DRSC/TRiP Functional Genomics Resources

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Protein Alignment wb and CCDC158

DIOPT Version :9

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:NP_001381883.1 Gene:CCDC158 / 339965 HGNCID:26374 Length:1117 Species:Homo sapiens


Alignment Length:1211 Identity:218/1211 - (18%)
Similarity:442/1211 - (36%) Gaps:297/1211 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly  1851 IPAP-----YRKLSEYESAYEKWNGRHWDFSQTKRRLQDYDSADILKLEAHAENLKFQSRKAVAT 1910
            ||:|     .|.|.||....:....|..:.::...:.:.|....::.|:...:.::.: |.|:|.
Human    68 IPSPGKEHFERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQME-RDAMAD 131

  Fly  1911 IGKREFAIKSMREDAVTQQHSVGLLRSEILQTLSDLHGYGKSAHYLSLPTALKQARFYLQAIRE- 1974
            |.:||   ...:||          ||:::..|:.:|    ::|..|. ...||.:...::.:|: 
Human   132 IRRRE---SQSQED----------LRNQLQNTVHEL----EAAKCLK-EDMLKDSNTQIEQLRKM 178

  Fly  1975 ---HDQMVQGIRST---------------NDCAWKHFYAMGNASDASFDESGRLEMLWRDLNQTN 2021
               |:.::|.|||.               :..:..||.::|:|          :..:.|:|:   
Human   179 MLSHEGVLQEIRSILVDFEEASGKKICEHDSMSTLHFRSLGSA----------ISKILRELD--- 230

  Fly  2022 HRVVDMRLQVDRVQEVENEAEDVLEHVRNLSIRVGESHQELDELNQRISDHLDPGYLEQGEGLLR 2086
               .::.....|:..||::.|.:....:|....:.:.||  |.:.|.||:|              
Human   231 ---TEISYLKGRIFPVEDQLEALKSESQNKIELLLQQHQ--DRIEQLISEH-------------- 276

  Fly  2087 LTVQRQIMLNGHLNQLDGYRILLN---TTLGVKTEQQREVRKHW---LPKAEKHASHLLARSNEY 2145
                 ::.:.|...:....|...|   :.:.:..||.|.....:   |...|...|.|.:...|.
Human   277 -----EVEITGLTEKASSARSQANSIQSQMEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREA 336

  Fly  2146 ARKFQPTRNGARIAMLASSAHSNITEAIN------------DARLASILA------KERVYEAQ- 2191
            .|.::.........::.  |:|.:|||..            |.:|..:||      ||...|.: 
Human   337 KRMYEDKTEELEKQLVL--ANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQ 399

  Fly  2192 -RTLYPSD-GSSM-IERAKHSL-HRSKQLQQ-EALKQMHKSNVLKDKLHRQEQQVEGIKSTIYDS 2251
             :.|:..| |:|: |:..:..| :|:.::|: |||.:..||. .:.::.||...::|...::.  
Human   400 NKRLWDRDTGNSITIDHLRRELDNRNMEVQRLEALLKALKSE-CQGQMERQMAAIQGKNESLE-- 461

  Fly  2252 GLRTNNISGQLQGLSDGSARRQAKD------SLEMADRTGEQMRAELQKAKDMQKSIQNMRNSFS 2310
              :.::::.||:...: ..|:..::      :||.::||...:...||   :.:::|:......:
Human   462 --KVSSLTAQLESTKE-MLRKVVEELTAKKMTLESSERTISDLTTSLQ---EKERAIEATNAEIT 520

  Fly  2311 NLEPDWEIKLGMAQENISLTQTNLRLANVSLSYLEQQAEKEQQVFEVWNNSMAQQLQQLRDQIAK 2375
            .|....::||...| ::.....:||........|:.|..::.:|.|:    :.||::.:...:.:
Human   521 KLRSRVDLKLQELQ-HLKNEGDHLRNVQTECEALKLQMTEKDKVIEI----LRQQIENMTQLVGQ 580

  Fly  2376 ARHAAEAIDVSLESLGPKCIRSYLPASYGLSTSNKIRMSFALSNHLESSPLIHLASSEGRHITLE 2440
            ....|.|:.|....|..:.              |..||.......|:......:...|.|...||
Human   581 HGRTAGAMQVEKAQLEKEI--------------NDRRMELKELKILKDKKDAKIRELEARVSDLE 631

  Fly  2441 LYKRRVRLVWNLGGTTATVTHPMVVHTRDPKY--DDAWYHVEANRT--LNLG---SLVVRRMNNY 2498
            |.|  |:|| |.|......       .:|.|.  |.....|:.:|:  .||.   .::.|...|.
Human   632 LEK--VKLV-NAGSERLRA-------VKDIKQERDQLLNEVKTSRSELNNLSEEYEVLKRNFRNK 686

  Fly  2499 GELTPPNPVIITGSTDTEHTRFYQSRSDRISLGGFASKDLQFTPGL--NVVVHQVEVD------- 2554
            .|........:.....:..:...|:|:...|:.|.....::...|:  .:...:.::|       
Human   687 SEEMEMTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQ 751

  Fly  2555 ---------NKPLGLWNFVTSEGSCGGSMVGAKESSASST-ARHFNGL-GYAQLMKTRPRPTRKN 2608
                     ||..   :|:..|.|        |.|...|| |...|.: |..::::::.|..::.
Human   752 FLEEAMTNANKEK---HFLKEEKS--------KLSQELSTVATEKNKMAGELEVLRSQERRLKEK 805

  Fly  2609 LFSVQMTFRTLDENALLFLAVDD--KNNRSVSVTLSRGRIMFRID--------YGDESKLE---- 2659
            :.::::   .||:.:|.|....|  :.....||.|   ::...:|        |...|.|:    
Human   806 VTNMEV---ALDKASLQFAECQDIIQRQEQESVRL---KLQHTLDIKELQGPGYTSNSSLKPRLL 864

  Fly  2660 --INTTKKY-NVGQWIKIEAAREFSAKRSTENGMLRVNNDRPISGAPTLPVNIHLLPDLSKTVYY 2721
              .:.|:.: ||.   ..::...|.:..||:...|:.:..|.:.         .||.:|...:  
Human   865 QPASVTRSHSNVP---SSQSTASFLSHHSTKANTLKEDPTRDLK---------QLLQELRSVI-- 915

  Fly  2722 LGGVPPGFTSGTSKAPGADNPFLGCMKDVQVNGETYDPLESSSYYGVEPSCKNMITKAGFSGNGY 2786
              ...|..:...::..|..:  ||.:                 |..||...::.||::....: .
Human   916 --NEEPAVSLSKTEEDGRTS--LGAL-----------------YVAVEDRVRDCITESSLRSD-M 958

  Fly  2787 LELPSQSLRKRSNTALVFRTLQPDCLLLLAAYPPEILGDYDAKDIKGNFSISLVDGQLHVWVNSG 2851
            ....:.|||..:..:....||..:.:.|.|.         |.:|..|.|:          :.::.
Human   959 CHRSNNSLRDSTEGSKSSETLSREPVTLHAG---------DREDPSGCFT----------FTSAA 1004

  Fly  2852 RSFIKMSSNSSQMNDGEFHVVHLIKTGRKLELMVDDELQEIRNLNGNPTVVSLPRDAGGLYIGGA 2916
            ...:|.|::.|..:..:...||.:.|.               ::.|:....|..|.|..::...:
Human  1005 SPSVKNSASRSFNSSPKKSPVHSLLTS---------------SVEGSIGSTSQYRSAKPIHSSDS 1054

  Fly  2917 PPHESYTPLAPT----------FVNLEGAIRDVVFNNRTIN 2947
            .......|:..|          ..:|:..:.|:...|:.::
Human  1055 VKDSQSPPIETTGKTCRKLQNRLESLQTLVEDLQLKNQAMS 1095

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 164..396 CDD:278484
EGF_Lam 401..450 CDD:238012
TNFRSF <407..507 CDD:304602
EGF_Lam 505..552 CDD:238012
Laminin_EGF 550..597 CDD:278482
Laminin_B 660..798 CDD:278481
EGF_Lam 851..900 CDD:238012
Laminin_EGF <943..971 CDD:278482
VSP 953..1414 CDD:146106
Laminin_EGF 974..1018 CDD:278482
EGF_Lam 1017..1065 CDD:238012
Laminin_EGF 1065..>1105 CDD:278482
EGF_Lam 1150..1197 CDD:238012
Laminin_EGF 1199..1247 CDD:278482
EGF_Lam 1247..1292 CDD:238012
Laminin_EGF 1294..1342 CDD:278482
Laminin_EGF 1340..1392 CDD:278482
Laminin_B 1486..1611 CDD:278481
EGF_Lam 1669..1716 CDD:238012
Laminin_EGF 1718..1767 CDD:278482
EGF_Lam 1772..1819 CDD:238012
CrfC <1933..2267 CDD:223771 74/382 (19%)
Laminin_II 2277..2400 CDD:283628 23/122 (19%)
LamG 2399..>2492 CDD:304605 22/99 (22%)
Laminin_G_2 2616..2755 CDD:280389 27/155 (17%)
Laminin_G_2 2804..2944 CDD:280389 22/149 (15%)
Laminin_G_2 3038..3169 CDD:280389
LamG 3192..3347 CDD:238058
CCDC158NP_001381883.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 848..902 10/56 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 959..1066 22/140 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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