DRSC/TRiP Functional Genomics Resources

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Protein Alignment wb and LAMB1

DIOPT Version :10

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:XP_054214165.1 Gene:LAMB1 / 3912 HGNCID:6486 Length:1810 Species:Homo sapiens


Alignment Length:2283 Identity:506/2283 - (22%)
Similarity:792/2283 - (34%) Gaps:850/2283 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   151 GGLYPPLFN-VVPRAQ-ISVNATCGQNGAEEYC---KQVGAKPCGICNA----HSSDRAKQRSIQ 206
            |..||...: ::.||| :||.:|||.:..|.||   .....|.|.|||:    |.:.......|:
Human    57 GSCYPATGDLLIGRAQKLSVTSTCGLHKPEPYCIVSHLQEDKKCFICNSQDPYHETLNPDSHLIE 121

  Fly   207 SLISSGSGSGSGSGFEEG----WWQSPTLQGGRQFEYVTILLDLKQTFQIFSVWLKSANSPRPAS 267
            :::::         |...    ||||   :.|  .|.|||.|||:..|. |:..:.:..:.|||:
Human   122 NVVTT---------FAPNRLKIWWQS---ENG--VENVTIQLDLEAEFH-FTHLIMTFKTFRPAA 171

  Fly   268 WILEKSLD-GINFEPWQYFGLSDADCQRRW-NLSGQNGKYVFQNDTEIICSTQFSKPGPLENG-V 329
            .::|:|.| |..:..::||..   ||:..: .:|....|.|    .:|||.:::|...|...| |
Human   172 MLIERSSDFGKTWGVYRYFAY---DCEASFPGISTGPMKKV----DDIICDSRYSDIEPSTEGEV 229

  Fly   330 LHASLLKNRPGATDQSPELMKFITTRYIRIRLQGMHSTANQDNSLDWLLDSPSLEKHSFYSLSQL 394
            :..:|..........||.:...:....:||:...:|:..  ||.||..::   :.:..:|::..:
Human   230 IFRALDPAFKIEDPYSPRIQNLLKITNLRIKFVKLHTLG--DNLLDSRME---IREKYYYAVYDM 289

  Fly   395 KVSARLDCNGHANRSHESPDDPLMQ---------CICQHNTCGAQCEQCCPLFQDRPY-----QM 445
            .|.....|.|||  |..:|.|...:         |:|:|||.|..||.|...:.|.|:     :.
Human   290 VVRGNCFCYGHA--SECAPVDGFNEEVEGMVHGHCMCRHNTKGLNCELCMDFYHDLPWRPAEGRN 352

  Fly   446 GGECEICQCYGHAESCTYDPF-------LDKGICQSCSNNTAGIECEFCEMGFYRELDAPLTDP- 502
            ...|:.|.|..|:.||.:|..       :..|:|..|.:||.|..||.|:..:|:..:..:.|| 
Human   353 SNACKKCNCNEHSISCHFDMAVYLATGNVSGGVCDDCQHNTMGRNCEQCKPFYYQHPERDIRDPN 417

  Fly   503 -CLPCSCNPARSTGGCQSDG--------------GSCNCLEGFQGKNCEECAPGYY---GDD--- 546
             |..|:|:||    |.|::|              |.|.|....:|::|:.|..|:|   .:|   
Human   418 FCERCTCDPA----GSQNEGICDSYTDFSTGLIAGQCRCKLNVEGEHCDVCKEGFYDLSSEDPFG 478

  Fly   547 CKRCECDERGSLGSTGSC---SGVCQCKLNVEGSTCSECAPGYFDLSAENAEGCTSCWC---SGV 605
            ||.|.|:..|::.....|   :|.|.||..|.|..|.:|.|.::.|| .:.:||..|.|   ..:
Human   479 CKSCACNPLGTIPGGNPCDSETGHCYCKRLVTGQHCDQCLPEHWGLS-NDLDGCRPCDCDLGGAL 542

  Fly   606 SQTCHSAKLQTLAFETLNDWKITDIQRVKPISIPVDAETNRLIFANELDEVEAIYW--------- 661
            :.:|.:...|.               ..:|..|           ..:.:|||..|:         
Human   543 NNSCFAESGQC---------------SCRPHMI-----------GRQCNEVEPGYYFATLDHYLY 581

  Fly   662 ---QASLG---------YLGNRLTSY----------GSRLQLVLS-------------------- 684
               :|:||         |:.:|:.|:          |:.|:..:.                    
Human   582 EAEEANLGPGVSIVERQYIQDRIPSWTGAGFVRVPEGAYLEFFIDNIPYSMEYDILIRYEPQLPD 646

  Fly   685 -WD--VIRGDRSGK-PTTGPNVILVGKNGLKIAFGDESLDGL-----------------GINLNV 728
             |:  ||...|.|: ||:       .:.|..|...|..:..|                 |.|..|
Human   647 HWEKAVITVQRPGRIPTS-------SRCGNTIPDDDNQVVSLSPGSRYVVLPRPVCFEKGTNYTV 704

  Fly   729 TLTEVGWY-------HVPPTVVDIKTRLRRTEGGDYHGESVTRSQFLSVLVSLDAVLIRAAFHTD 786
            .| |:..|       ..|.|::|....:...:..|          ..:|..|.|.|:..:|:.|.
Human   705 RL-ELPQYTSSDSDVESPYTLIDSLVLMPYCKSLD----------IFTVGGSGDGVVTNSAWETF 758

  Fly   787 QGETSLE--RAVIYSGGVELGGKSSSQVEQCLCPAGYTGLSCEGCAFGFKRIYENTSDHQILSKC 849
            |....||  |:|:.:...::                     |....|....:...|.        
Human   759 QRYRCLENSRSVVKTPMTDV---------------------CRNIIFSISALLHQTG-------- 794

  Fly   850 IPCPCNGH---SNSCDLQSGNCGDCMHNTFGDRCERCQLGYYGNPLQGTPNDCKRCACPLSEDSN 911
            :.|.|:..   |:.||...|.| .|..|..|..|.||..|.:|    ..|:.||.|.|.|....|
Human   795 LACECDPQGSLSSVCDPNGGQC-QCRPNVVGRTCNRCAPGTFG----FGPSGCKPCECHLQGSVN 854

  Fly   912 NFSPSCQLKSYNYMDLNPQFELIEHAEYICTQCP--EGYTGDHCQVCDDGYFGNPRQPGSSCQRC 974
            .|   |          ||          :..||.  :|.....|..|..|::|.|     |||.|
Human   855 AF---C----------NP----------VTGQCHCFQGVYARQCDRCLPGHWGFP-----SCQPC 891

  Fly   975 DCAG--GPCNVTTGECITCRGNTEGWHCERCKLGYWGDPAVG----CDPCHCHTEGSESG----- 1028
            .|.|  ..|:..||||:.|:..|.|.:||||..||:|||.:|    |.||.| .:|.:||     
Human   892 QCNGHADDCDPVTGECLNCQDYTMGHNCERCLAGYYGDPIIGSGDHCRPCPC-PDGPDSGRQFAR 955

  Fly  1029 LC--DSTDGQ--CLCKPRYAGQKCDECDVGY----ANVELRCPSCNC-------DPLGSLVQDRC 1078
            .|  |....|  |:|.|.|.|.:||:|..||    :.|...|..|.|       ||      :.|
Human   956 SCYQDPVTLQLACVCDPGYIGSRCDDCASGYFGNPSEVGGSCQPCQCHNNIDTTDP------EAC 1014

  Fly  1079 DPHTGQC-HCKEGVMGAKCHECQDGYFGMNAVAYRMDDLAALRQNSDSDDDEWELVPDTEDPNSE 1142
            |..||:| .|.....|..|..|:.||:|           .||||:                    
Human  1015 DKETGRCLKCLYHTEGEHCQFCRFGYYG-----------DALRQD-------------------- 1048

  Fly  1143 STVACEECHCSSVGSL-----SSD--CDKRTGQCACLANVTGRRCDKCRPGHWNLTAGEGCRDCR 1200
                |.:|.|:.:|::     .||  |||.||||.||.||.|:.||:|.|..|.|.:|.||..|.
Human  1049 ----CRKCVCNYLGTVQEHCNGSDCQCDKATGQCLCLPNVIGQNCDRCAPNTWQLASGTGCDPCN 1109

  Fly  1201 CDPHGSRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRCSACRSEGQVCDPHNGRCI 1265
            |:...|.|..||.:||||.|..|.||:.|:||.|.|:|                   ||.     
Human  1110 CNAAHSFGPSCNEFTGQCQCMPGFGGRTCSECQELFWG-------------------DPD----- 1150

  Fly  1266 CPKFTRGLGCGQCVPGTWGWQARLGCRECECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIG 1330
                                   :.||.|:||..|....||....|||.|.||..|.:||.|..|
Human  1151 -----------------------VECRACDCDPRGIETPQCDQSTGQCVCVEGVEGPRCDKCTRG 1192

  Fly  1331 YFG-YPECRRCGCDAEGSFTQADGSIACDSNGQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGCTR 1394
            |.| :|:|                                                  .|  |.:
Human  1193 YSGVFPDC--------------------------------------------------TP--CHQ 1205

  Fly  1395 CFCFGRSGECEQSDLSWGHIRMAESRNLSVQQIRPHSVPSSDYEYIVVVQMEGSSFHR--EDAEI 1457
            ||..            |..| :||..|.:                           ||  |.|:.
Human  1206 CFAL------------WDVI-IAELTNRT---------------------------HRFLEKAKA 1230

  Fly  1458 QRMNDLSLVPKSTGNVSIGAYGQFYHPLYFQLPPQFYGDRTSSYGGFLYFTLITEGAHKPLE-RN 1521
            .:::.:           ||.|.:                            .:.....|..| ::
Human  1231 LKISGV-----------IGPYRE----------------------------TVDSVERKVSEIKD 1256

  Fly  1522 ILGQYPLVQ--------LHAHSKLLLDFYEYEEFEYSLNVTHRVPLHESFWKYHHTSQAVDR--- 1575
            ||.|.|..:        .....||:.|..|       :.....|.|.::..:.:.|::.:|.   
Human  1257 ILAQSPAAEPLKNIGNLFEEAEKLIKDVTE-------MMAQVEVKLSDTTSQSNSTAKELDSLQT 1314

  Fly  1576 ------NTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMDAAIYIKGSTNLIAKGVERCKCPKRF 1634
                  ||:....:.:.  ||:               :.|    |:|:.:.|.|..:.....:..
Human  1315 EAESLDNTVKELAEQLE--FIK---------------NSD----IRGALDSITKYFQMSLEAEER 1358

  Fly  1635 DGLSCQDPGRSFYRWRNTTIVESVFIED----------------------LIGRAAPCHCNGRSS 1677
            ...|..:|        |:|:.:|..:.|                      |:...|     |:..
Human  1359 VNASTTEP--------NSTVEQSALMRDRVEDVMMERESQFKEKQEEQARLLDELA-----GKLQ 1410

  Fly  1678 DCDRETGVCQNCRGNTGGDHCHQCAEGFYGDPNSPHGCQACPCPETNRNFARGCNVWDGEVSCVC 1742
            ..|........|....|.    .|:|...|.||                    |...:||..|  
Human  1411 SLDLSAAAEMTCGTPPGA----SCSETECGGPN--------------------CRTDEGERKC-- 1449

  Fly  1743 KPGYTGRLCERCQAGYFGDPMRYPNTTCQPCNCHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQ 1807
                             |.|                     ||.             ||      
Human  1450 -----------------GGP---------------------GCG-------------GL------ 1457

  Fly  1808 AERHHLVDNGCKICDNCTLLLLDYMELVGNKLRRGMH-NMDLTGIPAPYRKLSEYESAYEKWNGR 1871
                                    :.:..|..::.|. :.|:....|...:||:.          
Human  1458 ------------------------VTVAHNAWQKAMDLDQDVLSALAEVEQLSKM---------- 1488

  Fly  1872 HWDFSQTKRRLQD-YDSADILKLEAHAENLKF-QSRKAVATIGKREFAIKSMREDAVTQQ----H 1930
               .|:.|.|..: ..||:.:.|:.:|...|. :|.:.:..:      ||.:| :.:||.    .
Human  1489 ---VSEAKLRADEAKQSAEDILLKTNATKEKMDKSNEELRNL------IKQIR-NFLTQDSADLD 1543

  Fly  1931 SVGLLRSEILQTLSDLHGYGKSAHYLSLPTALKQARFYLQAIREHDQMVQGIRSTNDCAWKHFYA 1995
            |:..:.:|:|:              :.:|:..:|.:...:.|||..:.:..:    :...:|   
Human  1544 SIEAVANEVLK--------------MEMPSTPQQLQNLTEDIRERVESLSQV----EVILQH--- 1587

  Fly  1996 MGNASDASFDESGRLEMLWRDLNQTNHRVVDMRLQVDRVQEVENEA---------------EDVL 2045
              :|:|.:     |.|||..:..:.:....|:::..|.|:|...||               ||:.
Human  1588 --SAADIA-----RAEMLLEEAKRASKSATDVKVTADMVKEALEEAEKAQVAAEKAIKQADEDIQ 1645

  Fly  2046 -----------------EHVRNLSIRVGESHQELDELNQRISDHL-DPGYLEQGEGLLRLTVQRQ 2092
                             |.:.|.|.|:.|..:.::||.::.:.:. :..|:|:    :..||::.
Human  1646 GTQNLLTSIESETAASEETLFNASQRISELERNVEELKRKAAQNSGEAEYIEK----VVYTVKQS 1706

  Fly  2093 I-----MLNGHLNQLDGYRILLNTTLGVKTEQQREVRKHWLPKAE---KHASHLLARSN------ 2143
            .     .|:|.|:  :.|:.:.| .:..|||:..:.|:    |||   ..|..|||::|      
Human  1707 AEDVKKTLDGELD--EKYKKVEN-LIAKKTEESADARR----KAEMLQNEAKTLLAQANSKLQLL 1764

  Fly  2144 -EYARKFQ 2150
             :..||::
Human  1765 KDLERKYE 1772

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 153..398 CDD:459653 68/260 (26%)
EGF_Lam 401..450 CDD:238012 18/62 (29%)
EGF_Lam 505..552 CDD:238012 19/66 (29%)
Laminin_EGF 550..597 CDD:395007 15/49 (31%)
Laminin_B 660..813 CDD:459652 41/233 (18%)
EGF_Lam 851..900 CDD:238012 16/51 (31%)
Laminin_EGF <943..971 CDD:395007 8/29 (28%)
Laminin_EGF 974..1018 CDD:395007 22/49 (45%)
EGF_Lam 1017..1065 CDD:238012 21/60 (35%)
Laminin_EGF 1065..>1105 CDD:395007 15/47 (32%)
EGF_Lam 1150..1197 CDD:238012 25/53 (47%)
Laminin_EGF 1199..1247 CDD:395007 20/47 (43%)
EGF_Lam 1247..1292 CDD:238012 2/44 (5%)
Laminin_EGF 1294..1342 CDD:395007 21/48 (44%)
Laminin_EGF 1340..1392 CDD:395007 1/51 (2%)
Laminin_B 1486..1626 CDD:459652 23/157 (15%)
EGF_Lam 1669..1716 CDD:238012 9/46 (20%)
Laminin_EGF 1718..1767 CDD:395007 6/48 (13%)
EGF_Lam 1772..1819 CDD:238012 4/46 (9%)
YhaN <1907..2141 CDD:443752 54/278 (19%)
SMC_prok_B <2123..>2390 CDD:274008 11/38 (29%)
Laminin_II 2279..2400 CDD:368703
LamG 2399..>2492 CDD:473984
LamG 2586..2753 CDD:238058
Laminin_G_2 2804..2944 CDD:460494
LamG 3018..3167 CDD:238058
LamG 3192..3347 CDD:238058
LAMB1XP_054214165.1 Laminin_N 59..293 CDD:459653 68/260 (26%)
EGF_Lam 295..347 CDD:238012 18/53 (34%)
EGF_Lam 359..411 CDD:238012 16/51 (31%)
Laminin_EGF 422..479 CDD:395007 16/60 (27%)
Laminin_EGF 482..536 CDD:395007 18/54 (33%)
EGF_Lam 533..>572 CDD:238012 9/64 (14%)
EGF_Lam 797..842 CDD:214543 16/49 (33%)
Laminin_EGF 845..893 CDD:395007 20/75 (27%)
Laminin_EGF 891..938 CDD:395007 21/46 (46%)
Laminin_EGF 941..997 CDD:395007 19/56 (34%)
Laminin_EGF 1000..1044 CDD:395007 16/60 (27%)
Laminin_EGF 1052..1106 CDD:395007 25/53 (47%)
Laminin_EGF 1108..1156 CDD:395007 24/94 (26%)
Laminin_EGF 1156..>1195 CDD:395007 18/38 (47%)
PTZ00121 <1248..1802 CDD:173412 123/732 (17%)
cc_LAMB1_C 1738..1810 CDD:411971 11/39 (28%)
Blue background indicates that the domain is not in the aligned region.

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