DRSC/TRiP Functional Genomics Resources

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Protein Alignment wb and lamb1a

DIOPT Version :9

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:NP_775382.1 Gene:lamb1a / 286830 ZFINID:ZDB-GENE-021226-1 Length:1785 Species:Danio rerio


Alignment Length:2288 Identity:507/2288 - (22%)
Similarity:814/2288 - (35%) Gaps:712/2288 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   134 GALRLLKTEDVYSSSFSGGLYPPLFN-VVPRA-QISVNATCGQNGAEEYC---KQVGAKPCGICN 193
            ||..|....::......|..||...: ::.|| |:...:|||.:..|.:|   .....|.|.:|:
Zfish    12 GAWALADVPELGDVCTEGSCYPATGDLLIGRAQQLLATSTCGVHKPEPFCIVSHLQEEKKCFVCD 76

  Fly   194 A-----HSSDRAKQRSIQSLISSGSGSGSGSGFEEGWWQSPTLQGGRQFEYVTILLDLKQTFQIF 253
            :     .::.:....||::::::.:.:..     :.||||   :.|  .|.|||.|||:..|. |
Zfish    77 SRQAYNETAHQVTSHSIENVVTTFAPNRL-----KTWWQS---ENG--LENVTIQLDLEAEFH-F 130

  Fly   254 SVWLKSANSPRPASWILEKSLD-GINFEPWQYFGLSDADCQRRWNLSGQNGKYVFQNDTEIICST 317
            :..:.:..:.|||:.::|:|.| |..::.::||..   ||:..:. |..:|.....:|  :||.|
Zfish   131 THLIMTFKTFRPAAMVIERSADFGNTWQVYRYFAY---DCESSFP-SVSHGPMTKVDD--VICDT 189

  Fly   318 QFSKPGPLENG-----VLHASLLKNRPGATDQSPELMKFITTRYIRIRLQGMHSTANQDNSLDWL 377
            ::|...|...|     ||..:.....|    .||.:...:....:|::...:|:..  ||.||..
Zfish   190 RYSDIEPSTEGEVIFRVLDPAFRIEDP----YSPRIQNMLKITNLRVKFTKLHTLG--DNLLDSR 248

  Fly   378 LDSPSLEKHSFYSLSQLKVSARLDCNGHANRSHESPDDPLMQ---------CICQHNTCGAQCEQ 433
            ::   :::..:|::..:.|.....|.|||  |..:|.|...:         |:|.|||.|..||:
Zfish   249 IE---IKEKYYYAIYDMVVRGNCFCYGHA--SECAPVDGTGEAVEGMVHGHCMCNHNTIGLNCER 308

  Fly   434 CCPLFQDRPYQMG-----GECEICQCYGHAESCTYDPFLDK-------GICQSCSNNTAGIECEF 486
            |...:.|.|::..     ..|:.|.|..|:.||.:|..:.:       |:|..|.:||.|..||.
Zfish   309 CQDFYHDLPWRPAEGRNTNACKKCHCNHHSHSCHFDMAVYRASGNVSGGVCDDCQHNTMGHNCEQ 373

  Fly   487 CEMGFYRELDAPLTDP--CLPCSCNPARSTGGCQSD----------GGSCNCLEGFQGKNCEECA 539
            |:..|::..:..:.||  |.||:|:|..|..|...|          .|.|.|....:|:.|::|.
Zfish   374 CKPFFHQHPEKDIRDPNICEPCNCDPVGSLNGGVCDPMTDVSLGLISGQCRCKPNVEGERCDQCK 438

  Fly   540 PGYYG--DD---CKRCECDERGSLGSTGSC---SGVCQCKLNVEGSTCSECAPGYFDLSAENAEG 596
            .|:||  :|   |:.|.|:..|::.....|   ||.|.||..|.|..|.:|.|.::.|| .:.:|
Zfish   439 QGHYGLSEDPLGCQPCTCNALGTVPGGSPCDTDSGNCYCKRLVTGRNCDQCLPQHWGLS-NDMDG 502

  Fly   597 CTSCWC---SGVSQTCHSAKLQTLAFETLNDWKITDIQRVKPISIPVDAETNRLIFANELDEVEA 658
            |..|.|   ..::..|                        .|:|  ...:....:|....|:||:
Zfish   503 CRPCDCDHGGAINNNC------------------------SPVS--GQCQCREHMFGRRCDQVES 541

  Fly   659 IYWQASLGYLGNRLTSYGSRLQLVLSWDVIRGDRSGKPTTGPNVILVGKN----------GLKI- 712
            .::..:|.:.     :|                .:.:...||.|.:|.:|          |:.. 
Zfish   542 GFYFIALDHY-----TY----------------EAEEAKFGPGVTVVPRNHPQDRSPTWTGIGFV 585

  Fly   713 -----AFGDESLDGLGINLNVTL------------TEVGWYHVPPTVVDIKTRLRRTEGGD---- 756
                 ||.:.|:|.:..::...|            .||....:.|.|:...:|...|...|    
Zfish   586 NVPEGAFLEFSIDNIPYSMEYDLIIRYEPQLPEQWEEVLMTVIRPRVITADSRCANTMPDDDNQM 650

  Fly   757 --YHGES--------VTRSQFLSVLVSLDAVLIRAAFHTDQGETSLERAV---------IYSGGV 802
              .|..|        |...:.|:..|.|...|..|........|.::..|         |:||..
Zfish   651 VSLHPGSRYVVLPRPVCFEEGLNYTVRLSLSLYSALSDVQSPYTLIDSIVLMPHCKNLDIFSGSG 715

  Fly   803 ELGGK--SSSQVE-----------QCLCPAGYTGLSCEGCAFGFKRIYENTSDHQILSKCIPCPC 854
            ..||.  ::|..|           |.:.....|.: |....|....:.     ||.:..|...|.
Zfish   716 TEGGNLVTNSAWENFQRYRCLENSQAVVKTPMTDI-CRNYIFSVSALL-----HQGVKACQCDPQ 774

  Fly   855 NGHSNSCDLQSGNCGDCMHNTFGDRCERCQLGYYGNPLQGTPNDCKRCACPLSEDSNNFSPSCQL 919
            ...|..||...|.| .|..|..|..|:||....:    .. |..|:.|.|         ||...:
Zfish   775 GSLSTVCDPSGGQC-QCRPNVVGRNCDRCAPATF----LFXPQGCRPCDC---------SPEGSV 825

  Fly   920 KSYNYMDLNPQFELIEHAEYICTQCPEGYTGDHCQVCDDGYFGNPRQPGSSCQRCDCAG--GPCN 982
            .||           ...|...| :|..|..|..|..|..||:|.|     :|:.|.|.|  ..|:
Zfish   826 HSY-----------CHEATGQC-ECIAGAYGRQCDRCLPGYWGFP-----NCRPCTCNGHAEQCD 873

  Fly   983 VTTGECITCRGNTEGWHCERCKLGYWGDPAVG----CDPCHCHT---EGSE-SGLC----DSTDG 1035
            ..||:|::||.:|.|.:||||..||:|||.:|    |.||.|..   .|.: ||.|    ||:..
Zfish   874 PQTGQCLSCRDHTTGHNCERCLGGYYGDPVLGSGDHCRPCMCPDGPGSGRQFSGACYKSPDSSQV 938

  Fly  1036 QCLCKPRYAGQKCDECDVGY----ANVELRCPSCNCDP-LGSLVQDRCDPHTGQC-HCKEGVMGA 1094
            .|:|...|.|.:|:||..||    ..|...|..|.|:. :..:..:.||..||.| .|.....|.
Zfish   939 FCVCNQGYKGARCEECAPGYYGNPHEVGGECRPCQCNSNIDMMDPESCDARTGACVKCLYHTEGE 1003

  Fly  1095 KCHECQDGYFGMNAVAYRMDDLAALRQNSDSDDDEWELVPDTEDPNSESTVACEECHCSSVGSL- 1158
            .|:.|:.||:| ||:                                  |.:|.:|.|:.:|:: 
Zfish  1004 SCNRCRLGYYG-NAL----------------------------------TQSCRKCVCNQMGTVE 1033

  Fly  1159 -------SSDCDKRTGQCACLANVTGRRCDKCRPGHWNLTAGEGCRDCRCDPHGSRGHECNPWTG 1216
                   :.:||..:|||.||.||.|:.||:|.|..||:.:|:||.||.|||:.|.|..||...|
Zfish  1034 EMCPSPGNCNCDLTSGQCLCLPNVVGQHCDQCAPDTWNMASGKGCEDCDCDPNHSFGSSCNEIMG 1098

  Fly  1217 QCDCKIGVGGQHCNECTEGFFGFSTEGCQRCSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPG 1281
            ||.||.|.||:.|.||.|.|                                             
Zfish  1099 QCSCKPGFGGRTCRECRELF--------------------------------------------- 1118

  Fly  1282 TWGWQARLGCRECECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFG-YPECRRCGCDAE 1345
             || ...:.|..|:||..|...|||:...|.|.|.||.||.:|||||.||.| :|:|.|      
Zfish  1119 -WG-NPEVKCHACDCDPRGIAEQQCNKVTGHCVCVEGVSGPRCDTCARGYTGEFPQCER------ 1175

  Fly  1346 GSFTQADGSIACDSNGQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGCTRCFCFGRSGECEQSDLS 1410
                                                          |.:||.             
Zfish  1176 ----------------------------------------------CHQCFA------------- 1181

  Fly  1411 WGHIRMAESRNLSVQQIRPHSVPSSDYEYIVVVQMEGSSFHREDAEIQRMNDLSLVPKSTGNVSI 1475
                                       |:.::|....:..||   .:|::|.:    |:||  ..
Zfish  1182 ---------------------------EWDIIVGDLTNQTHR---LVQKVNTI----KATG--IT 1210

  Fly  1476 GAYGQFYHPLYFQLPPQFYGDRTSSYGGFLYFTLITEGAHKPLERNILGQYPLVQLHAHSKLLLD 1540
            |.|....:.:                          |.:...: ||||.|.|..|.....:.||:
Zfish  1211 GPYQATINNV--------------------------ENSANSI-RNILAQNPATQPLTEIQGLLE 1248

  Fly  1541 FYE--YEEFEYSLNVTHRVPLHESFWKYHHTSQAVDR--NTLMAALQNIRHIFIRAFAFADFQEV 1601
            ...  ..|...:||:|     .|:..:....:.:.|.  .:|....|.:..      ...|.:|.
Zfish  1249 QATALMAEMNSNLNLT-----EETLSEISSDNNSTDTKLKSLKEEAQKLEQ------TVKDLREQ 1302

  Fly  1602 VLQNVHMDAAIYIKGSTNLIAKGVERCKCPKRFDGLSCQDPGRSFYRWRNTTIVESVFIEDLIGR 1666
            |....:.|    |:|:...:.:..|:.:..:.....|..||    |...|.:.......|:|:.:
Zfish  1303 VEFVKNSD----IRGARASVTRYYEQSQNAEIRANASTTDP----YNLVNQSATLRTETEELMNQ 1359

  Fly  1667 AAPCHCNGRSSDCDRETGVCQNCRGNTGGDHCHQCAEGFYGDPNSPHGCQACPCPETNRNFARGC 1731
            ... ..|.|..:..::   ..|..|........:.:|...|.|.....|....|           
Zfish  1360 TKE-EFNQRQDEFSKK---LDNLAGQLETLDLSELSEKTCGSPAGSENCADSRC----------- 1409

  Fly  1732 NVWDGEVSCVCKPGYTGRLCERCQAGYFGDPMRYPNTTCQPCNCHPDGIQTEGCDVETGRCYCRE 1796
                |.:|||...|  .|.|    .|                         ||||          
Zfish  1410 ----GGLSCVDMQG--SRKC----GG-------------------------EGCD---------- 1429

  Fly  1797 GVTGLKCDKCQAERHHLVDNGCKICDNCTLLLLDYMELVGNKLRRGMHNMDLTGIPAPYRKLSEY 1861
            |:|            .|..|..:...:..|.::..||.| :||.:.:..   ..:.|...||:..
Zfish  1430 GLT------------TLAHNAWQKAKDFDLEIISAMEEV-DKLSKMVSE---AKVKADEAKLNAQ 1478

  Fly  1862 E------SAYEKWNGRHWDFSQTKRRLQDY---DSADILKLEAHA---------------ENLKF 1902
            |      ...::.:..:.:..|..::::|:   |.||:..:||.|               :||..
Zfish  1479 EVLAKTNETKKRVDSSNEELRQLIKQIRDFLTQDGADLESIEAVANEVLQMQMPTTPAQLQNLTE 1543

  Fly  1903 QSRKAVATIGKREFAIKSMREDAVTQQHSVGLLRSEILQTLSDLHGYGKSAHYLSLPTALKQARF 1967
            :.|:.|.::...|         .:..|.:..:||:|.|                     |:||| 
Zfish  1544 EIRERVGSLTDVE---------DILNQSAADILRAESL---------------------LEQAR- 1577

  Fly  1968 YLQAIREHDQMVQGIRSTNDC---AWKHFYAMGNA-----SDASFDESGRLEMLWRDLNQTNHRV 2024
              :|.:|    ...::||.:.   |.:|.....|:     ..|:.|..|..::|....::|:...
Zfish  1578 --KARKE----ASDVKSTAEMVKEALQHAERAQNSVAEALKQAAVDIKGTQDLLVSVESETSDSE 1636

  Fly  2025 VDMRLQVDRVQEVENEAEDVLEHVRNLSIRVGESHQELDELN---QRISDHLDPGYLEQGEGLLR 2086
            :.:.....|:.::|::...:.|...|.||....:.:|.:.:|   :::...||....::...:..
Zfish  1637 LKLSNATRRLLKLESDVALLKEKALNTSISANSTEKEAESINALAEQLKKDLDSELKDKYSTVEE 1701

  Fly  2087 LTVQRQIMLNGHLNQLDGYRILLNTTLGVKTEQQREVRKHWLPKAEKHASHLLARSNEYARKFQP 2151
            |..|                         |.|...|.:|. ..|.::.|.:||.:::|   |.|.
Zfish  1702 LITQ-------------------------KAEGVAEAKKR-AEKLQEEARNLLLQASE---KLQL 1737

  Fly  2152 TRNGARIAMLASSAHSNITEAINDARLASILAKERVYEAQRTLYPSDGSSMIERAKHSLHRSKQL 2216
            .:|                             .|:.|:..:.|.....:.:::..|    ..|:|
Zfish  1738 LKN-----------------------------LEKNYDQNQKLLEDKANELVDLEK----AVKEL 1769

  Fly  2217 QQEALKQMHKSNV 2229
            .||.   .||..|
Zfish  1770 LQEI---SHKVTV 1779

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 164..396 CDD:278484 58/246 (24%)
EGF_Lam 401..450 CDD:238012 18/62 (29%)
TNFRSF <407..507 CDD:304602 35/122 (29%)
EGF_Lam 505..552 CDD:238012 19/61 (31%)
Laminin_EGF 550..597 CDD:278482 16/49 (33%)
Laminin_B 660..798 CDD:278481 30/188 (16%)
EGF_Lam 851..900 CDD:238012 13/48 (27%)
Laminin_EGF <943..971 CDD:278482 9/27 (33%)
VSP 953..1414 CDD:146106 142/489 (29%)
Laminin_EGF 974..1018 CDD:278482 22/49 (45%)
EGF_Lam 1017..1065 CDD:238012 20/59 (34%)
Laminin_EGF 1065..>1105 CDD:278482 13/41 (32%)
EGF_Lam 1150..1197 CDD:238012 21/54 (39%)
Laminin_EGF 1199..1247 CDD:278482 21/47 (45%)
EGF_Lam 1247..1292 CDD:238012 2/44 (5%)
Laminin_EGF 1294..1342 CDD:278482 25/48 (52%)
Laminin_EGF 1340..1392 CDD:278482 0/51 (0%)
Laminin_B 1486..1611 CDD:278481 22/128 (17%)
EGF_Lam 1669..1716 CDD:238012 7/46 (15%)
Laminin_EGF 1718..1767 CDD:278482 9/48 (19%)
EGF_Lam 1772..1819 CDD:238012 8/46 (17%)
CrfC <1933..2267 CDD:223771 55/308 (18%)
Laminin_II 2277..2400 CDD:283628
LamG 2399..>2492 CDD:304605
Laminin_G_2 2616..2755 CDD:280389
Laminin_G_2 2804..2944 CDD:280389
Laminin_G_2 3038..3169 CDD:280389
LamG 3192..3347 CDD:238058
lamb1aNP_775382.1 Laminin_N 40..266 CDD:278484 60/251 (24%)
EGF_Lam 268..320 CDD:238012 18/53 (34%)
Laminin_EGF <353..382 CDD:278482 10/28 (36%)
EGF_Lam 394..452 CDD:238012 17/57 (30%)
EGF_Lam 453..504 CDD:238012 17/51 (33%)
EGF_Lam 505..548 CDD:238012 9/68 (13%)
CBM6-CBM35-CBM36_like 552..>612 CDD:301364 12/75 (16%)
EGF_Lam 769..814 CDD:214543 14/49 (29%)
Laminin_EGF 817..865 CDD:278482 19/73 (26%)
EGF_Lam 862..907 CDD:238012 21/44 (48%)
Laminin_EGF <934..969 CDD:278482 12/34 (35%)
Laminin_EGF 972..1018 CDD:278482 16/80 (20%)
Laminin_EGF 1024..1078 CDD:278482 20/53 (38%)
Laminin_EGF 1081..1129 CDD:278482 24/94 (26%)
Laminin_EGF 1129..>1168 CDD:278482 21/38 (55%)
Apolipoprotein 1246..1393 CDD:279749 28/169 (17%)
SynN 1256..>1374 CDD:294095 24/137 (18%)
COG1340 1441..1730 CDD:224259 64/355 (18%)
MCP_signal 1448..1630 CDD:304920 42/222 (19%)
NusB_Sun 1530..>1611 CDD:294154 21/117 (18%)
Uso1_p115_C 1672..1774 CDD:282695 26/166 (16%)
IncA <1697..>1774 CDD:282066 22/141 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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