DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wb and Lamb2

DIOPT Version :9

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:NP_037106.1 Gene:Lamb2 / 25473 RGDID:2988 Length:1801 Species:Rattus norvegicus


Alignment Length:2424 Identity:526/2424 - (21%)
Similarity:794/2424 - (32%) Gaps:943/2424 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   151 GGLYPPLFN-VVPRA-QISVNATCGQNGAEEYC---KQVGAKPCGICNAH----SSDRAKQRSIQ 206
            |..||...: :|.|| :::.::|||.:..:.||   .....|.|.:|::.    :.|......||
  Rat    48 GSCYPATGDLLVGRADRLTASSTCGLHSPQPYCIVSHLQDEKKCFLCDSRRPFSARDNPNSHRIQ 112

  Fly   207 SLISSGSGSGSGSGFEEGWWQSPTLQGGRQFEYVTILLDLKQTFQIFSVWLKSANSPRPASWILE 271
            ::::|.:...     ...||||   :.|  ...|||.|||:..|. |:..:.:..:.|||:.::|
  Rat   113 NVVTSFAPQR-----RTAWWQS---ENG--VPMVTIQLDLEAEFH-FTHLIMTFKTFRPAAMLVE 166

  Fly   272 KSLD-GINFEPWQYFGLSDADC-----------QRRWNLSGQNGKYVFQNDTEIICSTQFSKPGP 324
            :|.| |..:..::||..   ||           .|||:              :::|.:::|:..|
  Rat   167 RSADFGRTWRVYRYFSY---DCGADFPGIPLAPPRRWD--------------DVVCESRYSEIEP 214

  Fly   325 LENG-VLHASLLKNRPGATDQSPELMKFITTRYIRIRLQGMHSTANQDNSLDWLLDSPSLEKHSF 388
            ...| |::..|....|.....|..:...:....:|:.|..:|:..  ||.||   ....:.:..:
  Rat   215 STEGEVIYRVLDPAIPIPDPYSSRIQNLLKITNLRVNLTRLHTLG--DNLLD---PRREIREKYY 274

  Fly   389 YSLSQLKVSARLDCNGHANRSHESPDDPLM-------QCICQHNTCGAQCEQCCPLFQDRPYQMG 446
            |:|.:|.:.....|.|||::...:|..|..       .|||:|||.|..||||...:||.|:...
  Rat   275 YALYELVIRGNCFCYGHASQCAPAPGAPAHAEGMVHGACICKHNTRGLNCEQCQDFYQDLPWHPA 339

  Fly   447 GE-----CEICQCYGHAESCTYDPF-------LDKGICQSCSNNTAGIECEFCEMGFYRELDAPL 499
            .:     |..|:|.||:.||.:|..       :..|:|..|.:||||..||.|...|||:....:
  Rat   340 EDGHTHACRKCECNGHSHSCHFDMAVYLASGNVSGGVCDGCQHNTAGRHCELCRPFFYRDPTKDM 404

  Fly   500 TDP--CLPCSCNPARSTGGCQSD----------GGSCNCLEGFQGKNCEECAPGYYG------DD 546
            .||  |.||.|:|..|..|.:.|          .|.|.|.|...|..|::|..|::|      ..
  Rat   405 RDPAACRPCDCDPMGSQDGGRCDSHDDPVLGLVSGQCRCKEHVVGTRCQQCRDGFFGLSASNPRG 469

  Fly   547 CKRCECDERGSL-GST--GSCSGVCQCKLNVEGSTCSECAPGYFDLSAENAEGCTSCWC---SGV 605
            |:||:|:.||:: |.|  .|.||.|.||..|.|..|..|.||::.|| .:..||..|.|   ..:
  Rat   470 CQRCQCNSRGTVPGGTPCDSSSGTCFCKRLVTGDGCDRCLPGHWGLS-HDLLGCRPCDCDVGGAL 533

  Fly   606 SQTCHSA----------------KLQTLAFETLND---WK--------ITDIQRVKPISIPVDAE 643
            ...|..|                ::|...|....|   |:        :..::|:         .
  Rat   534 DPQCDEATGQCPCRPHMIGRRCEQVQPGYFRPFLDHLTWEAEGAHGQVLEVVERL---------V 589

  Fly   644 TNR---------LIFANELDEVEAIYWQASLGYLGNRLTSYGSRLQLVLSWD------------V 687
            |||         .:...|..|||  :...||    .|...|    .|:|.|:            |
  Rat   590 TNRETPSWTGVGFVRLREGQEVE--FLVTSL----PRAMDY----DLLLRWEPQVPEQWAELELV 644

  Fly   688 IR--GDRSGKPTTG--------------PNV-ILVGKNGLKIAFGDESLDGLGINLNVTLTEVGW 735
            ::  |..|.....|              ||. :||....:.:.      .||...|.:.||..|.
  Rat   645 VQRPGPVSAHSPCGHVLPRDDRIQGMLHPNTRVLVFPRPVCLE------PGLSYKLKLKLTGTGG 703

  Fly   736 YHVPPTVVDIKTRLRRTEGGDYHGESVTRSQFLSVLVSLDAVLIRAAFHTD-----QGETSLER- 794
            ...|.|              .|.|..:    .:..||....||:...|...     :..|:.|| 
  Rat   704 RAHPET--------------PYSGSGI----LIDSLVLQPHVLMLEMFSGGDAAALERRTTFERY 750

  Fly   795 --------------------------AVIYSGGV----ELGGKSSSQVE----QCLCPAGYTGLS 825
                                      :::|:|.:    :..|..||:..    ||.|..|..|..
  Rat   751 RCHEEGLMPSKTPLSEACVPLLISASSLVYNGALPCQCDPQGSLSSECNPHGGQCRCKPGVVGRR 815

  Fly   826 CEGCAFGF-------------------KRIYENTS--------------DH-----QILSKCIPC 852
            |:.||.|:                   ..:.|.||              ||     .....|.||
  Rat   816 CDACATGYYGFGPAGCQACQCSPDGALSALCEGTSGQCLCRTGAFGLRCDHCQRGQWGFPNCRPC 880

  Fly   853 PCNGHSNSCDLQSGNCGDCMHNTFGDRCERCQLGYYGNPLQGTPNDCKRCACPLSEDS-NNFSPS 916
            .|||.::.||..:|.|..|...|.|:.||||..|::|:|.......|:.|.||....| .:|:.|
  Rat   881 VCNGRADECDAHTGACLGCRDYTGGEHCERCIAGFHGDPRLPYGGQCRPCPCPEGPGSQRHFATS 945

  Fly   917 CQLKSYNYMDLNPQFELIEHAEYICTQCPEGYTGDHCQVCDDGYFGNPRQPGSSCQRCDCAG--- 978
            |....|              ::.|...|..||||..|:.|..|:||:|.:||..||.|:|:|   
  Rat   946 CHRDGY--------------SQQIVCHCRAGYTGLRCEACAPGHFGDPSKPGGRCQLCECSGNID 996

  Fly   979 ----GPCNVTTGECITCRGNTEGWHCERCKLGYWGDPA-VGCDPCHCHTEGSESGLCDSTDGQCL 1038
                |.|:..||:|:.|..:|||.||..||.|:.|..| ..|..|.|:..|        ||.|  
  Rat   997 PTDPGACDPHTGQCLRCLHHTEGPHCGHCKPGFHGQAARQSCHRCTCNLLG--------TDPQ-- 1051

  Fly  1039 CKPRYAGQKCDECDVGYANVELRCPSCNCDPLGSLVQDRCDPHTGQCHCKEGVMGAKCHECQDGY 1103
                                  ||||                 |..|||                
  Rat  1052 ----------------------RCPS-----------------TDLCHC---------------- 1061

  Fly  1104 FGMNAVAYRMDDLAALRQNSDSDDDEWELVPDTEDPNSESTVACEECHCSSVGSLSSDCDKRTGQ 1168
                                              ||:                         |||
  Rat  1062 ----------------------------------DPS-------------------------TGQ 1067

  Fly  1169 CACLANVTGRRCDKCRPGHWNLTAGEGCRDCRCDPHGSRGHECNPWTGQCDCKIGVGGQHCNECT 1233
            |.||.:|.|..||:|.|..||.|:|.||:.|.|.|..:||..||.:||||.|..|.||:.|:||.
  Rat  1068 CPCLPHVQGLSCDRCAPNFWNFTSGRGCQPCACHPSRARGPTCNEFTGQCHCHAGFGGRTCSECQ 1132

  Fly  1234 EGFFGFSTEGCQRCSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPGTWGWQARLGCRECECDH 1298
            |..:|                   ||                            .|.||.|:||.
  Rat  1133 ELHWG-------------------DP----------------------------GLQCRACDCDP 1150

  Fly  1299 IGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFG-YPECRRCGCDAEGSFTQADGSIACDSNGQ 1362
            .|....||....|.|.||.|.||.:||.||.|:.| :|.|.                        
  Rat  1151 RGIDKPQCHRSTGHCSCRPGVSGVRCDQCARGFSGVFPACH------------------------ 1191

  Fly  1363 CPCKSLVVGLKCDTCMQSTFGLSAQNPEGCTRCFCFGRSGECEQSDLSWGHIRMAESRNLSVQQI 1427
             ||.:                             |||          .|..:         ||.:
  Rat  1192 -PCHA-----------------------------CFG----------DWDRV---------VQDL 1207

  Fly  1428 RPHSVPSSDYEYIVVVQMEGSSFHREDAEIQRMNDLSLVPKSTGNVSIGAYGQFYHPLYFQL--P 1490
            .                          |..:|:...:...:.||  .:||:...:..|..:|  .
  Rat  1208 A--------------------------ARTRRLEQWAQELQQTG--VLGAFESSFLNLQGKLGMV 1244

  Fly  1491 PQFYGDRTSSYGGFLYFTLITEGAH----KPLERNILGQYPLVQLHAHSKLLLDFYEYEEFEYSL 1551
            ......|.:|..........|||..    |..||       |.||.|      :..:.::..::.
  Rat  1245 QAIVAARNTSAASTAKLVEATEGLRHEIGKTTER-------LTQLEA------ELTDVQDENFNA 1296

  Fly  1552 NVTHRVPLHESFWKYHHTSQAVDRNTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMDAAIYIKG 1616
            |               |....::|:.|...| .:|.:                :.|:|   .:|.
  Rat  1297 N---------------HALSGLERDGLALNL-TLRQL----------------DQHLD---ILKH 1326

  Fly  1617 STNLIAKGVERCKCPKRFDGLSCQDPGRSFYRWRNTTIVESVFIEDLIGRAAPCHCNGRSSDCDR 1681
            |..|.|           :|.:.                                |.:.:|::.:|
  Rat  1327 SNFLGA-----------YDSIR--------------------------------HAHSQSTEAER 1348

  Fly  1682 ETGVCQNCRGNTGGDHCHQCAEGFYGDPNSPHGCQACPCPETN----------------RNFARG 1730
                    |.|         |..|           |.|.|.:|                .||.| 
  Rat  1349 --------RAN---------ASTF-----------AIPSPVSNSADTRRRAEVLMGAQRENFNR- 1384

  Fly  1731 CNVWDGEVSCVCKPGYTGRLCERCQ-----------AGYFGDPMRYPNTTCQPCNCHPDGIQTEG 1784
                    ..:......|||.....           .|..||         .||...|.|  ..|
  Rat  1385 --------QHLANQQALGRLSTHTHTLSLTGVNELVCGAPGD---------APCATSPCG--GAG 1430

  Fly  1785 CDVETGRCYCREGVTGLKCDKCQAERHHLVDNGCKICDNCTLLLLDYMELVGNKLRRGMHNMDLT 1849
            |..|.|:..|    .||.|....|.                      .:|.   |.|..|..   
  Rat  1431 CRDEDGQPRC----GGLGCSGAAAT----------------------ADLA---LGRARHTQ--- 1463

  Fly  1850 GIPAPYRKLSEYESAYEKWNGRHWDFSQTKRRLQDYDSADILKLEAHAENLKFQSRKAVATIGKR 1914
                     :|.:.|..:..|.....|:|:|:.::........|:           ||.|:.|:.
  Rat  1464 ---------AELQRALVEGGGILSRVSETRRQAEEAQQRAQAALD-----------KANASRGQV 1508

  Fly  1915 EFAIKSMRE------DAVTQQ----HSVGLLRSEILQTLSDLHGYGKSAHYLSLPTALKQARFYL 1969
            |.|.:.:||      |.::|:    .|:.::.:.:|.              :|:|.:.:|.:   
  Rat  1509 EQANQELRELIQNVKDFLSQEGADPDSIEMVATRVLD--------------ISIPASPEQIQ--- 1556

  Fly  1970 QAIREHDQMVQGIRSTNDCAWKHFYAMGNASDASFDESGRLEMLWRDLNQTNHRVVDMRLQVDRV 2034
               |...::.:.:||..|......:.||:..        |.|.|.:|..:...|....|.:.:.|
  Rat  1557 ---RLASEIAERVRSLADVDTILAHTMGDVR--------RAEQLLQDAQRARSRAEGERQKAETV 1610

  Fly  2035 QEVENEAE----DVLEHVRNLSIRVGESHQELDELNQRISDHLDPGYLEQGEGLLRLTVQRQIML 2095
            |....||:    .....:|...:....:.|.|.::.:|::                         
  Rat  1611 QAALEEAQRAQGAAQGAIRGAVVDTKNTEQTLQQVQERMA------------------------- 1650

  Fly  2096 NGHLNQLDGYRILLNTTLGVKTEQQREVRKHWLPKAEKHASHLLARSNEYARKFQPTRNGARIAM 2160
                          .|...:.:..:|..:.|.|.:|.|     |.|:..              ::
  Rat  1651 --------------GTEQSLNSASERARQLHALLEALK-----LKRAGN--------------SL 1682

  Fly  2161 LASSAHSNITEAINDARLASILAKERVYEAQRTLYPSDGSSMIERAKHSL----HRSKQLQQEAL 2221
            .||:|......|.:.||.|....:|:|.:..:|:     .::.||....:    .|::||:.||.
  Rat  1683 AASTAEETAGSAQSRAREAEKQLREQVGDQYQTV-----RALAERKAEGVLAAQARAEQLRDEAR 1742

  Fly  2222 KQMHKSNVLKDKLHRQEQQVEGIKSTIYDSGLRTNNI-SGQLQGLSDGSARRQAKDSLEMADRTG 2285
            ..:..:   :|||.|. |::||    .|:...|...: :.||.||.                   
  Rat  1743 GLLQAA---QDKLQRL-QELEG----TYEENERELEVKAAQLDGLE------------------- 1780

  Fly  2286 EQMRAELQKAKDMQKSIQN 2304
            .:||:.|| |.::|..|.|
  Rat  1781 ARMRSVLQ-AINLQVQIYN 1798

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 164..396 CDD:278484 58/252 (23%)
EGF_Lam 401..450 CDD:238012 20/60 (33%)
TNFRSF <407..507 CDD:304602 41/120 (34%)
EGF_Lam 505..552 CDD:238012 19/62 (31%)
Laminin_EGF 550..597 CDD:278482 20/49 (41%)
Laminin_B 660..798 CDD:278481 33/198 (17%)
EGF_Lam 851..900 CDD:238012 19/48 (40%)
Laminin_EGF <943..971 CDD:278482 13/27 (48%)
VSP 953..1414 CDD:146106 116/469 (25%)
Laminin_EGF 974..1018 CDD:278482 20/51 (39%)
EGF_Lam 1017..1065 CDD:238012 9/47 (19%)
Laminin_EGF 1065..>1105 CDD:278482 4/39 (10%)
EGF_Lam 1150..1197 CDD:238012 17/46 (37%)
Laminin_EGF 1199..1247 CDD:278482 20/47 (43%)
EGF_Lam 1247..1292 CDD:238012 3/44 (7%)
Laminin_EGF 1294..1342 CDD:278482 21/48 (44%)
Laminin_EGF 1340..1392 CDD:278482 2/51 (4%)
Laminin_B 1486..1611 CDD:278481 21/130 (16%)
EGF_Lam 1669..1716 CDD:238012 7/46 (15%)
Laminin_EGF 1718..1767 CDD:278482 12/75 (16%)
EGF_Lam 1772..1819 CDD:238012 13/46 (28%)
CrfC <1933..2267 CDD:223771 62/342 (18%)
Laminin_II 2277..2400 CDD:283628 8/28 (29%)
LamG 2399..>2492 CDD:304605
Laminin_G_2 2616..2755 CDD:280389
Laminin_G_2 2804..2944 CDD:280389
Laminin_G_2 3038..3169 CDD:280389
LamG 3192..3347 CDD:238058
Lamb2NP_037106.1 Laminin_N 60..284 CDD:278484 59/256 (23%)
EGF_Lam 286..338 CDD:238012 20/51 (39%)
EGF_Lam 350..402 CDD:238012 20/51 (39%)
Laminin_EGF 413..470 CDD:278482 15/56 (27%)
EGF_Lam 472..523 CDD:238012 22/51 (43%)
EGF_Lam 524..565 CDD:238012 6/40 (15%)
EGF_Lam 786..831 CDD:214543 12/44 (27%)
Laminin_EGF 834..882 CDD:278482 8/47 (17%)
Laminin_EGF 880..927 CDD:278482 18/46 (39%)
EGF_Lam 929..987 CDD:238012 22/71 (31%)
Laminin_EGF 989..>1031 CDD:278482 17/41 (41%)
Laminin_EGF 1041..1095 CDD:278482 32/177 (18%)
Laminin_EGF 1098..1146 CDD:278482 25/94 (27%)
Laminin_EGF 1146..>1185 CDD:278482 18/38 (47%)
Domain II 1193..1412 57/422 (14%)
Domain alpha 1413..1445 14/46 (30%)
Domain I 1446..1801 93/520 (18%)
DUF4398 <1446..1516 CDD:291044 18/117 (15%)
flagell_FliJ 1477..1617 CDD:131526 33/178 (19%)
HrpJ 1485..1673 CDD:301626 41/265 (15%)
MscS_porin 1582..1776 CDD:289559 48/272 (18%)
ATP-synt_B <1684..1795 CDD:304375 36/143 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1684..1703 7/18 (39%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 69 1.000 Domainoid score I9474
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

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