DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wb and Megf8

DIOPT Version :9

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:NP_609180.3 Gene:Megf8 / 34099 FlyBaseID:FBgn0031981 Length:2892 Species:Drosophila melanogaster


Alignment Length:2273 Identity:406/2273 - (17%)
Similarity:599/2273 - (26%) Gaps:995/2273 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly   119 RRNGKLQKSGGGAGGGALRLLKTEDVYSSSFSGGLYPPLFNVVPRAQISV-----------NATC 172
            |||..|...||..|.....|...|..........||.|        :||.           |..|
  Fly   612 RRNHTLLIVGGYHGNVNADLFAYELPQVLRVENTLYNP--------EISCRLHSSHTACLSNPEC 668

  Fly   173 GQNGAEEYC--KQVGAK------------------PCGICNAHSSDRAKQRSIQSLISSGSGSGS 217
            |...|:..|  :.:||.                  .|..|..|.|...|....::..|..|..|.
  Fly   669 GWCSADSSCYGRTIGANCTTNLQTTRCPGICPSLGDCHSCLVHGSQWGKSSGNKAAFSVASKLGL 733

  Fly   218 GS--------------------GFEEGWW-------QSPTLQGGRQ----FEYVTILLDLKQTFQ 251
            ..                    |...|||       :.|:|.....    ..|:.....:..|..
  Fly   734 NECTWCVQNAKCHHRDDNYGICGDSSGWWGDKGTEIRRPSLCTSTDRRPGLTYIKYHFPINYTMP 798

  Fly   252 ----IFSVWLKSANSPRPASWILEKSLDG------INF-EPWQYFGLSDADCQRRWNLSGQNGKY 305
                |.:..:....|| |.:...|..|:|      :.| .|           |.:||        
  Fly   799 DYVGIVNATMVDFASP-PFTTYFEHKLEGEMLARLVGFVRP-----------QHQWN-------- 843

  Fly   306 VFQNDTEIICSTQFSKPGPLENGVLHASL---LKNRPGATDQS----------------PELMKF 351
               |....:| |.:|      :.||.|.|   |......|.||                |..:.|
  Fly   844 ---NSAIQVC-TSYS------SAVLRAGLGLNLDELVNVTTQSSNQSYCSNVQLPTTEQPFTIDF 898

  Fly   352 ITTRYI------------RIRLQGMHSTANQDNSLDWLLDSPSLEKHSFYSLSQLKVSARLDCNG 404
            .|.|.|            ::.||.:|:  .|.|:..:....|      :||..         |..
  Fly   899 QTRRRIGGNGIYNAYQKTKMELQHLHN--GQLNAFTFEYLEP------YYSGK---------CTQ 946

  Fly   405 HANRSHESPDDPLMQCICQHNTCGAQCEQCCPLFQDRPYQMGGECEICQCYGHAESCTYDPFLDK 469
            ::|              |.|....|.| ..|||......:...|.|:|:..      |.|.|...
  Fly   947 YSN--------------CLHCLTDASC-AWCPLTNICHLRSVNETEVCKME------TLDTFHWS 990

  Fly   470 GIC---QSCSNNTAGIECEFCEMGFYRELDAPLTDPCLPCSCNPARSTGGCQSDGGSCNCLEGFQ 531
            .:.   ..|||.|..:.||.|                       |||        |.|.      
  Fly   991 YLISQPSQCSNCTNYVSCEAC-----------------------ARS--------GECE------ 1018

  Fly   532 GKNCEECAPGYYGDDCKRCECDERGSLGSTGS-------CSGVCQCKLNVEGSTCSECAPGYFDL 589
                      ::.:|. ||     |.:|.|.|       |...|:     |...|.||.      
  Fly  1019 ----------WWTEDA-RC-----GRIGKTNSSVRAVEHCPRSCR-----ERHGCQECL------ 1056

  Fly   590 SAENAEGCTSCWCSGVSQTCHSAKLQT--LAFETLNDW-------KITDIQRVKPISIP------ 639
                .|.....||...:| |.|..:.|  ..|....:|       :..:|...||...|      
  Fly  1057 ----GERGRCVWCEASAQ-CFSFSVYTSEYQFGMCREWVDQVVSRQTQEIADHKPQQTPHFLQQQ 1116

  Fly   640 -VDAETNR------------LIFANELDEVEAIYWQASLGY-LGNRLTSYGSRLQLVLSWDVIRG 690
             ...|.:|            ..|..: :.:|.|..|....| .||...:..|.......|...: 
  Fly  1117 CKSCEQHRNCSSCLRTLSCGWCFDRD-NPIEGICMQGDFSYSAGNCSLALNSSSHHDAEWAYAQ- 1179

  Fly   691 DRSGKPTTGPNVILVGKNGLKIAFGDESLDGLGIN-----LNVTLTEVGWYHVPPTVVDIKTRLR 750
                    .|:|             ||.  |||::     ...|.|: |.|:         ...|
  Fly  1180 --------CPDV-------------DEC--GLGLHDCHKEAKCTNTQ-GSYN---------CHCR 1211

  Fly   751 RTEGGDYHGESVTRSQFLSVLVSLDAVLIRAAFHTDQGETSLERAVIYSGGVELGGKSSSQVEQC 815
            |...||        .:|..|         |..:...|.                |..|......|
  Fly  1212 RGYIGD--------GKFSCV---------RTCYELCQN----------------GNCSGPPDYTC 1243

  Fly   816 LCPAGYTGLSCEGCAFGFKRIYENTSDHQILSKCIPCPCNGHSNSCDLQSGNCGDCMHNTFGDRC 880
            .|..|:||..|.                      :.|.||.|| :|:.:.|.|..|...:.|::|
  Fly  1244 RCALGWTGADCG----------------------LSCGCNNHS-TCNERLGKCDQCQDWSEGEKC 1285

  Fly   881 ERCQLGYYGNPLQGTPNDCKRCACPLSEDSNNFSPSCQLKSYNYMDLNPQFELIEHAEYICT--- 942
            |||:.|.|||..  .|:.|..|.|               ..:...||.           :|.   
  Fly  1286 ERCRQGSYGNAT--APHGCLPCEC---------------NGHGNQDLG-----------VCNVSN 1322

  Fly   943 ---QCPEGYTGDHCQVCDDGYFGNPRQPGSSCQRCDCAGGPCNVTTGECITCRGNTEGW----HC 1000
               .|.:...|.:|::|..||:|:||..|....:|:..|...|:......:.:.....|    ..
  Fly  1323 GECYCKDNTQGLNCELCAPGYYGDPRGGGKCYYQCESRGILTNIGKSAIGSYQSYRSPWGASLEV 1387

  Fly  1001 ERC----------------KLGY-WGDPAVGCDP-------------------------C----- 1018
            :.|                :|.: |...|:.||.                         |     
  Fly  1388 KECLWILQPKTLQAEKSLLQLEFQWQSLAMDCDENAVYIYDSLPDLTGATQQNQLLAVVCAPYSS 1452

  Fly  1019 ---------HC---HTEGSE----------------SGLCDS---TDGQ--CLCKPRYAGQKCDE 1050
                     |.   :.:|||                :|.|.|   .|.|  |:|...|.|..|: 
  Fly  1453 PRIIEARSSHVTVHYKQGSERRHFGFNALYSVMNCVAGSCISPHICDAQQRCVCPAGYVGASCE- 1516

  Fly  1051 CDVGYANVELRCPSCNCDPLGSLVQDRCDPHTGQCHCKE-GVMGAKC-------HECQDGYFGMN 1107
                   :|: ||| ||:  ...:|..||...|:|.|.. ...||.|       |......|...
  Fly  1517 -------IEI-CPS-NCN--AKRMQGFCDTEYGRCICSNANYAGADCGTLVQRNHLVMTELFNTQ 1570

  Fly  1108 AVAYRMDDLA-----------ALRQNS--------------------DSDDDEW-ELVPDTEDPN 1140
            .::..::.|.           |.|:.|                    |:.:..| ::..::..|.
  Fly  1571 LLSESLEHLRKTIPRFGHSVNADRRGSLWMFGGYSPNHGPLNDFRQFDTKNSTWLQVTVESSTPE 1635

  Fly  1141 SESTVACEECHCSSV----------GSLSSDC------------DKRTGQCAC------------ 1171
            ....:. ...|.|.:          |.:.::.            ::|..|...            
  Fly  1636 DRMPLG-RYFHASEIYVKKQIIYIYGGIGANSQLLNDFWMFSIQNQRWSQIKVEVEPPEADYEVD 1699

  Fly  1172 ----LANVT----------------GRRCDKCRP----------GHWNLTAGEGCR--------- 1197
                ||..|                |...:|.||          |.|...|..|.|         
  Fly  1700 VPPPLAGHTLTHIRYQEHESLILLGGLSLNKSRPLELWEFNLDTGRWQQLAAVGARMPVLYGHTS 1764

  Fly  1198 ----------------------------------------------------------------- 1197
                                                                             
  Fly  1765 VYHQETNSVYLFGGYSTEPQSNLYALDLQKLSWTELPSFRELNSPASLLPRARYFHSAVTTEHYM 1829

  Fly  1198 ----------------------------------------------DCRCDP-----------HG 1205
                                                          |...||           .|
  Fly  1830 ILYGGRTQPFNGTDVLIAYVYACNQWVRLTEDVELIGRVPASSYAEDMAIDPDTGAIYVIGGWDG 1894

  Fly  1206 SRGHE-----------CNPWT-GQCDCKIGVGGQHCNECT-EGFFGFSTEGCQRCSACRSEGQV- 1256
            |..|.           |..|: |:..|:..:|   |:.|| :..:.:|       |.|.|.|:. 
  Fly  1895 SSTHSHVTKITLPDDICQLWSNGKYQCRHYMG---CSYCTIQNTYSYS-------SHCFSHGRTP 1949

  Fly  1257 CDPHNGRCI----------------CPKFTRGLGCGQCVPGTWGWQARLG--CRECECDHIGSIG 1303
            |..|||..:                |..|..   ||.|: ..|.....:.  |.  .||..|..|
  Fly  1950 CANHNGTLVVNNGAACDDDWMASRNCSSFAT---CGACL-AAWPTHQEVAPVCH--WCDDCGIRG 2008

  Fly  1304 QQCSTGDGQCQCREGYSGRKCDTCAIGYFGYPECRRCGCDAEGSFTQADGSIACDSNGQCPCKSL 1368
             :|......|..|..:..::.....:|....|:|.:                             
  Fly  2009 -RCVPAGVDCGRRSAWCNKELSVGVLGLCPLPQCYQ----------------------------- 2043

  Fly  1369 VVGLKCDTCMQSTFGLSAQNPEGCTRCFCFGRSGECEQSDLSWGHIRMAESRNLSVQQIRPHSVP 1433
               |.|::||.......|:|..|...|..                ..:.|.....|.:..|  :|
  Fly  2044 ---LSCESCMLQPQCNWARNELGTVECIA----------------KELVEKNQYRVVESCP--LP 2087

  Fly  1434 SSDYEYIVVVQMEGSSFHREDAEIQRMNDLSLVPKSTGNVSIGAY-GQFYHPLYFQLPPQ---FY 1494
            ...||...:...:..:...::.:...|.:|.|.|.|...:..|.. |........|..|:   .|
  Fly  2088 CHTYENCSLCLSQTPTQDHQECKWSTMLNLCLTPSSQPLLCAGGVCGLVLEASELQRCPEPCHVY 2152

  Fly  1495 GDRTS----------SYGGFLYFTLITEGA--HKPLERNILGQYPLVQLHAHSKLLLDFYEYEEF 1547
            ...:|          :..||....:.||||  ||.       ::|       |....|.. |..:
  Fly  2153 TQCSSCLEHAHCGWCAREGFNGDGICTEGALEHKQ-------EHP-------SGSTCDLI-YASW 2202

  Fly  1548 EYSLNVTHRVPLHESFWKY------------HH-----TSQAVDRNTLMAALQNIRHIFIRAFAF 1595
            .....:||...:.   |.|            ||     :.|.:|.:|.      :.:..:.|..:
  Fly  2203 RNDSQLTHADVVS---WHYVQCPAENECINGHHNCDTVSEQCIDLDTA------VGYKCVCAQGY 2258

  Fly  1596 ADFQEVVLQNVHMDAAIYIKGSTNLIAKGVERCKCPKRFDGLSCQDPGRSFYRWRNTTIVESVFI 1660
            .:.|...|       .:..:|.........::|:|...:.|.:|                     
  Fly  2259 REEQGACL-------PVCSQGCVRGNCVSPDQCQCDFGYVGANC--------------------- 2295

  Fly  1661 EDLIGRAAPCHCNGRSSDCDRET--GVCQNCRGNTGGDHCHQCAEGFYGDPNSPHGCQACPCPET 1723
                  :..|.|||. |:|:..:  .:|..|..||.|:.|.:|...|.|:|...|.||  ||.:.
  Fly  2296 ------SIQCLCNGH-SNCESSSRLDICLKCHNNTMGEQCEKCQPLFVGNPREGHACQ--PCLDY 2351

  Fly  1724 NRNFARGCNVWDGE----------------------VSCV-CKPGYTGRLCERCQAGYF--GDPM 1763
            ....:..|..:|.:                      .:|: |.....|..|:.|..|||  .:.:
  Fly  2352 CHGHSDVCVAYDADPAVFNMTRSELERILQEGPAYNATCLRCGNHTAGDRCDSCLTGYFRGSEDL 2416

  Fly  1764 RYPNTTCQPCNCHPDGIQTEGCDVETG-RCYCREGVTG------------------LKCDKCQ 1807
               :..|:||.||..|   ..||..|| :|.|......                  ::|.||:
  Fly  2417 ---HKECRPCQCHGHG---NICDPVTGEKCNCANNTESDATCTAGGGKNSAQLCWMVQCSKCR 2473

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 164..396 CDD:278484 62/335 (19%)
EGF_Lam 401..450 CDD:238012 10/48 (21%)
TNFRSF <407..507 CDD:304602 21/102 (21%)
EGF_Lam 505..552 CDD:238012 8/46 (17%)
Laminin_EGF 550..597 CDD:278482 12/53 (23%)
Laminin_B 660..798 CDD:278481 25/143 (17%)
EGF_Lam 851..900 CDD:238012 19/48 (40%)
Laminin_EGF <943..971 CDD:278482 10/27 (37%)
VSP 953..1414 CDD:146106 122/811 (15%)
Laminin_EGF 974..1018 CDD:278482 10/89 (11%)
EGF_Lam 1017..1065 CDD:238012 18/110 (16%)
Laminin_EGF 1065..>1105 CDD:278482 12/47 (26%)
EGF_Lam 1150..1197 CDD:238012 16/110 (15%)
Laminin_EGF 1199..1247 CDD:278482 14/71 (20%)
EGF_Lam 1247..1292 CDD:238012 14/63 (22%)
Laminin_EGF 1294..1342 CDD:278482 10/47 (21%)
Laminin_EGF 1340..1392 CDD:278482 6/51 (12%)
Laminin_B 1486..1611 CDD:278481 28/156 (18%)
EGF_Lam 1669..1716 CDD:238012 17/48 (35%)
Laminin_EGF 1718..1767 CDD:278482 12/73 (16%)
EGF_Lam 1772..1819 CDD:238012 14/55 (25%)
CrfC <1933..2267 CDD:223771
Laminin_II 2277..2400 CDD:283628
LamG 2399..>2492 CDD:304605
Laminin_G_2 2616..2755 CDD:280389
Laminin_G_2 2804..2944 CDD:280389
Laminin_G_2 3038..3169 CDD:280389
LamG 3192..3347 CDD:238058
Megf8NP_609180.3 CUB 33..141 CDD:238001
KELCH repeat 228..268 CDD:276965
Kelch_4 369..414 CDD:290154
KELCH repeat 370..420 CDD:276965
KELCH repeat 425..476 CDD:276965
KELCH repeat 480..540 CDD:276965
EGF_3 1186..1220 CDD:289699 11/53 (21%)
EGF_Lam 1257..1302 CDD:238012 19/47 (40%)
EGF_Lam 1304..1354 CDD:238012 15/75 (20%)
CUB 1372..1484 CDD:238001 12/111 (11%)
Kelch_4 1584..1628 CDD:290154 5/43 (12%)
KELCH repeat 1585..1638 CDD:276965 6/52 (12%)
KELCH repeat 1642..1685 CDD:276965 4/42 (10%)
Kelch_3 1656..1710 CDD:290151 6/53 (11%)
KELCH repeat 1760..1813 CDD:276965 0/52 (0%)
Kelch_4 1760..1802 CDD:290154 0/41 (0%)
KELCH repeat 1817..1867 CDD:276965 0/49 (0%)
EGF_Lam 2299..2346 CDD:238012 17/47 (36%)
EGF_Lam 2422..2487 CDD:238012 14/55 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45445166
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR10574
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
22.030

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