DRSC/TRiP Functional Genomics Resources

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Protein Alignment wb and Lamc3

DIOPT Version :9

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:NP_035966.2 Gene:Lamc3 / 23928 MGIID:1344394 Length:1581 Species:Mus musculus


Alignment Length:1342 Identity:388/1342 - (28%)
Similarity:548/1342 - (40%) Gaps:383/1342 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   163 RAQISVNATCGQNGAEEYCKQVGAKPCGI-C-NAHSSDRAKQRSIQSLISSGSGSGSGSGFEEGW 225
            ||:.|  .|||: ..|::|..|||...|: | ....:|..::.....|....|...|      .|
Mouse    56 RAEAS--HTCGR-PPEDFCPHVGAPGAGLQCQRCDDADPGRRHDASYLTDFHSPDDS------TW 111

  Fly   226 WQSPTLQGGRQF-EYVTILLDLKQTFQIFSVWLKSANSPRPASW-ILEKSLDGINFEPWQYFGLS 288
            ||||::..|.|: ..|.:.|.|.:.::|..|.||...| ||.|: |.:::.....:||:||:   
Mouse   112 WQSPSMAFGVQYPTSVNLTLSLGKAYEITYVRLKFHTS-RPESFAIYKRTYASGPWEPYQYY--- 172

  Fly   289 DADCQRRWNLSGQNGKYVFQNDTEII--CSTQFSKPGPLENGVLHASLLKNRPGA--TDQSPELM 349
            .|.||:.:  ....|.|:...:.|.:  |:::||...||..|.:..|.|:.||.|  .::||.|.
Mouse   173 SASCQKTY--GRPEGHYLRPGEDERVAFCTSEFSDISPLNGGNVAFSTLEGRPSAYNFEESPVLQ 235

  Fly   350 KFITTRYIRIRLQGMHSTANQDNSLDWLLDSPSLEKHSFYSLSQLKVSARLDCNGHANRSHESPD 414
            :::|:..|.|.|..:::..      |.:...|.:.:..:|::|...|..|..|||||:....:..
Mouse   236 EWVTSTDILISLDRLNTFG------DDIFKDPRVLQSYYYAVSDFSVGGRCKCNGHASECEPNAA 294

  Fly   415 DPLMQCICQHNTCGAQCEQCCPLFQDRPYQMG-----GECEICQCYGHAESCTYDPFLDK----- 469
            ..| .|.|||||.|..||:|.|.|||||:..|     .||..|.|.||:|.||:|..|.:     
Mouse   295 GQL-ACRCQHNTTGVDCERCLPFFQDRPWARGTAEDANECLPCNCSGHSEECTFDRELYRSTGHG 358

  Fly   470 GICQSCSNNTAGIECEFCEMGFYRELDAPLTDPCLPCSCNPARSTGGCQSDGGSCNCLEGFQGKN 534
            |.||.|.::|.|..||.||..:||.  :|.| ||.||.|:||.|......:.|.|.|.....|..
Mouse   359 GHCQRCRDHTTGPHCERCEKNYYRW--SPKT-PCQPCDCHPAGSLSLQCDNSGVCPCKPTVTGWK 420

  Fly   535 CEECAPGYYG---DDCKRCECDERGSLGSTGSCSGVCQCKLNVEGSTCSECAPGYFDLSAENAEG 596
            |:.|.||::.   ..|:.|.|:..||||:....||.|.||.|||||.|..|.||.|:|...|..|
Mouse   421 CDRCLPGFHSLSEGGCRPCACNVAGSLGTCDPRSGNCPCKENVEGSLCDRCRPGTFNLQPHNPVG 485

  Fly   597 CTSCWCSGVSQTCHSAKLQTLAFET----------LNDWKITDIQRVKPISIPVDAETNRLIF-- 649
            |:||:|.|.|:.|..|    ..|:.          ...|:|..:...|.   |:....:.|:.  
Mouse   486 CSSCFCYGHSKVCSPA----AGFQEHHIRSDFRHGAGGWQIRSMGVSKR---PLQWSQSGLLLGL 543

  Fly   650 --ANELDEVEAIYWQASLGYLGNRLTSYGSRLQLVLSWDVIRGDRSGKPTTGPNVILVGKNGLKI 712
              ..||        .|...:||::..|||.  .::|:..|..|   |.|   |.:.|        
Mouse   544 RGGEEL--------SAPKKFLGDQRLSYGQ--PVILTLQVPPG---GSP---PPIQL-------- 584

  Fly   713 AFGDESLDGLGINLNVTLTEVGWYHVPPTVVDIKTRLRRTEGGDYHGESVTRSQFLSVLVSLDAV 777
                 .|:|.|:.|::..:.:      |:..|.:...|            .:.|||....|.:|.
Mouse   585 -----RLEGAGLALSLRPSSL------PSPQDTRQPRR------------VQLQFLLQETSEEAE 626

  Fly   778 LIRAAFHTDQGETSLERAVIYSGGVELG---------------------GKSSSQVEQCLCPAGY 821
            .....||..:..::|....|::.|...|                     ...:|.||.||||.||
Mouse   627 SPLPTFHFQRLLSNLTALSIWTSGQGPGHSGQVLLCEVQLTSAWPQRELAPPASWVETCLCPQGY 691

  Fly   822 TGLSCEGCAFGFKRIYENTSDHQILSKCIPCPCNGHSNSCDLQSGNCGDCMHNTFGDRCERCQLG 886
            ||..||.||.|:||...:...:   :.||||.||.| .:||..:|.| .|.|:|.|..||||..|
Mouse   692 TGQFCEFCALGYKREIPHGGPY---ANCIPCTCNQH-GTCDPNTGIC-LCGHHTEGPSCERCMPG 751

  Fly   887 YYGNPLQGTPNDCKRCACPLSEDSNNFSPSCQLKSYNYMDLNPQFELIEHAEYICTQCPEGYTGD 951
            :|||...|..:||:.|.||       ...:|.             .:.|..:.:||.||.|..|.
Mouse   752 FYGNAFSGRADDCQPCPCP-------GQSACA-------------TIPESGDVVCTHCPPGQRGR 796

  Fly   952 HCQVCDDGYFGNP------RQPGSSCQRCDCAGGPCNVTTGECITCRGNTEGWHCERCKLGYWGD 1010
            .|:.|:||:||:|      .||   |:||.|:|                                
Mouse   797 RCESCEDGFFGDPLGLSGAPQP---CRRCQCSG-------------------------------- 826

  Fly  1011 PAVGCDPCHCHTEGSESGLCDSTDGQCLCKPRYAGQKCDECDVGYANVELRCPSCNCDPLGSLVQ 1075
                                                          ||:|       :.:|:   
Mouse   827 ----------------------------------------------NVDL-------NAVGN--- 835

  Fly  1076 DRCDPHTGQC-HCKEGVMGAKCHECQDGYFGMNAVAYRMDDLAALRQNSDSDDDEWELVPDTEDP 1139
              ||||:|.| .|.....||.|..|::|::| :|||.|..|                        
Mouse   836 --CDPHSGHCLRCLYNTTGAHCEHCREGFYG-SAVATRPVD------------------------ 873

  Fly  1140 NSESTVACEECHCSSVGSLS-SDCDKRTGQCACLANVTGRRCDKCRPGHWNLTAGEGCRDCRCDP 1203
                  .|..|.|...||:| ..|:..||||.||..|:||.|.:|.||.::|.:|.||:.|:|.|
Mouse   874 ------KCAPCSCDLRGSVSEKTCNPVTGQCVCLPYVSGRDCSRCSPGFYDLQSGRGCQSCKCHP 932

  Fly  1204 HGSRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRCSACRSEGQVCDPHNGRCICPK 1268
            .||..::|:|.||||.|:.||.||.|:.|..||||||.:                          
Mouse   933 LGSLENKCHPKTGQCPCRPGVTGQACDRCQLGFFGFSIK-------------------------- 971

  Fly  1269 FTRGLGCGQCVPGTWGWQARLGCRECECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFG 1333
                                 |||:|.|..:|:...||.. :..|.||.|:.|.|||.|      
Mouse   972 ---------------------GCRDCRCSPLGAASSQCHE-NSTCVCRPGFVGYKCDRC------ 1008

  Fly  1334 YPECRRCGCDAEGSFTQADGSIACDSNGQCP-CKSLV----VGLKCDTCMQSTFGLSAQNPEG-C 1392
                       :.:|..|||...|.   :|| |.:||    ..||....:.          || .
Mouse  1009 -----------QDNFFLADGDTGCQ---ECPTCYALVKEEAAKLKARLMLM----------EGWL 1049

  Fly  1393 TRCFC---FG----RSGECEQSDLSWGHIRMAESRNLSVQQI 1427
            .|..|   :|    ..||....|:..||..:.|:|...:||:
Mouse  1050 QRSDCGSPWGPLDILQGEAPLGDVYQGHHLLQETRGTFLQQM 1091

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 164..396 CDD:278484 67/239 (28%)
EGF_Lam 401..450 CDD:238012 24/53 (45%)
TNFRSF <407..507 CDD:304602 46/109 (42%)
EGF_Lam 505..552 CDD:238012 16/49 (33%)
Laminin_EGF 550..597 CDD:278482 23/46 (50%)
Laminin_B 660..798 CDD:278481 28/137 (20%)
EGF_Lam 851..900 CDD:238012 23/48 (48%)
Laminin_EGF <943..971 CDD:278482 13/33 (39%)
VSP 953..1414 CDD:146106 122/481 (25%)
Laminin_EGF 974..1018 CDD:278482 3/43 (7%)
EGF_Lam 1017..1065 CDD:238012 3/47 (6%)
Laminin_EGF 1065..>1105 CDD:278482 13/40 (33%)
EGF_Lam 1150..1197 CDD:238012 22/47 (47%)
Laminin_EGF 1199..1247 CDD:278482 24/47 (51%)
EGF_Lam 1247..1292 CDD:238012 1/44 (2%)
Laminin_EGF 1294..1342 CDD:278482 14/47 (30%)
Laminin_EGF 1340..1392 CDD:278482 14/57 (25%)
Laminin_B 1486..1611 CDD:278481
EGF_Lam 1669..1716 CDD:238012
Laminin_EGF 1718..1767 CDD:278482
EGF_Lam 1772..1819 CDD:238012
CrfC <1933..2267 CDD:223771
Laminin_II 2277..2400 CDD:283628
LamG 2399..>2492 CDD:304605
Laminin_G_2 2616..2755 CDD:280389
Laminin_G_2 2804..2944 CDD:280389
Laminin_G_2 3038..3169 CDD:280389
LamG 3192..3347 CDD:238058
Lamc3NP_035966.2 Laminin_N 53..278 CDD:278484 69/242 (29%)
EGF_Lam 279..326 CDD:238012 23/47 (49%)
Laminin_EGF 336..392 CDD:278482 25/58 (43%)
EGF_Lam 391..437 CDD:238012 14/45 (31%)
Laminin_EGF 439..486 CDD:278482 23/46 (50%)
Laminin_B 550..669 CDD:278481 31/157 (20%)
EGF_Lam 718..765 CDD:238012 23/48 (48%)
EGF_Lam 766..814 CDD:238012 18/67 (27%)
Laminin_EGF 822..>864 CDD:278482 19/131 (15%)
Laminin_EGF 878..925 CDD:278482 21/46 (46%)
Laminin_EGF 928..976 CDD:278482 27/94 (29%)
EGF_Lam 976..1022 CDD:238012 18/63 (29%)
Domain II and I 1025..1581 20/77 (26%)
Laminin_I 1225..1470 CDD:283627
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1382..1413
GluZincin 1433..>1506 CDD:301352
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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