DRSC/TRiP Functional Genomics Resources

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Protein Alignment wb and LAMB4

DIOPT Version :10

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:XP_011514277.1 Gene:LAMB4 / 22798 HGNCID:6491 Length:1772 Species:Homo sapiens


Alignment Length:2291 Identity:489/2291 - (21%)
Similarity:769/2291 - (33%) Gaps:865/2291 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   165 QISVNATCGQNGAEEYC---KQVGAKPCGICNAH----SSDRAKQRSIQSLISSGSGSGSGSGFE 222
            |:..::|||.:.|::||   ...|.:.|.||::.    ..|:....:|:::|.|.....     |
Human    42 QLMASSTCGLSRAQKYCILSYLEGEQKCFICDSRFPYDPYDQPNSHTIENVIVSFEPDR-----E 101

  Fly   223 EGWWQSPTLQGGRQFEYVTILLDLKQTFQIFSVWLKSANSPRPASWILEKSLD-GINFEPWQYFG 286
            :.||||   :.|  .::|:|.|||:..|: ||..:.:..:.|||:.::|:|.| |.|::.::||.
Human   102 KKWWQS---ENG--LDHVSIRLDLEALFR-FSHLILTFKTFRPAAMLVERSTDYGHNWKVFKYFA 160

  Fly   287 LSDADCQRRW-NL-SGQNGKYVFQNDTEIICSTQFSKPGPLENG-----VLHASLLKNRPGATDQ 344
               .||...: |: |||     .|...:|:|.:::|...|...|     ||..|.....|    .
Human   161 ---KDCATSFPNITSGQ-----AQGVGDIVCDSKYSDIEPSTGGEVVLKVLDPSFEIENP----Y 213

  Fly   345 SPELMKFITTRYIRIRLQGMHSTANQDNSLDWLL---DSPSLEKHSFYSLSQLKVSARLDCNGHA 406
            ||.:...:|...:||....:|:..      |.||   .:.||:|: :|:|.::.|.....|||||
Human   214 SPYIQDLVTLTNLRINFTKLHTLG------DALLGRRQNDSLDKY-YYALYEMIVRGSCFCNGHA 271

  Fly   407 NRSHE---------SPDDPLM---QCICQHNTCGAQCEQCCPLFQDRPYQMGGE-----CEICQC 454
            :....         ||  |.|   ||:|||||.|..||:|...|||.|::...:     |..|.|
Human   272 SECRPMQKMRGDVFSP--PGMVHGQCVCQHNTDGPNCERCKDFFQDAPWRPAADLQDNACRSCSC 334

  Fly   455 YGHAESCTYDPF-------LDKGICQSCSNNTAGIECEFCEMGFYRELDAPLTDP--CLPCSCNP 510
            ..|:..|.:|..       |..|:|:.|.:||.|..|:.|...|||:....::||  |:||.|:|
Human   335 NSHSSRCHFDMTTYLASGGLSGGVCEDCQHNTEGQHCDRCRPLFYRDPLKTISDPYACIPCECDP 399

  Fly   511 ARSTGG--CQSD--------GGSCNCLEGFQGKNCEECAPGYYGDD------CKRCECDERGSLG 559
            ..:..|  |.|.        .|.|.|.|..:|..|::|.|.:||..      |:.|:|:..|||.
Human   400 DGTISGGICVSHSDPALGSVAGQCLCKENVEGAKCDQCKPNHYGLSATDPLGCQPCDCNPLGSLP 464

  Fly   560 STGSC---SGVCQCKLNVEGSTCSECAPGYFDLSAENAEGCTSCWC---SGVSQTCHSAKLQTLA 618
            .. :|   :|.|.|...|.|:.|.||..||:.| ..:..||:.|.|   ...|..|.....|...
Human   465 FL-TCDVDTGQCLCLSYVTGAHCEECTVGYWGL-GNHLHGCSPCDCDIGGAYSNVCSPKNGQCEC 527

  Fly   619 FETLNDWKITDIQRVKPISIPVDAETNRLIFANELDEVEAIYWQASLGYLGNRLTSYGSRLQLVL 683
            ..     .:|.....:|......|..|..::  |.:|...:   ..|..||:........:.:||
Human   528 RP-----HVTGRSCSEPAPGYFFAPLNFYLY--EAEEATTL---QGLAPLGSETFGQSPAVHVVL 582

  Fly   684 SWDVIRGDRSGKPTTGPNVILVGKNGLKIAFGDESLDGLGINLNV----------------TLTE 732
                      |:|..|..|...|....::      |.|.|:...|                |.:.
Human   583 ----------GEPVPGNPVTWTGPGFARV------LPGAGLRFAVNNIPFPVDFTIAIHYETQSA 631

  Fly   733 VGW-------------YHVPPTV--------VDIKTRL---------------------RRTEGG 755
            ..|             :.:|.|:        :...||:                     .:...|
Human   632 ADWTVQIVVNPPGGSEHCIPKTLQSKPQSFALPAATRIMLLPTPICLEPDVQYSIDVYFSQPLQG 696

  Fly   756 DYHGESVTRSQFLSVLVSLDA------------------VLIRAAFHTDQGETSLERAVI----- 797
            :.|..|......|.::..:::                  |.|.:|........:.||.:|     
Human   697 ESHAHSHVLVDSLGLIPQINSLENFCSKQDLDEYQLHNCVEIASAMGPQVLPGACERLIISMSAK 761

  Fly   798 -YSGGV---------------ELGGKSS------------------------------------- 809
             :.|.|               .|||:..                                     
Human   762 LHDGAVACKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDRCSTGSYDLGHHGCHPCHCHPQGSKD 826

  Fly   810 ---SQVE-QCLCPAGYTGLSCEGCA---FGFKRIYENTSDHQILSKCIPCPCNGHSNSCDLQSGN 867
               .||. ||.|....:|..|:.|.   |||             ..|.|||||..:..||.::|:
Human   827 TVCDQVTGQCPCHGEVSGRRCDRCLAGYFGF-------------PSCHPCPCNRFAELCDPETGS 878

  Fly   868 CGDCMHNTFGDRCERCQLGYYGNPLQGTPNDCKRCACPLSEDSNN-FSPSCQLKSYNYMDLNPQF 931
            |.:|...|.|..||||..||||||..|.|  |:.|.||....||. |:.||             :
Human   879 CFNCGGFTTGRNCERCIDGYYGNPSSGQP--CRPCLCPDDPSSNQYFAHSC-------------Y 928

  Fly   932 ELIEHAEYICTQCPEGYTGDHCQVCDDGYFGNPRQPGSSCQRCDCAGG-------PCNVTTGECI 989
            :.:..::.|| .|.:||||..|..|..|::||||..|:.||.|.|...       .|:..||||:
Human   929 QNLWSSDVIC-NCLQGYTGTQCGECSTGFYGNPRISGAPCQPCACNNNIDVTDPESCSRVTGECL 992

  Fly   990 TCRGNTEGWHCERCKLGYWGDPAVG--CDPCHCHTEGSESGLCDSTDGQCLCKPRYAGQKCDECD 1052
            .|..||:|.:|:.||.|::|. |:.  |..|.||..|.....|....|.||              
Human   993 RCLHNTQGANCQLCKPGHYGS-ALNQTCRRCSCHASGVSPMECPPGGGACL-------------- 1042

  Fly  1053 VGYANVELRCPSCNCDPLGSLVQDRCDPHTGQCHCKEGVMGAKCHECQDGYFGMNAVAYRMDDLA 1117
                          |||:                                               
Human  1043 --------------CDPV----------------------------------------------- 1046

  Fly  1118 ALRQNSDSDDDEWELVPDTEDPNSESTVACEECHCSSVGSLSSDCDKRTGQCACLANVTGRRCDK 1182
                                                            ||.|.||.||||..||:
Human  1047 ------------------------------------------------TGACPCLPNVTGLACDR 1063

  Fly  1183 CRPGHWNLTAGEGCRDCRCDPHGSRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRC 1247
            |..|:|||..|.||:.|.|||..|:...|:..||||.||:|.||:.|:||.|.::|         
Human  1064 CADGYWNLVPGRGCQSCDCDPRTSQSSHCDQLTGQCPCKLGYGGKRCSECQENYYG--------- 1119

  Fly  1248 SACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPGTWGWQARLGCRECECDHIGSIGQQCSTGDGQ 1312
                      ||.               |:|:|             |:|:..|:....|....|.
Human  1120 ----------DPP---------------GRCIP-------------CDCNRAGTQKPICDPDTGM 1146

  Fly  1313 CQCREGYSGRKCDTCAIGYFGYPECRRCGCDAEGSFTQADGSIACDSNGQCPCKSLVVGLKCDTC 1377
            |:||||.||::||.||.|:                            :.:.|           ||
Human  1147 CRCREGVSGQRCDRCARGH----------------------------SQEFP-----------TC 1172

  Fly  1378 MQSTFGLSAQNPEGCTRCFCFGRSGECEQSDLSWGHIRMAESRNLSVQQIRPHSVPSSD-YEYIV 1441
            :|            |..||        :|    |.|  ...|.:.:||.:...:....| .|.:.
Human  1173 LQ------------CHLCF--------DQ----WDH--TISSLSKAVQGLMRLAANMEDKRETLP 1211

  Fly  1442 VVQMEGSSFHREDAEIQRMNDLSLVPKSTGNVSIGAYGQFYHPLYFQLPPQFYGDRTSSYGGFLY 1506
            |.:.:........:||:|:                    ..||::    |.         |.||.
Human  1212 VCEADFKDLRGNVSEIERI--------------------LKHPVF----PS---------GKFLK 1243

  Fly  1507 FTLITEGAHKPLERNILGQYPLVQLHAHSKLLLDFYE-------------------YEEFEYSLN 1552
                .:..|..:.|.|:      ||:...|.:.:|.:                   .||.:...:
Human  1244 ----VKDYHDSVRRQIM------QLNEQLKAVYEFQDLKDTIERAKNEADLLLEDLQEEIDLQSS 1298

  Fly  1553 VTHR--VPLHESFWKYHHTSQAVD----------------RNTLMAALQNIRHIFIRAFAFADFQ 1599
            |.:.  ....|:..||:|.|.:.:                ||.|:..|..:..            
Human  1299 VLNASIADSSENIKKYYHISSSAEKKINETSSTINTSANTRNDLLTILDTLTS------------ 1351

  Fly  1600 EVVLQNVHMDAAIYIKGSTNLIAKGVERCKCP--KRFDGLSCQDPGRSFYRWRNTTIVESVFIED 1662
                           ||  ||..:.:::.|.|  :..:...|.|||       |...|       
Human  1352 ---------------KG--NLSLERLKQIKIPDIQILNEKVCGDPG-------NVPCV------- 1385

  Fly  1663 LIGRAAPCH---CNGRSSDCDRETGVCQNCRGNTGGDHCHQCAEGFYGDPNSPHGCQACPCPETN 1724
                ..||.   |.||...        :.|||                     .||.......||
Human  1386 ----PLPCGGALCTGRKGH--------RKCRG---------------------PGCHGSLTLSTN 1417

  Fly  1725 ------------RNFARGCNVWDGEVSCVCKPGYTGRLCERCQAGYFGDPMRYPNTTCQPCNCHP 1777
                        ||..:.......::..:.:.....:                 |...|      
Human  1418 ALQKAQEAKSIIRNLDKQVRGLKNQIESISEQAEVSK-----------------NNALQ------ 1459

  Fly  1778 DGIQTEGCDVETGRCYCREGVTGLKCDKCQAERHHLVDNGCKICDNCTLLLLDYMELVGN----- 1837
                            .||.:..::......|            :|..|    :::.|.|     
Human  1460 ----------------LREKLGNIRNQSDSEE------------ENINL----FIKKVKNFLLEE 1492

  Fly  1838 --------KLRRGMHNMDLTGIPAPYRKLSEYESAYEKWNGRHWDFSQTKRRL-QDYDSADILKL 1893
                    |:..|:.::.|   |.|.:.|::.....:|......|:...:.|| ::.|.|..|.:
Human  1493 NVPPEDIEKVANGVLDIHL---PIPSQNLTDELVKIQKHMQLCEDYRTDENRLNEEADGAQKLLV 1554

  Fly  1894 EAHAENLKFQSRKAVATIGKREFAIKSMREDAVTQQHSVGLLRSEILQTLSDLHGYGKSAHYLSL 1958
            :|.|      :.||...:...:..:..:::..:||    |...|.|.|..:::....|:.  |..
Human  1555 KAKA------AEKAANILLNLDKTLNQLQQAQITQ----GRANSTITQLTANITKIKKNV--LQA 1607

  Fly  1959 PTALKQARFYLQAIREHDQMVQGIRSTNDCAWKHFYAMGNA---SDASFDESGRLEMLWRDLNQT 2020
            ....::.:..|:..::...:..|:........:|.....||   ::::..::|.||..:.:|.: 
Human  1608 ENQTREMKSELELAKQRSGLEDGLSLLQTKLQRHQDHAVNAKVQAESAQHQAGSLEKEFVELKK- 1671

  Fly  2021 NHRVVDMRLQ--------VDRVQEVENEAEDVLEHVRNLSIRVGESHQELDELNQRISDHLDPGY 2077
            .:.::..:..        :.:|:::::.||.:          .|::..::    :||:   ||..
Human  1672 QYAILQRKTSTTGLTKETLGKVKQLKDAAEKL----------AGDTEAKI----RRIT---DPCI 1719

  Fly  2078 LEQGEGLLRLTVQRQIMLNGHLNQLDGYRILLNTTLGVKTEQQREVRKHWLPKAEKHASHLLARS 2142
            |..| |.:....:|....: ||...:|||                                 |.|
Human  1720 LPIG-GSISFHCRRHSSAS-HLRGFNGYR---------------------------------ANS 1749

  Fly  2143 NEYA-RKFQPTRNGAR 2157
            ||.| |:.:..||.:|
Human  1750 NERALRRVRYYRNPSR 1765

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 153..398 CDD:459653 70/250 (28%)
EGF_Lam 401..450 CDD:238012 24/65 (37%)
EGF_Lam 505..552 CDD:238012 19/62 (31%)
Laminin_EGF 550..597 CDD:395007 17/49 (35%)
Laminin_B 660..813 CDD:459652 36/289 (12%)
EGF_Lam 851..900 CDD:238012 24/48 (50%)
Laminin_EGF <943..971 CDD:395007 13/27 (48%)
Laminin_EGF 974..1018 CDD:395007 18/52 (35%)
EGF_Lam 1017..1065 CDD:238012 8/47 (17%)
Laminin_EGF 1065..>1105 CDD:395007 3/39 (8%)
EGF_Lam 1150..1197 CDD:238012 18/46 (39%)
Laminin_EGF 1199..1247 CDD:395007 20/47 (43%)
EGF_Lam 1247..1292 CDD:238012 5/44 (11%)
Laminin_EGF 1294..1342 CDD:395007 17/47 (36%)
Laminin_EGF 1340..1392 CDD:395007 4/51 (8%)
Laminin_B 1486..1626 CDD:459652 27/176 (15%)
EGF_Lam 1669..1716 CDD:238012 9/49 (18%)
Laminin_EGF 1718..1767 CDD:395007 4/60 (7%)
EGF_Lam 1772..1819 CDD:238012 3/46 (7%)
YhaN <1907..2141 CDD:443752 35/244 (14%)
SMC_prok_B <2123..>2390 CDD:274008 9/36 (25%)
Laminin_II 2279..2400 CDD:368703
LamG 2399..>2492 CDD:473984
LamG 2586..2753 CDD:238058
Laminin_G_2 2804..2944 CDD:460494
LamG 3018..3167 CDD:238058
LamG 3192..3347 CDD:238058
LAMB4XP_011514277.1 Laminin_N 28..263 CDD:459653 70/250 (28%)
EGF_Lam 264..320 CDD:238012 24/57 (42%)
Laminin_EGF 332..382 CDD:395007 17/49 (35%)
Laminin_EGF 395..452 CDD:395007 16/56 (29%)
EGF_Lam 454..503 CDD:238012 17/50 (34%)
EGF_Lam 505..549 CDD:238012 8/48 (17%)
EGF_Lam 768..809 CDD:238012 3/40 (8%)
Laminin_EGF 822..865 CDD:395007 14/55 (25%)
EGF_Lam 862..909 CDD:238012 24/48 (50%)
Laminin_EGF 970..>1012 CDD:395007 15/41 (37%)
Laminin_EGF 1033..1077 CDD:395007 24/166 (14%)
Laminin_EGF 1080..1128 CDD:395007 25/94 (27%)
EGF_Lam 1127..>1165 CDD:238012 17/50 (34%)
Mplasa_alph_rch 1254..>1714 CDD:275316 90/626 (14%)
Blue background indicates that the domain is not in the aligned region.

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