DRSC/TRiP Functional Genomics Resources

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Protein Alignment wb and LanB2

DIOPT Version :9

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:NP_001287009.1 Gene:LanB2 / 39118 FlyBaseID:FBgn0267348 Length:1639 Species:Drosophila melanogaster


Alignment Length:1180 Identity:372/1180 - (31%)
Similarity:527/1180 - (44%) Gaps:232/1180 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   101 MLAIASSESVTKKKPPQRRRNGKLQKSGGGAGGGALR------LLKTEDVYSSSFSGGLYPPLFN 159
            :.|..|:..:..::||.           ..|||..||      .|:..|.|.....  ..|...|
  Fly    22 LFASCSTAILGAQRPPI-----------NSAGGHELRGTTFMPALECYDPYGRPQK--CLPEFIN 73

  Fly   160 VVPRAQISVNATCGQNGAEEYCKQV---GAKPCGIC--NAHSSDRAKQRSIQSLISSGSGSGSGS 219
            ...:.||....|||:.....:|.|.   ..|.|..|  |.|:         .|.::......|.:
  Fly    74 AAYQLQIESTNTCGEQNDNHFCIQTMNQNHKNCEFCKYNDHN---------PSFLTDLHDPQSPT 129

  Fly   220 GFEEGWWQSPTLQGGRQF-EYVTILLDLKQTFQIFSVWLKSANSPRPASWILEK--SLDGINFEP 281
                 ||||.|:..|.|. .||.:.|.|.:::.|..|.: ...||||.|:.:.|  |..|    |
  Fly   130 -----WWQSETMFEGIQHPNYVNLTLHLGKSYDITYVRI-LFRSPRPESFTIYKRTSESG----P 184

  Fly   282 WQYFGLSDADCQRRWNLSGQNGKYVFQNDTEIICSTQFSKPGPLENGVLHASLLKNRPGAT--DQ 344
            |..:....|.|:..::|.........:.:...:|::::|...||.:|.:..|.|:.||...  ::
  Fly   185 WIPYQFYSATCRDTYSLPDSRAIRKGEGEAHALCTSEYSDISPLRDGEIAFSTLEGRPSGINFER 249

  Fly   345 SPELMKFITTRYIRIRLQGMHSTANQDNSLDWLLDSPSLEKHSFYSLSQLKVSARLDCNGHANRS 409
            |.||.:::|...|||.|..:::..      |.|.....:.|..||::|.:.|.||..|||||::.
  Fly   250 SGELQEWVTATDIRITLDRLNTFG------DELFGDSQVLKSYFYAISDIAVGARCKCNGHASKC 308

  Fly   410 HESP---DDPLMQCICQHNTCGAQCEQCCPLFQDRPYQMG-----GECEICQCYGHAESCTYDPF 466
            ..|.   .:..:.|.|:|||.|..|::|.||:.|..::..     .||:.|.|.|.|:.|.:|..
  Fly   309 VPSTGMHGERTLVCECRHNTDGPDCDRCLPLYNDLKWKRSTSTEVNECKACNCNGLADKCFFDAN 373

  Fly   467 L-----DKGICQSCSNNTAGIECEFCEMGFYRELDAPLTDPCLPCSCNPARSTG-GCQSDGGSCN 525
            |     ..|.|..|..|..|..||.|:..||...|.    .|:.|:|:|..|.. .|.|. |.|.
  Fly   374 LFNRTGHGGHCLDCRENRDGPNCERCKENFYMRDDG----YCVNCACDPVGSRSLQCNSH-GKCQ 433

  Fly   526 CLEGFQGKNCEECAPGYY---GDDCKRCECDERGSLGSTGSC---SGVCQCKLNVEGSTCSECAP 584
            |..|..|..|:.|...||   ...|::|.||..||..:|.:|   :|:|.||.||||..|:||.|
  Fly   434 CKPGVTGDKCDRCDNNYYQFGPHGCQQCGCDSGGSHQNTPACDTETGICFCKENVEGRRCNECKP 498

  Fly   585 GYFDLSAENAEGCTSCWCSGVSQTCHSAKLQTLAFETLN------DWKITDI-QRVKPI------ 636
            |:|:|...|..|||.|:|.|.:..|.:|...::...|.|      .|...|: ||...|      
  Fly   499 GFFNLDKNNRFGCTPCFCYGHTSECMTAPGYSIVSVTSNFNKFKERWTAADLNQREVDIKYNQYS 563

  Fly   637 -SIPVDAETNRLIFANELDEVEAIYWQASLGYLGNRLTSYGSRLQLVLSWDVIRGDRSGKPTTGP 700
             ||...|:.|           |.:|:||...:||::..||...|:..|.                
  Fly   564 RSIGTTAQGN-----------EHVYFQAPDRFLGDQRASYNRDLKFKLQ---------------- 601

  Fly   701 NVILVGKNGLKIAFGDESLDGLGINLNVTLTEVGWYHVPPTVVDIKTRLRRTEGGDYHGE-SVTR 764
               |||:.. .....|..|:|.|..:::.:...| ..:|...|...| .|..|..||..: |.:.
  Fly   602 ---LVGQVA-NTGVSDVILEGAGSRISLPIFAQG-NGIPDQGVKEYT-FRLHEHHDYQWQPSQSA 660

  Fly   765 SQFLSVLVSLDAVLIRAAFHTDQGETSLERAVIYSGGVELGGKSSSQVEQCLCPAGYTGLSCEGC 829
            ..|||:|.:|.|:.|||.:.. |||..|:...:.:......|..::.:|||.||.||.|..||.|
  Fly   661 RGFLSILSNLTAIKIRATYSV-QGEAILDDVELQTAHRGAAGHPATWIEQCTCPEGYLGQFCESC 724

  Fly   830 AFGFKRIYENTSDHQILSKCIPCPCNGHSNSCDLQSGNCGDCMHNTFGDRCERCQLGYYGNPLQG 894
            |.|::   .:.:.......||||.|:||::.||.::|.| .|.|||.||.|::|..|:|||.|.|
  Fly   725 APGYR---HSPARGGPFMPCIPCDCHGHADICDSETGRC-ICQHNTHGDNCDQCAKGFYGNALGG 785

  Fly   895 TPNDCKRCACP-------LSEDSNNFSPSCQLKSYNYMDLNPQFELIEHAEYICTQCPEGYTGDH 952
            ||||||||.||       ::||:                            .|||:||:||.|..
  Fly   786 TPNDCKRCPCPNDGACLQINEDT----------------------------VICTECPKGYFGSR 822

  Fly   953 CQVCDDGYFGNPRQPG-----SSCQRCDCAG-------GPCNVTTGECITCRGNTEGWHCERCKL 1005
            |:.|.||:||:|  .|     .:|:.|||.|       |.||.|||||:.|..||.|.||::|..
  Fly   823 CEQCSDGFFGDP--TGLLGEVQTCKSCDCNGNVDPNAVGNCNRTTGECLKCIHNTAGEHCDQCLS 885

  Fly  1006 GYWGDPAV----GCDPCHCHTEGSESG-----LCDSTDGQCLCKPRYAGQKCDECDVGYANVEL- 1060
            |::|||..    .||.|.|:..|:|..     .||...|||.|||...|:.|.||..||.|:.. 
  Fly   886 GHFGDPLALPHGRCDRCSCYEAGTEQDEQSITRCDQVTGQCQCKPNVIGRDCGECQPGYFNIRSG 950

  Fly  1061 -RCPSCNCDPLGSLVQDRCDPHTGQCHCKEGVMGAKCHECQDGYFGMNAVAYRMDDLAALRQNSD 1124
             .|.:|.|||:|| ....||.::|||||:.||||.:|.:|::.::|.                  
  Fly   951 NGCENCLCDPVGS-YNSTCDRYSGQCHCRPGVMGQRCDQCENYFYGF------------------ 996

  Fly  1125 SDDDEWELVPDTEDPNSESTVACEECHCSSVGSLSSDCDKRTGQCACLANVTGRRCDKCRPGHWN 1189
                              |:..|:.|.|...||....|| :.|||.|..||.|||||:|:...::
  Fly   997 ------------------SSEGCKPCECDESGSKGFQCD-QNGQCPCNDNVEGRRCDRCKENKYD 1042

  Fly  1190 LTAGEGCRDC 1199
              ...||.||
  Fly  1043 --RHRGCIDC 1050

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 164..396 CDD:278484 63/241 (26%)
EGF_Lam 401..450 CDD:238012 18/56 (32%)
TNFRSF <407..507 CDD:304602 33/112 (29%)
EGF_Lam 505..552 CDD:238012 17/50 (34%)
Laminin_EGF 550..597 CDD:278482 23/49 (47%)
Laminin_B 660..798 CDD:278481 38/138 (28%)
EGF_Lam 851..900 CDD:238012 27/48 (56%)
Laminin_EGF <943..971 CDD:278482 13/32 (41%)
VSP 953..1414 CDD:146106 98/270 (36%)
Laminin_EGF 974..1018 CDD:278482 25/54 (46%)
EGF_Lam 1017..1065 CDD:238012 20/54 (37%)
Laminin_EGF 1065..>1105 CDD:278482 19/39 (49%)
EGF_Lam 1150..1197 CDD:238012 19/46 (41%)
Laminin_EGF 1199..1247 CDD:278482 1/1 (100%)
EGF_Lam 1247..1292 CDD:238012
Laminin_EGF 1294..1342 CDD:278482
Laminin_EGF 1340..1392 CDD:278482
Laminin_B 1486..1611 CDD:278481
EGF_Lam 1669..1716 CDD:238012
Laminin_EGF 1718..1767 CDD:278482
EGF_Lam 1772..1819 CDD:238012
CrfC <1933..2267 CDD:223771
Laminin_II 2277..2400 CDD:283628
LamG 2399..>2492 CDD:304605
Laminin_G_2 2616..2755 CDD:280389
Laminin_G_2 2804..2944 CDD:280389
Laminin_G_2 3038..3169 CDD:280389
LamG 3192..3347 CDD:238058
LanB2NP_001287009.1 LamNT 61..296 CDD:214532 66/261 (25%)
EGF_Lam 298..347 CDD:238012 18/48 (38%)
Laminin_EGF 359..414 CDD:278482 19/58 (33%)
EGF_Lam 414..458 CDD:214543 15/44 (34%)
Laminin_EGF 461..511 CDD:278482 23/49 (47%)
LamB 572..697 CDD:214597 40/158 (25%)
TNFRSF <721..848 CDD:304602 59/160 (37%)
CRD2 724..771 CDD:276900 20/50 (40%)
EGF_Lam 743..791 CDD:238012 27/48 (56%)
Laminin_EGF 847..897 CDD:278482 23/49 (47%)
Laminin_EGF 902..953 CDD:278482 19/50 (38%)
Laminin_EGF 956..1004 CDD:278482 22/84 (26%)
Laminin_EGF 1004..1050 CDD:278482 20/48 (42%)
V_Alix_like 1122..1443 CDD:187408
Tar 1139..1521 CDD:223910
BAR 1308..1469 CDD:299863
vATP-synt_E 1474..>1629 CDD:304907
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45445146
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR10574
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
43.840

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