DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wb and CCDC186

DIOPT Version :9

Sequence 1:	NP_723870.1	Gene:	wb / 43946	FlyBaseID:	FBgn0261563	Length:	3375	Species:	Drosophila melanogaster
Sequence 2:	NP_001308758.1	Gene:	CCDC186 / 55088	HGNCID:	24349	Length:	898	Species:	Homo sapiens

Alignment Length:	811	Identity:	146/811 - (18%)
Similarity:	301/811 - (37%)	Gaps:	206/811 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1780 IQTEGCDV----ETGRCYCREGVTGLKCDK--CQ---------AERHHLVDNGCKICDNCTLLLL 1829
            ::.:.|::    |:.:......:..|..||  ||         |:.:::.|:|... |:|.
Human    22 LKEDSCNLFSGNESSKLENESKLLSLNTDKTLCQPNEHNNRIEAQENYIPDHGGGE-DSCA---- 81

  Fly  1830 DYMELVGNKLRRGMHNMD-----------------------LTGIPAPYRKLSEYESAYEK-WNG 1870
                    |...|..|.:                       :|.|....|..:..|||.|| ::.
Human    82 --------KTDTGSENSEQIANFPSGNFAKHISKTNETEQKVTQILVELRSSTFPESANEKTYSE 138

  Fly  1871 RHWDFSQTKRRLQDYDSA----DIL-KLEAHAENLKFQSRKAVATIGKREFAI----KSMREDAV 1926
            ..:|...||:.:....|.    |:| ::|:...:.:|...:....:.|.|.|:    |.:::..:
Human   139 SPYDTDCTKKFISKIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYL 203

  Fly  1927 TQQHSVGLLRSEILQTLSDLHGYGKSAHYLSLPTALKQARFYLQAIREHDQMVQGIRSTNDCAWK 1991
            .|:|.:..|..|                      ..|....::....|.|.:.:.::...:...:
Human   204 QQEHIIKKLIKE----------------------NKKHQELFVDICSEKDNLREELKKRTETEKQ 246

  Fly  1992 HFYAMGNASDASFDE------SGRLEMLWRDLNQTN-----HRVVDMRLQV--DRVQEVENEAED 2043
            |...: ...::..:|      :.|.:::.:|:...|     |:.:..|::.  .:.:|...|.|.
Human   247 HMNTI-KQLESRIEELNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEA 310

  Fly  2044 -VLEHVR-------------NLSIRVGESHQELDELNQRISD-HLDPGYLEQ------GE--GLL 2085
             |:::||             .|..::.::::||::...:|.. ..:.|.|.|      ||  .|:
Human   311 MVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLI 375

  Fly  2086 RLTVQRQIMLNGHL-----------NQLDGYR----ILLNTT--LGVKTEQQREVRKHWLPKAEK 2133
            |...:.:..:|.|:           .::|.::    .|..||  |....|:..::||:.....:.
Human   376 REIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKT 440

  Fly  2134 HASHLLARSNEYARKFQPTRNGARIAMLASS-----AHSNITEAINDAR---------LASILAK 2184
            :......:|||...|.:.|:......|...|     .|:.|.| :.|.:         |.::..|
Human   441 YQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKE-LEDLKRTFKEGMDELRTLRTK 504

  Fly  2185 ERVYEAQRTLYPSDGSSMIERAKHSLHRSKQLQQEALKQMHKSNVLKDKLHRQEQQVEGIKSTIY 2249
            .:..|.:|.....:    :.:.|..::|.|...|..|.::..::.|:::|.|.:|::|.:|..:.
Human   505 VKCLEDERLRTEDE----LSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIENLKEEVE 565

  Fly  2250 DSGLRTNNISGQLQGLSDGSARRQAKDSL--EMADRTGEQMRAE---LQKAKD--------MQKS 2301
            .    .|::...||...:||.:|:::..|  |.......|:::|   ||...|        :|..
Human   566 S----LNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQ 626

  Fly  2302 IQNMRNSFSNLEPDWEIKLGMAQENISLTQTNLRLANVSLSYLEQQAEKEQQVFEVWNNSMAQQL 2366
            .:.|:.:..|||.....:..:.:|.:...|..|......:..|..|.|:.:..........|..:
Human   627 CEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSI 691

  Fly  2367 QQLRDQIAKARHAAEAI-----DVSLESLGPKCIRSYLPASYGLSTSNKIRMSFALSNHLESSPL 2426
            :.|..|:.:||...:.:     |..:.|:|.:.           |:|..:.   |.|:..:.||
Human   692 KDLTKQLQQARRKLDQVESGSYDKEVSSMGSRS-----------SSSGSLN---ARSSAEDRSP- 741

  Fly  2427 IHLASSEGRHITLE---------LYKRRVRL 2448
                .:.|..:.::         |.:|.|||
Human   742 ----ENTGSSVAVDNFPQVDKAMLIERIVRL 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wb	NP_723870.1	Laminin_N	164..396	CDD:278484
		EGF_Lam	401..450	CDD:238012
		TNFRSF	<407..507	CDD:304602
		EGF_Lam	505..552	CDD:238012
		Laminin_EGF	550..597	CDD:278482
		Laminin_B	660..798	CDD:278481
		EGF_Lam	851..900	CDD:238012
		Laminin_EGF	<943..971	CDD:278482
		VSP	953..1414	CDD:146106
		Laminin_EGF	974..1018	CDD:278482
		EGF_Lam	1017..1065	CDD:238012
		Laminin_EGF	1065..>1105	CDD:278482
		EGF_Lam	1150..1197	CDD:238012
		Laminin_EGF	1199..1247	CDD:278482
		EGF_Lam	1247..1292	CDD:238012
		Laminin_EGF	1294..1342	CDD:278482
		Laminin_EGF	1340..1392	CDD:278482
		Laminin_B	1486..1611	CDD:278481
		EGF_Lam	1669..1716	CDD:238012
		Laminin_EGF	1718..1767	CDD:278482
		EGF_Lam	1772..1819	CDD:238012	10/53 (19%)
		CrfC	<1933..2267	CDD:223771	68/400 (17%)
		Laminin_II	2277..2400	CDD:283628	26/140 (19%)
		LamG	2399..>2492	CDD:304605	12/59 (20%)
		Laminin_G_2	2616..2755	CDD:280389
		Laminin_G_2	2804..2944	CDD:280389
		Laminin_G_2	3038..3169	CDD:280389
		LamG	3192..3347	CDD:238058
CCDC186	NP_001308758.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43		2/20 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	68..95		7/39 (18%)
		SMC_N	208..>594	CDD:330553	72/417 (17%)
		SMC_N	454..>737	CDD:330553	59/305 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	702..749		11/65 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1836
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900