DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wb and AGRN

DIOPT Version :9

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:NP_001292204.1 Gene:AGRN / 375790 HGNCID:329 Length:2068 Species:Homo sapiens


Alignment Length:2826 Identity:529/2826 - (18%)
Similarity:787/2826 - (27%) Gaps:1163/2826 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   277 INFEP-----------WQYFGLSDADCQRRWNLSGQNGKYVFQN-DTEIICSTQ---------FS 320
            :|.:|           |:|  |...|...|.:|.....|.|... ...:||..|         |.
Human    55 LNVDPVQHTYSCKVRVWRY--LKGKDLVARESLLDGGNKVVISGFGDPLICDNQVSTGDTRIFFV 117

  Fly   321 KPGPLENGVLHASLLKNRPGATDQSPELMKFITTRYIRIRLQGMHSTANQDNSLDWLLDSPSLEK 385
            .|.|......|    ||         |||  :.:..:||.|:                   :||:
Human   118 NPAPPYLWPAH----KN---------ELM--LNSSLMRITLR-------------------NLEE 148

  Fly   386 HSFYSLSQLKVSARLDCNGHANRSHESPDDPLMQCICQHNTCGAQCEQCCPLFQDRPYQMGGECE 450
            ..|             |......:|.:|..|.....|:...||                .|..||
Human   149 VEF-------------CVEDKPGTHFTPVPPTPPDACRGMLCG----------------FGAVCE 184

  Fly   451 ICQCYGHAE-----SCTYDPFLDKGICQSCSNNTAGIECEFCEMGFYRELDAPLTDPCLPCSCNP 510
                 .:||     ||         :|:.                          .|| |....|
Human   185 -----PNAEGPGRASC---------VCKK--------------------------SPC-PSVVAP 208

  Fly   511 ARSTGGCQSDGGSCNCLEGFQGKNCEECAPGYYGDDC--KRCECDE--------RGSLGSTGSCS 565
            .     |.||..:                   |.::|  :|.:|.:        ||..||...||
Human   209 V-----CGSDAST-------------------YSNECELQRAQCSQQRRIRLLSRGPCGSRDPCS 249

  Fly   566 GVCQCKLNVEGSTCSECAPGYFDLSAENAEGCT-SCWCSGVSQTCHSAKLQTLAFETLNDWKITD 629
            .| .|..   ||||           |.:|:|.| ||.|..   ||..|...|:......|:    
Human   250 NV-TCSF---GSTC-----------ARSADGLTASCLCPA---TCRGAPEGTVCGSDGADY---- 292

  Fly   630 IQRVKPISIPVDAETNRLIFANELDEVEAIY---------WQASLGYLGNRLTSYGSRLQLVLSW 685
                     |.:.:..|...|.:    |.::         .|.:|.                   
Human   293 ---------PGECQLLRRACARQ----ENVFKKFDGPCDPCQGALP------------------- 325

  Fly   686 DVIRGDRSGKPTTGPNVIL------------VGKNGLKIAFGDESLDG-----LGINLNVTLTEV 733
            |..|..|....|..|.::|            .|.:|  :.:.::.:.|     .|:.|.      
Human   326 DPSRSCRVNPRTRRPEMLLRPESCPARQAPVCGDDG--VTYENDCVMGRSGAARGLLLQ------ 382

  Fly   734 GWYHVPPTVVDIKTRLRRTEGGDYHGESVTRSQFLSVLV--------SLDAVLIRAAFH------ 784
                        |.|..:.:|.|...|.   .:|.:|.:        |.|.|....|:.      
Human   383 ------------KVRSGQCQGRDQCPEP---CRFNAVCLSRRGRPRCSCDRVTCDGAYRPVCAQD 432

  Fly   785 ---------TDQGETSLERAVIYSGGVELGGKSSSQVEQCLCPAGYTGLSCEG--CAFGFKRIYE 838
                     ..|.|...:||:        ..|.....:|...|       |.|  ||||.....:
Human   433 GRTYDSDCWRQQAECRQQRAI--------PSKHQGPCDQAPSP-------CLGVQCAFGATCAVK 482

  Fly   839 NTSDHQILSKCIP---------CPCNG--HSNSCDLQSGNC-----------GDCMHNTFGDRCE 881
            |   .|...:|:.         |..:|  :.::|:|::..|           |.|      |||.
Human   483 N---GQAACECLQACSSLYDPVCGSDGVTYGSACELEATACTLGREIQVARKGPC------DRCG 538

  Fly   882 RCQLGYYGNPLQGTPNDCKRCACPLSEDSNNFSPSCQLKSYNYMDLNPQFELIEHAEYICTQCPE 946
            :|:.|.......|      ||.|| ||......|.|....:.|..     |.:.|. :.||....
Human   539 QCRFGALCEAETG------RCVCP-SECVALAQPVCGSDGHTYPS-----ECMLHV-HACTHQIS 590

  Fly   947 GY--TGDHCQVCDDGY--FGNPRQPGSS-CQRCD-------CA------GGPCNVTTGECITCRG 993
            .:  :...|:.|.|..  ||.....|.. |.||:       |.      |..|.:....|:    
Human   591 LHVASAGPCETCGDAVCAFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYGSACELREAACL---- 651

  Fly   994 NTEGWHCERCKLGYWGDPAVGCDPCHCHTEGSESG--------LC---------DSTDGQCLCKP 1041
              :....|..:.|       .|:...|.:.||.||        ||         ||.||.|:|. 
Human   652 --QQTQIEEARAG-------PCEQAECGSGGSGSGEDGDCEQELCRQRGGIWDEDSEDGPCVCD- 706

  Fly  1042 RYAGQK------CDECDVGYANVELRCPSCNCDPLGSL---VQDRCD-------PHTGQCHCKEG 1090
             ::.|.      |....|.| :.|.......|:....|   .|..|.       |.....||.:.
Human   707 -FSCQSVPGSPVCGSDGVTY-STECELKKARCESQRGLYVAAQGACRGPTFAPLPPVAPLHCAQT 769

  Fly  1091 VMGAKCHECQDGYFGMNAVAYRMDDLAALRQNSDSDDDEWELVPDTEDPNSESTVACEECHCSSV 1155
            ..|.    |||     |..|.|...||..                   |::        |.|:..
Human   770 PYGC----CQD-----NITAARGVGLAGC-------------------PSA--------CQCNPH 798

  Fly  1156 GSLSSDCDKRTGQCACLANVTGRRCDKCRPGHWN----LTAG-EGCRDCRCDPHGSRGHECNPWT 1215
            ||....||..||||:|...|.|.|||:|.||.||    :|.| .||..|.|||.|:...:|...|
Human   799 GSYGGTCDPATGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGRSGCTPCSCDPQGAVRDDCEQMT 863

  Fly  1216 GQCDCKIGVGGQHCNECTEGFFGFSTEGCQ-------RCSACRSE-GQVCDPHNG--RCICPKFT 1270
            |.|.||.||.|..|.:|.:| ......||:       .|:..|.| |..|...:|  .|:||..|
Human   864 GLCSCKPGVAGPKCGQCPDG-RALGPAGCEADASAPATCAEMRCEFGARCVEESGSAHCVCPMLT 927

  Fly  1271 RGLGCGQCVPGTWGWQARLGCRECECDHI-GSIGQQCSTGDGQCQ-----CREGYSGRKCDTCAI 1329
                                |.|.....: ||.|   .|...:||     ||:|.          
Human   928 --------------------CPEANATKVCGSDG---VTYGNECQLKTIACRQGL---------- 959

  Fly  1330 GYFGYPECRRCGCDAEGSFTQADGSIACDSNGQCPCKSLVVGLKCDTCMQ---STFGL----SAQ 1387
                                    .|:..|.|  ||:..|......|...   :|.||    :..
Human   960 ------------------------QISIQSLG--PCQEAVAPSTHPTSASVTVTTPGLLLSQALP 998

  Fly  1388 NPEGCTRCFCFGRSGECEQSDLSWGHIRMAESRNLSVQQIRPH---SVPSSDYEYIVVVQ----- 1444
            .|.|.                |.......|.|:.......||.   |||.:....::.|.     
Human   999 APPGA----------------LPLAPSSTAHSQTTPPPSSRPRTTASVPRTTVWPVLTVPPTAPS 1047

  Fly  1445 -----------MEGSSFHREDAEIQRMNDLS------LVPKSTGNVSIGAYGQFYHPLYFQLPPQ 1492
                       ..||:....|.|:....:.|      |.|....:|:...            ||.
Human  1048 PAPSLVASAFGESGSTDGSSDEELSGDQEASGGGSGGLEPLEGSSVATPG------------PPV 1100

  Fly  1493 FYGDRTSSYGGFLYF-------TLITEGAHKPLERNILGQYPLVQLHAHSKLLLDFYEYEEFEYS 1550
               :|.|.|...|..       :|..||::.|..:...|           .|.|:..|.:|..|:
Human  1101 ---ERASCYNSALGCCSDGKTPSLDAEGSNCPATKVFQG-----------VLELEGVEGQELFYT 1151

  Fly  1551 LNVTHRVPLHESFWKYHHTSQAVDRNTLMAALQNIRHIFIRAFAFADFQEVVLQ----------- 1604
            ..:..  |..|.|.:   |:::::        ..:..:|..:....||:.|.|:           
Human  1152 PEMAD--PKSELFGE---TARSIE--------STLDDLFRNSDVKKDFRSVRLRDLGPGKSVRAI 1203

  Fly  1605 -NVHMDAAIYIKGSTNLIAKGVERCKCPKRFDGLSCQDPGRSFYRWRNTTIVESVFIEDLIGRAA 1668
             :||.|.....:...  :|:.:.|.....|...|..:.|.:...|:.:.....: ||......|.
Human  1204 VDVHFDPTTAFRAPD--VARALLRQIQVSRRRSLGVRRPLQEHVRFMDFDWFPA-FITGATSGAI 1265

  Fly  1669 PCHCNGRSSDCDR--ETGVCQNCRGNTGGDHCHQCAEGFYGDPNSPHGCQACPCPETNRNFARGC 1731
            ......|::...|  .:.|                      .|.:||                  
Human  1266 AAGATARATTASRLPSSAV----------------------TPRAPH------------------ 1290

  Fly  1732 NVWDGEVSCVCKPGYTGRLCERCQAGYFGDPMRYPNTTC----------------QPCNCHPDGI 1780
                        |.:|.:...:..|   ....|.|.||.                :||:..|   
Human  1291 ------------PSHTSQPVAKTTA---APTTRRPPTTAPSRVPGRRPPAPQQPPKPCDSQP--- 1337

  Fly  1781 QTEGCDVETGRCYCREGVT--------GLKCDKCQAERHHLVDNGCKICDNCTLLLLDYMELVGN 1837
                         |..|.|        |..| .|.|.|      |..:|:.              
Human  1338 -------------CFHGGTCQDWALGGGFTC-SCPAGR------GGAVCEK-------------- 1368

  Fly  1838 KLRRGMHNMDLTGIPAPYRKLSEYESAYEKWNGRHWDFSQTKRRLQDYDSADILKLEAHAENLKF 1902
                      :.|.|.|         |:|   ||.:                          |.|
Human  1369 ----------VLGAPVP---------AFE---GRSF--------------------------LAF 1385

  Fly  1903 QSRKAVATIGKREFAIKSMREDAVTQQHSVGLLRSEILQTLSDLHG-------YGKSAHYLSLPT 1960
            .:.:|..|: :.....:::....:...:  |..|.:....|:.|.|       .|.....|:...
Human  1386 PTLRAYHTL-RLALEFRALEPQGLLLYN--GNARGKDFLALALLDGRVQLRFDTGSGPAVLTSAV 1447

  Fly  1961 ALKQARFYLQAIREHDQMVQGIRSTNDCAWKHFYAMGNASDASFDESGRLEMLWRDLNQTNHRVV 2025
            .::..:::...:..|              |:.         .:....|...:|....:.|:...:
Human  1448 PVEPGQWHRLELSRH--------------WRR---------GTLSVDGETPVLGESPSGTDGLNL 1489

  Fly  2026 DMRLQVDRVQEVENEAEDVLEH------VRNLSIRVGESHQELDELNQRISDHLDPGYLEQGEGL 2084
            |..|.|..|.  |::|...||.      :|. .||:      ||..|||:...:.||...:|.| 
Human  1490 DTDLFVGGVP--EDQAAVALERTFVGAGLRG-CIRL------LDVNNQRLELGIGPGAATRGSG- 1544

  Fly  2085 LRLTVQRQIMLNGHLNQLDGYRILLNTTLGVKTEQQREVRKHWLPKAEKHASHLLARSNEYARKF 2149
                          :.:...:..|.|...|....|..|                   :..:..:.
Human  1545 --------------VGECGDHPCLPNPCHGGAPCQNLE-------------------AGRFHCQC 1576

  Fly  2150 QPTRNGARIAMLASSAHSNITEAINDARLASILAKERVYEAQRTLYPSDGSSMIERAKHSLHRSK 2214
            .|.|.|...|...|....|........|                :.|..|:    :.:..|.|..
Human  1577 PPGRVGPTCADEKSPCQPNPCHGAAPCR----------------VLPEGGA----QCECPLGREG 1621

  Fly  2215 QLQQEALKQMHKSNVLKDKLHRQEQQVEGIKSTIYDSGLRTNNISGQLQGLSDGSARRQAKDSLE 2279
            ...|.|                                      |||     |||..       .
Human  1622 TFCQTA--------------------------------------SGQ-----DGSGP-------F 1636

  Fly  2280 MADRTGEQMRAELQKAKDMQKSIQNMRNSFSNLEPDWEIKLGMAQENISLTQTNLRLANVSLSYL 2344
            :||                       .|.||:||                               
Human  1637 LAD-----------------------FNGFSHLE------------------------------- 1647

  Fly  2345 EQQAEKEQQVFEVWNNSMAQQLQQLRDQIAKARHAAE--AIDVSLESLGPKCIRSYLPASYGLST 2407
                                    ||.....||...|  |::|...:.||..:..|    .|..|
Human  1648 ------------------------LRGLHTFARDLGEKMALEVVFLARGPSGLLLY----NGQKT 1684

  Fly  2408 SNKIRMSFALSNHLESSPLIHLASSEGRHITLELYKRRVRLVWNLGGTTATVTHPMVVHTRDPKY 2472
            ..|                       |..::|.|..||:...::||...|      |:.:|:|..
Human  1685 DGK-----------------------GDFVSLALRDRRLEFRYDLGKGAA------VIRSREPVT 1720

  Fly  2473 DDAWYHVEANRTLNLGSLVV------------RRMNNYGELTPPNPVIITGSTDTEH-------T 2518
            ..||..|...|....|:|.|            .|...:..|....|:.:.|:.|...       :
Human  1721 LGAWTRVSLERNGRKGALRVGDGPRVLGESPKSRKVPHTVLNLKEPLYVGGAPDFSKLARAAAVS 1785

  Fly  2519 RFYQSRSDRISLGGFASKDLQFTPGLNVVVHQVEV-----------DNKP-LGLWNFVTSEGS-- 2569
            ..:......:||||   :.| .||  ..|:.||:|           ...| |...:.|..|.:  
Human  1786 SGFDGAIQLVSLGG---RQL-LTP--EHVLRQVDVTSFAGHPCTRASGHPCLNGASCVPREAAYV 1844

  Fly  2570 --CGGSMVG-------AKESSASSTARHFNGLGYAQLMKTRPRPTRKNLFSVQMTFRTLDENALL 2625
              |.|...|       .::|:.......|:|..:.:.:.........|...|.   .|||..||.
Human  1845 CLCPGGFSGPHCEKGLVEKSAGDVDTLAFDGRTFVEYLNAVTESELANEIPVP---ETLDSGALH 1906

  Fly  2626 FLAVDDKNNRSVS--------VTLSRGRIMFRIDYGDESKLEINTTKKYNVG------------- 2669
            .......|:..:|        :.|..|:...|.||...:.::.:....||:|             
Human  1907 SEKALQSNHFELSLRTEATQGLVLWSGKATERADYVALAIVDGHLQLSYNLGSQPVVLRSTVPVN 1971

  Fly  2670 --QWIKIEAAREFSAKRSTENGMLRVNNDRPISGAPTLPVNIHLLPDLSKTVYYLGGVPPGFTSG 2732
              :|:::.|.||      ...|.|:|.|:.|::|:.  |:....|.  :....:|||:|. ...|
Human  1972 TNRWLRVVAHRE------QREGSLQVGNEAPVTGSS--PLGATQLD--TDGALWLGGLPE-LPVG 2025

  Fly  2733 TSKAPGADNPFLGCMKDVQVNGETYDPLESS 2763
            .:........|:||::||.|.......||.:
Human  2026 PALPKAYGTGFVGCLRDVVVGRHPLHLLEDA 2056

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 164..396 CDD:278484 28/139 (20%)
EGF_Lam 401..450 CDD:238012 8/48 (17%)
TNFRSF <407..507 CDD:304602 17/104 (16%)
EGF_Lam 505..552 CDD:238012 8/48 (17%)
Laminin_EGF 550..597 CDD:278482 15/54 (28%)
Laminin_B 660..798 CDD:278481 28/186 (15%)
EGF_Lam 851..900 CDD:238012 13/70 (19%)
Laminin_EGF <943..971 CDD:278482 6/32 (19%)
VSP 953..1414 CDD:146106 129/537 (24%)
Laminin_EGF 974..1018 CDD:278482 8/56 (14%)
EGF_Lam 1017..1065 CDD:238012 18/70 (26%)
Laminin_EGF 1065..>1105 CDD:278482 11/49 (22%)
EGF_Lam 1150..1197 CDD:238012 24/51 (47%)
Laminin_EGF 1199..1247 CDD:278482 19/54 (35%)
EGF_Lam 1247..1292 CDD:238012 10/47 (21%)
Laminin_EGF 1294..1342 CDD:278482 9/53 (17%)
Laminin_EGF 1340..1392 CDD:278482 11/58 (19%)
Laminin_B 1486..1611 CDD:278481 28/143 (20%)
EGF_Lam 1669..1716 CDD:238012 6/48 (13%)
Laminin_EGF 1718..1767 CDD:278482 4/48 (8%)
EGF_Lam 1772..1819 CDD:238012 12/54 (22%)
CrfC <1933..2267 CDD:223771 53/346 (15%)
Laminin_II 2277..2400 CDD:283628 17/124 (14%)
LamG 2399..>2492 CDD:304605 20/92 (22%)
Laminin_G_2 2616..2755 CDD:280389 38/161 (24%)
Laminin_G_2 2804..2944 CDD:280389
Laminin_G_2 3038..3169 CDD:280389
LamG 3192..3347 CDD:238058
AGRNNP_001292204.1 NtA 44..146 CDD:308653 25/126 (20%)
KAZAL 196..242 CDD:197624 14/96 (15%)
KAZAL 272..317 CDD:197624 10/64 (16%)
KAZAL_FS 349..389 CDD:320757 7/59 (12%)
KAZAL_FS 421..461 CDD:238052 6/47 (13%)
KAZAL 489..534 CDD:197624 7/44 (16%)
KAZAL 554..599 CDD:197624 11/51 (22%)
KAZAL 619..664 CDD:197624 9/57 (16%)
KAZAL 704..750 CDD:197624 9/48 (19%)
Laminin_EGF 793..835 CDD:278482 21/41 (51%)
Laminin_EGF 847..>883 CDD:278482 16/35 (46%)
KAZAL 922..969 CDD:197624 17/105 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 995..1096 19/116 (16%)
SEA 1130..1254 CDD:214554 24/149 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1277..1334 13/111 (12%)
EGF 1333..1363 CDD:306513 10/52 (19%)
Laminin_G_1 1400..1531 CDD:278483 28/164 (17%)
EGF_CA 1555..1585 CDD:238011 7/48 (15%)
Laminin_G_1 1668..1803 CDD:278483 34/171 (20%)
EGF_CA 1825..1857 CDD:238011 7/31 (23%)
Laminin_G_1 1921..2051 CDD:278483 31/140 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 62 1.000 Domainoid score I10428
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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