DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wb and lamb4

DIOPT Version :10

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:NP_775383.2 Gene:lamb4 / 286831 ZFINID:ZDB-GENE-021226-2 Length:1827 Species:Danio rerio


Alignment Length:2305 Identity:504/2305 - (21%)
Similarity:791/2305 - (34%) Gaps:714/2305 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   154 YPPLFNVV--PRAQISVNATCGQNGAEEYC---KQVGAKPCGICNAHS--SDRAKQRS--IQSLI 209
            ||.|.:::  ..||::.::|||....:.||   .....:.|..|::.|  :|.....|  |:::|
Zfish    31 YPNLGDLMVGRAAQLAASSTCGLYRPQNYCILGYLENERKCFTCDSRSPYNDHHNPSSHRIENII 95

  Fly   210 SSGSGSGSGSGFEE----GWWQSPTLQGGRQFEYVTILLDLKQTFQIFSVWLKSANSPRPASWIL 270
            ::         |:.    .||||   :.|  ...|:|.|||:..|| ||..:.:..|.||||.::
Zfish    96 TT---------FQPERKMKWWQS---ENG--VHEVSIQLDLEAMFQ-FSHLILTFKSFRPASMLV 145

  Fly   271 EKSLD-GINFEPWQYFGLSDADCQRRWNLSGQNGKYVFQNDTEIICSTQFSKPGPLENGVLHASL 334
            |:|.| |..::.::||.   .||...:....:...:...   :::|.:::|...|...|.:   :
Zfish   146 ERSKDFGRTWKVFRYFA---EDCANSFPGISEGPAHSID---DLVCDSRYSGAEPSTEGEV---V 201

  Fly   335 LKNRPGATDQS--------PELMKFITTRYIRIRLQGMHSTANQDNSLDWLLDSPSLEKHSFYSL 391
            ||    |.|.|        ..:...||...:|:....:.:..  |..|.....:|. :|: :|:|
Zfish   202 LK----ALDPSFDIHDPYDSTIQGLITLTNLRVNFTRLLTLG--DTLLTRRKRNPQ-DKY-YYAL 258

  Fly   392 SQLKVSARLDCNGHANR-------SHESPDDPLM---QCICQHNTCGAQCEQCCPLFQDRPYQMG 446
            .::.|.....|||||::       ..::..:|.|   :|:|||||.|..||:|...:.|.|::.|
Zfish   259 YEMVVRGSCFCNGHASQCIPVDGARGDTFTEPGMVHGRCVCQHNTAGYNCERCQDFYHDAPWRPG 323

  Fly   447 GE-----CEICQCYGHAESCTYD-------PFLDKGICQSCSNNTAGIECEFCEMGFYRELDAPL 499
            |:     |:.|.|:||:|.|.::       ..:..|:|..|.||..|.:||.|...:|::....:
Zfish   324 GKADSDVCKRCNCHGHSEKCHFELARYLATGGVSGGVCDDCRNNRIGPQCELCGPFYYQDPQRSV 388

  Fly   500 TDP--CLPCSCNPARST--GGCQSDGGSCNCLEGFQGKNCEECAPGYYG---DD---CKRCECDE 554
            .||  |:||.|:...|.  |.|....|.|.|.:..:|:.|:.|..|:||   ||   |:.|.|:.
Zfish   389 DDPYACIPCDCDLDGSVDRGLCDPVNGQCVCKQNVEGERCDRCKVGFYGFSRDDPSGCQLCRCNF 453

  Fly   555 RGSLGSTGSC---SGVCQCKLNVEGSTCSECAPGYFDLSAENAEGCTSCWC--SGVSQT-CHSAK 613
            .|::.....|   :|.|.|:....||.|.:|.|||:.| .....||..|.|  .|..:| |.|..
Zfish   454 LGTIQVGNPCDPTTGRCICEHFAYGSQCDQCLPGYWGL-GNTVYGCIPCDCDIGGALKTECSSVD 517

  Fly   614 LQ-----TLAFETLN-----------DWKITDIQRVKPISIPVDAETNRLIFANELDEVEAIYWQ 662
            .|     .:..:..|           |:.|.:.:...|:::                 :......
Zfish   518 GQCKCRPNMVGQKCNDPAPGYFLAPLDFYIYEAENAAPLAV-----------------ISPFIGP 565

  Fly   663 ASLGYLGNRLTSYGSRLQLVLSWDVIRGDRSGKPTTGPNVILVGKNGLKIAFGDESLDGLGINLN 727
            ....|....:....::|.|.        ..:.||::.|                       ...:
Zfish   566 PPFVYPTEGIPERPTKLPLC--------PPAPKPSSVP-----------------------YREH 599

  Fly   728 VTLTEVGWYHVPPTVVDIKTRLRRTEGGDYHGESVTRSQFLSVLVSLDAVLIRAAFHTDQGETSL 792
            :|:......|.|...:.:.....|..|.|:   .::..:.  |:|..:.   |......||    
Zfish   600 ITVQPSPAPHNPQVTLPMCEHYFRQRGYDF---KISNGRL--VVVKREK---RQTRRRRQG---- 652

  Fly   793 ERAVIYSGG----VELGGKSSSQVEQCLCPAGYTGLSCEGCAFGFKRIYEN------------TS 841
            :|.:.:..|    :.|..:::.|      ...:|||       ||.|:.:.            |.
Zfish   653 QRTIPFEPGSPLQILLRQRANDQ------SITWTGL-------GFVRVQDGAGLRFTVSNIPATL 704

  Fly   842 DHQILSKCIPCPCNGHSNSCDLQSGNCGDCMHNTFGDRCERCQLGYYGNPLQGTPND--CKRCAC 904
            |:.::.:..|...:..:....:.|          ||...|||            |||  .|....
Zfish   705 DYYVVVRYEPESTDDWTAIVSILS----------FGSEDERC------------PNDQSNKMFTL 747

  Fly   905 PLS------------EDSNNF--------SPSCQLKSYNYMDLNPQFELIEHAEYICTQCPEGYT 949
            |.|            .|.|.:        .||....|.::: |.....||...|.:...|.:.|.
Zfish   748 PASGRTATLDLPVCLSDGNQYHVDITFRKQPSEDPHSSSFI-LIDSLGLIPKVESVPNFCSQSYL 811

  Fly   950 GD----HC-------------QVCD------DGYFGNPRQPGS---SCQRCDCAGGPCNVTTGEC 988
            ..    .|             :||:      ..:..|    |:   :|......|..|:...|:|
Zfish   812 SQFQQYRCIELAVQAGGQTLPEVCEMLIGSMSAFIHN----GAVSCNCHHVGAYGSSCSKFGGQC 872

  Fly   989 ITCRGNTEGWHCERCKLGYWGDPAVGCDPCHCHTEGSESGLCDSTDGQCLCKPRYAGQKCDECDV 1053
             .|:.|..|..|:.|....:|....||.||.|...||.:.|||.|.|||.|:....|.:|:.|..
Zfish   873 -QCKPNVIGRCCDSCAPLTYGLGPNGCSPCDCDRSGSTTELCDQTTGQCSCRDGITGLQCNRCYP 936

  Fly  1054 GYANVELRCPSCNCDPLGSLVQDRCDPHTGQC-HCKEGVMGAKCHECQDGYFGMNAVAYRMDDLA 1117
            ||....| |..|.|:.|.    |.|||.||.| .|:|...|..|..|::||.|            
Zfish   937 GYYGFPL-CRRCQCNRLA----DICDPITGDCLDCREHSAGRNCERCEEGYVG------------ 984

  Fly  1118 ALRQNSDSDDDEWELVPDTEDPNSESTVACEECHCSSVG------SLSSDCDKRTG--QCACLAN 1174
                                ||.|..  .||.|.|..:.      :.|.:.|.|:|  .|.||..
Zfish   985 --------------------DPVSGQ--PCEPCLCPDLNGSGRFFAFSCNKDPRSGAPYCECLPG 1027

  Fly  1175 VTGRRCDKCRPGHW---NLTAGEGCRDCRC----DPHGSRGHECNPWTGQC-DCKIGVGGQHCNE 1231
            .||.:||.|.||.:   .|..|. |::|.|    ||..  |..|:|.||:| .|.....|..|..
Zfish  1028 HTGPQCDSCSPGFYGDLRLPGGR-CKECCCNNNIDPRD--GDACDPVTGECLRCLHNTEGPRCQS 1089

  Fly  1232 CTEGFFGFS-TEGCQRCSACRSEGQ-----------VCDPHNGRCICPKFTRGLGCGQCVPGTWG 1284
            |..|::|.: .:.|:.|| |...|.           .||...|:|.|....:|..|.:|..|.|.
Zfish  1090 CKRGYYGNALAQDCKECS-CDRRGTDDSKCPAGSPCFCDQDTGQCPCRPGVQGALCNECDDGYWN 1153

  Fly  1285 WQARLGCRECECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFGYP--ECRRCGCDAEGS 1347
            .....||:.|.|:...::...|....|||.|:..|.||.||.|...:||.|  :|..|.|:.||:
Zfish  1154 MDGDYGCQPCNCNREHALNYICDKITGQCLCQPEYGGRICDECGPNHFGNPDLQCMFCDCNLEGT 1218

  Fly  1348 FTQADGSIACDS-NGQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGCTRCFCFGRSGECEQSDLSW 1411
            ...     |||: .|:|.||..|.|..||.|...    ...|...|..|.......|...|||| 
Zfish  1219 VHP-----ACDAYTGECLCKPGVTGPFCDECAPG----HNNNFPACEPCHACNYLWEKIISDLS- 1273

  Fly  1412 GHIRMAESRNLSVQQIRPHSVPSSDYEYIVVVQMEGSSFHREDAEIQRMNDLSLVPKSTGNVSIG 1476
                      |..::|........|:              |...|:|.:.:|.   :...||   
Zfish  1274 ----------LDAERIETMMPCPEDF--------------RSRPELQHLQNLL---EKLQNV--- 1308

  Fly  1477 AYGQFYHPLYFQLPPQFYGDRTSSYGGFLYFTLITEGAHKPLERNILGQYPLVQLHAHSKLLLDF 1541
                                             :..||...|::                     
Zfish  1309 ---------------------------------LNMGAQDELKK--------------------- 1319

  Fly  1542 YEYEEFEYSLNVTHRVPLHESFWKYHHTSQAVDRNTLM--------AALQNIRHIFIRAFAFADF 1598
                             |.|...:..:.::.:|.|.::        ..:.|||..|.:       
Zfish  1320 -----------------LEELLARIRNETEIIDPNIIIIDPTLLLNTDIDNIRLEFNK------- 1360

  Fly  1599 QEVVLQNVHMDAAIYIKGSTNLIAKGVERC--KCPKRFDGLS-----------CQDPGRSFYRWR 1650
               :|:|:...|.   ||....| |.|...  |..|.:|..:           .|:..|.     
Zfish  1361 ---LLKNLREKAK---KGPVTDI-KAVNDIFNKIKKFYDEFTDSEKKVEAAKKVQEASRK----- 1413

  Fly  1651 NTTIVESVFIEDLIGRAAPCHCNGRSSDCDRETGVCQNCRGNTGGDHCHQCAEGFYGDPNSPHGC 1715
               ..|.|.:|     .|.|.. |.....:|:.....  ..|...:.|     |..||..    |
Zfish  1414 ---TREKVTLE-----LAKCQI-GEMDKLERKVKALS--AANINEEVC-----GAPGDAE----C 1458

  Fly  1716 QACPCPETNRNFARGCNVWDGEVSCVCKPGYTGRLCERCQAGYFGDPMRYPNTTCQPCNCHPDGI 1780
            :...|                          .|.||.:|     |.|   ..|...|.:.:...:
Zfish  1459 EKAKC--------------------------GGALCGKC-----GGP---DCTGSLPISLNASKL 1489

  Fly  1781 --QTEGCDVETGRCYCREGVTGLKCDKCQAERHHLVDNGCKICDNCTLLLLDYMELVGNKLRR-- 1841
              .||            :.:|.|:....:|      |...:.....|..:.|..|.:.:|:.|  
Zfish  1490 AEMTE------------KNITALRSQLKEA------DAQLRNASEMTSYVKDQAENMMDKINRTK 1536

  Fly  1842 GMHNMDLTGIPAPYRKLSEYESAYEKWNGRHWDFSQTKRRLQD--YDSADILKLEAHAENLKFQS 1904
            ..:..:.|...|...|:..|                    |||  ....||.||           
Zfish  1537 TKYEQEKTDTKALIEKVKIY--------------------LQDELVKPEDIEKL----------- 1570

  Fly  1905 RKAVATI--GKREFAIKSMREDAVTQQHSVGLLRSEILQTLSDLHGYGKSAHYLSLPTALKQARF 1967
            ..||.:|  .|....||.|.||              |.:.|:::..:.....||.     |||:.
Zfish  1571 ANAVLSIQLPKSPDEIKDMIED--------------IKKILANITEFNDDLEYLE-----KQAKI 1616

  Fly  1968 YLQAIREHDQMVQGIRSTNDCAWKHFYAMGNASDASFDESGRLEMLWRDLNQTNHRVVDMRLQVD 2032
                                        .||..:.:.:...|.|::                   
Zfish  1617 ----------------------------AGNMKERAKEILNRTELI------------------- 1634

  Fly  2033 RVQEVENEAEDVLEHVRNLSIRVGESHQELDELNQRISDHLDPGYLEQGEGLLRLTVQRQIMLNG 2097
            .|:|:|....|..|....:...:.|:.|..|.:.::::: .:| .|:..|..|.||..:.:    
Zfish  1635 NVKEIEKALNDTAELHDKIFNDLDEAEQNNDVIREKVNE-TEP-KLKNIEDHLNLTRAKTL---- 1693

  Fly  2098 HLNQLDGYRILLNTTLGVKTEQQREVRKHWLPKAEKHASHLLARSNEYARKFQPTRNGARIAMLA 2162
                ||....|.|     |||..|...|    :|:..|...|..:|:..:..:..:.......| 
Zfish  1694 ----LDEIEALKN-----KTEMNRAQGK----EAKDTADAALNSANDTGKDLEELKEQFERLKL- 1744

  Fly  2163 SSAHSNITEAINDARLASILAKERVYEAQR-TLYPSDGSSMIERAKHSLHRSKQLQQEALKQMHK 2226
            :|.:.|::...|: ||.:|     ..||:. ..|..|....||..:..:..|.:.:.|.:|:   
Zfish  1745 NSTNQNVSSEANE-RLKNI-----TMEAENLAKYVEDKMKEIEDLEEKILLSNERKDEMMKE--- 1800

  Fly  2227 SNVLKDKLHRQEQQVEGIKSTIYDSGLRTN 2256
                   |...:::.:.:|..|.|...|.|
Zfish  1801 -------LEALQKEADDLKKFIVDKVQRYN 1823

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 153..398 CDD:459653 64/265 (24%)
EGF_Lam 401..450 CDD:238012 21/63 (33%)
EGF_Lam 505..552 CDD:238012 19/54 (35%)
Laminin_EGF 550..597 CDD:395007 15/49 (31%)
Laminin_B 660..813 CDD:459652 21/156 (13%)
EGF_Lam 851..900 CDD:238012 10/50 (20%)
Laminin_EGF <943..971 CDD:395007 7/53 (13%)
Laminin_EGF 974..1018 CDD:395007 12/43 (28%)
EGF_Lam 1017..1065 CDD:238012 20/47 (43%)
Laminin_EGF 1065..>1105 CDD:395007 17/40 (43%)
EGF_Lam 1150..1197 CDD:238012 18/57 (32%)
Laminin_EGF 1199..1247 CDD:395007 17/53 (32%)
EGF_Lam 1247..1292 CDD:238012 15/55 (27%)
Laminin_EGF 1294..1342 CDD:395007 18/49 (37%)
Laminin_EGF 1340..1392 CDD:395007 17/52 (33%)
Laminin_B 1486..1626 CDD:459652 18/147 (12%)
EGF_Lam 1669..1716 CDD:238012 8/46 (17%)
Laminin_EGF 1718..1767 CDD:395007 7/48 (15%)
EGF_Lam 1772..1819 CDD:238012 7/48 (15%)
YhaN <1907..2141 CDD:443752 46/235 (20%)
SMC_prok_B <2123..>2390 CDD:274008 27/135 (20%)
Laminin_II 2279..2400 CDD:368703
LamG 2399..>2492 CDD:473984
LamG 2586..2753 CDD:238058
Laminin_G_2 2804..2944 CDD:460494
LamG 3018..3167 CDD:238058
LamG 3192..3347 CDD:238058
lamb4NP_775383.2 Laminin_N 30..265 CDD:459653 64/265 (24%)
EGF_Lam 266..324 CDD:238012 19/57 (33%)
EGF_Lam 333..386 CDD:238012 16/52 (31%)
Laminin_EGF 397..446 CDD:395007 16/48 (33%)
EGF_Lam 449..498 CDD:238012 15/49 (31%)
EGF_Lam 500..>539 CDD:238012 8/38 (21%)
EGF_Lam 853..898 CDD:214543 11/45 (24%)
Laminin_EGF 901..949 CDD:395007 20/48 (42%)
EGF_Lam 946..993 CDD:238012 21/84 (25%)
EGF_Lam 994..1049 CDD:238012 17/54 (31%)
Laminin_EGF 1054..1098 CDD:395007 16/45 (36%)
Laminin_EGF 1106..1165 CDD:395007 17/59 (29%)
EGF_Lam 1162..1205 CDD:238012 15/42 (36%)
EGF_Lam 1211..1259 CDD:238012 18/56 (32%)
Domain II 1258..1449 47/322 (15%)
PRK03918 <1292..1822 CDD:235175 140/830 (17%)
Domain alpha 1450..1476 12/68 (18%)
Domain I 1477..1827 93/498 (19%)
cc_LAMB4_C 1756..1825 CDD:411972 19/84 (23%)
Blue background indicates that the domain is not in the aligned region.

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