DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wb and lamb1b

DIOPT Version :10

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:NP_001264059.1 Gene:lamb1b / 556605 ZFINID:ZDB-GENE-041210-197 Length:1767 Species:Danio rerio


Alignment Length:2474 Identity:510/2474 - (20%)
Similarity:813/2474 - (32%) Gaps:925/2474 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   151 GGLYPPLFN-VVPRA-QISVNATCGQNGAEEYCKQVGAKPCGICNAHSSDR-------AKQRSIQ 206
            |..||...: ::.|| :::.::|||.|..||:| .|......:|....|.|       ....:|:
Zfish    31 GSCYPATGDLLIGRAHRLTASSTCGLNSPEEFC-MVNILEDTVCFECDSRRLYNEFTHPDSHTIE 94

  Fly   207 SLISSGSGSGSGSGFEEGWWQSPTLQGGRQFEYVTILLDLKQTFQIFSVWLKSANSPRPASWILE 271
            :::::.:.:..     :.||||   :.|  .|.|||.|||:..|. |:..:.:..:.|||:.::|
Zfish    95 NVVTTFAPNRL-----KTWWQS---ENG--VENVTIQLDLEAEFH-FTHLIMTFRTFRPAAMLIE 148

  Fly   272 KSLD-GINFEPWQYFGLSDADCQRRWNLSGQNGKYVFQNDTEIICSTQFSKPGPLENGVLHASLL 335
            :|.| |..::.::|:..   :|...:   ....|...:...::||.:::|...|...|.:...:|
Zfish   149 RSADYGRTWQVYRYYAF---NCDESY---PHVPKGPIKKVDDVICDSRYSGMEPSTEGEVIFRVL 207

  Fly   336 KNRPGATD-QSPELMKFITTRYIRIRLQGMHSTANQDNSLDWLLDSPSLEKHSFYSLSQLKVSAR 399
            .......| .||.:...:....:||.::.:|...:..|.      .....|..||::..:.:...
Zfish   208 DPAFKIPDPYSPHIQNLLKITNLRIAMEKLHKLGDLSNY------RKEARKKYFYAVYDMVIRGN 266

  Fly   400 LDCNGHANR----SHESPDDPLM--QCICQHNTCGAQCEQCCPLFQDRPYQ--MGGE---CEICQ 453
            ..|.|||::    .:|:..:.::  .|:|.|:|.|..||:|...:||:|::  :|.|   |:.|:
Zfish   267 CFCYGHASKCAPIGNEAGVEGMVHGHCMCNHHTTGLNCEECEDFYQDQPWRPAVGRETNACKKCE 331

  Fly   454 CYGHAESCTYD--PFLDK-----GICQSCSNNTAGIECEFCEMGFYRELDAPLTDP--CLPCSCN 509
            |..|::||.:|  .:|..     |:|..|.:||.|..||.|:..:|:.....:.||  |.||.|:
Zfish   332 CNRHSDSCHFDMAVYLSSGNRSGGVCDDCEHNTQGQWCENCKPFYYKHPQRDIRDPRICEPCDCD 396

  Fly   510 PARS--TGGCQSD--------GGSCNCLEGFQGKNCEECAPGYYG--DD---CKRCECDERGSLG 559
            |..|  .|.|.|.        .|.|:|....:|:.|:.|..|:||  ||   |:.|.|:..|:|.
Zfish   397 PRGSLYEGLCDSATNVMRDMIAGQCHCKANVEGQRCDHCKKGHYGLSDDPLGCRSCSCNPLGTLP 461

  Fly   560 STGSC---SGVCQCKLNVEGSTCSECAPGYFDLSAENAEGCTSCWC---SGVSQTCHSAKLQTLA 618
            ....|   :|.|.||..|.|..|.:|.|.::.|| .:.:||..|.|   ..::..|.....|...
Zfish   462 GGTPCDIQTGSCYCKRLVTGRNCDQCLPQHWGLS-NDMDGCRPCDCDVGGALNNNCSQETGQCAC 525

  Fly   619 FETLNDWKITDIQRVKPISIPVDAETNRLIFANELDEVEAIYWQASLGY--LGNRLTSYGSRLQL 681
            .|.:                          |....|::::.|:.|:|.:  ......|:|..:::
Zfish   526 KEHM--------------------------FGRRCDQLQSGYYFAALDHYIYEAEFASFGPAVKV 564

  Fly   682 VLSWDVIRGDRSGKPT-TGPNVILVGKNGLKIAFGDESLDGLGINLN------------------ 727
            |..  .:..||  ||| ||...:.|.:.           :.|..|:|                  
Zfish   565 VQR--PLPQDR--KPTWTGTGFVNVPEG-----------ETLTFNINNFPRSMEYNLMIRYEPLL 614

  Fly   728 --------------------------------VTLTEVGWYHVPPTVVDIKTRLRRT-------- 752
                                            |:|.....|.|.|..|.::|....|        
Zfish   615 PDEWEQVIVKLERPRDIDQSTHCTTTYDDEQMVSLHPGSRYVVVPNPVCLETGQNYTLKISFPQY 679

  Fly   753 EGGDYHGESVTRSQFLSVLVSL-DAVLIRAAFHTD------QGETSLERAVIYSGGVELGGKSSS 810
            ...:||....|....|.:|..: |..|.....|..      |....|||:               
Zfish   680 SSYNYHSSPRTLVDSLVLLPEVQDLDLFCGGDHQQKNWEMFQKYRCLERS--------------- 729

  Fly   811 QVEQCLCPAGYTGLSCEGCAFGFKRIYENTSDHQILSKCIPCPCNGH---SNSCDLQSGNCGDCM 872
               |.:.....|.: |:...|....:..|.:        :.|.|:..   |..||...|.| .|.
Zfish   730 ---QSVIKIPLTDI-CKDYIFSVSALLHNGA--------LECKCDPRGSLSTVCDPIGGQC-QCR 781

  Fly   873 HNTFGDRCERCQLGYYGNPLQGTPNDCKRCAC-PLSEDSNNFSPSCQLKSYNYMDLNPQFELIEH 936
            .|..|..|:.|....|   |.| |:.|:.|.| ||...:....||           |.|      
Zfish   782 PNVSGKNCDACAPATY---LFG-PSGCRACDCNPLGSQNLFCHPS-----------NGQ------ 825

  Fly   937 AEYICTQCPEGYTGDHCQVCDDGYFGNPRQPGSSCQRCDCAGG--PCNVTTGECITCRGNTEGWH 999
                |. |..|..|..|..|...::|.|     :|:.|.|.|.  .|:..||:|:.|||:|.|.:
Zfish   826 ----CL-CVPGAFGRQCGNCKPNHWGYP-----TCKPCSCNGNSEQCHPLTGKCLNCRGHTSGHN 880

  Fly  1000 CERCKLGYWGDPAVG----CDPCHCHTEGSESGL-----C----DSTDGQCLCKPRYAGQKCDEC 1051
            ||||:.||.....:|    |.||.| ..|..||:     |    ::....|:|...|.|.||:||
Zfish   881 CERCESGYHRSTLLGSRDQCRPCMC-PNGPGSGMQFSESCYQNPNTLQMVCVCNAGYKGPKCEEC 944

  Fly  1052 DVG-YANVEL---RCPSCNCDPLGSL-VQD--RCDPHTGQC-HCKEGVMGAKCHECQDGYFGMNA 1108
            ..| |.|..:   ||..|.|:  |:: :||  .||..||.| .|.....|.:|..|..||:|   
Zfish   945 ASGYYGNTRVPGGRCHPCQCN--GNINMQDPESCDARTGACLKCLFHTDGTECQYCSRGYYG--- 1004

  Fly  1109 VAYRMDDLAALRQNSDSDDDEWELVPDTEDPNSESTVACEECHCSSVGSLSS-------DCDKRT 1166
                                         |..|::   |..|.|:.|||...       :||:.:
Zfish  1005 -----------------------------DARSQN---CRRCMCNLVGSSRQSCVDGLCECDRIS 1037

  Fly  1167 GQCACLANVTGRRCDKCRPGHWNLTAGEGCRDCRCDPHGSRGHECNPWTGQCDCKIGVGGQHCNE 1231
            |||.||..|.|:.||:|.|..||:.:|.||:.|||.|..|....|:..:|||.||.|.||:.|.|
Zfish  1038 GQCPCLPGVEGQLCDRCAPNTWNINSGRGCQPCRCHPEHSYSSSCDLLSGQCSCKPGFGGKTCEE 1102

  Fly  1232 CTEGFFGFSTEGCQRCSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPGTWGWQARLGCRECEC 1296
            |.|.|:|                   ||                            .:.|..|:|
Zfish  1103 CRELFWG-------------------DP----------------------------EVECHACDC 1120

  Fly  1297 DHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFG-YPECRRCGCDAEGSFTQADGSIACDSN 1360
            |..|...|||:...|.|.|.||.:||:||||..|:.| :|:|                       
Zfish  1121 DPRGIATQQCNKTSGDCVCIEGVAGRRCDTCGRGFVGTFPDC----------------------- 1162

  Fly  1361 GQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGCTRCFCFGRSGECEQSDLSWGHIRMAESRNL-SV 1424
                                         |.|..||        .:.|::.|.:.....|.: :|
Zfish  1163 -----------------------------EACHYCF--------REWDVNVGELTNHTQRLVDTV 1190

  Fly  1425 QQIRPHSVPSSDYEYIVVVQMEGSSFHR--EDAEIQR--MNDLSLVPKSTGNVSIGAYGQFYHPL 1485
            ::::...|.:...:.|..:..|......  ||.::|:  .:...::.|::...|:          
Zfish  1191 EEMKDSGVATPYKDIIKSLDDESRQLREILEDDKVQQTFAHTQRMMKKASETASL---------- 1245

  Fly  1486 YFQLPPQFYGDRTSSYGGFLYFTLITEGAHKPLERNILGQYPLVQLHAHSKLLLDFYEYEEFEYS 1550
                                        ..|.::|              |:..||....:     
Zfish  1246 ----------------------------LRKSMDR--------------SETDLDMVSTD----- 1263

  Fly  1551 LNVTHRVPLHESFWKYHHTSQAV-DRNTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMD--AAI 1612
                            ||  :|: |..:|....||::.|      .:|.|:.||...|.|  .|:
Zfish  1264 ----------------HH--RAIKDLKSLTKEAQNLQEI------TSDKQQQVLNIKHSDPRGAV 1304

  Fly  1613 -----YIKGSTNLIAKGVERCKCPKRFDGLSCQDPGRSFYRWRNT-TIVESVFIEDLIGRAAPCH 1671
                 |.:.|.....:..:....|.|...|..:|......|..|. .:...::.:    |.:...
Zfish  1305 DSIRDYYRESAEADFRVSQAISEPVRQSALLRKDTEAKLERTENEFNLKHQLYTQ----RLSKIE 1365

  Fly  1672 CNGRSSDCDRETGVCQNCRGNTGGDHCHQCAEGFYGDPNSPHGCQACPCPETNRNFARGCNVWDG 1736
            ....|:|..|.:.  |.|.|..|.|.|..|.                         ..||...||
Zfish  1366 TELNSTDLSRLSR--QVCGGAAGLDGCKDCG-------------------------GLGCKHEDG 1403

  Fly  1737 EVSCVCKPGYTGRLCERCQAGYFGDPMRYPNTTCQPCNCHPDGIQTEGCDVETGRCYCREGVTGL 1801
            ...|               .|                         ||||....|          
Zfish  1404 MSHC---------------GG-------------------------EGCDTIVTR---------- 1418

  Fly  1802 KCDKCQAERHHLVDNGCKICDNCTLLLLDYMELVGNKLRRGMHNMDLTGIPAPYRKLSEYESAYE 1866
                                                                             
Zfish  1419 ----------------------------------------------------------------- 1418

  Fly  1867 KWNGRHWDFSQTKRRLQDYDSADILKLEAHAENLKFQSRKAVATIGKREFAIKSMREDAVTQQHS 1931
                                |.|.|.   .|:||.                              
Zfish  1419 --------------------SQDSLN---KAKNLD------------------------------ 1430

  Fly  1932 VGLLRSEILQTLSDLHGYGKSAHYLSLPTALKQARFYLQAIREHDQMVQGIRSTNDCAWKHFYAM 1996
                 .|:|.||                                                     
Zfish  1431 -----QEVLHTL----------------------------------------------------- 1437

  Fly  1997 GNASDASFDESGRLEMLWRDLNQTNHRVVDMRLQVDRVQEVENEAEDVLEHVRNLSIRVGESHQE 2061
                              :::::.|..|.|.|   .|..|.:..|:|||........||.:::::
Zfish  1438 ------------------KEVDKLNRMVSDAR---GRADEAKLSAQDVLLRANQSKARVEQTNED 1481

  Fly  2062 LDELNQRISDHL----DPGYLEQGEGLLRLTVQRQIMLNGHLNQLDGYRILLNTTLGVKTEQQRE 2122
            |..|.|:|.|.|    ||..:|:        |..::|           ::.|..:.|.......|
Zfish  1482 LRNLIQQIRDFLTNETDPKRIEE--------VANEVM-----------KLSLPVSSGALKNMTTE 1527

  Fly  2123 VRKHWLPKAEKHASHLLARSNEYARKFQPTRNGARIAMLASSAHSNITEAINDARLASILAKERV 2187
            :|        ||.:.|....:..::..:.|||..|:...|.:|:...|           ..|...
Zfish  1528 IR--------KHVARLTNVEDILSQTAEKTRNAERLLEQAKAANKKAT-----------TLKHTS 1573

  Fly  2188 YEAQRTLYPSDGSSMIERAKHSLHRSKQLQQEALKQMHKSNVLKDKLHRQEQQVEGIKSTIYDSG 2252
            .|.::||..:|             |::....|.:|...:.      |::..||:..::|....:.
Zfish  1574 DEVKKTLEDTD-------------RAQTAANEKIKAAERD------LNQTNQQITSVQSKTEATE 1619

  Fly  2253 LRTNNISGQ---LQGLSDGSARRQAKDSLEMADRTGEQMRAELQKAKDMQKSIQNMRNSFSNLE- 2313
            .:.::.:|:   |:|..|...|:.|:.| ..||:|..|       |:|....:::.......|. 
Zfish  1620 FKLSSSTGRMVNLEGDLDDLQRKTAETS-RSADQTQRQ-------AEDTTAELEHTERDLDTLVL 1676

  Fly  2314 PDWEIKLGMAQENISLTQTNLRLANVSLSYLEQQAEKEQQVFEVWNNSMAQQLQQLRDQIAKARH 2378
            |.:::..|:..                        :|...||:.  ...|:||||          
Zfish  1677 PKYQLASGLID------------------------QKAAGVFDA--RQKAEQLQQ---------- 1705

  Fly  2379 AAEAIDVSLESLGPKCIRSYLPASYGLSTSNKIRMSFALSNHL---ESSPLIHLASSEGRHITLE 2440
              ||.|:.::            |:..|....::..|||.:.|:   :|..|..| .:|.|.:..|
Zfish  1706 --EAKDLLID------------ATNKLQRLRELERSFAANQHILMGKSQELEGL-ENEARDVLQE 1755

  Fly  2441 LYKR 2444
            |.::
Zfish  1756 LSQK 1759

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 153..398 CDD:459653 56/255 (22%)
EGF_Lam 401..450 CDD:238012 18/59 (31%)
EGF_Lam 505..552 CDD:238012 21/61 (34%)
Laminin_EGF 550..597 CDD:395007 16/49 (33%)
Laminin_B 660..813 CDD:459652 37/220 (17%)
EGF_Lam 851..900 CDD:238012 16/51 (31%)
Laminin_EGF <943..971 CDD:395007 7/27 (26%)
Laminin_EGF 974..1018 CDD:395007 20/49 (41%)
EGF_Lam 1017..1065 CDD:238012 20/60 (33%)
Laminin_EGF 1065..>1105 CDD:395007 16/43 (37%)
EGF_Lam 1150..1197 CDD:238012 22/53 (42%)
Laminin_EGF 1199..1247 CDD:395007 20/47 (43%)
EGF_Lam 1247..1292 CDD:238012 2/44 (5%)
Laminin_EGF 1294..1342 CDD:395007 22/48 (46%)
Laminin_EGF 1340..1392 CDD:395007 1/51 (2%)
Laminin_B 1486..1626 CDD:459652 22/147 (15%)
EGF_Lam 1669..1716 CDD:238012 10/46 (22%)
Laminin_EGF 1718..1767 CDD:395007 6/48 (13%)
EGF_Lam 1772..1819 CDD:238012 5/46 (11%)
YhaN <1907..2141 CDD:443752 34/237 (14%)
SMC_prok_B <2123..>2390 CDD:274008 50/270 (19%)
Laminin_II 2279..2400 CDD:368703 20/121 (17%)
LamG 2399..>2492 CDD:473984 13/49 (27%)
LamG 2586..2753 CDD:238058
Laminin_G_2 2804..2944 CDD:460494
LamG 3018..3167 CDD:238058
LamG 3192..3347 CDD:238058
lamb1bNP_001264059.1 Laminin_N 33..265 CDD:459653 56/255 (22%)
EGF_Lam 267..318 CDD:238012 16/50 (32%)
EGF_CA 330..380 CDD:473889 17/49 (35%)
EGF_Lam 392..450 CDD:238012 19/57 (33%)
EGF_Lam 451..502 CDD:238012 17/51 (33%)
EGF_Lam 504..542 CDD:214543 7/63 (11%)
EGF_Lam 759..804 CDD:214543 16/49 (33%)
Laminin_EGF 807..855 CDD:395007 18/74 (24%)
EGF_Lam 852..890 CDD:238012 18/37 (49%)
EGF_Lam 902..957 CDD:238012 18/55 (33%)
EGF_Lam 961..1012 CDD:238012 19/87 (22%)
Laminin_EGF 1014..1067 CDD:395007 21/52 (40%)
Laminin_EGF 1070..1118 CDD:395007 23/94 (24%)
EGF_Lam 1118..1162 CDD:214543 21/43 (49%)
SMC_prok_B <1179..1757 CDD:274008 158/1052 (15%)
cc_LAMB1_C 1695..1767 CDD:411971 21/92 (23%)
Blue background indicates that the domain is not in the aligned region.

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