DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wb and alp7

DIOPT Version :9

Sequence 1:	NP_723870.1	Gene:	wb / 43946	FlyBaseID:	FBgn0261563	Length:	3375	Species:	Drosophila melanogaster
Sequence 2:	NP_594820.1	Gene:	alp7 / 2543382	PomBaseID:	SPAC890.02c	Length:	474	Species:	Schizosaccharomyces pombe

Alignment Length:	413	Identity:	83/413 - (20%)
Similarity:	137/413 - (33%)	Gaps:	158/413 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 IASSPDKKKKSPQSSR----------RHKTKSGLIIESNI-----ADSESMLAIASSESVTKKKP 115
            ::||.|..::||.||.          .|:.:.|...||.|     :..|||.|......:|.|..
pombe     5 VSSSTDYSRRSPSSSSIGTNETDHTGFHEKRQGASSESLIPPAQRSSEESMPAPKLFPKLTSKPN 69

  Fly   116 PQ--------RRRNGKLQKSGGGAGGGALRLLKTEDVYSSSFSGGLYPPLFNVVPRAQISVNATC 172
            ||        :|.:.:||         ||.|.|:.|     |||         .||....::...
pombe    70 PQLNLKDTLNKRVSDRLQ---------ALELNKSFD-----FSG---------TPRPMHPISHPL 111

  Fly   173 GQNGAEEYCKQVGAKPCGICNAHSSDRAKQRSIQSLI---------SSGSGSGSG------SGFE 222
            .|:...|:                  :.::|:::|::         ||.:.|..|      |.|.
pombe   112 SQHKTPEF------------------KHRKRNVESILTPKNPSLFSSSNAASQRGSLNTAPSNFA 158

  Fly   223 EGWWQS---------PTLQGGRQFEYVTILLDLKQTFQIFSVWLKS--ANSPRPASWILEKSLDG 276
            .....|         |.|..| .|...|....|..     .|.||.  .||..|::
pombe   159 YSHSSSLQTSASSRPPVLSNG-SFPRQTNTAPLNP-----PVHLKDNIRNSATPST--------- 208

  Fly   277 INFEPWQYFGLSDADCQRRWNLSG---QNGKYVFQNDTEI------ICSTQFSKPGPLENGVLHA 332
                       |.||...::.::.   |..||    :.||      :..| :.:...|:|.:::.
pombe   209 -----------SQADIPTQYPINSTQKQQAKY----EAEIEGYKAKLAGT-YHEISVLQNTIVNV 257

  Fly   333 S---------LLKNRPGATDQSPELMKFITTRYIRIRL------------QGMHSTANQDNSLDW 376
            |         |.:.|.|....||      :|:...:||            :|.::....|..:..
pombe   258 SGQLIAVNDQLQQLRSGKASTSP------STKDTNMRLVEGHNEETLALQRGKYTQEEVDKLIQE 316

  Fly   377 LLDSPSLEKHSFYSLSQL-KVSA 398
            .::..:.:.|:.||.... |::|
pombe   317 RMEKVAEDLHAQYSAKHTQKINA 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wb	NP_723870.1	Laminin_N	164..396	CDD:278484	48/288 (17%)
		EGF_Lam	401..450	CDD:238012
		TNFRSF	<407..507	CDD:304602
		EGF_Lam	505..552	CDD:238012
		Laminin_EGF	550..597	CDD:278482
		Laminin_B	660..798	CDD:278481
		EGF_Lam	851..900	CDD:238012
		Laminin_EGF	<943..971	CDD:278482
		VSP	953..1414	CDD:146106
		Laminin_EGF	974..1018	CDD:278482
		EGF_Lam	1017..1065	CDD:238012
		Laminin_EGF	1065..>1105	CDD:278482
		EGF_Lam	1150..1197	CDD:238012
		Laminin_EGF	1199..1247	CDD:278482
		EGF_Lam	1247..1292	CDD:238012
		Laminin_EGF	1294..1342	CDD:278482
		Laminin_EGF	1340..1392	CDD:278482
		Laminin_B	1486..1611	CDD:278481
		EGF_Lam	1669..1716	CDD:238012
		Laminin_EGF	1718..1767	CDD:278482
		EGF_Lam	1772..1819	CDD:238012
		CrfC	<1933..2267	CDD:223771
		Laminin_II	2277..2400	CDD:283628
		LamG	2399..>2492	CDD:304605
		Laminin_G_2	2616..2755	CDD:280389
		Laminin_G_2	2804..2944	CDD:280389
		Laminin_G_2	3038..3169	CDD:280389
		LamG	3192..3347	CDD:238058
alp7	NP_594820.1	Kinetocho_Slk19	316..407	CDD:289479	5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100395
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900