DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wb and Lamb1

DIOPT Version :10

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:XP_003750185.1 Gene:Lamb1 / 298941 RGDID:1306311 Length:1834 Species:Rattus norvegicus


Alignment Length:2345 Identity:525/2345 - (22%)
Similarity:807/2345 - (34%) Gaps:856/2345 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   100 SMLAIASSESVTKK------KPPQRRRNGKLQKSGGGAGGGAL-------------RLLKTEDVY 145
            |.|.::..|...|:      :||.|..:.:||    |...|.|             |:...|..:
  Rat    14 SPLYLSRKEDTKKRRAACLPRPPSRAASPRLQ----GLDMGVLQVFAFGVLALWGTRVCAQEPEF 74

  Fly   146 S-SSFSGGLYPPLFN-VVPRAQ-ISVNATCGQNGAEEYC---KQVGAKPCGICNA----HSSDRA 200
            | ....|..||...: ::.||| :||.:|||.:..|.||   .....|.|.||::    |.:...
  Rat    75 SYGCAEGSCYPATGDLLIGRAQKLSVTSTCGLHKPEPYCIVSHLQEDKKCFICDSRDPYHETLNP 139

  Fly   201 KQRSIQSLISSGSGSGSGSGFEEG----WWQSPTLQGGRQFEYVTILLDLKQTFQIFSVWLKSAN 261
            ....|::::::         |...    ||||   :.|  .|.||:.|||:..|. |:..:.:..
  Rat   140 DSHLIENVVTT---------FAPNRLKIWWQS---ENG--VENVTVQLDLEAEFH-FTHLIMTFK 189

  Fly   262 SPRPASWILEKSLD-GINFEPWQYFGLSDADCQRRW-NLSGQNGKYVFQNDTEIICSTQFSKPGP 324
            :.|||:.::|:|.| |..:..::||..   ||:..: .:|....|.|    .:|||.:::|...|
  Rat   190 TFRPAAMLIERSSDFGKTWGVYRYFAY---DCESSFPGISTGPMKKV----DDIICDSRYSDIEP 247

  Fly   325 LENG-VLHASLLKNRPGATDQSPELMKFITTRYIRIRLQGMHSTANQDNSLDWLLDSPSLEKHSF 388
            ...| |:..:|..........||.:...:....:||:...:|:..  ||.||..::   :.:..:
  Rat   248 STEGEVIFRALDPAFKIEDPYSPRIQNLLKITNLRIKFVKLHTLG--DNLLDSRME---IREKYY 307

  Fly   389 YSLSQLKVSARLDCNGHANRSHESPDDPLMQ---------CICQHNTCGAQCEQCCPLFQDRPY- 443
            |::..:.|.....|.|||  |..:|.|...:         |:|:|||.|..||.|...:.|.|: 
  Rat   308 YAVYDMVVRGNCFCYGHA--SECAPVDGFNEEVEGMVHGHCMCRHNTKGLNCELCMDFYHDLPWR 370

  Fly   444 ----QMGGECEICQCYGHAESCTYD--PFL-----DKGICQSCSNNTAGIECEFCEMGFYRELDA 497
                :....|:.|.|..|:.||.:|  .||     ..|:|.:|.:||.|..||.|:..:::..:.
  Rat   371 PAEGRNSNACKKCNCNEHSSSCHFDMAVFLATGNVSGGVCDNCQHNTMGRNCEQCKPFYFQHPER 435

  Fly   498 PLTDP--CLPCSCNPARSTGGCQSDG----------GSCNCLEGFQGKNCEECAPGYY---GDD- 546
            .:.||  |.||:|:||.|..|...||          |.|.|....:|:.|:.|..|:|   .:| 
  Rat   436 DIRDPNLCEPCTCDPAGSENGGICDGYTDFSVGLIAGQCRCKLHVEGERCDVCKEGFYDLSAEDP 500

  Fly   547 --CKRCECDERGSLGSTGSC---SGVCQCKLNVEGSTCSECAPGYFDLSAENAEGCTSCWC---S 603
              ||.|.|:..|::.....|   :|.|.||..|.|..|.:|.|.::.|| .:.:||..|.|   .
  Rat   501 FGCKSCACNPLGTIPGGNPCDSETGYCYCKRLVTGQRCDQCLPQHWGLS-NDLDGCRPCDCDLGG 564

  Fly   604 GVSQTCHSAKLQTLAFETLNDWKITDIQRVKPISIPVDAETNRLIFANELDEVEAIYW------- 661
            .::.:|.....|......:                          ...:.:|||:.|:       
  Rat   565 ALNNSCSEDSGQCSCLPHM--------------------------IGRQCNEVESGYYFTTLDHY 603

  Fly   662 -----QASLG---------YLGNRLTSY----------GSRLQLVLS------------------ 684
                 :|:||         |:.:|:.|:          |:.|:..:.                  
  Rat   604 IYEAEEANLGPGVVVVERRYIQDRIPSWTGPGFVRVPEGAYLEFFIDNIPHSMEYEILIRYEPQL 668

  Fly   685 ---WD--VIRGDRSGK-PTTGPNVILVGKNGLKIAFGDESLDGL-----------------GINL 726
               |:  ||...|.|: ||:       .:.|..:...|..:..|                 |:|.
  Rat   669 PDHWEKAVITVQRPGRIPTS-------SRCGNTVPDDDNQVVSLSPGSRYVVLPRPVCFEKGMNY 726

  Fly   727 NVTLTEVGWY-------HVPPTVVD-------IKTRLRRTEGGDYHGESVTRSQFLSVLVSLDAV 777
            .|.| |:..|       ..|.|::|       .|:....|.||...|| ||.|            
  Rat   727 TVRL-ELPQYTASGSDVESPYTLIDSLVLMPYCKSLDIFTVGGSGDGE-VTNS------------ 777

  Fly   778 LIRAAFHTDQGETSLE--RAVIYSGGVELGGKSSSQVEQCLCPAGYTGLSCEGCAFGFKRIYENT 840
                |:.|.|....||  |:|:.:...::                     |....|....:.   
  Rat   778 ----AWETFQRYRCLENSRSVVKTPMTDV---------------------CRNIIFSISALI--- 814

  Fly   841 SDHQILSKCIPCPCNGHSNSCDLQSGNCGDCMHNTFGDRCERCQLGYYGNPLQGTPNDCKRCACP 905
              ||....|...|....|:.||...|.| .|..|..|..|.||..|.:|    ..||.||.|.|.
  Rat   815 --HQAGLACECDPQGSLSSVCDPNGGQC-QCRPNVVGRTCNRCAPGTFG----FGPNGCKPCDCH 872

  Fly   906 LSEDSNNFSPSCQLKSYNYMDLNPQFELIEHAEYICTQCP--EGYTGDHCQVCDDGYFGNPRQPG 968
            |....:.|                       .:.:..||.  :|.....|..|..|::|.|    
  Rat   873 LQGSVSAF-----------------------CDAVTGQCHCFQGIYARQCDRCLPGFWGFP---- 910

  Fly   969 SSCQRCDCAG--GPCNVTTGECITCRGNTEGWHCERCKLGYWGDPAVG----CDPCHCHTEGSES 1027
             |||.|.|.|  ..|:..||||::|:..|.|.:||||..||:|||.:|    |.||.| .:|.:|
  Rat   911 -SCQPCQCNGHAEDCDTVTGECLSCQDYTTGHNCERCLAGYYGDPIIGSGDHCRPCPC-PDGPDS 973

  Fly  1028 G-----LC--DSTDGQ--CLCKPRYAGQKCDECDVGY----ANVELRCPSCNC-------DPLGS 1072
            |     .|  |....|  |:|.|.|.|.:||.|..||    ::....|..|.|       ||   
  Rat   974 GRQFARSCYQDPVTLQLACVCDPGYIGSRCDGCASGYFGNPSDFGGSCQPCQCHHNIDTTDP--- 1035

  Fly  1073 LVQDRCDPHTGQC-HCKEGVMGAKCHECQDGYFGMNAVAYRMDDLAALRQNSDSDDDEWELVPDT 1136
               :.||..||:| .|.....|..|..||.||:|           .||||:              
  Rat  1036 ---EACDKETGRCLKCLYHTEGDHCQFCQHGYYG-----------DALRQD-------------- 1072

  Fly  1137 EDPNSESTVACEECHCSSVGSL-----SSD--CDKRTGQCACLANVTGRRCDKCRPGHWNLTAGE 1194
                      |.:|.|:.:|::     .||  |||.||||:||.||.|:.||:|.|..|.|.:|.
  Rat  1073 ----------CRKCVCNYLGTVREHCNGSDCHCDKTTGQCSCLPNVIGQNCDRCAPHTWQLASGT 1127

  Fly  1195 GCRDCRCDPHGSRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRCSACRSEGQVCDP 1259
            ||..|.|:...|.|..||.:||||.|..|.||:.|:||.|.|:|                   ||
  Rat  1128 GCEPCNCNAVHSFGPSCNEFTGQCQCMPGFGGRTCSECQELFWG-------------------DP 1173

  Fly  1260 HNGRCICPKFTRGLGCGQCVPGTWGWQARLGCRECECDHIGSIGQQCSTGDGQCQCREGYSGRKC 1324
            .                            :.||.|:||..|....||....|||.|.||..|.:|
  Rat  1174 D----------------------------VECRACDCDPRGIETPQCDQSTGQCVCVEGVEGPRC 1210

  Fly  1325 DTCAIGYFG-YPECRRCGCDAEGSFTQADGSIACDSNGQCPCKSLVVGLKCDTCMQSTFGLSAQN 1388
            |.|..||.| :|:|                                                  .
  Rat  1211 DKCTRGYSGVFPDC--------------------------------------------------T 1225

  Fly  1389 PEGCTRCFCFGRSGECEQSDLSWGHIRMAESRNLSVQQIRPHSVPSSDYEYIVVVQMEGSSFHRE 1453
            |  |.:||..            |..| :.|..|      |.|.                   ..|
  Rat  1226 P--CHQCFAL------------WDVI-IGELTN------RTHK-------------------FLE 1250

  Fly  1454 DAEIQRMNDLSLVPKSTGNVSIGAYGQFYHPLYFQLPPQFYGDRTSSYGGFLYFTLITEGAHKPL 1518
            .|:..:::.:           ||.|.:                             ..:...|.:
  Rat  1251 KAKALKISGV-----------IGPYRE-----------------------------TVDSVEKKV 1275

  Fly  1519 E--RNILGQYPLVQLHAHSKLLLDFYEYEEFE-YSLNVTHR-----VPLHESFWKYHHTSQAVDR 1575
            .  |:||.|.|..:...:..:|     :||.| .:.:||.:     |.|.::..:.:.|:..:|.
  Rat  1276 NEIRDILAQSPAAEPLKNIGIL-----FEEAEKLTKDVTEKMAQVEVKLSDTASRSNSTAGELDA 1335

  Fly  1576 ------------NTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMDAAIYIKGSTNLIAKGVE-R 1627
                        |.|...|:.|::        :|                |:|:.:.|.|..: .
  Rat  1336 LQAEAGSLDKTVNELAEQLEFIKN--------SD----------------IQGALDSITKYFQIS 1376

  Fly  1628 CKCPKRFDGLSCQDPGRSFYRWRNTTIVESVFIED----------------------LIGRAAPC 1670
            .:..||.:. |..||        |:|:.:|....|                      |:...|  
  Rat  1377 LEAEKRVNA-STTDP--------NSTVEQSALTRDRVEDLMLERESQFKEKQEEQARLLDELA-- 1430

  Fly  1671 HCNGRSSDCDRETGVCQNCRGNTGGDHCHQCAEGFYGDPNSPHGCQACPCPETNRNFARGCNVWD 1735
               |:....|........|..:.|.|    |:|...|.||                    |...:
  Rat  1431 ---GKLQSLDLSAAAEMTCGTHPGAD----CSESECGGPN--------------------CRTDE 1468

  Fly  1736 GEVSCVCKPGYTGRLCERCQAGYFGDPMRYPNTTCQPCNCHPDGIQTEGCDVETGRCYCREGVTG 1800
            ||..|                   |.|                     ||.          |:..
  Rat  1469 GEKKC-------------------GGP---------------------GCG----------GLVT 1483

  Fly  1801 LKCDKCQAERHHLVDNGCKICDNCTLLLLDYMELVGN-----KLRRGMHNMDLTGIPAPYRKLSE 1860
            :.         |.........|...|..|..:|.:..     |:|......:...:      |.:
  Rat  1484 VA---------HSAWQKAMDFDRDVLNALAEVEQLSKMVSEAKVRADEAKQNAQDV------LLK 1533

  Fly  1861 YESAYEKWNGRHWDFSQTKRRLQDY---DSADILKLEAHA---------------ENLKFQSRKA 1907
            ..:..||.:..:.|.....::::|:   ||||:..:||.|               :||....|:.
  Rat  1534 TNATREKVDRSNEDLRNLIKQIRDFLTEDSADLDSIEAVANEVLKMEMPSTPQQLQNLTEDIRER 1598

  Fly  1908 VATIGKREFAIKSMREDAVTQQHSVGLLRSEILQTLSDLHGYGKSAHYLSLPT-----ALKQAR- 1966
            |.|:.:.|         .:.||.:..:.|:|:|  |.:.....|||..:.:..     ||::|. 
  Rat  1599 VETLSQVE---------VILQQSAADIARAELL--LEEAKRASKSATDVKVTADMVKEALEEAEK 1652

  Fly  1967 ---FYLQAIREHDQMVQGIRSTNDCAWKHFYAMGNASDASFDESGRLEMLWRDLNQTNHRVVDMR 2028
               ...:||::.|:.:||.        ::......:..|:.:|:         |...:.|:..:.
  Rat  1653 AQVAAEKAIKQADEDIQGT--------QNLLTSIESETAASEET---------LTNASQRISKLE 1700

  Fly  2029 LQVDRVQE--VENEAE-DVLEHVRNLSIRVGESHQELDELNQRISDHLDPGYLEQGEGLLRLTVQ 2090
            ..|:.::.  .:|..| |.:|.|      |....|..||:.:.:...||..|.:           
  Rat  1701 RNVEELKRKAAQNSGEADYIEKV------VYSVKQSADEVKKTLDGELDEKYKK----------- 1748

  Fly  2091 RQIMLNGHLNQLDGYRILLNTTLGVKTEQQREVRKHWLPKAE---KHASHLLARSN-------EY 2145
                              :.:.:..|||:..:.|:    |||   ..|..|||::|       :.
  Rat  1749 ------------------VESLIAQKTEESADARR----KAELLQNEAKTLLAQANSKLQLLEDL 1791

  Fly  2146 ARKFQ 2150
            .||::
  Rat  1792 ERKYE 1796

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 153..398 CDD:459653 66/260 (25%)
EGF_Lam 401..450 CDD:238012 18/62 (29%)
EGF_Lam 505..552 CDD:238012 21/62 (34%)
Laminin_EGF 550..597 CDD:395007 15/49 (31%)
Laminin_B 660..813 CDD:459652 44/240 (18%)
EGF_Lam 851..900 CDD:238012 16/48 (33%)
Laminin_EGF <943..971 CDD:395007 8/29 (28%)
Laminin_EGF 974..1018 CDD:395007 22/49 (45%)
EGF_Lam 1017..1065 CDD:238012 20/60 (33%)
Laminin_EGF 1065..>1105 CDD:395007 16/47 (34%)
EGF_Lam 1150..1197 CDD:238012 25/53 (47%)
Laminin_EGF 1199..1247 CDD:395007 20/47 (43%)
EGF_Lam 1247..1292 CDD:238012 2/44 (5%)
Laminin_EGF 1294..1342 CDD:395007 21/48 (44%)
Laminin_EGF 1340..1392 CDD:395007 1/51 (2%)
Laminin_B 1486..1626 CDD:459652 25/159 (16%)
EGF_Lam 1669..1716 CDD:238012 10/46 (22%)
Laminin_EGF 1718..1767 CDD:395007 6/48 (13%)
EGF_Lam 1772..1819 CDD:238012 4/46 (9%)
YhaN <1907..2141 CDD:443752 47/248 (19%)
SMC_prok_B <2123..>2390 CDD:274008 11/38 (29%)
Laminin_II 2279..2400 CDD:368703
LamG 2399..>2492 CDD:473984
LamG 2586..2753 CDD:238058
Laminin_G_2 2804..2944 CDD:460494
LamG 3018..3167 CDD:238058
LamG 3192..3347 CDD:238058
Lamb1XP_003750185.1 Laminin_N 83..317 CDD:459653 66/260 (25%)
EGF_Lam 319..371 CDD:238012 18/53 (34%)
EGF_Lam 383..435 CDD:238012 17/51 (33%)
Laminin_EGF 446..503 CDD:395007 17/56 (30%)
EGF_Lam 505..556 CDD:238012 16/51 (31%)
EGF_Lam 557..>596 CDD:238012 7/64 (11%)
EGF_Lam 821..866 CDD:214543 17/49 (35%)
Laminin_EGF 869..917 CDD:395007 16/75 (21%)
EGF_Lam 914..959 CDD:238012 21/44 (48%)
Laminin_EGF 965..1021 CDD:395007 18/56 (32%)
Laminin_EGF 1024..1068 CDD:395007 17/60 (28%)
Laminin_EGF 1076..1129 CDD:395007 24/52 (46%)
Laminin_EGF 1132..1180 CDD:395007 24/94 (26%)
Laminin_EGF 1180..>1219 CDD:395007 18/38 (47%)
YhaN 1250..>1723 CDD:443752 111/672 (17%)
SMC_prok_B 1504..>1824 CDD:274008 69/366 (19%)
cc_LAMB1_C 1762..1834 CDD:411971 11/39 (28%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.