DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wb and Lama4

DIOPT Version :10

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:NP_001296376.1 Gene:Lama4 / 309816 RGDID:1560062 Length:1817 Species:Rattus norvegicus


Alignment Length:1926 Identity:434/1926 - (22%)
Similarity:763/1926 - (39%) Gaps:441/1926 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly  1659 FIEDLIGRAAPCHCNGRSSDCDRETGVCQNCRGNTGGDHCHQCAEGFYGDP--NSPHGCQACPCP 1721
            |.....|..:||.|||.|.:|...:|.|.:|:.||.|:||.:|..|:.||.  .:|..||.||||
  Rat    71 FFRTSSGECSPCDCNGNSHECLDGSGFCLHCQRNTTGEHCERCLAGYIGDSIRGAPRFCQPCPCP 135

  Fly  1722 ETN-RNFARGCNVWDGEVSCVCKPGYTGRLCERCQAGYFGDPMRYPNTTCQPCNCHPD---GIQT 1782
            ..: .|||..|...:|.|.|:||..|.|..||||..||:|:|:.. .:||:.|:|..:   .:..
  Rat   136 LPHLANFAESCFRKNGAVRCMCKENYAGPNCERCAPGYYGNPLLI-GSTCKKCDCSGNSDPNLIF 199

  Fly  1783 EGCDVETGRC-YCREGVTGLKCDK------------------------CQAERHHLVDNGCKI-- 1820
            |.||..||:| .|....||.||::                        |.:.....::.|.::  
  Rat   200 EDCDEITGQCRNCLRNTTGFKCERCAPGYYGDARIAKNCAVCNCGGGPCDSVTGECLEEGFELPT 264

  Fly  1821 -CDNCTLLLLDYMELV----------------GNKLRRGMHNMDLTGIPAPYRKLSEYESAYEKW 1868
             ||.|...|.|.:.|.                |....|.:.:|:.| |.....:|||.|:.|   
  Rat   265 GCDKCVWDLTDDLRLAALSIEESKSGLLSVSSGAAAHRHVTDMNST-IHLLKTRLSERENQY--- 325

  Fly  1869 NGRHWDFSQTKRRLQDYDSADILK-LEAHAENLKFQ----SRKAVATIGKREFAIKSMREDAVTQ 1928
                     |.|::|..:|.:.|: |.:..|.|..:    |||. ..:.|............|.|
  Rat   326 ---------TLRKIQINNSENTLRSLLSDVEELDEKGSRASRKG-TLVEKESTDTIDQATQLVEQ 380

  Fly  1929 QHSVGLLRSEILQTLSDLHGYGKSAHYLSLPTALKQARFYLQAIREHDQMVQGIRSTNDCAWKHF 1993
            .||   :|.:|.:..|.:..||::...  .|..:.:.....|      :|:..|||.     :.|
  Rat   381 AHS---MRDKIQEINSKMLYYGENQEL--GPEEIAEKLVLAQ------KMLDEIRSR-----QPF 429

  Fly  1994 YAMGNASDASFDESGRLEML-----WRDLNQTNHRVVDMRL-QVD----RVQEVENEAEDVLEHV 2048
            .......|...||.  .|:|     |:.|:.....::.:.| |:|    ::.:::......|:||
  Rat   430 LTHRELVDEEADEV--QELLSQAENWQRLHNDTRSLLPVVLEQLDDYNAKLSDLQESINQALDHV 492

  Fly  2049 R---NLSIRVGESHQELDELNQRISDHLD---PGYLEQGEGLL--RLTVQR--QIMLN--GHLNQ 2101
            |   :::..:....::.::.::|:.:.::   .......:.|:  |||::.  :|:.|  |...:
  Rat   493 RDAEDMNRAITSKQRDHEKQHERVKEQMEAVGTSLSLSADSLITPRLTLEELDEIIKNASGIYAE 557

  Fly  2102 LDGYRILLNTTLGVKTEQQREVRKHWLPKAEKHASHLLARSNEYARKFQPT-RNG-ARIAMLASS 2164
            :||.:..|...|...:....::    :.:|..||.:|...:||.:|....: .|| .:.|:.||:
  Rat   558 IDGAKNELQGKLSNLSNLSHDL----VQEAVDHAYNLQQEANELSRNLHSSDMNGLVQKALDASN 618

  Fly  2165 AHSNITEAINDARLASILA---KERVYEA------QRTLYPSDGSSMIERAKHSLHRSKQLQQEA 2220
            .:.||...:::|...:.||   .:|:|:|      |...:..:..:::.:|:....::.....||
  Rat   619 VYENIANYVSEANETAELALNITDRIYDAVSGIDTQIVYHKDESDNLLNQARELQAKADSSSDEA 683

  Fly  2221 LKQ--------MHKSNVLKDKLHRQEQQVEGIKSTIYDSGLRTNNISGQLQGLSDGSARR---QA 2274
            :..        :.:...|:|||      .|.:|               |||....|.|.:   |.
  Rat   684 VADTSRRVGGALWRKGALRDKL------TEAVK---------------QLQAAERGDAHQRLGQT 727

  Fly  2275 KDSLEMADRTGEQMRAELQKAKDMQKSIQNMRNSFSNLEPD-WEIKLGMAQENI-SLTQTNLRLA 2337
            |..:|.|::|   ..|..|....|..::.|...:....:.. :...:..|::.: :||:...||.
  Rat   728 KLIIEEANKT---TMAVQQVTTPMANNLSNWSQNLQTFDSSAYNTAVNSARDAVRNLTEVVPRLL 789

  Fly  2338 NVSLSYLEQQAEKEQQVFEVWNNSMAQQLQQLRDQIAKARHAAEAIDVSLESLGPKCIRSYLPAS 2402
            . .|..:||:...         ::::..:|::|:.||:.|..|..|.||:...|...:..:...|
  Rat   790 G-QLRTVEQKRPA---------SNVSASIQRVRELIAQTRSVASKIQVSMLFDGHSAVEVHPKVS 844

  Fly  2403 YGLSTSNKIRMSFALSNHLESSP--------------LIHLASSEGR--HITLELYKRRVRLVWN 2451
            .     :.::...::|.:::..|              :::|.|...:  ::.|.:....:..|:|
  Rat   845 V-----DDLKAFTSISLYMKPPPKPAEPTGAWVEDQFVLYLGSKTAKKEYMGLAIKNDNLVYVYN 904

  Fly  2452 LGGTTATVTHPMVVHTRDPKYDDAW--YHVEANRTLNLGSLV-VRRMNNYGE--LTPPNPVIITG 2511
            ||.....:       ..|.|...:|  |.          |:| :.|:..:|:  ||.|:      
  Rat   905 LGTKDVEI-------LLDSKPVSSWPAYF----------SIVKIERVGKHGKVFLTVPS------ 946

  Fly  2512 STDTEHTRFYQSRSDRISLGGFASKD--LQFTP------------------GLNV-----VVHQV 2551
            .:.|...:|       |..|.||..|  |..||                  .||:     .:...
  Rat   947 LSSTAEEKF-------IKKGEFAGDDSLLDLTPEDTVFYVGGVPANFKLPASLNLPSYSGCLELA 1004

  Fly  2552 EVDNKPLGLWNF-------VTSEGSCGGSMVGAKESSASSTARHFNGLGYAQLMKTRPRPTRKNL 2609
            .::|..:.|:||       ......|....:...:|.|:|  ..|:|..||.:...    ||:..
  Rat  1005 TLNNDVISLYNFKHIYNMDPAKSVPCARDKLAFTQSRAAS--YFFDGSSYAVVRDI----TRRGK 1063

  Fly  2610 FSVQMT-----FRTLDENALLFLAVDDKNNRSVSVTLSRGRIMFRIDYGDES----------KLE 2659
            |. |:|     .||..:|.|:.|.|:  .:...|:.:..|.:....|:|..:          |.:
  Rat  1064 FG-QVTRFDIEIRTPADNGLVLLMVN--GSMFFSLEMRNGYLHVFYDFGFSNGPVHLEDTLKKAQ 1125

  Fly  2660 INTTKKYNVGQWIKIEAAREFSAKRSTENGMLRVNNDRPISGAPTLPVNIHLLPDLSKTVYYLGG 2724
            ||..|.:            |.|.....:..|:.|.:.|.:.........|..      |..|:||
  Rat  1126 INDAKYH------------EISIIYHNDKKMILVVDRRHVKSTDNEKKKIPF------TDIYIGG 1172

  Fly  2725 VPPG-FTSGTSKA--PGADNPFLGCMKDVQVNGETYDPLESSSYYGVEPSC--KNMIT-KAGFSG 2783
            .|.. ..|.|.:|  | .|..|.||||..|...:.::.||.....||...|  .::|: :|.|:|
  Rat  1173 APQEVLQSRTLRAHLP-LDINFRGCMKGFQFQKKDFNLLEQKETLGVGYGCPEDSLISRRAYFNG 1236

  Fly  2784 NGYLELPSQSLRKRS-----NTALVFRTLQPDCLLLLAAYPPEILGDYDAKDIKGNFSISLVDGQ 2843
            ..::    .|.:|.|     .....||||||:.||.           |.|......|||||.:|.
  Rat  1237 QSFI----ASTQKISFFDGFEGGFNFRTLQPNGLLF-----------YYASGSDDVFSISLDNGT 1286

  Fly  2844 LHVWVNSGRSFIKMSSNSSQMNDGEFHVVHLIKTGRKLELMVDDELQEIRNL---NGNPTVVSLP 2905
            :.:.|..    ||:.|...|.:||..|.|....:..:.||:||......:|.   ...||..:..
  Rat  1287 VVMDVKG----IKVKSADKQYHDGLSHFVVTTVSATRYELVVDKSRLGSKNPTKGKAEPTQTTEK 1347

  Fly  2906 RDAGGLYIGGAPPHESYTPLAPTFVNLEGAIRDVVFN--NRTINFNDALTFANVQIGRNGPLMGS 2968
            :    .|.||       :|::|.:.|..|.|.:..|.  :|.:...|...::.           .
  Rat  1348 K----FYFGG-------SPISPQYANFTGCISNAYFTRLDRDVEVEDFQRYSE-----------K 1390

  Fly  2969 LKGGLYDVLLKTEPMI-----GKSFT---ASPEGCKRIGSYSYEP-------------------- 3005
            :...||:..:::.|:.     ||:.:   .:.:|.|...:.|::|                    
  Rat  1391 VHTSLYECPIESSPLFLLHKKGKNSSKPKTNKQGEKSKDAPSWDPIGLKFLERKASRDSHCHLSS 1455

  Fly  3006 ------NAFKFGDDIYSYSQLKLPERHFWQRN-FHLSFDFRSFYPNGMLYLSPGSKEKPKHYVAL 3063
                  :|:::|....|..:.:..:..|.::: |.:....||  .:||::..  |.::...::.|
  Rat  1456 SPRAIEHAYQYGGTANSRQEFEHIQGDFGEKSQFAIRLKTRS--SHGMIFYV--SDQEENDFMTL 1516

  Fly  3064 VLKDGQLVLVVR-GRRREELQLTAKLNDGEWHRVTISCHDRKVTMSVEIGRTDQKTSAQM----- 3122
            .|..|:||.:.. |.::.:::...|.:||.||.|..               ..:|:|.::     
  Rat  1517 FLAHGRLVFMFNVGHKKLKIRSQEKYSDGLWHDVIF---------------IREKSSGRLVIDGL 1566

  Fly  3123 -----KLPKKIGASQL---LLVGGLPQSPVKVSSDLYVR-LEPFKGCLRRVSINNNTQDLARPGK 3178
                 :||....|.::   :.:||:  :|.:...::.:. :..|.|||..:.:|.  ..:|...:
  Rat  1567 RVLEERLPPSDAAWKIKGPIYLGGV--APGRAVKNVQINSVYSFSGCLGNLQLNG--ASIASASQ 1627

  Fly  3179 HSNVGQCFP-TVERGSYFPGD-AYAIYKKNFNVGKYLDLETEFRTSELSGILLSVSDPNGFPALS 3241
            ..:|..||. .:|.|:||..: .|.:..::||:|...::..|.|....||.|:.....|| ..|:
  Rat  1628 TFSVTPCFEGPMETGTYFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVHGHSVNG-EYLN 1691

  Fly  3242 LELHNGNIIFSCDPGNGAPMRVESSLPTKYALCDNKWHNISALYDGEQIVLRIDQLPAVISVGNQ 3306
            :.:.:|.:|...   |.......:|:..|..|||.:||.|:.:.|...:.|.:|.  .|..|...
  Rat  1692 VHMKSGQVIVKV---NNGVRDFSTSVTPKQNLCDGRWHRITVIRDSNVVQLDVDS--EVNHVVGP 1751

  Fly  3307 GNAGKVQTRSPLYIGGLPESAPSGSLISRENFKGCIRHVSI 3347
            .|...|..|.|:::||:|||..:..|...:.|.|||||..|
  Rat  1752 LNPKPVDHREPVFVGGVPESLLTPRLTPSKPFTGCIRHFVI 1792

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 153..398 CDD:459653
EGF_Lam 401..450 CDD:238012
EGF_Lam 505..552 CDD:238012
Laminin_EGF 550..597 CDD:395007
Laminin_B 660..813 CDD:459652
EGF_Lam 851..900 CDD:238012
Laminin_EGF <943..971 CDD:395007
Laminin_EGF 974..1018 CDD:395007
EGF_Lam 1017..1065 CDD:238012
Laminin_EGF 1065..>1105 CDD:395007
EGF_Lam 1150..1197 CDD:238012
Laminin_EGF 1199..1247 CDD:395007
EGF_Lam 1247..1292 CDD:238012
Laminin_EGF 1294..1342 CDD:395007
Laminin_EGF 1340..1392 CDD:395007
Laminin_B 1486..1626 CDD:459652
EGF_Lam 1669..1716 CDD:238012 20/48 (42%)
Laminin_EGF 1718..1767 CDD:395007 23/49 (47%)
EGF_Lam 1772..1819 CDD:238012 15/74 (20%)
YhaN <1907..2141 CDD:443752 47/255 (18%)
SMC_prok_B <2123..>2390 CDD:274008 61/290 (21%)
Laminin_II 2279..2400 CDD:368703 25/122 (20%)
LamG 2399..>2492 CDD:473984 16/111 (14%)
LamG 2586..2753 CDD:238058 45/184 (24%)
Laminin_G_2 2804..2944 CDD:460494 41/144 (28%)
LamG 3018..3167 CDD:238058 31/164 (19%)
LamG 3192..3347 CDD:238058 47/155 (30%)
Lama4NP_001296376.1 EGF_Lam 81..130 CDD:238012 20/48 (42%)
EGF_Lam 131..185 CDD:238012 24/54 (44%)
EGF_Lam 187..238 CDD:238012 13/50 (26%)
Laminin_I 291..547 CDD:310534 57/287 (20%)
mukB <434..>742 CDD:235316 67/337 (20%)
Laminin_II 727..854 CDD:368703 27/144 (19%)
LamG 853..1008 CDD:214598 32/184 (17%)
LamG 1044..1202 CDD:238058 45/185 (24%)
LamG 1232..1372 CDD:238058 46/169 (27%)
LamG 1483..1618 CDD:238058 31/155 (20%)
LamG 1642..1793 CDD:238058 48/157 (31%)
Blue background indicates that the domain is not in the aligned region.

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