DRSC/TRiP Functional Genomics Resources

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Protein Alignment wb and LAMA4

DIOPT Version :9

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:NP_001098676.2 Gene:LAMA4 / 3910 HGNCID:6484 Length:1823 Species:Homo sapiens


Alignment Length:1938 Identity:462/1938 - (23%)
Similarity:760/1938 - (39%) Gaps:459/1938 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly  1659 FIEDLIGRAAPCHCNGRSSDCDRETGVCQNCRGNTGGDHCHQCAEGFYGDP--NSPHGCQACPCP 1721
            |...|.|...||.|||.|::|...:|.|.:|:.||.|:||.:|.:|:.||.  .:|..||.||||
Human    71 FFHTLSGECVPCDCNGNSNECLDGSGYCVHCQRNTTGEHCEKCLDGYIGDSIRGAPQFCQPCPCP 135

  Fly  1722 ETN-RNFARGCNVWDGEVSCVCKPGYTGRLCERCQAGYFGDPMRYPNTTCQPCNCHPD---GIQT 1782
            ..: .|||..|...:|.|.|:|...|.|..||||..||:|:|:.. .:||:.|:|..:   .:..
Human   136 LPHLANFAESCYRKNGAVRCICNENYAGPNCERCAPGYYGNPLLI-GSTCKKCDCSGNSDPNLIF 199

  Fly  1783 EGCDVETGRC-YCREGVTGLKCDKCQAERHH---LVDNGCKI----------------------- 1820
            |.||..||:| .|....||.||::| |..::   .:...|.:                       
Human   200 EDCDEVTGQCRNCLRNTTGFKCERC-APGYYGDARIAKNCAVCNCGGGPCDSVTGECLEEGFEPP 263

  Fly  1821 ---------CDNCTLLLLDYMELVGNKLRRGMHN-MDLTGIPAPYR--------------KLSEY 1861
                     ||.|...|.|.:.|....:..|... :.::...|.:|              ||||.
Human   264 TGMDCPTISCDKCVWDLTDDLRLAALSIEEGKSGVLSVSSGAAAHRHVNEINATIYLLKTKLSER 328

  Fly  1862 ESAYEKWNGRHWDFSQTKRRLQDYDSADILK-----LEAHAENLKFQSRKAVATIGKREFAIKSM 1921
            |:.|            ..|::|..::.:.:|     :|...|.....|||. ..:.|......:.
Human   329 ENQY------------ALRKIQINNAENTMKSLLSDVEELVEKENQASRKG-QLVQKESMDTINH 380

  Fly  1922 REDAVTQQHSVGLLRSEILQTLSDLHGYGKSAHYLSLPTALKQARFYLQAIREHDQMVQGIRSTN 1986
            ....|.|.|.   :|.:|.:..:.:..||:. |.|| |..:.:.....|      :|::.|||. 
Human   381 ASQLVEQAHD---MRDKIQEINNKMLYYGEE-HELS-PKEISEKLVLAQ------KMLEEIRSR- 433

  Fly  1987 DCAWKHFYAMGNASDASFDESGRLEML-----WRDL-NQT--------------NHRVVDMRLQV 2031
                :.|:......|...||:  .|:|     |:.| |:|              |.::.|::..:
Human   434 ----QPFFTQRELVDEEADEA--YELLSQAESWQRLHNETRTLFPVVLEQLDDYNAKLSDLQEAL 492

  Fly  2032 DRVQEVENEAEDVLEHVRNLSIRVGESHQE-----LDELNQRISDHLD----PGYLEQGEGLLRL 2087
            |:......:||| :........|..|..||     ::.:|..:|...|    |          ||
Human   493 DQALNYVRDAED-MNRATAARQRDHEKQQERVREQMEVVNMSLSTSADSLTTP----------RL 546

  Fly  2088 TVQR--QIMLN--GHLNQLDGYRILLNTTLGVKTEQQREVRKHWLPKAEKHASHLLARSNEYARK 2148
            |:..  .|:.|  |...::||.:    :.|.||......:....:.:|..||..|...:||.:||
Human   547 TLSELDDIIKNASGIYAEIDGAK----SELQVKLSNLSNLSHDLVQEAIDHAQDLQQEANELSRK 607

  Fly  2149 FQPT-RNG-ARIAMLASSAHSNITEAINDARLASILA---KERVYEA-----QRTLYPSDGSSMI 2203
            ...: .|| .:.|:.||:.:.||...:::|...:..|   .:|:|:|     .:.:|..|.|   
Human   608 LHSSDMNGLVQKALDASNVYENIVNYVSEANETAEFALNTTDRIYDAVSGIDTQIIYHKDES--- 669

  Fly  2204 ERAKHSLHRSKQLQQEALKQMHKSNVLKDKLHRQEQQVEGIKSTIYDSGLRT--NNISGQLQGLS 2266
               ::.|:::::||.:|  :......:.|...|    |.|  :....|.|:|  ::...|||...
Human   670 ---ENLLNQARELQAKA--ESSSDEAVADTSRR----VGG--ALARKSALKTRLSDAVKQLQAAE 723

  Fly  2267 DGSARR---QAKDSLEMADRTGEQMRAELQKAKDMQKSIQNMRNSFSNLEPDWEIKLGMAQENIS 2328
            .|.|::   |::...|.|:||          ..::|::...|.|:.:|    |...|.....:..
Human   724 RGDAQQRLGQSRLITEEANRT----------TMEVQQATAPMANNLTN----WSQNLQHFDSSAY 774

  Fly  2329 LTQTN------LRLANVSLSYLEQQAEKEQQVFEVWNNSMAQQLQQLRDQIAKARHAAEAIDVSL 2387
            .|..|      ..|..|....|:|....||:...   ::::..:|::|:.||:.|..|..|.||:
Human   775 NTAVNSARDAVRNLTEVVPQLLDQLRTVEQKRPA---SNVSASIQRIRELIAQTRSVASKIQVSM 836

  Fly  2388 ESLGPKCIRSY-------LPASYGLSTSNKIRMSFALSNHLESSPLIHLASSEGR--HITLELYK 2443
            ...|...:..:       |.|...||...|..:............:::|.|...:  ::.|.:..
Human   837 MFDGQSAVEVHSRTSMDDLKAFTSLSLYMKPPVKRPELTETADQFILYLGSKNAKKEYMGLAIKN 901

  Fly  2444 RRVRLVWNLGGTTATVTHPMVVHTRDPKYDDAW-------------YHVEANRTL-NLGSLVVRR 2494
            ..:..|:|||  |..|..|:     |.|...:|             .|.:...|: :|.|....:
Human   902 DNLVYVYNLG--TKDVEIPL-----DSKPVSSWPAYFSIVKIERVGKHGKVFLTVPSLSSTAEEK 959

  Fly  2495 MNNYGELTPPNPVIITGSTDTEHTRFYQSRSDRISLGGFASKDLQFT----PGLNVVVHQVEVDN 2555
            ....||.:..:.::   ..|.|.|.||        :||..|.....|    ||....:....::|
Human   960 FIKKGEFSGDDSLL---DLDPEDTVFY--------VGGVPSNFKLPTSLNLPGFVGCLELATLNN 1013

  Fly  2556 KPLGLWNF-------VTSEGSCGGSMVGAKESSASSTARHFNGLGYAQLMKTRPRPTRKNLFSVQ 2613
            ..:.|:||       .::...|....:...:|.|:|  ..|:|.|||.:...    ||:..|...
Human  1014 DVISLYNFKHIYNMDPSTSVPCARDKLAFTQSRAAS--YFFDGSGYAVVRDI----TRRGKFGQV 1072

  Fly  2614 MTF----RTLDENALLFLAVDDKNNRSVSVTLSRGRIMFRI-----------DYGDE-------- 2655
            ..|    ||..:|.|:.|.|:             |.:.||:           |:|..        
Human  1073 TRFDIEVRTPADNGLILLMVN-------------GSMFFRLEMRNGYLHVFYDFGFSGGPVHLED 1124

  Fly  2656 --SKLEINTTKKYNVGQWIKIEAAREFSAKRSTENGMLRVNNDRPISGAPTLPVNIHLLPDLSKT 2718
              .|.:||..|.:            |.|.....:..|:.|.:.|.:.......:.|..      |
Human  1125 TLKKAQINDAKYH------------EISIIYHNDKKMILVVDRRHVKSMDNEKMKIPF------T 1171

  Fly  2719 VYYLGGVPPGFTSGTSKAPGADNP----FLGCMKDVQVNGETYDPLESSSYYGVEPSC--KNMIT 2777
            ..|:||.||....  |:|..|..|    |.||||..|...:.::.||.:...||...|  .::|:
Human  1172 DIYIGGAPPEILQ--SRALRAHLPLDINFRGCMKGFQFQKKDFNLLEQTETLGVGYGCPEDSLIS 1234

  Fly  2778 -KAGFSGNGYLELPSQSLRKRS-----NTALVFRTLQPDCLLLLAAYPPEILGDYDAKDIKGNFS 2836
             :|.|:|..::    .|::|.|     .....||||||:.||...|...::            ||
Human  1235 RRAYFNGQSFI----ASIQKISFFDGFEGGFNFRTLQPNGLLFYYASGSDV------------FS 1283

  Fly  2837 ISLVDGQLHVWVNSGRSFIKMSSNSSQMNDGEFHVVHLIKTGRKLELMVDDELQEIRNLNGNPTV 2901
            |||.:|.:.:.|..    ||:.|...|.|||..|.|....:..:.||:||    :.|..:.|||.
Human  1284 ISLDNGTVIMDVKG----IKVQSVDKQYNDGLSHFVISSVSPTRYELIVD----KSRVGSKNPTK 1340

  Fly  2902 VSLPRDAGG---LYIGGAPPHESYTPLAPTFVNLEGAIRDVVFN--NRTINFNDALTFANVQIGR 2961
            ..:.:....   .|.||       :|::..:.|..|.|.:..|.  :|.:...|...:..     
Human  1341 GKIEQTQASEKKFYFGG-------SPISAQYANFTGCISNAYFTRVDRDVEVEDFQRYTE----- 1393

  Fly  2962 NGPLMGSLKGGLYDVLLKTEPMI-----GKSF-----TASPEGCKRIGSYSYEPNAFKFGDDIYS 3016
                  .:...||:..:::.|:.     ||:.     :.:.:|.|...:.|::|.|         
Human  1394 ------KVHTSLYECPIESSPLFLLHKKGKNLSKPKASQNKKGGKSKDAPSWDPVA--------- 1443

  Fly  3017 YSQLKLPER------------------HFWQ--------RNF-HLSFDF----------RSFYPN 3044
               ||||||                  |.:|        :.| ||..||          |:...:
Human  1444 ---LKLPERNTPRNSHCHLSNSPRAIEHAYQYGGTANSRQEFEHLKGDFGAKSQFSIRLRTRSSH 1505

  Fly  3045 GMLYLSPGSKEKPKHYVALVLKDGQLVLVVR-GRRREELQLTAKLNDGEWHRVTISCHDRKVTMS 3108
            ||::..  |.::...::.|.|..|:||.:.. |.::.:::...|.|||.||.| |...:|.....
Human  1506 GMIFYV--SDQEENDFMTLFLAHGRLVYMFNVGHKKLKIRSQEKYNDGLWHDV-IFIRERSSGRL 1567

  Fly  3109 VEIG-----RTDQKTSAQMKLPKKIGASQLLLVGGLPQSPVKVSSDLYVR-LEPFKGCLRRVSIN 3167
            |..|     .:...|.|..|:...|      .:||:  :|.|...::.:. :..|.|||..:.:|
Human  1568 VIDGLRVLEESLPPTEATWKIKGPI------YLGGV--APGKAVKNVQINSIYSFSGCLSNLQLN 1624

  Fly  3168 NNTQDLARPGKHSNVGQCFP-TVERGSYFPGD-AYAIYKKNFNVGKYLDLETEFRTSELSGILLS 3230
            .  ..:....:..:|..||. .:|.|:||..: .|.:..::||:|...::..|.|....||.|:.
Human  1625 G--ASITSASQTFSVTPCFEGPMETGTYFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVH 1687

  Fly  3231 VSDPNGFPALSLELHNGNIIFSCDPGNGAPMR-VESSLPTKYALCDNKWHNISALYDGEQIVLRI 3294
            ....|| ..|::.:.||.:|...:.|    :| ..:|:..|.:|||.:||.|:.:.|...:.|.:
Human  1688 GHSVNG-EYLNVHMKNGQVIVKVNNG----IRDFSTSVTPKQSLCDGRWHRITVIRDSNVVQLDV 1747

  Fly  3295 DQLPAVISVGNQGNAGKVQTRSPLYIGGLPESAPSGSLISRENFKGCIRHVSI 3347
            |.  .|..|....|...:..|.|:::||:|||..:..|...:.|.|||||..|
Human  1748 DS--EVNHVVGPLNPKPIDHREPVFVGGVPESLLTPRLAPSKPFTGCIRHFVI 1798

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 164..396 CDD:278484
EGF_Lam 401..450 CDD:238012
TNFRSF <407..507 CDD:304602
EGF_Lam 505..552 CDD:238012
Laminin_EGF 550..597 CDD:278482
Laminin_B 660..798 CDD:278481
EGF_Lam 851..900 CDD:238012
Laminin_EGF <943..971 CDD:278482
VSP 953..1414 CDD:146106
Laminin_EGF 974..1018 CDD:278482
EGF_Lam 1017..1065 CDD:238012
Laminin_EGF 1065..>1105 CDD:278482
EGF_Lam 1150..1197 CDD:238012
Laminin_EGF 1199..1247 CDD:278482
EGF_Lam 1247..1292 CDD:238012
Laminin_EGF 1294..1342 CDD:278482
Laminin_EGF 1340..1392 CDD:278482
Laminin_B 1486..1611 CDD:278481
EGF_Lam 1669..1716 CDD:238012 20/48 (42%)
Laminin_EGF 1718..1767 CDD:278482 22/49 (45%)
EGF_Lam 1772..1819 CDD:238012 15/53 (28%)
CrfC <1933..2267 CDD:223771 85/378 (22%)
Laminin_II 2277..2400 CDD:283628 28/135 (21%)
LamG 2399..>2492 CDD:304605 22/108 (20%)
Laminin_G_2 2616..2755 CDD:280389 38/167 (23%)
Laminin_G_2 2804..2944 CDD:280389 41/144 (28%)
Laminin_G_2 3038..3169 CDD:280389 35/147 (24%)
LamG 3192..3347 CDD:238058 48/156 (31%)
LAMA4NP_001098676.2 EGF_Lam 81..130 CDD:238012 20/48 (42%)
EGF_Lam 131..185 CDD:238012 23/54 (43%)
EGF_Lam 187..238 CDD:238012 15/51 (29%)
Laminin_I 296..554 CDD:283627 60/299 (20%)
SPEC 339..531 CDD:295325 43/211 (20%)
COG1340 426..724 CDD:224259 76/333 (23%)
Prefoldin 510..609 CDD:298833 27/112 (24%)
Laminin_II 734..861 CDD:283628 30/143 (21%)
LamG 835..1012 CDD:238058 37/194 (19%)
LamG 1049..1207 CDD:238058 46/196 (23%)
LamG 1237..1376 CDD:238058 46/169 (27%)
LamG 1492..1624 CDD:238058 33/142 (23%)
LamG 1648..1799 CDD:238058 49/158 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100395
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
43.670

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