DRSC/TRiP Functional Genomics Resources

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Protein Alignment wb and LAMB3

DIOPT Version :10

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:NP_000219.2 Gene:LAMB3 / 3914 HGNCID:6490 Length:1172 Species:Homo sapiens


Alignment Length:1664 Identity:331/1664 - (19%)
Similarity:511/1664 - (30%) Gaps:659/1664 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   556 GSLGSTGSCS-GVC----------QCKLNVEGSTCSECAPGYFDLSAENAEGCTS--------CW 601
            |.|.:..:|| |.|          :.:.....|||....|..:         ||.        |.
Human    13 GLLHAQQACSRGACYPPVGDLLVGRTRFLRASSTCGLTKPETY---------CTQYGEWQMKCCK 68

  Fly   602 C-SGVSQTCHSAKLQTLA--------FETLNDWKITDIQRVKPISIPVDAETNRLIFANELDEVE 657
            | |......:|.:::.:|        :::.||        |.|:|:.:|.:..     .:|.|| 
Human    69 CDSRQPHNYYSHRVENVASSSGPMRWWQSQND--------VNPVSLQLDLDRR-----FQLQEV- 119

  Fly   658 AIYWQASL--GYLGNRLTSYGSRLQLVLSWDV---IRGD--------RSGKPTT----------- 698
            .:.:|..:  |.|..|.:.:|.      :|.|   :..|        |.|:|.:           
Human   120 MMEFQGPMPAGMLIERSSDFGK------TWRVYQYLAADCTSTFPRVRQGRPQSWQDVRCQSLPQ 178

  Fly   699 GPNVILVGKNGLKIAFG-DESLDGLGINLNVTLTEVGWYHVPPTVVDIK---TRLRRTEGGDYHG 759
            .||..|   ||.|:... .:.:.|:....:..:.|||      .:.:::   |||.......||.
Human   179 RPNARL---NGGKVQLNLMDLVSGIPATQSQKIQEVG------EITNLRVNFTRLAPVPQRGYHP 234

  Fly   760 ESVTRSQFLSVLVSLDAVLIRAAFHTDQGETSLERAVIYSGGVELGGKSSSQVEQCLCPAGYTGL 824
            .|                   |.:...|              :.|.|       .|.|       
Human   235 PS-------------------AYYAVSQ--------------LRLQG-------SCFC------- 252

  Fly   825 SCEGCAFGFKRIYENTSDHQILSKCIPCPCNGHSNSCDLQSGNCGDCMHNTFGDRCERCQLGYYG 889
                              |....:|.|.|......|..:|..:...|.|||.|..||||...|..
Human   253 ------------------HGHADRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNN 299

  Fly   890 NPLQGTPNDCKRCACPLSEDSNNFSPSCQLKSYNYMDLNPQFELIEHAEYICTQCPEGYTGDHCQ 954
            .|                     :.|:                             ||       
Human   300 RP---------------------WRPA-----------------------------EG------- 307

  Fly   955 VCDDGYFGNPRQPGSSCQRCDCAGGPCNVTTGECITCRGNTEGWHCERCKLGYWGDPAVGCDPCH 1019
                       |....||||||.|                    |.|.|..    ||||     .
Human   308 -----------QDAHECQRCDCNG--------------------HSETCHF----DPAV-----F 332

  Fly  1020 CHTEGSESGLCDSTDGQCLCKPRYAGQKCDECDVGY-------ANVELRCPSCNCDPLGSLVQDR 1077
            ..::|:..|:||:      |:....|:.|:.|.:.|       |:::..|.||.|||.|::....
Human   333 AASQGAYGGVCDN------CRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAP 391

  Fly  1078 CDPHTGQCHCKEGVMGAKCHECQDGYFGMNAVAYRMDDLAALRQNSDSDDDEWELVPDTEDPNSE 1142
            |||.||||.|||.|.|.:|..|:.|:.|:...                            :|.  
Human   392 CDPVTGQCVCKEHVQGERCDLCKPGFTGLTYA----------------------------NPQ-- 426

  Fly  1143 STVACEECHCSSVGS-LSSDCDKRTGQCACLANVTGRRCDKCRPGHWNLTAGEGCRDCRCDPHGS 1206
               .|..|.|:.:|| ....||:.:|:|.||.||.|.:||:|.|.||.|.:|:||..|.||||.|
Human   427 ---GCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNS 488

  Fly  1207 RGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRCSACRSEGQVCDPHNGRCICPKFTR 1271
            ...:||.:||||.|:.|.||..|:                .:|.|                    
Human   489 LSPQCNQFTGQCPCREGFGGLMCS----------------AAAIR-------------------- 517

  Fly  1272 GLGCGQCVPGTWGWQARLGCRECECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFG-YP 1335
                 ||...|:| ....|||.|:||..|:.|..|....|:|.||.|.:|.:||.|..||.. ||
Human   518 -----QCPDRTYG-DVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLTGPRCDQCQRGYCNRYP 576

  Fly  1336 ECRRCGCDAEGSFTQADGSIACDSNGQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGCTRCFCFGR 1400
            .|                                  :.|..|.|:                   .
Human   577 VC----------------------------------VACHPCFQT-------------------Y 588

  Fly  1401 SGECEQSDLSWGHIRMA----------ESRNLS---------VQQIRP-HSVPSSDYEYIVVVQM 1445
            ..:..:..|.:|.:|.|          |.|.|:         ::|||. .|.|:...:.:..|..
Human   589 DADLREQALRFGRLRNATASLWSGPGLEDRGLASRILDAKSKIEQIRAVLSSPAVTEQEVAQVAS 653

  Fly  1446 EGSSFHREDAEIQRMNDLSLVPKSTGNVSIGAYGQFYHPLYFQLPPQFYGDRTSSYGGFLYFTLI 1510
            ...|..|....:|.  ||.|..::                 ..||...                 
Human   654 AILSLRRTLQGLQL--DLPLEEET-----------------LSLPRDL----------------- 682

  Fly  1511 TEGAHKPLERNILGQYPLVQLHAHSKLLLDFYE--YEEFEYSLNVTHRVPLHESFWKYHHTSQAV 1573
                 :.|:|:..|             ||..|:  .|:||...:.............|..::||.
Human   683 -----ESLDRSFNG-------------LLTMYQRKREQFEKISSADPSGAFRMLSTAYEQSAQAA 729

  Fly  1574 ----DRNTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMDAAIYIKGSTNLIAKGVERCKCPKRF 1634
                |.:.|:..|::.|.         :.:.:|.|.......    ||..|:|..:|....|   
Human   730 QQVSDSSRLLDQLRDSRR---------EAERLVRQAGGGGGT----GSPKLVALRLEMSSLP--- 778

  Fly  1635 DGLSCQDPGRSFYRWRNTTIVESVFIEDLIGRA-----APCHCNGRSSDCDRETGVCQNCRGNTG 1694
                  |...:|.:              |.|.:     .|..|.|.....|..|.....|||   
Human   779 ------DLTPTFNK--------------LCGNSRQMACTPISCPGELCPQDNGTACGSRCRG--- 820

  Fly  1695 GDHCHQCAEGFYGDPNSPHGCQACPCPETNRNFARGCNVWDGEVSCVCKPGYTGRLCERCQAGYF 1759
                                    ..|.     |.|..:..|:|:...: |:..:|....|.   
Human   821 ------------------------VLPR-----AGGAFLMAGQVAEQLR-GFNAQLQRTRQM--- 852

  Fly  1760 GDPMRYPNTTCQPCNCHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQAERHHLVDNGCKIC--- 1821
               :|....:..........::|:   |...|....|.|...:. ..|..|..|.|......   
Human   853 ---IRAAEESASQIQSSAQRLETQ---VSASRSQMEEDVRRTRL-LIQQVRDFLTDPDTDAATIQ 910

  Fly  1822 -------------DNCTLL-LLDYMELVGNKLRRGMHNMDLTGIPAPYRKLSEYESAYEKWNGRH 1872
                         |:.|:| .::.::.:..:|    .|:||.                       
Human   911 EVSEAVLALWLPTDSATVLQKMNEIQAIAARL----PNVDLV----------------------- 948

  Fly  1873 WDFSQTKRRLQDYDSADILKLEAHAENLKFQSRKAVATIGKREFAIKSMREDAVTQQ-------- 1929
              .||||:     |.|...:|:|.||..:   .:|.|..|:.|..:.::|:..|..|        
Human   949 --LSQTKQ-----DIARARRLQAEAEEAR---SRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQG 1003

  Fly  1930 --HSVGLLRSEILQTLSDLHGYGKSAHYLSLPTAL-KQARFYLQAIRE--HDQMVQGIRSTNDCA 1989
              .|:.|::..:.:....|....|      |.|:: ||...:...:.|  |....||..:..   
Human  1004 TSRSLRLIQDRVAEVQQVLRPAEK------LVTSMTKQLGDFWTRMEELRHQARQQGAEAVQ--- 1059

  Fly  1990 WKHFYAMGNASDASFDESG--RLEMLWRDLNQTNHRVVDMRLQVDRVQEVENEAEDVLEHVRNLS 2052
             ....|.|.:..|...:.|  |::..:.:|.....:...:..|..|:|.|:.|||::......:.
Human  1060 -AQQLAEGASEQALSAQEGFERIKQKYAELKDRLGQSSMLGEQGARIQSVKTEAEELFGETMEMM 1123

  Fly  2053 IRVGESHQE-----------------LDELNQRISDHLD 2074
            .|:.:...|                 |::..::|.||::
Human  1124 DRMKDMELELLRGSQAIMLRSADLTGLEKRVEQIRDHIN 1162

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 153..398 CDD:459653
EGF_Lam 401..450 CDD:238012
EGF_Lam 505..552 CDD:238012
Laminin_EGF 550..597 CDD:395007 10/51 (20%)
Laminin_B 660..813 CDD:459652 31/180 (17%)
EGF_Lam 851..900 CDD:238012 15/48 (31%)
Laminin_EGF <943..971 CDD:395007 3/27 (11%)
Laminin_EGF 974..1018 CDD:395007 11/43 (26%)
EGF_Lam 1017..1065 CDD:238012 11/54 (20%)
Laminin_EGF 1065..>1105 CDD:395007 20/39 (51%)
EGF_Lam 1150..1197 CDD:238012 22/47 (47%)
Laminin_EGF 1199..1247 CDD:395007 17/47 (36%)
EGF_Lam 1247..1292 CDD:238012 7/44 (16%)
Laminin_EGF 1294..1342 CDD:395007 20/48 (42%)
Laminin_EGF 1340..1392 CDD:395007 3/51 (6%)
Laminin_B 1486..1626 CDD:459652 24/145 (17%)
EGF_Lam 1669..1716 CDD:238012 8/46 (17%)
Laminin_EGF 1718..1767 CDD:395007 9/48 (19%)
EGF_Lam 1772..1819 CDD:238012 9/46 (20%)
YhaN <1907..2141 CDD:443752 38/200 (19%)
SMC_prok_B <2123..>2390 CDD:274008
Laminin_II 2279..2400 CDD:368703
LamG 2399..>2492 CDD:473984
LamG 2586..2753 CDD:238058
Laminin_G_2 2804..2944 CDD:460494
LamG 3018..3167 CDD:238058
LamG 3192..3347 CDD:238058
LAMB3NP_000219.2 LamNT 20..248 CDD:214532 54/298 (18%)
EGF_Lam 249..304 CDD:238012 19/100 (19%)
Laminin_EGF 316..366 CDD:395007 20/84 (24%)
Laminin_EGF 379..428 CDD:395007 22/81 (27%)
Laminin_EGF 431..478 CDD:395007 21/46 (46%)
Laminin_EGF 481..534 CDD:395007 26/94 (28%)
EGF_Lam 534..576 CDD:214543 17/41 (41%)
Domain II 579..785 49/300 (16%)
GumC 626..>980 CDD:442439 88/523 (17%)
Domain alpha 786..816 7/43 (16%)
Domain I 817..1170 76/436 (17%)
Smc <838..>1092 CDD:440809 55/311 (18%)
cc_LAMB3_C 1102..1172 CDD:411974 12/61 (20%)
Blue background indicates that the domain is not in the aligned region.

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