DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wb and lamb2l

DIOPT Version :10

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:XP_692838.6 Gene:lamb2l / 553337 ZFINID:ZDB-GENE-030131-4205 Length:1836 Species:Danio rerio


Alignment Length:2402 Identity:512/2402 - (21%)
Similarity:806/2402 - (33%) Gaps:892/2402 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   151 GGLYPPLFN-VVPRA-QISVNATCGQNGAEEYC---KQVGAKPCGIC--------NAHSSDRAKQ 202
            |..||...| ::.|| .::.::|||.:|.|.||   ....::.|.||        |.|......:
Zfish    30 GSCYPATGNLLIGRAINLTTSSTCGLDGPEPYCIVSHLKDSEKCFICDSENPYDANYHRDSHRVE 94

  Fly   203 RSIQSLISSGSGSGSGSGFEEGWWQSPTLQGGRQFEYVTILLDLKQTFQIFSVWLKSANSPRPAS 267
            ..|..:.|:|         |..|||:...:     |.|::.|:|:..|. |:..:....:.|||:
Zfish    95 NVIYPMDSTG---------ELTWWQAVNGE-----ENVSVRLNLEAEFH-FTHLIMKFKTFRPAA 144

  Fly   268 WILEKSLD-GINFEPWQYFGLSDADCQRRW-NLSGQNGKYVFQNDTEIICSTQFSKPGPLENG-- 328
            .|:|:|.| |..:..::||..   :|.:.: .:...:.:::    .|:||..::|...|..:|  
Zfish   145 MIIERSSDFGRTWRIYRYFAY---NCTKTFPRVPAHSLRFI----DEVICEERYSDIEPSTDGEV 202

  Fly   329 ---VLHASLLKNRPGATDQSPELMKFITTRYIRIRLQGMHSTANQDNSLDWLLDSPSLEKHSFYS 390
               ||..::....|.:.|    :...:....:||....:|:..  ||.||   ..|.:.:..:|:
Zfish   203 IYKVLDPAIHVKDPYSLD----IQDLLRITNLRINFTKLHTLG--DNLLD---RRPDVLQKYYYA 258

  Fly   391 LSQLKVSARLDCNGHANRSHESP-----DDPLM--QCICQHNTCGAQCEQCCPLFQDRPYQ---- 444
            |.:|.|.....|.|||:.....|     |..::  :|:|:|||.|..||:|...:.|.|::    
Zfish   259 LYELVVRGSCFCYGHASECAPVPGVTTRDSGMIHGRCVCKHNTVGLNCERCRDFYHDAPWRPAET 323

  Fly   445 -MGGECEICQCYGHAESCTYDPF-------LDKGICQSCSNNTAGIECEFCEMGFYRELDAPLTD 501
             ....|..|.|.||:..|.:|..       :..|:|.:|.:||.|..||.|:..:|::.:..:.|
Zfish   324 DNAHTCRECNCNGHSNQCHFDMAVYLATGNVSGGVCNNCLHNTMGRNCESCKPFYYQDPEKDIRD 388

  Fly   502 P--CLPCSCNPARSTGG--CQSD--------GGSCNCLEGFQGKNCEECAPGYYG---DD---CK 548
            |  |:||.|:|..|..|  |.|.        ||.|.|.:..:|:.|:.|..|:||   ||   |:
Zfish   389 PAACVPCDCDPVGSVEGGVCDSHTDLDLGMIGGQCRCKQNVRGQRCDYCKEGHYGLSLDDPLGCQ 453

  Fly   549 RCECDERG--SLG-STGSCSGVCQCKLNVEGSTCSECAPGYFDLSAENAEGCTSCWC---SGVSQ 607
            .|.||.||  :|| .....||.|.||..|.|..|::|.|.|:.||.:.| ||..|.|   ...|.
Zfish   454 PCNCDPRGITTLGVPCDQISGDCSCKRYVTGRYCNQCLPEYWGLSHDLA-GCRPCNCDFGGATSS 517

  Fly   608 TCHSAKLQTLAFETLNDWKITDIQRVKPISIPVDAETNRLIFANELD----EVEAIYWQA----- 663
            .|.....|......|...:.:::|..              .|...||    |.||:..::     
Zfish   518 RCMMDSGQCDCRPHLIGRQCSEVQPA--------------FFCASLDYYKYEAEAVMGRSPEDLT 568

  Fly   664 ------------SLGYLGNRLTSYG----------------SRLQLVLSWDVIRGDRS-GKPT-- 697
                        .:.:|.|:|..:.                .:||...|...:..:|. |:..  
Zfish   569 LPGSPRPQAETDCVQHLNNQLRRHRRHRHIAQQQRAALRRIRQLQQTPSVSSVHRERQPGQMVTW 633

  Fly   698 TGPNVILVGKNG-----------------LKIAFGDESLDG-------LGINLNVTL-------T 731
            |||....| |:|                 :.|.:..||.:.       ..:||.::|       |
Zfish   634 TGPGFARV-KDGAGLEFAISNIPYAMEYDIMIRYEPESTEDWEALVSVTSVNLPISLRCGNMLPT 697

  Fly   732 EVGWYHVP-----------------PT---VVDIKTRLRRTEGGDYHGESVTRSQFLSVLVSLDA 776
            | ..|.||                 |.   ||.|  |.:|      |..|   .:.|:..:.:|:
Zfish   698 E-QLYTVPMPHNVRYIKMPKPFCFEPNNRYVVSI--RFQR------HAVS---HRHLTAFILIDS 750

  Fly   777 VLI------RAAFHTDQGETSLER--------------------------------AVIYSG--G 801
            :::      ...|..|:|.....|                                |::::|  |
Zfish   751 LVLIPRYEELTGFQGDEGADERRRQEMESYMCLESFMTMPMPALAELCTSLICSISAIMHNGALG 815

  Fly   802 VELGGKSSSQVE------QCLCPAGYTGLSCEGCA---FGFKRIYENTSD--------------- 842
            .:...:.|...|      ||.|.....|..|..||   :||........|               
Zfish   816 CQCDPQGSLSAECDRVGGQCRCKPNVIGRKCNQCAPGTYGFGPYGCTVCDCHSQGSVGHHCDPVT 880

  Fly   843 ------HQIL----SKCIP----------CPCNGHSNSCDLQSGNCGDCMHNTFGDRCERCQLGY 887
                  |..:    |:|.|          |.||.|:.|||.:||.|.||..||.|..||||..||
Zfish   881 GQCMCRHGAIGRQCSECQPGQWGFPNCRQCQCNSHAESCDPESGACYDCRDNTAGQLCERCVDGY 945

  Fly   888 YGNPLQGTPNDCKRCACPLSEDSNNFS-PSCQLKSYNYMDLNPQFELIEHA--EYICTQCPEGYT 949
            ||||..|:...|:.|.||...||.:.: .||:               :::|  :.:| ||.:||.
Zfish   946 YGNPALGSGEHCRPCPCPGHPDSGHSNGASCE---------------VDYASNQILC-QCGQGYA 994

  Fly   950 GDHCQVCDDGYFGNPRQPGSSCQRCDCAGG-------PCNVTTGECITCRGNTEGWHCERCKLGY 1007
            |..|..|..||:|:|..||.||:.|.|.|.       .|:..||.|:.|..||:|..|..|||||
Zfish   995 GPRCDRCAPGYYGDPEHPGGSCRPCQCNGNIDPQDPESCDPRTGLCLKCLYNTDGDSCSECKLGY 1059

  Fly  1008 WGDPAV-GCDPCHCHTEGSESGLCDSTDGQCLCKPRYAGQKCDECDVGYANVELRCPSCNCDPLG 1071
            :|:..: .|..|.|.|.|:....|  |||.|                                  
Zfish  1060 YGNALIQDCRRCTCVTAGTLPNSC--TDGVC---------------------------------- 1088

  Fly  1072 SLVQDRCDPHTGQCHCKEGVMGAKCHECQDGYFGMNAVAYRMDDLAALRQNSDSDDDEWELVPDT 1136
                                                                             
Zfish  1089 ----------------------------------------------------------------- 1088

  Fly  1137 EDPNSESTVACEECHCSSVGSLSSDCDKRTGQCACLANVTGRRCDKCRPGHWNLTAGEGCRDCRC 1201
                                    .|||:||||.|..|:.|..||:|...|||..:..||..|.|
Zfish  1089 ------------------------QCDKQTGQCPCKQNIIGHNCDQCATNHWNFGSDCGCEPCGC 1129

  Fly  1202 DPHGSRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRCSACRSEGQVCDPHNGRCIC 1266
            ....:....||.::|||.|:.|.||:.|||| |.|.                             
Zfish  1130 VQPNALSTHCNMFSGQCHCQPGFGGRQCNEC-EAFH----------------------------- 1164

  Fly  1267 PKFTRGLGCGQCVPGTWGWQARLGCRECECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGY 1331
                            || ..|:.|.||.|..:||...||....|.|.|::|.||::||.||.|:
Zfish  1165 ----------------WG-DPRVQCEECNCHPLGSETSQCDRTTGACVCKDGASGQRCDECARGF 1212

  Fly  1332 FG-YPECRRCGCDAEGSFTQADGSIACDSNGQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGCTRC 1395
            .| :|:|..|.                      ||..|...:.|..                   
Zfish  1213 TGNFPKCVPCH----------------------PCFQLWDDVVCQV------------------- 1236

  Fly  1396 FCFGRSGECEQSDLSWGHIRMAESRNLSVQQIRPHSVPS-SDYEYIVVVQMEGSSFHREDAEIQR 1459
                      :.||:  |.     |::....:....||. ||..   ::::|     ::.|:.|.
Zfish  1237 ----------RRDLT--HF-----RDIIAMILEKGEVPGVSDKR---ILELE-----KKLAQAQE 1276

  Fly  1460 M-NDLSLVPKSTGNVSIGAYGQFYHPLYFQLPPQFYGDRTSSYGGFLYFTLITEGAHKPLERNIL 1523
            : .|                                |||..::                   |::
Zfish  1277 LVRD--------------------------------GDREGTF-------------------NLI 1290

  Fly  1524 GQYPLVQLHAHSKL----LLDFYEYEEFEYSLNVTHRVPLHESFWKYHHTS---QAVDRNTLMAA 1581
            .| .:..|.|...|    |:....      .||||..   |.:..|.:.|:   :..|.|..:..
Zfish  1291 SQ-TVDDLRAEIALTDGRLMGVIR------DLNVTTD---HNNDLKQNLTALEKELKDLNNTLHQ 1345

  Fly  1582 LQNIRHIFIRAFAFADFQEVVLQNVHMDAAIYIKGSTNLIAKGVERCKC----PKRFDGLSCQDP 1642
            |:.....::.|.....|..|:.         |.:.|.|    ..:||..    |        |.|
Zfish  1346 LRRELENYLTAGLAEQFANVLK---------YYQRSLN----SEQRCNASVYGP--------QSP 1389

  Fly  1643 GRSFYRWRNTTIVESVFIEDLIGRAAPCH------CNGRSSDCDRETGVCQN--CRGNTGGDHCH 1699
            .......||.|.......:|.:.|.|..:      ..|::.:.:|:.....|  |.|:..|    
Zfish  1390 VEQSQDTRNRTEALLKDKKDSLLRTATANNKSLSELEGKAHEINRKVHHLSNKVCGGHANG---- 1450

  Fly  1700 QCAEGFYGDPNSPHGCQACPCPETNRNFARGCNVWDGEVSCVCKPGYTGRLCERCQAGYFGDPMR 1764
                      |....|:..||.      ..||...||.:.|      .||.|.            
Zfish  1451 ----------NVNGSCEESPCG------GAGCRGSDGVLKC------GGRGCN------------ 1481

  Fly  1765 YPNTTCQPCNCHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQAERHHLVDNGCKICDNCTLLLL 1829
                            .|.|..|:.                        :||..::..|.| .:.
Zfish  1482 ----------------GTVGASVKA------------------------LDNADEVHKNLT-AVS 1505

  Fly  1830 DYMELVGNKLRRGMHNMDLTGIPAPYR--------KLSEYESAYEKWNGRHWDFSQTKRRLQDYD 1886
            :.::.:..|||      |:..:....:        |....:..:||.|....:|.|..:...:.:
Zfish  1506 EELQTMAKKLR------DIATLTQTVKTQAKETLDKAQNKKDMFEKSNKMLKNFIQKIKDFLNEE 1564

  Fly  1887 SADILKLEAHAENLKFQS----RKAVATIGKREFAIKSMREDAVTQQHSVGLLR--SEILQTLSD 1945
            .||...:|..|:.:...|    |..:..:      ::.:::..|...:..|:..  ||.|..::|
Zfish  1565 GADPESIEKVAQQVLAISLPVNRTVIVNL------VEQIKDSIVNLTNVEGVFNHTSEQLAKVND 1623

  Fly  1946 LHGYGKSAHYLSLPTALKQARFYLQAIREHDQMVQGIRSTNDCAWKHFYAMGNASDASFDESGRL 2010
            |               ||:|:                                  ||.....|..
Zfish  1624 L---------------LKKAQ----------------------------------DAKTQADGVS 1639

  Fly  2011 EMLWRDLNQTNHRVVDMRLQVDRVQEVENEAEDVLEHVRNLSIRVGESHQELDELNQRISDHLDP 2075
            :    ::|:|...:...:..:.:.:|..:.|...|::::|::..|.:   :|..|:..::|    
Zfish  1640 D----NINKTKEALETSQNAIKKAEEEMSTALKNLKNIQNITAMVDD---KLLNLDNNLTD---- 1693

  Fly  2076 GYLEQGEGLLRLTVQRQIMLNGHLNQLDGYRILLNTTLGVKTEQQREVRKHWLPKAEKHASHLLA 2140
                   .::||           :|..:|..:|.|     ||||.||:.|.  .||:        
Zfish  1694 -------VMMRL-----------VNLSNGVDLLKN-----KTEQNREMAKE--AKAQ-------- 1725

  Fly  2141 RSNEYARKFQPTRNGARIAMLASSAHSNITEAINDARLASILAKERVYEA---------QRTL-Y 2195
                       :.|..|.|       ..:.|.:.:|.......||:|..|         |:.: .
Zfish  1726 -----------SDNATREA-------EGLQEELTNAETLYKQLKEKVDSAGGTGEGNVNQKAIEM 1772

  Fly  2196 PSDGSSMIERAKHSLHRSKQLQQEALKQMHKSNVLKDKLHRQEQQVEGIKSTIYDSGLRTNN 2257
            ..:...::::|...:...|:|:::..|...|....:|:|...|:.|.||:..|....|..||
Zfish  1773 KKEAEDLLKKATMGMETLKKLERKFNKNEQKMQQQRDELTDLEKNVTGIREYIRSKVLAYNN 1834

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 153..398 CDD:459653 63/264 (24%)
EGF_Lam 401..450 CDD:238012 17/60 (28%)
EGF_Lam 505..552 CDD:238012 22/62 (35%)
Laminin_EGF 550..597 CDD:395007 21/49 (43%)
Laminin_B 660..813 CDD:459652 43/279 (15%)
EGF_Lam 851..900 CDD:238012 27/58 (47%)
Laminin_EGF <943..971 CDD:395007 13/27 (48%)
Laminin_EGF 974..1018 CDD:395007 19/51 (37%)
EGF_Lam 1017..1065 CDD:238012 9/47 (19%)
Laminin_EGF 1065..>1105 CDD:395007 0/39 (0%)
EGF_Lam 1150..1197 CDD:238012 17/46 (37%)
Laminin_EGF 1199..1247 CDD:395007 17/47 (36%)
EGF_Lam 1247..1292 CDD:238012 3/44 (7%)
Laminin_EGF 1294..1342 CDD:395007 21/48 (44%)
Laminin_EGF 1340..1392 CDD:395007 5/51 (10%)
Laminin_B 1486..1626 CDD:459652 25/146 (17%)
EGF_Lam 1669..1716 CDD:238012 7/54 (13%)
Laminin_EGF 1718..1767 CDD:395007 10/48 (21%)
EGF_Lam 1772..1819 CDD:238012 5/46 (11%)
YhaN <1907..2141 CDD:443752 38/235 (16%)
SMC_prok_B <2123..>2390 CDD:274008 28/145 (19%)
Laminin_II 2279..2400 CDD:368703
LamG 2399..>2492 CDD:473984
LamG 2586..2753 CDD:238058
Laminin_G_2 2804..2944 CDD:460494
LamG 3018..3167 CDD:238058
LamG 3192..3347 CDD:238058
lamb2lXP_692838.6 Laminin_N 32..266 CDD:459653 63/264 (24%)
EGF_Lam 267..320 CDD:238012 17/52 (33%)
EGF_Lam 332..384 CDD:238012 16/51 (31%)
Laminin_EGF 395..452 CDD:395007 19/56 (34%)
EGF_Lam 454..505 CDD:238012 22/51 (43%)
EGF_Lam 506..>545 CDD:238012 7/52 (13%)
EGF_Lam 816..861 CDD:214543 11/44 (25%)
Laminin_EGF 864..912 CDD:395007 6/47 (13%)
EGF_Lam 910..954 CDD:238012 26/43 (60%)
Laminin_EGF 960..1016 CDD:395007 22/71 (31%)
Laminin_EGF 1019..1063 CDD:395007 18/43 (42%)
Laminin_EGF <1089..1129 CDD:395007 19/39 (49%)
EGF_Lam 1126..1168 CDD:238012 19/88 (22%)
Laminin_EGF 1175..1215 CDD:395007 17/39 (44%)
COG4372 1245..>1436 CDD:443500 46/280 (16%)
Mplasa_alph_rch 1492..>1818 CDD:275316 76/449 (17%)
cc_LAMB_C 1766..1835 CDD:411969 16/69 (23%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.