Protein Alignment wb and LAMC2

DIOPT Version :10

• Sequence 1: NP_723870.1
• Gene: wb / 43946
• FlyBaseID: FBgn0261563
• Length: 3375
• Species: Drosophila melanogaster
• Sequence 2: XP_054192520.1
• Gene: LAMC2 / 3918
• HGNCID: 6493
• Length: 1256
• Species: Homo sapiens
• Alignment Length: 735
• Identity: 228/735 - (31%)
• Similarity: 330/735 - (44%)
• Gaps: 159/735 - (21%)

  Fly   450 EICQCYGHAESCTYDPFLDKGI-----CQSCSNNTAGIECEFCEMGFYRELDAPLTDPCLPCSCN 509
            |:|.|.|.:..|.:|..|.:..     |.:|::||.||.||.|:.||||..:   .|.||||:||
Human    89 EVCDCNGKSRQCIFDRELHRQTGNGFRCLNCNDNTDGIHCEKCKNGFYRHRE---RDRCLPCNCN 150

  Fly   510 PARSTGGCQSDGGSCNCLEGFQGKNCEECAPGYY---GDDC--------KRCECDERGSLGSTGS 563
            ...|......:.|.|:|..|..|..|:.|.||::   ...|        .:|:||   ..|..|.
Human   151 SKGSLSARCDNSGRCSCKPGVTGARCDRCLPGFHMLTDAGCTQDQRLLDSKCDCD---PAGIAGP 212

  Fly   564 C-SGVCQCKLNVEGSTCSECAPGYFDLSAENAEGCTSCWCSGVSQTCHSA------KLQTLAFET 621
            | :|.|.||..|.|..|..|..||::|...|.||||.|:|.|.|.:|.|:      |:.:...:.
Human   213 CDAGRCVCKPAVTGERCDRCRSGYYNLDGGNPEGCTQCFCYGHSASCRSSAEYSVHKITSTFHQD 277

  Fly   622 LNDWKITDIQR-VKPISIPVDAETNRLIFANELDEVEAIYWQASLGYLGNRLTSYGSRLQLVLSW 685
            ::.||.  :|| ..|..:.. ::.::.:|:: ...::.:|:.|...:|||:..|||..    ||:
Human   278 VDGWKA--VQRNGSPAKLQW-SQRHQDVFSS-AQRLDPVYFVAPAKFLGNQQVSYGQS----LSF 334

  Fly   686 DVIRGDRSGKPTTGPNVILVGKNGLKIAFGDESLDGLGINLNVTLTEVGWYHVPPTVVDIKTRLR 750
            | .|.||.|:..:..:|||.|. ||:|.   ..|..||..|...||:...:           ||.
Human   335 D-YRVDRGGRHPSAHDVILEGA-GLRIT---APLMPLGKTLPCGLTKTYTF-----------RLN 383

  Fly   751 RTEGGDYHGESVTRSQFLSVLVSLDAVLIRAAFHTDQGETS---LERAVIYSGGVELGGKSSSQV 812
            .....:: ...::..::..:|.:|.|:.|||.:    ||.|   ::...:.|.. .:.|..:..|
Human   384 EHPSNNW-SPQLSYFEYRRLLRNLTALRIRATY----GEYSTGYIDNVTLISAR-PVSGAPAPWV 442

  Fly   813 EQCLCPAGYTGLSCEGCAFGFKRIYENTSDHQILSKCIPCPCNGHSNSCDLQSGNCGDCMHNTFG 877
            |||:||.||.|..|:.||.|:||   :::.......||||.|.| ..:||..:|:|..      |
Human   443 EQCICPVGYKGQFCQDCASGYKR---DSARLGPFGTCIPCNCQG-GGACDPDTGDCYS------G 497

  Fly   878 D-----RCERCQLGYYGNPLQGTPNDCKRCACPLSEDSNNFSPSCQLKSYNYMDLNPQFELIEHA 937
            |     .|..|.:|:|.:|  ..|..||.|.|     .|.||.|          :.|:.|
Human   498 DENPDIECADCPIGFYNDP--HDPRSCKPCPC-----HNGFSCS----------VMPETE----- 540

  Fly   938 EYICTQCPEGYTGDHCQVCDDGYFGNP---RQPGSSCQRCDC-------AGGPCNVTTGECITCR 992
            |.:|..||.|.||..|::|.|||||:|   ..|...||.|.|       |.|.|:..||.|:.|.
Human   541 EVVCNNCPPGVTGARCELCADGYFGDPFGEHGPVRPCQPCQCNNNVDPSASGNCDRLTGRCLKCI 605

  Fly   993 GNTEGWHCERCKLGYWGD-----PAVGCDPCHCHTEGSESGLCDSTDGQCLCKPRYAGQKCDECD 1052
            .||.|.:|::||.||:||     ||..|..|:|:..|||...|.| ||.|:|||.:.|..|:
Human   606 HNTAGIYCDQCKAGYFGDPLAPNPADKCRACNCNPMGSEPVGCRS-DGTCVCKPGFGGPNCE--- 666

  Fly  1053 VGYANVELRCPSCNCDPLGSLVQDRCDPHTGQCHCKEGVMGAKCHECQDGYFGMNAVAYRMDDLA 1117
                :....||:|.     :.|:.:.|....|..                         ||:.|.
Human   667 ----HGAFSCPACY-----NQVKIQMDQFMQQLQ-------------------------RMEALI 697

  Fly  1118 ALRQNSDSDDDEWELVPDTE 1137
            :..|..|.      :|||||
Human   698 SKAQGGDG------VVPDTE 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wb	NP_723870.1	Laminin_N	153..398	CDD:459653
		EGF_Lam	401..450	CDD:238012	228/735 (31%)
		EGF_Lam	505..552	CDD:238012	16/57 (28%)
		Laminin_EGF	550..597	CDD:395007	19/47 (40%)
		Laminin_B	660..813	CDD:459652	41/155 (26%)
		EGF_Lam	851..900	CDD:238012	16/53 (30%)
		Laminin_EGF	<943..971	CDD:395007	14/30 (47%)
		Laminin_EGF	974..1018	CDD:395007	22/55 (40%)
		EGF_Lam	1017..1065	CDD:238012	17/47 (36%)
		Laminin_EGF	1065..>1105	CDD:395007	4/39 (10%)
		EGF_Lam	1150..1197	CDD:238012
		Laminin_EGF	1199..1247	CDD:395007
		EGF_Lam	1247..1292	CDD:238012
		Laminin_EGF	1294..1342	CDD:395007
		Laminin_EGF	1340..1392	CDD:395007
		Laminin_B	1486..1626	CDD:459652
		EGF_Lam	1669..1716	CDD:238012
		Laminin_EGF	1718..1767	CDD:395007
		EGF_Lam	1772..1819	CDD:238012
		YhaN	<1907..2141	CDD:443752
		SMC_prok_B	<2123..>2390	CDD:274008
		Laminin_II	2279..2400	CDD:368703
		LamG	2399..>2492	CDD:473984
		LamG	2586..2753	CDD:238058
		Laminin_G_2	2804..2944	CDD:460494
		LamG	3018..3167	CDD:238058
		LamG	3192..3347	CDD:238058
LAMC2	XP_054192520.1	EGF_CA	91..149	CDD:473889	24/60 (40%)
		EGF_Lam	146..190	CDD:238012	14/43 (33%)
		Laminin_EGF	202..247	CDD:395007	19/47 (40%)
		LamB	308..433	CDD:214597	40/150 (27%)
		EGF_Lam	524..572	CDD:238012	23/67 (34%)
		EGF_Lam	579..628	CDD:238012	19/48 (40%)
		EGF_Lam	635..>667	CDD:238012	15/39 (38%)
		CCDC158	<677..>1216	CDD:464943	13/66 (20%)