DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wb and lamb1a

DIOPT Version :10

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:NP_775382.1 Gene:lamb1a / 286830 ZFINID:ZDB-GENE-021226-1 Length:1785 Species:Danio rerio


Alignment Length:2288 Identity:507/2288 - (22%)
Similarity:814/2288 - (35%) Gaps:712/2288 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   134 GALRLLKTEDVYSSSFSGGLYPPLFN-VVPRA-QISVNATCGQNGAEEYC---KQVGAKPCGICN 193
            ||..|....::......|..||...: ::.|| |:...:|||.:..|.:|   .....|.|.:|:
Zfish    12 GAWALADVPELGDVCTEGSCYPATGDLLIGRAQQLLATSTCGVHKPEPFCIVSHLQEEKKCFVCD 76

  Fly   194 A-----HSSDRAKQRSIQSLISSGSGSGSGSGFEEGWWQSPTLQGGRQFEYVTILLDLKQTFQIF 253
            :     .::.:....||::::::.:.:..     :.||||   :.|  .|.|||.|||:..|. |
Zfish    77 SRQAYNETAHQVTSHSIENVVTTFAPNRL-----KTWWQS---ENG--LENVTIQLDLEAEFH-F 130

  Fly   254 SVWLKSANSPRPASWILEKSLD-GINFEPWQYFGLSDADCQRRWNLSGQNGKYVFQNDTEIICST 317
            :..:.:..:.|||:.::|:|.| |..::.::||..   ||:..:. |..:|.....:|  :||.|
Zfish   131 THLIMTFKTFRPAAMVIERSADFGNTWQVYRYFAY---DCESSFP-SVSHGPMTKVDD--VICDT 189

  Fly   318 QFSKPGPLENG-----VLHASLLKNRPGATDQSPELMKFITTRYIRIRLQGMHSTANQDNSLDWL 377
            ::|...|...|     ||..:.....|    .||.:...:....:|::...:|:..  ||.||..
Zfish   190 RYSDIEPSTEGEVIFRVLDPAFRIEDP----YSPRIQNMLKITNLRVKFTKLHTLG--DNLLDSR 248

  Fly   378 LDSPSLEKHSFYSLSQLKVSARLDCNGHANRSHESPDDPLMQ---------CICQHNTCGAQCEQ 433
            ::   :::..:|::..:.|.....|.|||  |..:|.|...:         |:|.|||.|..||:
Zfish   249 IE---IKEKYYYAIYDMVVRGNCFCYGHA--SECAPVDGTGEAVEGMVHGHCMCNHNTIGLNCER 308

  Fly   434 CCPLFQDRPYQMG-----GECEICQCYGHAESCTYDPFLDK-------GICQSCSNNTAGIECEF 486
            |...:.|.|::..     ..|:.|.|..|:.||.:|..:.:       |:|..|.:||.|..||.
Zfish   309 CQDFYHDLPWRPAEGRNTNACKKCHCNHHSHSCHFDMAVYRASGNVSGGVCDDCQHNTMGHNCEQ 373

  Fly   487 CEMGFYRELDAPLTDP--CLPCSCNPARSTGGCQSD----------GGSCNCLEGFQGKNCEECA 539
            |:..|::..:..:.||  |.||:|:|..|..|...|          .|.|.|....:|:.|::|.
Zfish   374 CKPFFHQHPEKDIRDPNICEPCNCDPVGSLNGGVCDPMTDVSLGLISGQCRCKPNVEGERCDQCK 438

  Fly   540 PGYYG--DD---CKRCECDERGSLGSTGSC---SGVCQCKLNVEGSTCSECAPGYFDLSAENAEG 596
            .|:||  :|   |:.|.|:..|::.....|   ||.|.||..|.|..|.:|.|.::.|| .:.:|
Zfish   439 QGHYGLSEDPLGCQPCTCNALGTVPGGSPCDTDSGNCYCKRLVTGRNCDQCLPQHWGLS-NDMDG 502

  Fly   597 CTSCWC---SGVSQTCHSAKLQTLAFETLNDWKITDIQRVKPISIPVDAETNRLIFANELDEVEA 658
            |..|.|   ..::..|                        .|:|  ...:....:|....|:||:
Zfish   503 CRPCDCDHGGAINNNC------------------------SPVS--GQCQCREHMFGRRCDQVES 541

  Fly   659 IYWQASLGYLGNRLTSYGSRLQLVLSWDVIRGDRSGKPTTGPNVILVGKN----------GLKI- 712
            .::..:|.:.     :|                .:.:...||.|.:|.:|          |:.. 
Zfish   542 GFYFIALDHY-----TY----------------EAEEAKFGPGVTVVPRNHPQDRSPTWTGIGFV 585

  Fly   713 -----AFGDESLDGLGINLNVTL------------TEVGWYHVPPTVVDIKTRLRRTEGGD---- 756
                 ||.:.|:|.:..::...|            .||....:.|.|:...:|...|...|    
Zfish   586 NVPEGAFLEFSIDNIPYSMEYDLIIRYEPQLPEQWEEVLMTVIRPRVITADSRCANTMPDDDNQM 650

  Fly   757 --YHGES--------VTRSQFLSVLVSLDAVLIRAAFHTDQGETSLERAV---------IYSGGV 802
              .|..|        |...:.|:..|.|...|..|........|.::..|         |:||..
Zfish   651 VSLHPGSRYVVLPRPVCFEEGLNYTVRLSLSLYSALSDVQSPYTLIDSIVLMPHCKNLDIFSGSG 715

  Fly   803 ELGGK--SSSQVE-----------QCLCPAGYTGLSCEGCAFGFKRIYENTSDHQILSKCIPCPC 854
            ..||.  ::|..|           |.:.....|.: |....|....:.     ||.:..|...|.
Zfish   716 TEGGNLVTNSAWENFQRYRCLENSQAVVKTPMTDI-CRNYIFSVSALL-----HQGVKACQCDPQ 774

  Fly   855 NGHSNSCDLQSGNCGDCMHNTFGDRCERCQLGYYGNPLQGTPNDCKRCACPLSEDSNNFSPSCQL 919
            ...|..||...|.| .|..|..|..|:||....:    ...|..|:.|.|         ||...:
Zfish   775 GSLSTVCDPSGGQC-QCRPNVVGRNCDRCAPATF----LFXPQGCRPCDC---------SPEGSV 825

  Fly   920 KSYNYMDLNPQFELIEHAEYICTQCPEGYTGDHCQVCDDGYFGNPRQPGSSCQRCDCAG--GPCN 982
            .||           ...|...| :|..|..|..|..|..||:|.|     :|:.|.|.|  ..|:
Zfish   826 HSY-----------CHEATGQC-ECIAGAYGRQCDRCLPGYWGFP-----NCRPCTCNGHAEQCD 873

  Fly   983 VTTGECITCRGNTEGWHCERCKLGYWGDPAVG----CDPCHCHT---EGSE-SGLC----DSTDG 1035
            ..||:|::||.:|.|.:||||..||:|||.:|    |.||.|..   .|.: ||.|    ||:..
Zfish   874 PQTGQCLSCRDHTTGHNCERCLGGYYGDPVLGSGDHCRPCMCPDGPGSGRQFSGACYKSPDSSQV 938

  Fly  1036 QCLCKPRYAGQKCDECDVGY----ANVELRCPSCNCDP-LGSLVQDRCDPHTGQC-HCKEGVMGA 1094
            .|:|...|.|.:|:||..||    ..|...|..|.|:. :..:..:.||..||.| .|.....|.
Zfish   939 FCVCNQGYKGARCEECAPGYYGNPHEVGGECRPCQCNSNIDMMDPESCDARTGACVKCLYHTEGE 1003

  Fly  1095 KCHECQDGYFGMNAVAYRMDDLAALRQNSDSDDDEWELVPDTEDPNSESTVACEECHCSSVGSL- 1158
            .|:.|:.||:| ||:                                  |.:|.:|.|:.:|:: 
Zfish  1004 SCNRCRLGYYG-NAL----------------------------------TQSCRKCVCNQMGTVE 1033

  Fly  1159 -------SSDCDKRTGQCACLANVTGRRCDKCRPGHWNLTAGEGCRDCRCDPHGSRGHECNPWTG 1216
                   :.:||..:|||.||.||.|:.||:|.|..||:.:|:||.||.|||:.|.|..||...|
Zfish  1034 EMCPSPGNCNCDLTSGQCLCLPNVVGQHCDQCAPDTWNMASGKGCEDCDCDPNHSFGSSCNEIMG 1098

  Fly  1217 QCDCKIGVGGQHCNECTEGFFGFSTEGCQRCSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPG 1281
            ||.||.|.||:.|.||.|.|                                             
Zfish  1099 QCSCKPGFGGRTCRECRELF--------------------------------------------- 1118

  Fly  1282 TWGWQARLGCRECECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFG-YPECRRCGCDAE 1345
             || ...:.|..|:||..|...|||:...|.|.|.||.||.:|||||.||.| :|:|.|      
Zfish  1119 -WG-NPEVKCHACDCDPRGIAEQQCNKVTGHCVCVEGVSGPRCDTCARGYTGEFPQCER------ 1175

  Fly  1346 GSFTQADGSIACDSNGQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGCTRCFCFGRSGECEQSDLS 1410
                                                          |.:||.             
Zfish  1176 ----------------------------------------------CHQCFA------------- 1181

  Fly  1411 WGHIRMAESRNLSVQQIRPHSVPSSDYEYIVVVQMEGSSFHREDAEIQRMNDLSLVPKSTGNVSI 1475
                                       |:.::|....:..||   .:|::|.:    |:||  ..
Zfish  1182 ---------------------------EWDIIVGDLTNQTHR---LVQKVNTI----KATG--IT 1210

  Fly  1476 GAYGQFYHPLYFQLPPQFYGDRTSSYGGFLYFTLITEGAHKPLERNILGQYPLVQLHAHSKLLLD 1540
            |.|....:.:                          |.:...: ||||.|.|..|.....:.||:
Zfish  1211 GPYQATINNV--------------------------ENSANSI-RNILAQNPATQPLTEIQGLLE 1248

  Fly  1541 FYE--YEEFEYSLNVTHRVPLHESFWKYHHTSQAVDR--NTLMAALQNIRHIFIRAFAFADFQEV 1601
            ...  ..|...:||:|     .|:..:....:.:.|.  .:|....|.:..      ...|.:|.
Zfish  1249 QATALMAEMNSNLNLT-----EETLSEISSDNNSTDTKLKSLKEEAQKLEQ------TVKDLREQ 1302

  Fly  1602 VLQNVHMDAAIYIKGSTNLIAKGVERCKCPKRFDGLSCQDPGRSFYRWRNTTIVESVFIEDLIGR 1666
            |....:.|    |:|:...:.:..|:.:..:.....|..||    |...|.:.......|:|:.:
Zfish  1303 VEFVKNSD----IRGARASVTRYYEQSQNAEIRANASTTDP----YNLVNQSATLRTETEELMNQ 1359

  Fly  1667 AAPCHCNGRSSDCDRETGVCQNCRGNTGGDHCHQCAEGFYGDPNSPHGCQACPCPETNRNFARGC 1731
            ... ..|.|..:..::   ..|..|........:.:|...|.|.....|....|           
Zfish  1360 TKE-EFNQRQDEFSKK---LDNLAGQLETLDLSELSEKTCGSPAGSENCADSRC----------- 1409

  Fly  1732 NVWDGEVSCVCKPGYTGRLCERCQAGYFGDPMRYPNTTCQPCNCHPDGIQTEGCDVETGRCYCRE 1796
                |.:|||...|  .|.|    .|                         ||||          
Zfish  1410 ----GGLSCVDMQG--SRKC----GG-------------------------EGCD---------- 1429

  Fly  1797 GVTGLKCDKCQAERHHLVDNGCKICDNCTLLLLDYMELVGNKLRRGMHNMDLTGIPAPYRKLSEY 1861
            |:|            .|..|..:...:..|.::..||.| :||.:.:..   ..:.|...||:..
Zfish  1430 GLT------------TLAHNAWQKAKDFDLEIISAMEEV-DKLSKMVSE---AKVKADEAKLNAQ 1478

  Fly  1862 E------SAYEKWNGRHWDFSQTKRRLQDY---DSADILKLEAHA---------------ENLKF 1902
            |      ...::.:..:.:..|..::::|:   |.||:..:||.|               :||..
Zfish  1479 EVLAKTNETKKRVDSSNEELRQLIKQIRDFLTQDGADLESIEAVANEVLQMQMPTTPAQLQNLTE 1543

  Fly  1903 QSRKAVATIGKREFAIKSMREDAVTQQHSVGLLRSEILQTLSDLHGYGKSAHYLSLPTALKQARF 1967
            :.|:.|.::...|         .:..|.:..:||:|.|                     |:||| 
Zfish  1544 EIRERVGSLTDVE---------DILNQSAADILRAESL---------------------LEQAR- 1577

  Fly  1968 YLQAIREHDQMVQGIRSTNDC---AWKHFYAMGNA-----SDASFDESGRLEMLWRDLNQTNHRV 2024
              :|.:|    ...::||.:.   |.:|.....|:     ..|:.|..|..::|....::|:...
Zfish  1578 --KARKE----ASDVKSTAEMVKEALQHAERAQNSVAEALKQAAVDIKGTQDLLVSVESETSDSE 1636

  Fly  2025 VDMRLQVDRVQEVENEAEDVLEHVRNLSIRVGESHQELDELN---QRISDHLDPGYLEQGEGLLR 2086
            :.:.....|:.::|::...:.|...|.||....:.:|.:.:|   :::...||....::...:..
Zfish  1637 LKLSNATRRLLKLESDVALLKEKALNTSISANSTEKEAESINALAEQLKKDLDSELKDKYSTVEE 1701

  Fly  2087 LTVQRQIMLNGHLNQLDGYRILLNTTLGVKTEQQREVRKHWLPKAEKHASHLLARSNEYARKFQP 2151
            |..|                         |.|...|.:|. ..|.::.|.:||.:::|   |.|.
Zfish  1702 LITQ-------------------------KAEGVAEAKKR-AEKLQEEARNLLLQASE---KLQL 1737

  Fly  2152 TRNGARIAMLASSAHSNITEAINDARLASILAKERVYEAQRTLYPSDGSSMIERAKHSLHRSKQL 2216
            .:|                             .|:.|:..:.|.....:.:::..|    ..|:|
Zfish  1738 LKN-----------------------------LEKNYDQNQKLLEDKANELVDLEK----AVKEL 1769

  Fly  2217 QQEALKQMHKSNV 2229
            .||.   .||..|
Zfish  1770 LQEI---SHKVTV 1779

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 153..398 CDD:459653 62/260 (24%)
EGF_Lam 401..450 CDD:238012 18/62 (29%)
EGF_Lam 505..552 CDD:238012 19/61 (31%)
Laminin_EGF 550..597 CDD:395007 16/49 (33%)
Laminin_B 660..813 CDD:459652 36/205 (18%)
EGF_Lam 851..900 CDD:238012 13/48 (27%)
Laminin_EGF <943..971 CDD:395007 9/27 (33%)
Laminin_EGF 974..1018 CDD:395007 22/49 (45%)
EGF_Lam 1017..1065 CDD:238012 20/59 (34%)
Laminin_EGF 1065..>1105 CDD:395007 13/41 (32%)
EGF_Lam 1150..1197 CDD:238012 21/54 (39%)
Laminin_EGF 1199..1247 CDD:395007 21/47 (45%)
EGF_Lam 1247..1292 CDD:238012 2/44 (5%)
Laminin_EGF 1294..1342 CDD:395007 25/48 (52%)
Laminin_EGF 1340..1392 CDD:395007 0/51 (0%)
Laminin_B 1486..1626 CDD:459652 24/143 (17%)
EGF_Lam 1669..1716 CDD:238012 7/46 (15%)
Laminin_EGF 1718..1767 CDD:395007 9/48 (19%)
EGF_Lam 1772..1819 CDD:238012 8/46 (17%)
YhaN <1907..2141 CDD:443752 43/244 (18%)
SMC_prok_B <2123..>2390 CDD:274008 20/107 (19%)
Laminin_II 2279..2400 CDD:368703
LamG 2399..>2492 CDD:473984
LamG 2586..2753 CDD:238058
Laminin_G_2 2804..2944 CDD:460494
LamG 3018..3167 CDD:238058
LamG 3192..3347 CDD:238058
lamb1aNP_775382.1 Laminin_N 31..266 CDD:459653 62/260 (24%)
EGF_Lam 268..320 CDD:238012 18/53 (34%)
Laminin_EGF <353..382 CDD:395007 10/28 (36%)
EGF_Lam 394..452 CDD:238012 17/57 (30%)
EGF_Lam 453..504 CDD:238012 17/51 (33%)
EGF_Lam 505..548 CDD:238012 9/68 (13%)
EGF_Lam 769..814 CDD:214543 14/49 (29%)
Laminin_EGF 817..865 CDD:395007 19/73 (26%)
EGF_Lam 862..907 CDD:238012 21/44 (48%)
Laminin_EGF <934..969 CDD:395007 12/34 (35%)
Laminin_EGF 972..1018 CDD:395007 16/80 (20%)
Laminin_EGF 1024..1078 CDD:395007 20/53 (38%)
Laminin_EGF 1081..1129 CDD:395007 24/94 (26%)
Laminin_EGF 1129..>1168 CDD:395007 21/38 (55%)
Myosin_tail_1 1247..>1756 CDD:460256 119/698 (17%)
cc_LAMB1_C 1712..1784 CDD:411971 21/108 (19%)
Blue background indicates that the domain is not in the aligned region.

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