DRSC/TRiP Functional Genomics Resources

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Protein Alignment wb and LAMC2

DIOPT Version :9

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:NP_005553.2 Gene:LAMC2 / 3918 HGNCID:6493 Length:1193 Species:Homo sapiens


Alignment Length:735 Identity:228/735 - (31%)
Similarity:330/735 - (44%) Gaps:159/735 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   450 EICQCYGHAESCTYDPFLDKGI-----CQSCSNNTAGIECEFCEMGFYRELDAPLTDPCLPCSCN 509
            |:|.|.|.:..|.:|..|.:..     |.:|::||.||.||.|:.||||..:   .|.||||:||
Human    26 EVCDCNGKSRQCIFDRELHRQTGNGFRCLNCNDNTDGIHCEKCKNGFYRHRE---RDRCLPCNCN 87

  Fly   510 PARSTGGCQSDGGSCNCLEGFQGKNCEECAPGYY---GDDC--------KRCECDERGSLGSTGS 563
            ...|......:.|.|:|..|..|..|:.|.||::   ...|        .:|:||   ..|..|.
Human    88 SKGSLSARCDNSGRCSCKPGVTGARCDRCLPGFHMLTDAGCTQDQRLLDSKCDCD---PAGIAGP 149

  Fly   564 C-SGVCQCKLNVEGSTCSECAPGYFDLSAENAEGCTSCWCSGVSQTCHSA------KLQTLAFET 621
            | :|.|.||..|.|..|..|..||::|...|.||||.|:|.|.|.:|.|:      |:.:...:.
Human   150 CDAGRCVCKPAVTGERCDRCRSGYYNLDGGNPEGCTQCFCYGHSASCRSSAEYSVHKITSTFHQD 214

  Fly   622 LNDWKITDIQR-VKPISIPVDAETNRLIFANELDEVEAIYWQASLGYLGNRLTSYGSRLQLVLSW 685
            ::.||.  :|| ..|..:.. ::.::.:|:: ...::.:|:.|...:|||:..|||..    ||:
Human   215 VDGWKA--VQRNGSPAKLQW-SQRHQDVFSS-AQRLDPVYFVAPAKFLGNQQVSYGQS----LSF 271

  Fly   686 DVIRGDRSGKPTTGPNVILVGKNGLKIAFGDESLDGLGINLNVTLTEVGWYHVPPTVVDIKTRLR 750
            | .|.||.|:..:..:|||.|. ||:|.   ..|..||..|...||:...:           ||.
Human   272 D-YRVDRGGRHPSAHDVILEGA-GLRIT---APLMPLGKTLPCGLTKTYTF-----------RLN 320

  Fly   751 RTEGGDYHGESVTRSQFLSVLVSLDAVLIRAAFHTDQGETS---LERAVIYSGGVELGGKSSSQV 812
            .....:: ...::..::..:|.:|.|:.|||.:    ||.|   ::...:.|.. .:.|..:..|
Human   321 EHPSNNW-SPQLSYFEYRRLLRNLTALRIRATY----GEYSTGYIDNVTLISAR-PVSGAPAPWV 379

  Fly   813 EQCLCPAGYTGLSCEGCAFGFKRIYENTSDHQILSKCIPCPCNGHSNSCDLQSGNCGDCMHNTFG 877
            |||:||.||.|..|:.||.|:||   :::.......||||.|.| ..:||..:|:|..      |
Human   380 EQCICPVGYKGQFCQDCASGYKR---DSARLGPFGTCIPCNCQG-GGACDPDTGDCYS------G 434

  Fly   878 D-----RCERCQLGYYGNPLQGTPNDCKRCACPLSEDSNNFSPSCQLKSYNYMDLNPQFELIEHA 937
            |     .|..|.:|:|.:|  ..|..||.|.|     .|.||.|          :.|:.|     
Human   435 DENPDIECADCPIGFYNDP--HDPRSCKPCPC-----HNGFSCS----------VMPETE----- 477

  Fly   938 EYICTQCPEGYTGDHCQVCDDGYFGNP---RQPGSSCQRCDC-------AGGPCNVTTGECITCR 992
            |.:|..||.|.||..|::|.|||||:|   ..|...||.|.|       |.|.|:..||.|:.|.
Human   478 EVVCNNCPPGVTGARCELCADGYFGDPFGEHGPVRPCQPCQCNNNVDPSASGNCDRLTGRCLKCI 542

  Fly   993 GNTEGWHCERCKLGYWGD-----PAVGCDPCHCHTEGSESGLCDSTDGQCLCKPRYAGQKCDECD 1052
            .||.|.:|::||.||:||     ||..|..|:|:..|||...|.| ||.|:|||.:.|..|:   
Human   543 HNTAGIYCDQCKAGYFGDPLAPNPADKCRACNCNPMGSEPVGCRS-DGTCVCKPGFGGPNCE--- 603

  Fly  1053 VGYANVELRCPSCNCDPLGSLVQDRCDPHTGQCHCKEGVMGAKCHECQDGYFGMNAVAYRMDDLA 1117
                :....||:|.     :.|:.:.|....|..                         ||:.|.
Human   604 ----HGAFSCPACY-----NQVKIQMDQFMQQLQ-------------------------RMEALI 634

  Fly  1118 ALRQNSDSDDDEWELVPDTE 1137
            :..|..|.      :|||||
Human   635 SKAQGGDG------VVPDTE 648

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 164..396 CDD:278484
EGF_Lam 401..450 CDD:238012 228/735 (31%)
TNFRSF <407..507 CDD:304602 24/61 (39%)
EGF_Lam 505..552 CDD:238012 16/57 (28%)
Laminin_EGF 550..597 CDD:278482 19/47 (40%)
Laminin_B 660..798 CDD:278481 39/140 (28%)
EGF_Lam 851..900 CDD:238012 16/53 (30%)
Laminin_EGF <943..971 CDD:278482 14/30 (47%)
VSP 953..1414 CDD:146106 64/200 (32%)
Laminin_EGF 974..1018 CDD:278482 22/55 (40%)
EGF_Lam 1017..1065 CDD:238012 17/47 (36%)
Laminin_EGF 1065..>1105 CDD:278482 4/39 (10%)
EGF_Lam 1150..1197 CDD:238012
Laminin_EGF 1199..1247 CDD:278482
EGF_Lam 1247..1292 CDD:238012
Laminin_EGF 1294..1342 CDD:278482
Laminin_EGF 1340..1392 CDD:278482
Laminin_B 1486..1611 CDD:278481
EGF_Lam 1669..1716 CDD:238012
Laminin_EGF 1718..1767 CDD:278482
EGF_Lam 1772..1819 CDD:238012
CrfC <1933..2267 CDD:223771
Laminin_II 2277..2400 CDD:283628
LamG 2399..>2492 CDD:304605
Laminin_G_2 2616..2755 CDD:280389
Laminin_G_2 2804..2944 CDD:280389
Laminin_G_2 3038..3169 CDD:280389
LamG 3192..3347 CDD:238058
LAMC2NP_005553.2 EGF_Lam 28..78 CDD:238012 19/52 (37%)
EGF_Lam 83..127 CDD:238012 14/43 (33%)
Laminin_EGF 139..184 CDD:278482 19/47 (40%)
LamB 245..370 CDD:214597 40/150 (27%)
EGF_Lam 461..509 CDD:238012 23/67 (34%)
EGF_Lam 516..565 CDD:238012 19/48 (40%)
EGF_Lam 572..>604 CDD:238012 15/39 (38%)
Domain II and I 603..1193 16/89 (18%)
PspA_IM30 851..1058 CDD:281941
SPEC 891..1111 CDD:295325
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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