DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wb and Ush2a

DIOPT Version :9

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:NP_067383.3 Gene:Ush2a / 22283 MGIID:1341292 Length:5193 Species:Mus musculus


Alignment Length:3091 Identity:567/3091 - (18%)
Similarity:852/3091 - (27%) Gaps:1436/3091 - (46%)


- Green bases have known domain annotations that are detailed below.


  Fly   162 PRAQISVNATCGQNGAEEYCKQVGAKPCGICNAHSSDRAKQRSIQ-SLISSGSGSGSGSGFEEGW 225
            ||...||...|..|||       |..|     .|...|....:.. |.|:....:.|        
Mouse   306 PRVHPSVQQYCIPNGA-------GDTP-----EHRMSRLNPEAHPLSFINDDDVATS-------- 350

  Fly   226 WQSPTLQGGRQ-FEYVTILLDLKQ-TFQIFSVWLKSANSPRPASWILEKSLDGINFEPWQYFGLS 288
            |.|.......| :|.|.|.:||:. .:|:..|..:.::....|..|..|..|...:|.||||.  
Mouse   351 WISHVFTNITQLYEGVAISIDLENGQYQVLKVITQFSSLQPVAIRIQRKKADSSPWEDWQYFA-- 413

  Fly   289 DADCQRRWNLSGQNGKYVFQNDTEIICSTQFSKPGPLENGVLHASLL----KNRPGATD--QSPE 347
                 |..::.|.......:|...:.| .|.....|..:|.:...||    |:|||..|  .|..
Mouse   414 -----RNCSVWGMKDNEDLENPNSVNC-LQLPDFIPFSHGNVTFDLLTSGQKHRPGYNDFYNSSV 472

  Fly   348 LMKFITTRYIRIRLQGMHSTANQDNSLDWLLDSPSLEKHSFYSLSQLKVSARLDCNGHANRSHES 412
            |.:|:....||:...|.:..|.  :::||        :|.:|::.::.||.|..|:|||.....:
Mouse   473 LQEFMRATQIRLHFHGQYYPAG--HTVDW--------RHQYYAVDEIIVSGRCQCHGHAETCDRT 527

  Fly   413 --PDDPLMQCICQ-HN-TCGAQCEQCCPLFQDRPYQMGG-----ECEICQCYGHAESCTYDPFLD 468
              |    .:|:|. |: |.|.||::|.||:.|:|::.|.     .|:.|||:|||.||.||..:|
Mouse   528 RRP----YRCLCSPHSFTEGPQCDRCSPLYNDKPFRSGDNVNAFNCKPCQCHGHASSCHYDASVD 588

  Fly   469 K----------GICQSCSNNTAGIECEFCEMGFYRELDAPLTDPCLPCSCNPARSTGGCQSDGGS 523
            .          |:|..|.::|.|..||.|:..|||.:.|   ||..|                  
Mouse   589 PFPLEHNRGGGGVCDDCQHHTTGRHCESCQDYFYRPVGA---DPAAP------------------ 632

  Fly   524 CNCLEGFQGKNCEECAPGYYGDDCKRCECDERGSLGSTGSC---SGVCQCKLNVEGSTCSECAPG 585
                                 |.||.|:|:..|:...:..|   .|.|.||..|.|..|.:|..|
Mouse   633 ---------------------DACKLCDCNRAGTRNGSLHCDPIGGQCDCKRRVSGRQCLQCQDG 676

  Fly   586 YFDLSAENAEGCTSCWCSGVSQTCHSAKLQTLAFETLNDWKITDIQRVKPISIPVDAETNRLIFA 650
            ::||.|.:.:||..|.|:                                               
Mouse   677 FYDLQALDPDGCRPCNCN----------------------------------------------- 694

  Fly   651 NELDEVEAIYWQASLGYLGNRLTSYGSRLQLVLSWDVIRGDRSGKPTTGPNVILVGKNGLKIAFG 715
                                                                             
Mouse   695 ----------------------------------------------------------------- 694

  Fly   716 DESLDGLGINLNVTLTEVGWYHVPPTVVDIKTRLRRTEGGDYHGESVTRSQFLSVLVSLDAVLIR 780
                                   |...||          ||                        
Mouse   695 -----------------------PSGTVD----------GD------------------------ 702

  Fly   781 AAFHTDQGETSLERAVIYSGGVELGGKSSSQVEQCLCPAGYTGLSCEGCAFGFKRIYENTSDHQI 845
            ...|.:.|                         ||.|.|...||.|..|.||||           
Mouse   703 ITCHQNSG-------------------------QCSCKANVIGLRCNRCNFGFK----------- 731

  Fly   846 LSKCIPCPCNGHSNSCDLQSGNCGDCMHNTFGDRCERCQLGYYGNPLQGTPNDCKRCACPLSEDS 910
                            .|||.|         ||.||.||                          
Mouse   732 ----------------FLQSFN---------GDGCEPCQ-------------------------- 745

  Fly   911 NNFSPSCQLKSYNYMDLNPQFELIEHAEYICTQCPEGYTGDHCQVCDDGYFGNPRQPGSSCQRCD 975
                  |.|.                                               ||..|.||
Mouse   746 ------CNLH-----------------------------------------------GSVNQLCD 757

  Fly   976 CAGGPCNVTTGECITCRGNTEGWHCERCKLGYWGDPAVGCDPCHCHTEGSESG-LCDSTDGQCLC 1039
            ...|.|        .|:...:|..|:.|:..::|.|...|:.|.|...||:.| :||:..|||:|
Mouse   758 PLSGQC--------ACKKEAKGLKCDSCRENFYGLPWSACEVCDCSKAGSQPGTVCDTETGQCVC 814

  Fly  1040 KPRYAGQKCDECDVGYANVELR----CPSCNCDPLGSLVQD-RCDPHTGQCHCKEGVMGAKCHEC 1099
            ||...|::|.:|..||.|:...    |.:|||:.:|::... |||..||||.||.||.|.:||:|
Mouse   815 KPNVGGRQCSQCKAGYFNLYQNDSHLCLTCNCEKMGTVNGSLRCDKSTGQCPCKLGVTGLRCHQC 879

  Fly  1100 QDGYFGMNAVAYRMDDLAALRQNSDSDDDEWELVPDTEDPNSESTVACEECHCSSVGSL-SSDCD 1163
            :...|.:.     ||                       :|.     .|:.|.|.|:|:| .|.||
Mouse   880 KPHRFNLT-----MD-----------------------NPQ-----GCQACDCDSLGTLPGSMCD 911

  Fly  1164 KRTGQCACLANVTGRRCDKCRPGHWNLTA-GEGCRDCRCDPHGSRGHECNPWTGQCDC-KIGVGG 1226
            ..:|||.||.:..||||::|:||.::..: ..||..|.|...|:..|.||..||||.| .....|
Mouse   912 PISGQCLCLPHRQGRRCEQCQPGFYSSPSNATGCLPCLCHTAGAVSHICNSVTGQCSCHDPSTTG 976

  Fly  1227 QHCNECTEGFFGFSTEGCQRCSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPGTWGWQARLGC 1291
            :.|::|.|.:|.|                  ||..||                           |
Mouse   977 RSCHQCQESYFRF------------------DPLTGR---------------------------C 996

  Fly  1292 RECECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFGYPECRRCGCDAEGSFTQADGSIA 1356
            |.|.| |:.                 |.|...||..                             
Mouse   997 RPCHC-HVA-----------------GASNGTCDAV----------------------------- 1014

  Fly  1357 CDSNGQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGCTRCFCFGRSGECEQSDLSWGHIRMAESRN 1421
               .|||.||..|.|.|||||:.....|...|..||::        ...|.....|.::.:.:.|
Mouse  1015 ---TGQCFCKEFVTGSKCDTCVPGASHLDVNNLLGCSK--------TPSQQPPPRGWVQSSSTIN 1068

  Fly  1422 LSVQQIRPHSVPSSDY-EYIVVVQMEGSSFHREDAEIQRMNDLSLVPKSTGNVSIGAYGQFYHPL 1485
            :|..   |...|::.: .|         :..|..:||....|                   .||.
Mouse  1069 VSWS---PPECPNAHWLTY---------TLFRNGSEIYTTED-------------------EHPY 1102

  Fly  1486 YFQLPPQFYGDRTSSYGGFLYFTLITEGAHKPLERNILGQYPLVQLHAHSKLLLDFYEY--EEFE 1548
            |.|   .|.....|.:..:.|:          :|.:        .:|:.::.:...||.  |..|
Mouse  1103 YTQ---YFLDTSLSPHTAYSYY----------IETS--------NVHSSTRSIPVIYETKPEVSE 1146

  Fly  1549 YSLNVTHRVPLHESFWKYHHTSQAVDRNTL-MAALQNIRHIFIRAFAFADFQEVVLQNVHMDAAI 1612
            ..||:||.:|:            ..|..|| ...|.|                            
Mouse  1147 GHLNLTHIIPV------------GSDSITLTWTGLSN---------------------------- 1171

  Fly  1613 YIKGSTNLIAKGVERCKCPKRFDGLSCQDPGRSFYRWRNTTIVESVFIEDLIGRAAPCHCNGRSS 1677
                |::.:||.|           |||             |.|:|                    
Mouse  1172 ----SSDPVAKYV-----------LSC-------------TPVDS-------------------- 1188

  Fly  1678 DCDRETGVCQNCRGNTGGDHCHQCAEGFYGDPNSPHGCQACPCPETNRNFARGCNVWD---GEVS 1739
                 |..|.:..|                             |||:      ..:|:   ....
Mouse  1189 -----TEPCVSYEG-----------------------------PETS------ATIWNLVPFTQY 1213

  Fly  1740 CVCKPGYTGRLCERCQAGYFGDPMRYPNTTCQPCNCHPDGIQTEGCDVETGRCYCREGVTGLKCD 1804
            |....|.|...|      ::..|:........|        ||:|                    
Mouse  1214 CFSVQGCTNESC------FYSLPIIVTTAQAPP--------QTQG-------------------- 1244

  Fly  1805 KCQAERHHLVDNGCKICDNCTLLLLDYMELVGNKLRRGMHNMDLTGIPAPYRKLSEYESAYEKWN 1869
                                                           |...              
Mouse  1245 -----------------------------------------------PPTV-------------- 1248

  Fly  1870 GRHWDFSQTKRRLQ---DYDSADILKLEAHAENLKFQSRKAVATIGKREFAIKSMREDAVTQQHS 1931
               |..|.|:.|::   ..||..|:      .:.:...|:.::|           .|..|.:.| 
Mouse  1249 ---WKISPTELRIEWSPPVDSNGII------ISYELYMRRWLST-----------EESLVFESH- 1292

  Fly  1932 VGLLRSEILQTLSDLHGYGKSAHYLSLPTALKQARFYLQAIREHDQMVQGIRSTNDCAWKHFYAM 1996
             ||:.|.     |.|.....|.:.|..|    ||..::..:..|.:....:.:.|          
Mouse  1293 -GLVSSH-----SALQSVNPSKNLLQQP----QASTFISGLEPHTEYAFRVLAVN---------- 1337

  Fly  1997 GNASDASFDESGRLEMLWRDLNQTNHRVVDMRLQVDRVQEVENEAEDVLEHVRNLSIRVGESHQE 2061
                     .:||:...|                                    .|.|.|||   
Mouse  1338 ---------MAGRVSSAW------------------------------------ASERTGES--- 1354

  Fly  2062 LDELNQRISDHLDPGYLEQGEGLLRLTVQRQIMLNGHLNQLDGYRILLNTTLGVKTEQQREVRKH 2126
                   :...:.|                                                   
Mouse  1355 -------VPVFMAP--------------------------------------------------- 1361

  Fly  2127 WLPKAEKHASHLLARSNEYARKFQPTRNGARIAMLASSAHSNITEAINDARLASILAKERVYEAQ 2191
              |.....:.|.|:.|.|     :|..|..|                                  
Mouse  1362 --PSVSPLSPHSLSVSWE-----KPAENFTR---------------------------------- 1385

  Fly  2192 RTLYPSDGSSMIERAKHSLHRSKQLQQEALKQMHKSNVLKDKLHRQEQQVEGIKSTIYDSGLRTN 2256
                                                                             
Mouse  1386 ----------------------------------------------------------------- 1385

  Fly  2257 NISGQLQGLSDGSARRQAKDSLEMADRTGEQMRAELQKAKDMQKSIQNMRNSFSNLEPDWEIKLG 2321
               |::.|                                                     .|:.
Mouse  1386 ---GEIIG-----------------------------------------------------YKIS 1394

  Fly  2322 MAQENISLTQTNLRLANVSLSYLEQQAEKEQQVFEVWNNSMAQQLQQLRDQIAKARHAAEAIDVS 2386
            |..|:..|....:                                     ..:|..|.|::.|.|
Mouse  1395 MVSEHFPLHDVPV-------------------------------------MCSKMVHFAKSQDQS 1422

  Fly  2387 LESLGPKCIRSYLPASYGLSTSNKIRMSFALSNHLESSPLIHLASSEGRHITLELYKRRVRLVWN 2451
            ....|.:..|:|               ||.:|          |..|.| .:|..|         .
Mouse  1423 YIVRGLEPYRTY---------------SFTVS----------LCDSVG-CVTSAL---------G 1452

  Fly  2452 LGGTTATVTHPMVVHTRDPKYDDAWYHVEANRTLNLGSLVVRRMNNYGELTPPNPVIITG-STDT 2515
            .|.|.|...                                      .:|.||   ::|| ::.|
Mouse  1453 SGQTLAAAP--------------------------------------AQLRPP---MVTGVNSTT 1476

  Fly  2516 EHTRFYQSRSDRISLGGFASKDLQFTPGLNVVVHQVEVDNKPLGLWNFVTSEGSCGGSMVGAKES 2580
            .|.|                    :.|...|        |.|..|::....:.|...:      :
Mouse  1477 VHIR--------------------WLPPAGV--------NGPPPLYHLERKKSSLPAA------T 1507

  Fly  2581 SASSTARHFNGLGYAQLMKTRPRPTRKNLFSVQMTFRTLDENALLFLAVDDKNNRS-VSVTLSRG 2644
            :|.:....|.|.||.:.    ||....:...::.:|||.....|:.||:...:... .::.|..|
Mouse  1508 AAVTKGTRFVGHGYCRF----PRTAHADFIGIKASFRTRVPEGLILLALSPGDQEEYFTLQLKNG 1568

  Fly  2645 RIMFRIDYGDESKL-EINTT----KKYNVGQWIKIEAAREFSAKRSTENGMLRVN----NDRPIS 2700
            |..|.  |..:..| |:..|    :.|..|:|.:|.|.|..:..:.|.:|....:    |...::
Mouse  1569 RPYFL--YNSQGTLVEVTPTDDPSQGYRDGEWHEIIAVRHQAFGQITLDGQYTGSSSSLNGSSVT 1631

  Fly  2701 GAPTLPVNIHLLPDLSKTVYYLGGVPPGFTSGTSKAPGADNPFLGCMKDVQV------NGETYDP 2759
            |              ..|..::||||.|.:....:.......|:||:|||.:      :| |:.|
Mouse  1632 G--------------GYTGLFVGGVPQGHSVLQKRLEIIQRGFVGCLKDVFIMKGYSPSG-TWLP 1681

  Fly  2760 LE---SSSYYGVEPSCK----NMITKAGFSGNGYLELPSQSLR--KRSNTALVFRTLQPDCLLLL 2815
            |:   |.....|.||.:    |:.....|.|.|:|||||.:..  |....:|.|:|.|.:.||| 
Mouse  1682 LDWQSSEEQVNVHPSWEGCPTNLEEGVQFLGAGFLELPSDTFHAAKDFEISLKFQTDQLNGLLL- 1745

  Fly  2816 AAYPPEILGDYDAKDIKGNFSISLVDGQLHVWVNSGRSFIKMSSNSSQMN-DGEFHVVHLIKTGR 2879
                  .:.:.:..|.   .::.|..|.|....||...|.::.......: ||:::.|.:.|.|.
Mouse  1746 ------FIHNTEGPDF---LAVELKRGLLSFKFNSSLVFTRVDLRLGLADCDGKWNTVSIKKEGS 1801

  Fly  2880 KLELMVDDELQEIRNLNGNPTVVSLPRDAGGLYIGGAPP--HESY--TPLAPTFVNLEGAIRDVV 2940
            .:.:.|:...:......|.|.:|:.|     :|:||.|.  .::|  ..|.|.|   .|.:::|.
Mouse  1802 VVSVRVNALKKSTSQAGGQPLLVNSP-----VYLGGIPRELQDAYRHLTLEPGF---RGCVKEVA 1858

  Fly  2941 FNNRTINFNDALTFANVQIGRNGPLMGSLK---GGLYDVLLKTEPMIGKSFTASPEGCKRIGSYS 3002
            |....:....:::...|::.::|.|.....   ||...:|:..    |...:....|.:....|.
Mouse  1859 FARGVVVNLASVSSRAVRVNQDGCLSSDSTVNCGGNDSILVYR----GSQQSVYESGLQPFTEYL 1919

  Fly  3003 YEPNAFKFGDDIYSYSQLKLPERHFWQRNFHLSFDFRSFYPNGMLYLSPGSKEKPKHYVALVLKD 3067
            |...|...|..:.|          .|.|...|.             .:|.|...|....::   :
Mouse  1920 YRVTASHEGGAVSS----------DWSRGRTLG-------------TAPQSVPTPSRAQSI---N 1958

  Fly  3068 GQLV-------LVVRGRRREELQLTAKLNDGEWHRV---TISCHDRKVTMSVEIG-RTDQKTSAQ 3121
            |..|       .||:| ..|:..|.|...|....||   :...||......|.|| ......:..
Mouse  1959 GSSVEVAWNEPAVVKG-VLEKYVLKAYSEDSSQPRVPSASTELHDTSTHSGVLIGLHPFHSYTVT 2022

  Fly  3122 MKLPKKIG---ASQLLLVGGLPQSPVKVSSDLYVRL 3154
            :....:.|   :||.|.:....::|.:|.:.:.|.|
Mouse  2023 LTACSRAGCTESSQALSISTPQEAPQEVQAPVAVAL 2058

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 164..396 CDD:278484 57/240 (24%)
EGF_Lam 401..450 CDD:238012 18/57 (32%)
TNFRSF <407..507 CDD:304602 41/118 (35%)
EGF_Lam 505..552 CDD:238012 5/46 (11%)
Laminin_EGF 550..597 CDD:278482 16/49 (33%)
Laminin_B 660..798 CDD:278481 7/137 (5%)
EGF_Lam 851..900 CDD:238012 10/48 (21%)
Laminin_EGF <943..971 CDD:278482 2/27 (7%)
VSP 953..1414 CDD:146106 128/469 (27%)
Laminin_EGF 974..1018 CDD:278482 11/43 (26%)
EGF_Lam 1017..1065 CDD:238012 20/52 (38%)
Laminin_EGF 1065..>1105 CDD:278482 19/40 (48%)
EGF_Lam 1150..1197 CDD:238012 21/48 (44%)
Laminin_EGF 1199..1247 CDD:278482 17/48 (35%)
EGF_Lam 1247..1292 CDD:238012 4/44 (9%)
Laminin_EGF 1294..1342 CDD:278482 7/47 (15%)
Laminin_EGF 1340..1392 CDD:278482 14/51 (27%)
Laminin_B 1486..1611 CDD:278481 21/127 (17%)
EGF_Lam 1669..1716 CDD:238012 3/46 (7%)
Laminin_EGF 1718..1767 CDD:278482 9/51 (18%)
EGF_Lam 1772..1819 CDD:238012 4/46 (9%)
CrfC <1933..2267 CDD:223771 31/333 (9%)
Laminin_II 2277..2400 CDD:283628 12/122 (10%)
LamG 2399..>2492 CDD:304605 11/92 (12%)
Laminin_G_2 2616..2755 CDD:280389 36/154 (23%)
Laminin_G_2 2804..2944 CDD:280389 34/144 (24%)
Laminin_G_2 3038..3169 CDD:280389 27/131 (21%)
LamG 3192..3347 CDD:238058
Ush2aNP_067383.3 LamGL 145..280 CDD:214722
Laminin_N 313..513 CDD:295486 56/237 (24%)
EGF_Lam 514..562 CDD:238012 18/51 (35%)
EGF_Lam 571..636 CDD:238012 27/106 (25%)
Laminin_EGF 638..688 CDD:278482 16/49 (33%)
Laminin_EGF 691..741 CDD:278482 27/279 (10%)
EGF_Lam 743..788 CDD:238012 17/131 (13%)
EGF_Lam 792..832 CDD:214543 18/39 (46%)
Laminin_EGF 844..894 CDD:278482 23/82 (28%)
EGF_Lam 896..945 CDD:238012 20/48 (42%)
EGF_Lam 947..997 CDD:238012 21/94 (22%)
EGF_Lam 998..>1035 CDD:238012 19/86 (22%)
fn3 1055..1128 CDD:278470 18/124 (15%)
FN3 1153..1235 CDD:238020 29/215 (13%)
FN3 1239..1351 CDD:238020 33/286 (12%)
FN3 1362..1445 CDD:214495 27/304 (9%)
Laminin_G_2 1539..1669 CDD:280389 36/145 (25%)
LamG 1707..1857 CDD:238058 42/167 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1931..1955 7/46 (15%)
FN3 1947..2042 CDD:238020 22/98 (22%)
FN3 2134..2230 CDD:238020
FN3 2232..2304 CDD:238020
FN3 2320..2419 CDD:238020
FN3 2423..2516 CDD:238020
FN3 2524..2610 CDD:238020
FN3 2612..2710 CDD:238020
FN3 2715..2807 CDD:238020
FN3 2809..2911 CDD:238020
FN3 2916..2993 CDD:238020
FN3 <3441..3486 CDD:238020
FN3 3582..3668 CDD:238020
FN3 3672..3753 CDD:238020
FN3 3769..3854 CDD:238020
FN3 3867..3952 CDD:238020
FN3 3956..4053 CDD:238020
FN3 4153..4239 CDD:238020
FN3 4260..4343 CDD:238020
FN3 4348..4431 CDD:238020
FN3 4435..4519 CDD:238020
FN3 4521..4619 CDD:238020
FN3 4645..4722 CDD:238020
FN3 4724..4800 CDD:238020
FN3 4817..4918 CDD:238020
PDZ-binding 5191..5193
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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