGFYGNP 801

  Fly   965 RQPGSS---CQRCDCAG-------GPCNVTTGECITCRGNTEGWHCERCKLGYWGDPAVGCDPCH 1019
            ...|.:   |.:|.|.|       |.|:..||.|:.|.|:|.|.|||:|:|||:|          
Zfish   802 LGWGGTVQPCVKCQCNGNVDANAVGVCDHMTGRCLKCLGHTTGDHCEKCRLGYYG---------- 856

  Fly  1020 CHTEGSESGLCDSTDGQCLCKPRYAGQKCDECDVGYANVELRCPSCNCDPLGSLVQDRCDPHTGQ 1084
                                                                             
Zfish   857 ----------------------------------------------------------------- 856

  Fly  1085 CHCKEGVMGAKCHECQDGYFGMNAVAYRMDDLAALRQNSDSDDDEWELVPDTEDPNSESTVACEE 1149
                                  ||:|.:::                   |:.:         |:.
Zfish   857 ----------------------NALANQLN-------------------PERK---------CKP 871

  Fly  1150 CHCSSVGSLSS--DCDKRTGQCACLANVTGRRCDKCRPGHWNLTAGEGCRDCRCDPHGSRGHECN 1212
            |.|:..|:..|  ||...||.|.||.:||||.|.:|..|::||..|.||..|.|:|.||....|:
Zfish   872 CACNVAGTSGSPNDCHPNTGNCVCLGHVTGRDCGQCEAGYFNLQPGLGCEMCNCNPIGSLSSACH 936

  Fly  1213 PWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRCSACRSEGQVCDPHNGRCICPKFTRGLGCGQ 1277
            |.||||.|:.||.|..|:.|..||||||:.                                   
Zfish   937 PITGQCMCRTGVEGMSCDTCRMGFFGFSSR----------------------------------- 966

  Fly  1278 CVPGTWGWQARLGCRECECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFGYPECRRCGC 1342
                        |||.|.||.:||...||. .:|.|.||.|:.|.|||.|...|:          
Zfish   967 ------------GCRACNCDPMGSTSMQCH-NNGTCSCRNGFVGYKCDKCEQNYY---------- 1008

  Fly  1343 DAEGSFTQADGSIACDSNGQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGCTRCFCFGRSGECEQS 1407
                                                        ||          ..|.:||:.
Zfish  1009 --------------------------------------------QN----------RLSHQCEEC 1019

  Fly  1408 DLSWGHIRMAESRNLSVQQIRPHSVPSSDYEYIVVVQMEGSSFHREDAEIQRMNDLSLVPKSTGN 1472
            .:.:..||...|:..:                                   |:.:|.|:      
Zfish  1020 PVCYSIIRDQASKLKA-----------------------------------RLQELELL------ 1043

  Fly  1473 VSIGAYGQFYHPLYFQLPPQFYGDRTSSYGGFLYFTLITEGAHKPLERNILGQYPLVQLHAHSKL 1537
                                     .|||....|..                ||...|.|.|...
Zfish  1044 -------------------------LSSYDCNRYSR----------------QYRGHQQHRHQHN 1067

  Fly  1538 LLDFYEYEEFEYSLNVTHRVPLHESFWKYHHTSQAVDRNTL--MAALQNIRHIFIRAFAFADFQE 1600
            .||.:..::     .|...:|                 |.|  :.|:|..|..||:.|:..:...
Zfish  1068 DLDNHIQKD-----QVEDYLP-----------------NALEDLLAIQEAREAFIKQFSQLETSA 1110

  Fly  1601 VVLQNVHMDAAIYIKGSTNLIAKGVERCKCPKRFDGLSCQDPGRSFYRWRNTTIVESVFIEDLIG 1665
            ..||                                          .:.||.             
Zfish  1111 QTLQ------------------------------------------LQLRNI------------- 1120

  Fly  1666 RAAPCHCNGRSSDCDRETGVCQNCRGNTGGDHCHQCAEGFYGDPNSPHGCQACPCPETNRNFARG 1730
             |...:||                                                  ..|||: 
Zfish  1121 -ATALNCN--------------------------------------------------LTNFAK- 1133

  Fly  1731 CNVWDGEVSCVCKPGYTGRLCERCQAGYFGDPMRYPNTTCQPCNCHPDGIQTEGCDVETGRCYCR 1795
                                                         ||:..:|:..:.|     ||
Zfish  1134 ---------------------------------------------HPEEGKTQKVENE-----CR 1148

  Fly  1796 EGVTGLKCDKCQAERHHLVDNGCKICDNCTLLLLDYMELVGNKLRRGMHNMDLTGIPAPYRKLSE 1860
            |                |||         ||.....|:   ::|::....::...|||...|   
Zfish  1149 E----------------LVD---------TLSTALNMQ---DQLQKMTVELNSMAIPAVIPK--- 1182

  Fly  1861 YESAYEKWNGRHWDFSQTKRRLQDYDSADIL-----KLEAHAENLKFQSRKAVATIGKREF-AIK 1919
               ...|||.             ..:.:::|     .:.||.|    |..:.|..:..|.: .:.
Zfish  1183 ---EPNKWNA-------------IVNESEVLVKSHTDMAAHIE----QVAEDVFKMANRTYLQLV 1227

  Fly  1920 SMREDAVTQQHSVGLL-RSEILQTLSDLHGYGKSAHYLSLPTALKQARFYLQAIREHDQMVQGIR 1983
            ::.||..|:.|...|. :.|.:|.|.:           :|...:.:......::::|:..:..| 
Zfish  1228 TLLEDNSTESHIQDLTEKLEEMQQLKE-----------NLTLEVNETLVTHLSLQKHNAEIADI- 1280

  Fly  1984 STNDCAWKHFYAMGNASDASFDE----SGRLEMLWRDLNQTNHRVVDMRLQVDRVQEVE-NEAED 2043
                        :.|.: ||..|    .|...::..:.|.|:......:..|...|..: .|:||
Zfish  1281 ------------LHNIT-ASLSELRRTDGNFTLVVEETNMTSFSQTFNQTNVTAAQNPQLTESED 1332

  Fly  2044 VLEHVRNLSIRVGESHQELDELNQRISDHLDPGYLEQGEGLLRLTVQRQIMLNGHLNQL----DG 2104
            ::....||.|.|    |..:.|..:..:.:.|. ::..:..|: |||       .|.||    :|
Zfish  1333 LMNRTTNLDISV----QSKEHLVNKTREEIQPD-MDSAKNNLK-TVQ-------ELKQLTAAVEG 1384

  Fly  2105 YRI--LLNTTLGVKTEQQ--------REVRKHWLPKAEKHASHLLARSN--------EYARKFQP 2151
            .::  :.:...|.:.|.:        :::.:.| |:....:...|.|..        |..::.:.
Zfish  1385 LKVSAVSSVVTGKEVEAEILSLQKSLQDMEQDW-PQLPTLSKSFLKREKMLNEKTLVEVKKRVKQ 1448

  Fly  2152 TRNGARIAMLASSAHSNITEAINDARLASILAKERVYEAQRTLYPSDGSSMIERAKHSLHRSKQL 2216
            |..     |:..|. .|.|:|.:.|:.|         ||.......|..:...:.|...|.|.||
Zfish  1449 TEK-----MIKPSV-ENATDADSTAKQA---------EASADTVAKDAKASFTQGKRIKHASGQL 1498

  Fly  2217 QQ------EALKQMHKSNVLKD-KLHRQEQQVEGIKSTIYDSGLRTNNISGQLQGLSDG----SA 2270
            :.      |.|.::.....||. .|..:|..|.  .|::.||.....|   ||:..:|.    .:
Zfish  1499 RSALDVTLEQLSELESQTALKQATLEAEEDMVS--SSSVIDSMETAKN---QLESFTDMLTLLLS 1558

  Fly  2271 RRQAKDSLEMADR----TGEQMRAELQKAKD---MQKSIQNMRNSFSNLEPDWEIKLGMAQENIS 2328
            :.:|...||..||    |..::|. ||.|.:   :...||.:||:.|:.|..        .:|:.
Zfish  1559 QMEADVVLENYDRILNETAVRLRV-LQGAVESPSLTGKIQRLRNAASDQEKQ--------MQNLE 1614

  Fly  2329 LTQTNLRLANVSLSYLEQQAEK 2350
            .:..::|....||:.:.|...|
Zfish  1615 ESLQDIRKERDSLTDIAQNLPK 1636

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 164..396 CDD:278484 67/238 (28%)
EGF_Lam 401..450 CDD:238012 19/53 (36%)
TNFRSF <407..507 CDD:304602 34/111 (31%)
EGF_Lam 505..552 CDD:238012 15/50 (30%)
Laminin_EGF 550..597 CDD:278482 24/46 (52%)
Laminin_B 660..798 CDD:278481 33/143 (23%)
EGF_Lam 851..900 CDD:238012 24/48 (50%)
Laminin_EGF <943..971 CDD:278482 12/30 (40%)
VSP 953..1414 CDD:146106 106/472 (22%)
Laminin_EGF 974..1018 CDD:278482 20/50 (40%)
EGF_Lam 1017..1065 CDD:238012 0/47 (0%)
Laminin_EGF 1065..>1105 CDD:278482 0/39 (0%)
EGF_Lam 1150..1197 CDD:238012 22/48 (46%)
Laminin_EGF 1199..1247 CDD:278482 23/47 (49%)
EGF_Lam 1247..1292 CDD:238012 1/44 (2%)
Laminin_EGF 1294..1342 CDD:278482 18/47 (38%)
Laminin_EGF 1340..1392 CDD:278482 2/51 (4%)
Laminin_B 1486..1611 CDD:278481 23/126 (18%)
EGF_Lam 1669..1716 CDD:238012 2/46 (4%)
Laminin_EGF 1718..1767 CDD:278482 3/48 (6%)
EGF_Lam 1772..1819 CDD:238012 10/46 (22%)
CrfC <1933..2267 CDD:223771 70/368 (19%)
Laminin_II 2277..2400 CDD:283628 21/81 (26%)
LamG 2399..>2492 CDD:304605
Laminin_G_2 2616..2755 CDD:280389
Laminin_G_2 2804..2944 CDD:280389
Laminin_G_2 3038..3169 CDD:280389
LamG 3192..3347 CDD:238058
lamc3XP_687343.5 Laminin_N 46..268 CDD:278484 68/242 (28%)
EGF_Lam 269..314 CDD:238012 19/45 (42%)
Laminin_EGF 326..382 CDD:278482 19/60 (32%)
EGF_Lam 382..426 CDD:214543 13/44 (30%)
Laminin_EGF 429..476 CDD:278482 24/46 (52%)
Laminin_B 540..659 CDD:278481 31/139 (22%)
EGF_Lam 710..751 CDD:238012 21/42 (50%)
Laminin_EGF 814..861 CDD:278482 22/143 (15%)
EGF_Lam 871..921 CDD:238012 22/49 (45%)
Laminin_EGF 923..971 CDD:278482 26/94 (28%)
EGF_Lam 970..1010 CDD:238012 18/94 (19%)
ApoLp-III_like 1233..1386 CDD:304399 36/190 (19%)
PspA 1388..1607 CDD:224755 52/240 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 66 1.000 Domainoid score I9990
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.