DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wb and Ntn4

DIOPT Version :9

Sequence 1:	NP_723870.1	Gene:	wb / 43946	FlyBaseID:	FBgn0261563	Length:	3375	Species:	Drosophila melanogaster
Sequence 2:	NP_001100250.1	Gene:	Ntn4 / 299737	RGDID:	1565947	Length:	630	Species:	Rattus norvegicus

Alignment Length:	619	Identity:	162/619 - (26%)
Similarity:	245/619 - (39%)	Gaps:	145/619 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 PPLFNVVPRAQISVNATCGQNGAEEY----------CKQVGAKPCGICNAHSSDRAKQRSIQSLI 209
            |.:.|:....::..:.|||||..|.:          |:|   ..|..||...|..|...|..
  Rat    36 PRMGNLALGRKLQADTTCGQNATELFCFYSENADLTCRQ---PKCDKCNGAHSHLAHPPSAM--- 94

  Fly   210 SSGSGSGSGSGFEEGWWQSPTLQGGRQFEYVTILLDLKQTFQIFSVWLKSANSPRPASWILEKSL 274
                 :.|...|...||||     ........|.|||:..| .|:..:....|||||:.:|::|.
  Rat    95 -----ADSSFRFPRTWWQS-----AEDVHREKIQLDLEAEF-YFTHLIMVFKSPRPAAMVLDRSQ 148

  Fly   275 D-GINFEPWQYFGLSDADCQRRWNLSGQNGKYVFQNDTEIICSTQFSKPGPLENG-VLHASLLKN 337
            | |..::|::||.   .:|...:.|.....|      ...||::::|.|.|...| |:..:|...
  Rat   149 DFGKTWKPYKYFA---TNCSATFGLEDDVVK------KGAICTSRYSNPFPCTGGEVIFRALSPP 204

  Fly   338 RPGATDQSPELMKFITTRYIRIRLQGMHSTANQDNSLDWLLDSPSLEKHSF--YSLSQLKVSARL 400
            .......|.::.:.:....:|:||....|...|.|.|       :.:.|.|  |::....|....
  Rat   205 YDIENPYSAKVQEQLKITNLRVRLLKRQSCPCQRNDL-------NAKPHHFTHYAIYDFIVKGSC 262

  Fly   401 DCNGHAN--------RSHESPDDPLM---QCICQHNTCGAQCEQCCPLFQDRPYQMG-------G 447
            .|||||:        |..::|....:   :|:|:|||.|:.|:.|.||:.|||::..       .
  Rat   263 FCNGHADQCLPVEGFRPVKAPGAFHVVHGKCMCKHNTAGSHCQHCAPLYNDRPWEAADGRTGAPN 327

  Fly   448 ECEICQCYGHAESCTYDPFL-------DKGICQSCSNNTAGIECEFCEMGFYRELDAPLT--DPC 503
            ||..|:|.|||::|.:|..:       ..|:|.:|.:||.|..|:.|:.||||:|..|.:  |.|
  Rat   328 ECRTCKCNGHADTCHFDINVWEASGNRSGGVCNNCQHNTEGQHCQRCKPGFYRDLRRPFSAPDAC 392

  Fly   504 LPCSCNPA-------RSTGGCQSDGGSCNCLEGFQGKNCEECAPGY--YGD-DCKRCECDERGSL 558
            ..|||:|.       .|...|....|.|.|..|..|.:|:.|..||  :|| .|:.|:|  .||.
  Rat   393 KACSCHPVGSAILPFSSVTFCDPSNGDCPCKPGVAGPHCDRCMVGYWGFGDYGCRPCDC--AGSC 455

  Fly   559 GS-TGSC----------------------------------------SGVCQCKLNVEGSTCSEC 582
            .. ||.|                                        ||.|:||..|.|:..:.|
  Rat   456 DPLTGDCISSNADVDWYHEVPAFHSLHNKSEPGWEWEDEQGFSALRHSGKCECKEQVLGNPKAFC 520

  Fly   583 APGY-----FDLSAENAEGCTSCWCSGVSQTCHSAKLQTL-AFETLNDWKITDIQRVKPISIP-- 639
            ...|     ..:.:.:.:|..:.....:.:...:.||:.| ...||.....|:.....||..|
  Rat   521 GMKYSYVLKIKILSAHDKGSHAEVNVKIKKVLQATKLKILRGKRTLYPESWTNRGCTCPILNPGL 585

  Fly   640 -------VDAETNRLIFANELDEVEAIYWQASLG 666
                   .|..|.||| .|....|:.  |:.:||
  Rat   586 EYLVAGYEDVRTGRLI-VNMKSFVQP--WKPALG 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wb	NP_723870.1	Laminin_N	164..396	CDD:278484	60/245 (24%)
		EGF_Lam	401..450	CDD:238012	21/66 (32%)
		TNFRSF	<407..507	CDD:304602	40/126 (32%)
		EGF_Lam	505..552	CDD:238012	19/56 (34%)
		Laminin_EGF	550..597	CDD:278482	16/92 (17%)
		Laminin_B	660..798	CDD:278481	3/7 (43%)
		EGF_Lam	851..900	CDD:238012
		Laminin_EGF	<943..971	CDD:278482
		VSP	953..1414	CDD:146106
		Laminin_EGF	974..1018	CDD:278482
		EGF_Lam	1017..1065	CDD:238012
		Laminin_EGF	1065..>1105	CDD:278482
		EGF_Lam	1150..1197	CDD:238012
		Laminin_EGF	1199..1247	CDD:278482
		EGF_Lam	1247..1292	CDD:238012
		Laminin_EGF	1294..1342	CDD:278482
		Laminin_EGF	1340..1392	CDD:278482
		Laminin_B	1486..1611	CDD:278481
		EGF_Lam	1669..1716	CDD:238012
		Laminin_EGF	1718..1767	CDD:278482
		EGF_Lam	1772..1819	CDD:238012
		CrfC	<1933..2267	CDD:223771
		Laminin_II	2277..2400	CDD:283628
		LamG	2399..>2492	CDD:304605
		Laminin_G_2	2616..2755	CDD:280389
		Laminin_G_2	2804..2944	CDD:280389
		Laminin_G_2	3038..3169	CDD:280389
		LamG	3192..3347	CDD:238058
Ntn4	NP_001100250.1	Laminin_N	43..260	CDD:278484	61/249 (24%)
		EGF_Lam	261..320	CDD:238012	20/58 (34%)
		Laminin_EGF	332..392	CDD:278482	22/59 (37%)
		Laminin_EGF	395..449	CDD:278482	18/53 (34%)
		NTR_netrin-4_like	517..626	CDD:239633	22/103 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000