DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wb and lamc1

DIOPT Version :10

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:NP_775384.1 Gene:lamc1 / 286832 ZFINID:ZDB-GENE-021226-3 Length:1593 Species:Danio rerio


Alignment Length:1236 Identity:361/1236 - (29%)
Similarity:523/1236 - (42%) Gaps:306/1236 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 PPLFNVVPRAQISVNATCGQNGAEEYCKQVG----AKPCGICNAHSSDRAKQRSIQSLISSGSGS 215
            |...|....|.:....||| :..||:|.|.|    .|.|.|||| :..|....::..       :
Zfish    36 PEFVNAAFNATVVATNTCG-SPPEEFCVQTGVTGVTKSCHICNA-ADPRLHHGAVYL-------T 91

  Fly   216 GSGSGFEEGWWQSPTLQGGRQF-EYVTILLDLKQTFQIFSVWLKSANSPRPASWILEK--SLDGI 277
            ......:..||||.|:..|.|: ..:.:.|.|.::|.|..|.||...| ||.|:.:.|  |.|| 
Zfish    92 DYNQPVQPTWWQSQTMLAGIQYPNSINLTLHLGKSFDITYVRLKFHTS-RPESFAIYKRSSEDG- 154

  Fly   278 NFEPWQYFGLSDADCQRRWNLSGQNGKYVFQNDTEIICSTQFSKPGPLENGVLHASLLKNRPGA- 341
            .:.|:||:   ...|::.::.:.:......:::.:.:|:.:||...||..|.:..|.|:.||.| 
Zfish   155 PWTPYQYY---SGSCEKTYSKNNRGFIRTGEDEQQALCTDEFSDISPLYGGNVAFSTLEGRPSAY 216

  Fly   342 -TDQSPELMKFITTRYIRIRLQGMHSTANQDNSL-DWLLDSPSLEKHSFYSLSQLKVSARLDCNG 404
             .|.||.|..::|...||:       |.|:.|:. |.:.:.|.:.|..:|::|...|..|..|||
Zfish   217 NFDNSPVLQDWVTATDIRV-------TLNRLNTFGDEVFNDPKVLKSYYYAISDFAVGGRCKCNG 274

  Fly   405 HANRSHESPDDPLMQCICQHNTCGAQCEQCCPLFQDRPYQMG-----GECEICQCYGHAESCTYD 464
            ||:...::....|: |.|:|||.||.|..|.|.:.|||::..     .||..|.|.|.:..|.:|
Zfish   275 HASECVKNEYSKLV-CNCKHNTEGADCNVCKPFYNDRPWRRATAENPNECLPCNCNGKSAECYFD 338

  Fly   465 PFLDK-----GICQSCSNNTAGIECEFCEMGFYRELDAPLTDPCLPCSCNPARSTGGCQSDGGSC 524
            |.|.:     |.|::|::||.|.:||.|...:|||...   ..||.|.|||..|......:.|.|
Zfish   339 PELYRATGHGGHCRNCADNTDGPKCERCLANYYREASG---QRCLSCGCNPVGSLSTQCDNTGRC 400

  Fly   525 NCLEGFQGKNCEECAPGYYG---DDCKRCECDERGSLGSTGSCSGVCQCKLNVEGSTCSECAPGY 586
            :|..|..|..|:.|.|||:.   ..|:.|.|:..||.......:|.||||.||:|..|..|..||
Zfish   401 SCKPGVMGDKCDRCQPGYHSLSEAGCRPCSCNPAGSTQECDVQTGRCQCKENVDGFNCDRCKLGY 465

  Fly   587 FDLSAENAEGCTSCWCSGVSQTCHSA------KLQTLAFETLND-WKITDIQRVKPISIPVDAET 644
            |:|..:|.:|||.|:|...|..|.||      |: |..|:..:: ||  ..|| ...|:||....
Zfish   466 FNLDPQNPQGCTPCFCFQHSTVCESADGYSVHKI-TSTFDRDDEGWK--GKQR-DDSSVPVQWSP 526

  Fly   645 NRLIFANELDEVEAIYWQASLGYLGNRLTSYGSRLQLVLSWDVIRGDRSGKPTTGPNVILVGKNG 709
            :....:...::...||:.|...:|.|:|.|||.  .|.|::.:.|.|                  
Zfish   527 SSGEISLISEDYFPIYFVAPDKFLHNQLLSYGQ--NLTLNFRIQRHD------------------ 571

  Fly   710 LKIAFGDESLDGLGINLNVTLTEVGWYHVPPTVVDIKTRLRRTEGGDYHGE-SVTRSQFLSVLVS 773
            .:::..|..|:|.|:.:.|.|...|..:..........||..|.  ||... ::..:.|..:|.:
Zfish   572 ARLSAEDVVLEGSGLRVAVPLIAQGNSYPGEETQTFVFRLHDTT--DYPWRPTIKHADFQKLLYN 634

  Fly   774 LDAVLIRAAFHTDQGETSLERAVIYSGGVEL------GGKSSSQVEQCLCPAGYTGLSCEGCAFG 832
            |.:::||..:..        ::..|...|.|      .|..:..||:|.||.||.|..||.|..|
Zfish   635 LTSIMIRGTYSA--------QSAGYLDNVSLVTARRGPGTPARWVEKCTCPQGYLGQHCEQCDQG 691

  Fly   833 FKRIYENTSDHQILSKCIPCPCNGHSNSCDLQSGNCGDCMHNTFGDRCERCQLGYYGNPLQGTPN 897
            |:|   :..:.:..|.|..|.|||||::||.::|.| :|.|||.|..||||:.|:||:...|:.:
Zfish   692 FRR---SRPELRRFSTCERCNCNGHSDTCDPETGMC-NCQHNTAGLSCERCKDGFYGDSTVGSSS 752

  Fly   898 DCKRCACPLSEDSNNFSPSCQLKSYNYMDLNPQFELIEHAEYICTQCPEGYTGDHCQVCDDGYFG 962
            |||.|.||.       ..:|.:             :.:..|.:||.||.|.||..|::||||:||
Zfish   753 DCKACPCPA-------GATCAV-------------VPKTNEVVCTNCPTGTTGKRCELCDDGFFG 797

  Fly   963 NP---RQPGSSCQRCDC-------AGGPCNVTTGECITCRGNTEGWHCERCKLGYWGDPAVGCDP 1017
            :|   :.|..:|:.|.|       |.|.||..:|||:.|..||.|..|:|||.|::||...    
Zfish   798 DPLGEKGPVRACRACSCNNNIEPNAVGNCNRESGECLKCIYNTAGVFCDRCKQGFYGDARA---- 858

  Fly  1018 CHCHTEGSESGLCDSTDGQCLCKPRYAGQKCDECDVGYANVELRCPSCNCDPLGSLVQDRCDPHT 1082
                                                  |||..:|..|.|.|.|::  ||     
Zfish   859 --------------------------------------ANVADKCKPCKCSPYGTV--DR----- 878

  Fly  1083 GQCHCKEGVMGAKCHECQDGYFGMNAVAYRMDDLAALRQNSDSDDDEWELVPDTEDPNSESTVAC 1147
                                                                             
Zfish   879 ----------------------------------------------------------------- 878

  Fly  1148 EECHCSSVGSLSSDCDKRTGQCACLANVTGRRCDKCRPGHWNLTAGEGCRDCRCDPHGSRGHECN 1212
             :..||.|          ||||.||.:|..|.|..|..|.:||.:|:||..|.|:|.||...:|:
Zfish   879 -QTACSQV----------TGQCPCLPHVINRDCGACELGFYNLQSGKGCERCNCNPIGSTNGQCD 932

  Fly  1213 PWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRCSACRSEGQVCDPHNGRCICPKFTRGLGCGQ 1277
            ..:|||:|:.||.||||..|...|||||:.                                   
Zfish   933 IVSGQCECQPGVTGQHCERCEVNFFGFSSS----------------------------------- 962

  Fly  1278 CVPGTWGWQARLGCRECECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYF---GYPECRR 1339
                        ||:.|:||..||...||.. ||:|.||.|:.|.:||.|...||   ..|.|::
Zfish   963 ------------GCKPCDCDPEGSESAQCKE-DGRCHCRPGFVGSRCDMCEENYFYNRSTPGCQQ 1014

  Fly  1340 C 1340
            |
Zfish  1015 C 1015

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 153..398 CDD:459653 71/252 (28%)
EGF_Lam 401..450 CDD:238012 20/53 (38%)
EGF_Lam 505..552 CDD:238012 17/49 (35%)
Laminin_EGF 550..597 CDD:395007 19/46 (41%)
Laminin_B 660..813 CDD:459652 33/159 (21%)
EGF_Lam 851..900 CDD:238012 24/48 (50%)
Laminin_EGF <943..971 CDD:395007 14/30 (47%)
Laminin_EGF 974..1018 CDD:395007 20/50 (40%)
EGF_Lam 1017..1065 CDD:238012 4/47 (9%)
Laminin_EGF 1065..>1105 CDD:395007 6/39 (15%)
EGF_Lam 1150..1197 CDD:238012 18/46 (39%)
Laminin_EGF 1199..1247 CDD:395007 22/47 (47%)
EGF_Lam 1247..1292 CDD:238012 1/44 (2%)
Laminin_EGF 1294..1342 CDD:395007 22/50 (44%)
Laminin_EGF 1340..1392 CDD:395007 1/1 (100%)
Laminin_B 1486..1626 CDD:459652
EGF_Lam 1669..1716 CDD:238012
Laminin_EGF 1718..1767 CDD:395007
EGF_Lam 1772..1819 CDD:238012
YhaN <1907..2141 CDD:443752
SMC_prok_B <2123..>2390 CDD:274008
Laminin_II 2279..2400 CDD:368703
LamG 2399..>2492 CDD:473984
LamG 2586..2753 CDD:238058
Laminin_G_2 2804..2944 CDD:460494
LamG 3018..3167 CDD:238058
LamG 3192..3347 CDD:238058
lamc1NP_775384.1 LamNT 30..268 CDD:214532 71/252 (28%)
EGF_Lam 269..314 CDD:238012 20/45 (44%)
Laminin_EGF 326..379 CDD:395007 19/55 (35%)
Laminin_EGF 382..429 CDD:395007 16/46 (35%)
Laminin_EGF 429..476 CDD:395007 19/46 (41%)
Laminin_B 542..672 CDD:459652 33/159 (21%)
EGF_Lam 707..749 CDD:238012 22/42 (52%)
Laminin_EGF 812..856 CDD:395007 19/43 (44%)
EGF_Lam 867..917 CDD:238012 24/132 (18%)
EGF_Lam 919..964 CDD:214543 22/91 (24%)
Laminin_EGF 967..1013 CDD:395007 20/46 (43%)
Domain II and I. /evidence=ECO:0000250 1014..1593 1/2 (50%)
235kDa-fam <1028..>1577 CDD:130673
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.