DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wb and Lamc1

DIOPT Version :9

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:NP_034813.2 Gene:Lamc1 / 226519 MGIID:99914 Length:1607 Species:Mus musculus


Alignment Length:2272 Identity:517/2272 - (22%)
Similarity:795/2272 - (34%) Gaps:846/2272 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 PPLFNVVPRAQISVNATCGQNGAEEYCKQVG----AKPCGICNAHSSDRAKQRSIQSLISSGSGS 215
            |...|......:....||| ...||||.|.|    .|.|.:|:      |.|:.:|         
Mouse    50 PEFVNAAFNVTVVATNTCG-TPPEEYCVQTGVTGVTKSCHLCD------AGQQHLQ--------- 98

  Fly   216 GSGSGF--------EEGWWQSPTLQGGRQF-EYVTILLDLKQTFQIFSVWLKSANSPRPASWILE 271
             .|:.|        :..||||.|:..|.|: ..:.:.|.|.:.|.|..|.||...| ||.|:.:.
Mouse    99 -HGAAFLTDYNNQADTTWWQSQTMLAGVQYPNSINLTLHLGKAFDITYVRLKFHTS-RPESFAIY 161

  Fly   272 KSL--DGINFEPW---QYFGLSDADCQRRWNLSGQNGKYVFQNDTEIICSTQFSKPGPLENGVLH 331
            |..  ||    ||   ||:   ...|:..::.:.:.......::.:.:|:.:||...||..|.:.
Mouse   162 KRTREDG----PWIPYQYY---SGSCENTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGNVA 219

  Fly   332 ASLLKNRPGA--TDQSPELMKFITTRYIRIRLQGMHSTANQDNSL-DWLLDSPSLEKHSFYSLSQ 393
            .|.|:.||.|  .|.||.|.:::|...||:       |.|:.|:. |.:.:.|.:.|..:|::|.
Mouse   220 FSTLEGRPSAYNFDNSPVLQEWVTATDIRV-------TLNRLNTFGDEVFNDPKVLKSYYYAISD 277

  Fly   394 LKVSARLDCNGHANRSHESPDDPLMQCICQHNTCGAQCEQCCPLFQDRPY-----QMGGECEICQ 453
            ..|..|..|||||:...::..|.|| |.|:|||.|..||:|.|.|.|||:     :...||..|.
Mouse   278 FAVGGRCKCNGHASECVKNEFDKLM-CNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCD 341

  Fly   454 CYGHAESCTYDPFLDK-----GICQSCSNNTAGIECEFCEMGFYRELDAPLTDPCLPCSCNPARS 513
            |.|.::.|.:||.|.:     |.|.:|.:||.|.:||.|...|:|   ...|:.|.||.|:|..|
Mouse   342 CNGRSQECYFDPELYRSTGHGGHCTNCRDNTDGAKCERCRENFFR---LGNTEACSPCHCSPVGS 403

  Fly   514 TGGCQSDGGSCNCLEGFQGKNCEECAPGYYG---DDCKRCECDERGSLGSTGSCSGVCQCKLNVE 575
            ........|.|:|..|..|..|:.|.||::.   ..|:.|.||..||.......:|.|.||.|||
Mouse   404 LSTQCDSYGRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPCSCDPSGSTDECNVETGRCVCKDNVE 468

  Fly   576 GSTCSECAPGYFDLSAENAEGCTSCWCSGVSQTCHSAKLQTL-----AFETLND-WKITDIQRVK 634
            |..|..|.||:|:|.:.|.:|||.|:|.|.|..|.:|...::     .|:...| |::.  ||  
Mouse   469 GFNCERCKPGFFNLESSNPKGCTPCFCFGHSSVCTNAVGYSVYDISSTFQIDEDGWRVE--QR-- 529

  Fly   635 PISIPVDAETNRLIFANELDEVEAI-------YWQASLGYLGNRLTSYGSRLQLVLSWDVIRGDR 692
                  |.....|.::::..::..|       |:.|.:.:|||::.|||..|.  .|:.|.|.| 
Mouse   530 ------DGSEASLEWSSDRQDIAVISDSYFPRYFIAPVKFLGNQVLSYGQNLS--FSFRVDRRD- 585

  Fly   693 SGKPTTGPNVILVGKNGLKIAFGDESLDGLGINLNVTLTEVGWYHVPPTVVDIKTRLRRTEGGDY 757
                             .:::..|..|:|.|:.::|.|...|  :..|:...:|...|..|..||
Mouse   586 -----------------TRLSAEDLVLEGAGLRVSVPLIAQG--NSYPSETTVKYIFRLHEATDY 631

  Fly   758 HGE-SVTRSQFLSVLVSLDAVLIRAAFHTDQGETSLERAVIYSGGVEL------GGKSSSQVEQC 815
            ... :::..:|..:|.:|.::.||..:.        ||:..|...|.|      .|..::.||.|
Mouse   632 PWRPALSPFEFQKLLNNLTSIKIRGTYS--------ERSAGYLDDVTLQSARPGPGVPATWVESC 688

  Fly   816 LCPAGYTGLSCEGCAFGFKRIYENTSDHQILSKCIPCPCNGHSNSCDLQSGNCGDCMHNTFGDRC 880
            .||.||.|..||.|..|::|   .|......|.|:.|.|||||.:||.::|.| ||..||.|..|
Mouse   689 TCPVGYGGQFCETCLPGYRR---ETPSLGPYSPCVLCTCNGHSETCDPETGVC-DCRDNTAGPHC 749

  Fly   881 ERCQLGYYGNPLQGTPNDCKRCACPLSEDSNNFSPSCQLKSYNYMDLNPQFELIEHAEYICTQCP 945
            |:|..||||:...||.:||:.|.||       ...||.:             :.:..|.:||.||
Mouse   750 EKCSDGYYGDSTLGTSSDCQPCPCP-------GGSSCAI-------------VPKTKEVVCTHCP 794

  Fly   946 EGYTGDHCQVCDDGYFGNP---RQPGSSCQRCDC-------AGGPCNVTTGECITCRGNTEGWHC 1000
            .|..|..|::|||||||:|   ..|...|:.|.|       |.|.||..||||:.|..||.|::|
Mouse   795 TGTAGKRCELCDDGYFGDPLGSNGPVRLCRPCQCNDNIDPNAVGNCNRLTGECLKCIYNTAGFYC 859

  Fly  1001 ERCKLGYWGDPAVGCDPCHCHTEGSESGLCDSTDGQCLCKPRYAGQKCDECDVGYANVELRCPSC 1065
            :|||.|::|:|..                                          .|...:|.:|
Mouse   860 DRCKEGFFGNPLA------------------------------------------PNPADKCKAC 882

  Fly  1066 NCDPLGSLVQDRCDPHTGQCHCKEGVMGAKCHECQDGYFGMNAVAYRMDDLAALRQNSDSDDDEW 1130
            .|:|.|::.|                                                       
Mouse   883 ACNPYGTVQQ------------------------------------------------------- 892

  Fly  1131 ELVPDTEDPNSESTVACEECHCSSVGSLSSDCDKRTGQCACLANVTGRRCDKCRPGHWNLTAGEG 1195
                                        .|.|:..||||.||.:|:||.|..|.||::||.:|:|
Mouse   893 ----------------------------QSSCNPVTGQCQCLPHVSGRDCGTCDPGYYNLQSGQG 929

  Fly  1196 CRDCRCDPHGSRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRCSACRSEGQVCDPH 1260
            |..|.|...||...:|:..||||:|:.|:.||||..|....|||..|                  
Mouse   930 CERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCETNHFGFGPE------------------ 976

  Fly  1261 NGRCICPKFTRGLGCGQCVPGTWGWQARLGCRECECDHIGSIGQQCSTGDGQCQCREGYSGRKCD 1325
                                         ||:.|:|.|.||:..||.. ||:|:||||:.|.:||
Mouse   977 -----------------------------GCKPCDCHHEGSLSLQCKE-DGRCECREGFVGNRCD 1011

  Fly  1326 TCAIGYF---GYPECRRCGCDAEGSFTQADGSIACDSNGQCPCKSLVVGLKCDTCMQSTFGLSAQ 1387
            .|...||   .:|.|:                       :||.                      
Mouse  1012 QCEENYFYNRSWPGCQ-----------------------ECPA---------------------- 1031

  Fly  1388 NPEGCTRCFCFGRSGECEQSDLSWGHIRMAESRNLSVQQIRPHSVPSSDYEYIVVVQMEGSSFHR 1452
                     |:                      .|...::..|.|...:.|.::           
Mouse  1032 ---------CY----------------------RLVKDKVAEHRVKLQELESLI----------- 1054

  Fly  1453 EDAEIQRMNDLSLVPKSTGNVSIGAYGQFYHPLYFQLPPQFYGDRTSSYGGFLYFTLITEGAHKP 1517
              |.:...:|:                         :..|.:.||.                 |.
Mouse  1055 --ANLGTGDDM-------------------------VTDQAFEDRL-----------------KE 1075

  Fly  1518 LERNILGQYPLVQLHAHSKLLLDFYEYEEFEYSLNVTHRVPLHESFWKYHHTSQAVDRNTLMAAL 1582
            .||.:            :.||.:..|.::                          ||:| ||..|
Mouse  1076 AEREV------------TDLLREAQEVKD--------------------------VDQN-LMDRL 1101

  Fly  1583 QNIR---HIFIRAFAFADFQEVVLQNVHMDAAIYIKGSTNLIAKGVERCKCPKRFDGLSCQDPGR 1644
            |.:.   |..|..          |||:                                      
Mouse  1102 QRVNSSLHSQISR----------LQNI-------------------------------------- 1118

  Fly  1645 SFYRWRNTTIVESVFIEDLIGRAAPCHCNGRSSDCDRETGVCQNCRGNTGGDHCHQCAEGFYGDP 1709
                 |||       ||                    |||:... |..:..:...|..|      
Mouse  1119 -----RNT-------IE--------------------ETGILAE-RARSRVESTEQLIE------ 1144

  Fly  1710 NSPHGCQACPCPETNRNFARGCNVWDGEVSCVCKPGYTGRLCERCQAGYFGDPMRYPNTTCQPCN 1774
                                                ...|..|:.:.......:..|.:|.:|  
Mouse  1145 ------------------------------------IASRELEKAKMAAANVSITQPESTGEP-- 1171

  Fly  1775 CHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQAERHHLVDNGCKICDNCTLLLLDYMELVGNKL 1839
                                                           :|.|||..:         
Mouse  1172 -----------------------------------------------NNMTLLAEE--------- 1180

  Fly  1840 RRGMHNMDLTGIPAPYRKLSEYESAYEKWNGRHWDFSQTKRRLQDYDSADILKL-------EAHA 1897
                           .|||:|                   |..|:.|  ||:::       .|.|
Mouse  1181 ---------------ARKLAE-------------------RHKQEAD--DIVRVAKTANETSAEA 1209

  Fly  1898 ENLKFQSRKAVATIGKREFAIKSMREDAVTQQHSVGLLRSEILQTLSDLHGYGKSAHYLSLPTAL 1962
            .||..::     ..|:.:.|::                       :.:|:...:.|..:|.....
Mouse  1210 YNLLLRT-----LAGENQTALE-----------------------IEELNRKYEQAKNISQDLEK 1246

  Fly  1963 KQARFYLQAIREHDQMVQGIRSTNDCAWKHFYAMGNA-----SDASFDESGRLEMLWRDLNQTNH 2022
            :.||.:.:|.|..|:.|:            .||....     |:|..:|:.:::....||:    
Mouse  1247 QAARVHEEAKRAGDKAVE------------IYASVAQLTPVDSEALENEANKIKKEAADLD---- 1295

  Fly  2023 RVVDMRLQVDRVQEVENEAEDV--LEH-VRNLSIRVGESHQELDELNQRISDHLDPGYLEQGEGL 2084
            |::|.:|     ::.|:..||:  .|| |:||..:.....|..|:|..|..  ......|:....
Mouse  1296 RLIDQKL-----KDYEDLREDMRGKEHEVKNLLEKGKAEQQTADQLLARAD--AAKALAEEAAKK 1353

  Fly  2085 LRLTVQRQIMLNGHLNQLDGYRILLNTTLGVKTEQQREVRKHWLPKAEKHASHLLARSNEYARKF 2149
            .|.|:|.   .|..||.|..:...:|..   ||..:..:|:  :|...:    .:|.:||..|: 
Mouse  1354 GRSTLQE---ANDILNNLKDFDRRVNDN---KTAAEEALRR--IPAINR----TIAEANEKTRE- 1405

  Fly  2150 QPTRNGARIAMLASSAHSNITEAINDA----RLASILAKERV---YEAQRTL-----YPSDGSSM 2202
                  |::|:  .:|.::.|||.|.|    |:||.:.|...   .:|:||.     ..::.:.|
Mouse  1406 ------AQLAL--GNAAADATEAKNKAHEAERIASAVQKNATSTKADAERTFGEVTDLDNEVNGM 1462

  Fly  2203 IERAKHSLHRSKQLQQEALKQMHKSNVLKDKLHRQEQQVEGIKSTIYDSGLRTNNISGQLQGLS- 2266
            :.:.:.:.:..|:.|.:|.:.|..:.:........|......|:::.....:.||:..||..|. 
Mouse  1463 LRQLEEAENELKKKQDDADQDMMMAGMASQAAQEAELNARKAKNSVSSLLSQLNNLLDQLGQLDT 1527

  Fly  2267 ---------DGSARRQAKDSLEMA--DRTGEQMRAELQKAK----DMQKSIQNMRNSFSNLE 2313
                     :||..: |||.::.:  ||....:.:|.:|.:    |..:.|..:.....|||
Mouse  1528 VDLNKLNEIEGSLNK-AKDEMKASDLDRKVSDLESEARKQEAAIMDYNRDIAEIIKDIHNLE 1588

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 164..396 CDD:278484 69/252 (27%)
EGF_Lam 401..450 CDD:238012 23/53 (43%)
TNFRSF <407..507 CDD:304602 40/109 (37%)
EGF_Lam 505..552 CDD:238012 16/49 (33%)
Laminin_EGF 550..597 CDD:278482 20/46 (43%)
Laminin_B 660..798 CDD:278481 33/138 (24%)
EGF_Lam 851..900 CDD:238012 25/48 (52%)
Laminin_EGF <943..971 CDD:278482 14/30 (47%)
VSP 953..1414 CDD:146106 106/473 (22%)
Laminin_EGF 974..1018 CDD:278482 21/50 (42%)
EGF_Lam 1017..1065 CDD:238012 2/47 (4%)
Laminin_EGF 1065..>1105 CDD:278482 5/39 (13%)
EGF_Lam 1150..1197 CDD:238012 19/46 (41%)
Laminin_EGF 1199..1247 CDD:278482 20/47 (43%)
EGF_Lam 1247..1292 CDD:238012 1/44 (2%)
Laminin_EGF 1294..1342 CDD:278482 22/50 (44%)
Laminin_EGF 1340..1392 CDD:278482 2/51 (4%)
Laminin_B 1486..1611 CDD:278481 21/127 (17%)
EGF_Lam 1669..1716 CDD:238012 6/46 (13%)
Laminin_EGF 1718..1767 CDD:278482 2/48 (4%)
EGF_Lam 1772..1819 CDD:238012 1/46 (2%)
CrfC <1933..2267 CDD:223771 75/363 (21%)
Laminin_II 2277..2400 CDD:283628 9/43 (21%)
LamG 2399..>2492 CDD:304605
Laminin_G_2 2616..2755 CDD:280389
Laminin_G_2 2804..2944 CDD:280389
Laminin_G_2 3038..3169 CDD:280389
LamG 3192..3347 CDD:238058
Lamc1NP_034813.2 LamNT 42..282 CDD:214532 72/263 (27%)
EGF_Lam 283..328 CDD:238012 23/45 (51%)
Laminin_EGF 340..394 CDD:278482 19/56 (34%)
Laminin_EGF 396..443 CDD:278482 14/46 (30%)
Laminin_EGF 443..490 CDD:278482 20/46 (43%)
LamB 551..676 CDD:214597 36/154 (23%)
Laminin_EGF 722..761 CDD:278482 22/39 (56%)
EGF_Lam 770..818 CDD:238012 21/67 (31%)
Laminin_EGF 826..873 CDD:278482 21/88 (24%)
Laminin_EGF 882..930 CDD:278482 23/130 (18%)
EGF_Lam 933..978 CDD:214543 20/91 (22%)
EGF_Lam 980..1027 CDD:238012 21/47 (45%)
Domain II and I 1029..1607 154/997 (15%)
SPEC 1047..1252 CDD:295325 64/543 (12%)
MA 1089..1300 CDD:214599 65/498 (13%)
V_Alix_like 1178..>1310 CDD:187408 35/225 (16%)
DUF5089 1198..1403 CDD:293607 53/267 (20%)
SH3BP5 1359..1585 CDD:283045 52/247 (21%)
ATP-synt_B <1391..1503 CDD:304375 25/124 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.