DRSC/TRiP Functional Genomics Resources

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Protein Alignment wb and LAMB3

DIOPT Version :9

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:NP_000219.2 Gene:LAMB3 / 3914 HGNCID:6490 Length:1172 Species:Homo sapiens


Alignment Length:1664 Identity:331/1664 - (19%)
Similarity:511/1664 - (30%) Gaps:659/1664 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   556 GSLGSTGSCS-GVC----------QCKLNVEGSTCSECAPGYFDLSAENAEGCTS--------CW 601
            |.|.:..:|| |.|          :.:.....|||....|..:         ||.        |.
Human    13 GLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETY---------CTQYGEWQMKCCK 68

  Fly   602 C-SGVSQTCHSAKLQTLA--------FETLNDWKITDIQRVKPISIPVDAETNRLIFANELDEVE 657
            | |......:|.:::.:|        :::.||        |.|:|:.:|.:..     .:|.|| 
Human    69 CDSRQPHNYYSHRVENVASSSGPMRWWQSQND--------VNPVSLQLDLDRR-----FQLQEV- 119

  Fly   658 AIYWQASL--GYLGNRLTSYGSRLQLVLSWDV---IRGD--------RSGKPTT----------- 698
            .:.:|..:  |.|..|.:.:|.      :|.|   :..|        |.|:|.:           
Human   120 MMEFQGPMPAGMLIERSSDFGK------TWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQ 178

  Fly   699 GPNVILVGKNGLKIAFG-DESLDGLGINLNVTLTEVGWYHVPPTVVDIK---TRLRRTEGGDYHG 759
            .||..|   ||.|:... .:.:.|:....:..:.|||      .:.:::   |||.......||.
Human   179 RPNARL---NGGKVQLNLMDLVSGIPATQSQKIQEVG------EITNLRVNFTRLAPVPQRGYHP 234

  Fly   760 ESVTRSQFLSVLVSLDAVLIRAAFHTDQGETSLERAVIYSGGVELGGKSSSQVEQCLCPAGYTGL 824
            .|                   |.:...|              :.|.|       .|.|       
Human   235 PS-------------------AYYAVSQ--------------LRLQG-------SCFC------- 252

  Fly   825 SCEGCAFGFKRIYENTSDHQILSKCIPCPCNGHSNSCDLQSGNCGDCMHNTFGDRCERCQLGYYG 889
                              |....:|.|.|......|..:|..:...|.|||.|..||||...|..
Human   253 ------------------HGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNN 299

  Fly   890 NPLQGTPNDCKRCACPLSEDSNNFSPSCQLKSYNYMDLNPQFELIEHAEYICTQCPEGYTGDHCQ 954
            .|                     :.|:                             ||       
Human   300 RP---------------------WRPA-----------------------------EG------- 307

  Fly   955 VCDDGYFGNPRQPGSSCQRCDCAGGPCNVTTGECITCRGNTEGWHCERCKLGYWGDPAVGCDPCH 1019
                       |....||||||.|                    |.|.|..    ||||     .
Human   308 -----------QDAHECQRCDCNG--------------------HSETCHF----DPAV-----F 332

  Fly  1020 CHTEGSESGLCDSTDGQCLCKPRYAGQKCDECDVGY-------ANVELRCPSCNCDPLGSLVQDR 1077
            ..::|:..|:||:      |:....|:.|:.|.:.|       |:::..|.||.|||.|::....
Human   333 AASQGAYGGVCDN------CRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAP 391

  Fly  1078 CDPHTGQCHCKEGVMGAKCHECQDGYFGMNAVAYRMDDLAALRQNSDSDDDEWELVPDTEDPNSE 1142
            |||.||||.|||.|.|.:|..|:.|:.|:...                            :|.  
Human   392 CDPVTGQCVCKEHVQGERCDLCKPGFTGLTYA----------------------------NPQ-- 426

  Fly  1143 STVACEECHCSSVGS-LSSDCDKRTGQCACLANVTGRRCDKCRPGHWNLTAGEGCRDCRCDPHGS 1206
               .|..|.|:.:|| ....||:.:|:|.||.||.|.:||:|.|.||.|.:|:||..|.||||.|
Human   427 ---GCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNS 488

  Fly  1207 RGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRCSACRSEGQVCDPHNGRCICPKFTR 1271
            ...:||.:||||.|:.|.||..|:                .:|.|                    
Human   489 LSPQCNQFTGQCPCREGFGGLMCS----------------AAAIR-------------------- 517

  Fly  1272 GLGCGQCVPGTWGWQARLGCRECECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFG-YP 1335
                 ||...|:| ....|||.|:||..|:.|..|....|:|.||.|.:|.:||.|..||.. ||
Human   518 -----QCPDRTYG-DVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYP 576

  Fly  1336 ECRRCGCDAEGSFTQADGSIACDSNGQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGCTRCFCFGR 1400
            .|                                  :.|..|.|:                   .
Human   577 VC----------------------------------VACHPCFQT-------------------Y 588

  Fly  1401 SGECEQSDLSWGHIRMA----------ESRNLS---------VQQIRP-HSVPSSDYEYIVVVQM 1445
            ..:..:..|.:|.:|.|          |.|.|:         ::|||. .|.|:...:.:..|..
Human   589 DADLREQALRFGRLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVAS 653

  Fly  1446 EGSSFHREDAEIQRMNDLSLVPKSTGNVSIGAYGQFYHPLYFQLPPQFYGDRTSSYGGFLYFTLI 1510
            ...|..|....:|.  ||.|..::                 ..||...                 
Human   654 AILSLRRTLQGLQL--DLPLEEET-----------------LSLPRDL----------------- 682

  Fly  1511 TEGAHKPLERNILGQYPLVQLHAHSKLLLDFYE--YEEFEYSLNVTHRVPLHESFWKYHHTSQAV 1573
                 :.|:|:..|             ||..|:  .|:||...:.............|..::||.
Human   683 -----ESLDRSFNG-------------LLTMYQRKREQFEKISSADPSGAFRMLSTAYEQSAQAA 729

  Fly  1574 ----DRNTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMDAAIYIKGSTNLIAKGVERCKCPKRF 1634
                |.:.|:..|::.|.         :.:.:|.|.......    ||..|:|..:|....|   
Human   730 QQVSDSSRLLDQLRDSRR---------EAERLVRQAGGGGGT----GSPKLVALRLEMSSLP--- 778

  Fly  1635 DGLSCQDPGRSFYRWRNTTIVESVFIEDLIGRA-----APCHCNGRSSDCDRETGVCQNCRGNTG 1694
                  |...:|.:              |.|.:     .|..|.|.....|..|.....|||   
Human   779 ------DLTPTFNK--------------LCGNSRQMACTPISCPGELCPQDNGTACGSRCRG--- 820

  Fly  1695 GDHCHQCAEGFYGDPNSPHGCQACPCPETNRNFARGCNVWDGEVSCVCKPGYTGRLCERCQAGYF 1759
                                    ..|.     |.|..:..|:|:...: |:..:|....|.   
Human   821 ------------------------VLPR-----AGGAFLMAGQVAEQLR-GFNAQLQRTRQM--- 852

  Fly  1760 GDPMRYPNTTCQPCNCHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQAERHHLVDNGCKIC--- 1821
               :|....:..........::|:   |...|....|.|...:. ..|..|..|.|......   
Human   853 ---IRAAEESASQIQSSAQRLETQ---VSASRSQMEEDVRRTRL-LIQQVRDFLTDPDTDAATIQ 910

  Fly  1822 -------------DNCTLL-LLDYMELVGNKLRRGMHNMDLTGIPAPYRKLSEYESAYEKWNGRH 1872
                         |:.|:| .::.::.:..:|    .|:||.                       
Human   911 EVSEAVLALWLPTDSATVLQKMNEIQAIAARL----PNVDLV----------------------- 948

  Fly  1873 WDFSQTKRRLQDYDSADILKLEAHAENLKFQSRKAVATIGKREFAIKSMREDAVTQQ-------- 1929
              .||||:     |.|...:|:|.||..:   .:|.|..|:.|..:.::|:..|..|        
Human   949 --LSQTKQ-----DIARARRLQAEAEEAR---SRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQG 1003

  Fly  1930 --HSVGLLRSEILQTLSDLHGYGKSAHYLSLPTAL-KQARFYLQAIRE--HDQMVQGIRSTNDCA 1989
              .|:.|::..:.:....|....|      |.|:: ||...:...:.|  |....||..:..   
Human  1004 TSRSLRLIQDRVAEVQQVLRPAEK------LVTSMTKQLGDFWTRMEELRHQARQQGAEAVQ--- 1059

  Fly  1990 WKHFYAMGNASDASFDESG--RLEMLWRDLNQTNHRVVDMRLQVDRVQEVENEAEDVLEHVRNLS 2052
             ....|.|.:..|...:.|  |::..:.:|.....:...:..|..|:|.|:.|||::......:.
Human  1060 -AQQLAEGASEQALSAQEGFERIKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMM 1123

  Fly  2053 IRVGESHQE-----------------LDELNQRISDHLD 2074
            .|:.:...|                 |::..::|.||::
Human  1124 DRMKDMELELLRGSQAIMLRSADLTGLEKRVEQIRDHIN 1162

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 164..396 CDD:278484
EGF_Lam 401..450 CDD:238012
TNFRSF <407..507 CDD:304602
EGF_Lam 505..552 CDD:238012
Laminin_EGF 550..597 CDD:278482 10/51 (20%)
Laminin_B 660..798 CDD:278481 29/165 (18%)
EGF_Lam 851..900 CDD:238012 15/48 (31%)
Laminin_EGF <943..971 CDD:278482 3/27 (11%)
VSP 953..1414 CDD:146106 124/469 (26%)
Laminin_EGF 974..1018 CDD:278482 11/43 (26%)
EGF_Lam 1017..1065 CDD:238012 11/54 (20%)
Laminin_EGF 1065..>1105 CDD:278482 20/39 (51%)
EGF_Lam 1150..1197 CDD:238012 22/47 (47%)
Laminin_EGF 1199..1247 CDD:278482 17/47 (36%)
EGF_Lam 1247..1292 CDD:238012 7/44 (16%)
Laminin_EGF 1294..1342 CDD:278482 20/48 (42%)
Laminin_EGF 1340..1392 CDD:278482 3/51 (6%)
Laminin_B 1486..1611 CDD:278481 20/130 (15%)
EGF_Lam 1669..1716 CDD:238012 8/46 (17%)
Laminin_EGF 1718..1767 CDD:278482 9/48 (19%)
EGF_Lam 1772..1819 CDD:238012 9/46 (20%)
CrfC <1933..2267 CDD:223771 30/164 (18%)
Laminin_II 2277..2400 CDD:283628
LamG 2399..>2492 CDD:304605
Laminin_G_2 2616..2755 CDD:280389
Laminin_G_2 2804..2944 CDD:280389
Laminin_G_2 3038..3169 CDD:280389
LamG 3192..3347 CDD:238058
LAMB3NP_000219.2 LamNT 20..248 CDD:214532 54/298 (18%)
EGF_Lam 249..304 CDD:238012 19/100 (19%)
EGF_Lam 315..369 CDD:238012 21/88 (24%)
Laminin_EGF 379..428 CDD:278482 22/81 (27%)
Laminin_EGF 431..478 CDD:278482 21/46 (46%)
Laminin_EGF 481..534 CDD:278482 26/94 (28%)
EGF_Lam 534..576 CDD:214543 17/41 (41%)
Domain II 579..785 49/300 (16%)
Domain alpha 786..816 7/43 (16%)
Domain I 817..1170 76/436 (17%)
MA 844..1071 CDD:214599 50/283 (18%)
MCP_signal 862..1076 CDD:304920 48/264 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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