DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wb and LAMB2

DIOPT Version :9

Sequence 1:	NP_723870.1	Gene:	wb / 43946	FlyBaseID:	FBgn0261563	Length:	3375	Species:	Drosophila melanogaster
Sequence 2:	NP_002283.3	Gene:	LAMB2 / 3913	HGNCID:	6487	Length:	1798	Species:	Homo sapiens

Alignment Length:	2302	Identity:	537/2302 - (23%)
Similarity:	782/2302 - (33%)	Gaps:	791/2302 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 GGLYPPLFN-VVPRA-QISVNATCGQNGAEEYC---KQVGAKPCGICNAH----SSDRAKQRSIQ 206
            |..||...: :|.|| :::.::|||.||.:.||   .....|.|.:|::.    :.|......||
Human    45 GSCYPATGDLLVGRADRLTASSTCGLNGPQPYCIVSHLQDEKKCFLCDSRRPFSARDNPHSHRIQ 109

  Fly   207 SLISSGSGSGSGSGFEEGWWQSPTLQGGRQFEYVTILLDLKQTFQIFSVWLKSANSPRPASWILE 271
            ::::|.:.....:     ||||   :.|  ...|||.|||:..|. |:..:.:..:.|||:.::|
Human   110 NVVTSFAPQRRAA-----WWQS---ENG--IPAVTIQLDLEAEFH-FTHLIMTFKTFRPAAMLVE 163

  Fly   272 KSLD-GINFEPWQYFGLSDADC-----------QRRWNLSGQNGKYVFQNDTEIICSTQFSKPGP 324
            :|.| |..:..::||..   ||           .|.|:              :::|.:::|:..|
Human   164 RSADFGRTWHVYRYFSY---DCGADFPGVPLAPPRHWD--------------DVVCESRYSEIEP 211

  Fly   325 LENG-VLHASLLKNRPGATDQSPELMKFITTRYIRIRLQGMHSTANQDNSLDWLLDSPSLEKHSF 388
            ...| |::..|....|.....|..:...:....:|:.|..:|:..  ||.||   ....:.:..:
Human   212 STEGEVIYRVLDPAIPIPDPYSSRIQNLLKITNLRVNLTRLHTLG--DNLLD---PRREIREKYY 271

  Fly   389 YSLSQLKVSARLDCNGHANRSHESPDDPLM-------QCICQHNTCGAQCEQCCPLFQDRPYQMG 446
            |:|.:|.|.....|.|||:....:|..|..       .|||:|||.|..||||...::|.|::..
Human   272 YALYELVVRGNCFCYGHASECAPAPGAPAHAEGMVHGACICKHNTRGLNCEQCQDFYRDLPWRPA 336

  Fly   447 GE-----CEICQCYGHAESCTYDPF-------LDKGICQSCSNNTAGIECEFCEMGFYRELDAPL 499
            .:     |..|:|:||..||.:|..       :..|:|..|.:||||..||.|...|||:....|
Human   337 EDGHSHACRKCECHGHTHSCHFDMAVYLASGNVSGGVCDGCQHNTAGRHCELCRPFFYRDPTKDL 401

  Fly   500 TDP--CLPCSCNPARSTGGCQSD----------GGSCNCLEGFQGKNCEECAPGYYG---DD--- 546
            .||  |..|.|:|..|..|.:.|          .|.|.|.|...|..|::|..|::|   .|
Human   402 RDPAVCRSCDCDPMGSQDGGRCDSHDDPALGLVSGQCRCKEHVVGTRCQQCRDGFFGLSISDRLG 466

  Fly   547 CKRCECDERGSLGSTGSC---SGVCQCKLNVEGSTCSECAPGYFDLSAENAEGCTSCWC------ 602
            |:||:|:.||::..:..|   ||.|.||..|.|..|..|.||::.|| .:..||..|.|
Human   467 CRRCQCNARGTVPGSTPCDPNSGSCYCKRLVTGRGCDRCLPGHWGLS-HDLLGCRPCDCDVGGAL 530

  Fly   603 -----SGVSQTCH---------SAKLQTLAFETLND---WKITDIQRVKPISIPVDAETNRLIFA 650
                 .|..| ||         ..::|...|....|   |               :||..|   .
Human   531 DPQCDEGTGQ-CHCRQHMVGRRCEQVQPGYFRPFLDHLIW---------------EAEDTR---G 576

  Fly   651 NELDEVEAIY-------WQASLGYL----GNRLTSYGSRLQLVLSWDVIRGDRSGKPTTGPNV-I 703
            ..||.||.:.       |..| |::    |..|....:.:...:.:|::.......|.....: :
Human   577 QVLDVVERLVTPGETPSWTGS-GFVRLQEGQTLEFLVASVPKAMDYDLLLRLEPQVPEQWAELEL 640

  Fly   704 LVGKNGLKIAFG--------DESLDGLGINLNVTLTEVGWYHVPPTVV--------DIKTRLRRT 752
            :|.:.|...|..        |:.:.|       ||.....|.:.|..|        .:..:|.||
Human   641 IVQRPGPVPAHSLCGHLVPKDDRIQG-------TLQPHARYLIFPNPVCLEPGISYKLHLKLVRT 698

  Fly   753 EGG-----DYHGESVTRSQFLSVLVSLDAVLIRAAFHTDQGETSLERAVIYSGG--VELGGKSSS 810
            .|.     .|.|..:    .:..||.|..||:            ||   ::|||  ..|..:::.
Human   699 GGSAQPETPYSGPGL----LIDSLVLLPRVLV------------LE---MFSGGDAAALERQATF 744

  Fly   811 QVEQC----LCPAGYTGLSCEGCA---FGFKRIYENTSDHQILSKCIPCPCNGH---SNSCDLQS 865
            :..||    |.|:..:  ..|.||   .....:        |.:..:||.||..   |:.|:...
Human   745 ERYQCHEEGLVPSKTS--PSEACAPLLISLSTL--------IYNGALPCQCNPQGSLSSECNPHG 799

  Fly   866 GNCGDCMHNTFGDRCERCQLGYYGNPLQGTPNDCKRCACPLSEDSNNFSPSCQLKSYNYMDLNPQ 930
            |.| .|.....|.||:.|..||||    ..|..|:.|.|   ......|..|:..|...:
Human   800 GQC-LCKPGVVGRRCDLCAPGYYG----FGPTGCQACQC---SHEGALSSLCEKTSGQCL----- 851

  Fly   931 FELIEHAEYICTQCPEGYTGDHCQVCDDGYFGNPRQPGSSCQRCDCAG--GPCNVTTGECITCRG 993
                         |..|..|..|..|..|.:|.|     ||:.|.|.|  ..||..||.|:.||.
Human   852 -------------CRTGAFGLRCDRCQRGQWGFP-----SCRPCVCNGHADECNTHTGACLGCRD 898

  Fly   994 NTEGWHCERCKLGYWGDPAV----GCDPCHC-HTEGSESGLCDSTDGQ-------CLCKPRYAGQ 1046
            :|.|.|||||..|:.|||.:    .|.||.| ...||:.....|....       |.|:..|.|.
Human   899 HTGGEHCERCIAGFHGDPRLPYGGQCRPCPCPEGPGSQRHFATSCHQDEYSQQIVCHCRAGYTGL 963

  Fly  1047 KCDECDVGY----ANVELRCPSCNC----DPLGSLVQDRCDPHTGQC-HCKEGVMGAKCHECQDG 1102
            :|:.|..|:    :....||..|.|    ||:.   .|.|||||||| .|.....|..|..|:.|
Human   964 RCEACAPGHFGDPSRPGGRCQLCECSGNIDPMD---PDACDPHTGQCLRCLHHTEGPHCAHCKPG 1025

  Fly  1103 YFGMNAVAYRMDDLAALRQNSDSDDDEWELVPDTEDPNSESTVACEECHCSSVGS-----LSSD- 1161
            :.|.           |.||                        :|..|.|:.:|:     .|.|
Human  1026 FHGQ-----------AARQ------------------------SCHRCTCNLLGTNPQQCPSPDQ 1055

  Fly  1162 --CDKRTGQCACLANVTGRRCDKCRPGHWNLTAGEGCRDCRCDPHGSRGHECNPWTGQCDCKIGV 1224
              ||..:|||.||.||.|..||:|.|..||||:|.||:.|.|.|..:||..||.:||||.|:.|.
Human  1056 CHCDPSSGQCPCLPNVQGPSCDRCAPNFWNLTSGHGCQPCACHPSRARGPTCNEFTGQCHCRAGF 1120

  Fly  1225 GGQHCNECTEGFFGFSTEGCQRCSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPGTWGWQARL 1289
            ||:.|:||.|..:|                   ||                            .|
Human  1121 GGRTCSECQELHWG-------------------DP----------------------------GL 1138

  Fly  1290 GCRECECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFG-YPECRRCGCDAEGSFTQADG 1353
            .|..|:||..|....||....|.|.||.|.||.:||.||.|:.| :|.|.
Human  1139 QCHACDCDSRGIDTPQCHRFTGHCSCRPGVSGVRCDQCARGFSGIFPACH--------------- 1188

  Fly  1354 SIACDSNGQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGCTRCFCFGRSGECEQSDLSWGHIRMAE 1418
                      ||.:                             |||......| ||: ...:..|
Human  1189 ----------PCHA-----------------------------CFGDWDRVVQ-DLA-ARTQRLE 1212

  Fly  1419 SRNLSVQQIRPHSVPSSDYEYIVVVQMEGSSFHREDAEIQRMNDLSLVPKSTG--NVSIGAYGQF 1481
            .|...:||..            |:...|.|.:|.::       .|.:|....|  |.|..:..|.
Human  1213 QRAQELQQTG------------VLGAFESSFWHMQE-------KLGIVQGIVGARNTSAASTAQL 1258

  Fly  1482 YHPLYFQLPPQFYGDRTSSYGGFLYFTLITEGAHKPLERNILGQYP--LVQLHAHSKLLLDFYEY 1544
            ..                              |.:.|.|.| |:..  |.||.|      |..:.
Human  1259 VE------------------------------ATEELRREI-GEATEHLTQLEA------DLTDV 1286

  Fly  1545 EEFEYSLNVTHRVPLHESFWKYHHTSQAVDRNTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMD 1609
            ::..::.|               |....::|:.|...| .:|.:                :.|:|
Human  1287 QDENFNAN---------------HALSGLERDRLALNL-TLRQL----------------DQHLD 1319

  Fly  1610 AAIYIKGSTNLIAKGVERCKCPKRFDGLSCQDPGRSFYRWRNTTIVESVFIEDLIGRAAPCHCNG 1674
               .:|.|..|.|           :|.:.                                |.:.
Human  1320 ---LLKHSNFLGA-----------YDSIR--------------------------------HAHS 1338

  Fly  1675 RSSDCDRETGVCQNCRGNTGGDHCHQCAEGFYGDPNSPHGCQACPCPETNRNFAR-------GCN 1732
            :|::.:|        |.||                    ...|.|.|.:|...||       ...
Human  1339 QSAEAER--------RANT--------------------SALAVPSPVSNSASARHRTEALMDAQ 1375

  Fly  1733 VWDGEVSCVCKPGYTGRLCERCQ-----------AGYFGDPMRYPNTTCQPCNCHPDGIQTEGCD 1786
            ..|.....:......|:|.....           .|..||         .||...|.|  ..||.
Human  1376 KEDFNSKHMANQRALGKLSAHTHTLSLTDINELVCGAPGD---------APCATSPCG--GAGCR 1429

  Fly  1787 VETGRCYCREGVTGLKCD--------------KCQAERHHLVDNGCKICDNCTLLLLDYMELVGN 1837
            .|.|:..|    .||.|:              ..|||....:..|..|
Human  1430 DEDGQPRC----GGLSCNGAAATADLALGRARHTQAELQRALAEGGSI----------------- 1473

  Fly  1838 KLRRGMHNMDLTGIPAPYRKLSE----YESAYEKWNGRHWDFSQTKRRLQ--------------- 1883
                      |:.:....|:.||    .::|.:|.|.......|..:.||
Human  1474 ----------LSRVAETRRQASEAQQRAQAALDKANASRGQVEQANQELQELIQSVKDFLNQEGA 1528

  Fly  1884 DYDSADI-------LKLEAHAENLKFQSRKAVATIGKREFAIKSMRE-DAVTQQHSVGLLR--SE 1938
            |.||.::       |.:.|.||    |.:.....|.:|   ::|:.: ||:..: :||.:|  .:
Human  1529 DPDSIEMVATRVLELSIPASAE----QIQHLAGAIAER---VRSLADVDAILAR-TVGDVRRAEQ 1585

  Fly  1939 ILQTLSDLHGYGKSAHYLSLPTALKQARFYLQAIREHDQMVQGIRSTNDCAWKHFYAMGNASDAS 2003
            :||.......:.:..         ||....:||..|..|..|||            |.|....|.
Human  1586 LLQDARRARSWAEDE---------KQKAETVQAALEEAQRAQGI------------AQGAIRGAV 1629

  Fly  2004 FDESGRLEMLWRDLNQTNHRVVDMRLQVDRVQEVENEAEDVLEHVRNLSIRVGESHQELDELNQ- 2067
            .|.        ||..||.:          :|||....||..|.       ..||..::||.|.:
Human  1630 ADT--------RDTEQTLY----------QVQERMAGAERALS-------SAGERARQLDALLEA 1669

  Fly  2068 ----RISDHLDPGYLEQGEGLLRLTVQR-QIMLNGHLNQLDGYRILLNTTLGVKTEQQREVRKHW 2127
                |..:.|.....|:..|..:...|. :.:|.|.|.                 :|.:.|:
Human  1670 LKLKRAGNSLAASTAEETAGSAQGRAQEAEQLLRGPLG-----------------DQYQTVK--- 1714

  Fly  2128 LPKAEKHASHLLARSNEYARKFQPTRNGARIAMLASSAHSNITEAINDARLASILAKERVYEAQR 2192
             ..||:.|..:||..             ||...|...|. ::.:|..| :|..:...|..||...
Human  1715 -ALAERKAQGVLAAQ-------------ARAEQLRDEAR-DLLQAAQD-KLQRLQELEGTYEENE 1763

  Fly  2193 TLYPSDGSSM--IERAKHSLHRSKQLQ 2217
            ....|..:.:  :|....|:.::..||
Human  1764 RALESKAAQLDGLEARMRSVLQAINLQ 1790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wb	NP_723870.1	Laminin_N	164..396	CDD:278484	59/252 (23%)
		EGF_Lam	401..450	CDD:238012	19/60 (32%)
		TNFRSF	<407..507	CDD:304602	40/120 (33%)
		EGF_Lam	505..552	CDD:238012	19/62 (31%)
		Laminin_EGF	550..597	CDD:278482	18/49 (37%)
		Laminin_B	660..798	CDD:278481	30/170 (18%)
		EGF_Lam	851..900	CDD:238012	18/51 (35%)
		Laminin_EGF	<943..971	CDD:278482	8/27 (30%)
		VSP	953..1414	CDD:146106	146/492 (30%)
		Laminin_EGF	974..1018	CDD:278482	22/49 (45%)
		EGF_Lam	1017..1065	CDD:238012	15/59 (25%)
		Laminin_EGF	1065..>1105	CDD:278482	18/44 (41%)
		EGF_Lam	1150..1197	CDD:238012	25/54 (46%)
		Laminin_EGF	1199..1247	CDD:278482	20/47 (43%)
		EGF_Lam	1247..1292	CDD:238012	3/44 (7%)
		Laminin_EGF	1294..1342	CDD:278482	21/48 (44%)
		Laminin_EGF	1340..1392	CDD:278482	2/51 (4%)
		Laminin_B	1486..1611	CDD:278481	18/126 (14%)
		EGF_Lam	1669..1716	CDD:238012	6/46 (13%)
		Laminin_EGF	1718..1767	CDD:278482	11/66 (17%)
		EGF_Lam	1772..1819	CDD:238012	16/60 (27%)
		CrfC	<1933..2267	CDD:223771	62/295 (21%)
		Laminin_II	2277..2400	CDD:283628
		LamG	2399..>2492	CDD:304605
		Laminin_G_2	2616..2755	CDD:280389
		Laminin_G_2	2804..2944	CDD:280389
		Laminin_G_2	3038..3169	CDD:280389
		LamG	3192..3347	CDD:238058
LAMB2	NP_002283.3	Laminin_N	57..281	CDD:278484	61/256 (24%)
		EGF_Lam	283..335	CDD:238012	19/51 (37%)
		EGF_Lam	347..399	CDD:238012	20/51 (39%)
		Laminin_EGF	410..467	CDD:278482	16/56 (29%)
		EGF_Lam	469..520	CDD:238012	20/51 (39%)
		EGF_Lam	521..562	CDD:238012	8/41 (20%)
		Laminin_EGF	783..831	CDD:278482	18/52 (35%)
		Laminin_EGF	831..879	CDD:278482	16/73 (22%)
		EGF_Lam	876..921	CDD:238012	21/44 (48%)
		EGF_Lam	926..984	CDD:238012	14/57 (25%)
		Laminin_EGF	986..>1028	CDD:278482	18/44 (41%)
		EGF_Lam	1037..1093	CDD:238012	25/55 (45%)
		Laminin_EGF	1095..1143	CDD:278482	24/94 (26%)
		Laminin_EGF	1143..>1182	CDD:278482	18/38 (47%)
		Domain II	1190..1409		59/411 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1338..1364		9/53 (17%)
		Domain alpha	1410..1442		14/46 (30%)
		Domain I	1443..1798		91/465 (20%)
		MA	1445..1701	CDD:214599	66/336 (20%)
		ATP-synt_B	<1453..1541	CDD:304375	18/114 (16%)
		HrpJ	1483..1670	CDD:301626	54/240 (23%)
		V-ATPase_G_2	1648..1755	CDD:293604	30/149 (20%)
		ATP-synt_B	<1680..1792	CDD:304375	28/147 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9858
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910