DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wb and Ccdc186

DIOPT Version :9

Sequence 1:	NP_723870.1	Gene:	wb / 43946	FlyBaseID:	FBgn0261563	Length:	3375	Species:	Drosophila melanogaster
Sequence 2:	NP_739563.1	Gene:	Ccdc186 / 213993	MGIID:	2445022	Length:	917	Species:	Mus musculus

Alignment Length:	717	Identity:	138/717 - (19%)
Similarity:	266/717 - (37%)	Gaps:	167/717 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1783 EGCDVETG---------RCYCREGVTGLKCDKCQAERHHLVD-----NGCKICDNC--------T 1825
            |...:|||         |..|:   |...|.:.:.:..|:.|     |.|...|.|        .
Mouse    52 ESSRLETGAELLSLDSDRILCQ---TNEHCSQIEVQESHIPDCGSGENSCANTDTCPEDSGQIDD 113

  Fly  1826 LLLLDYMELVGNKLRRGMHNMDLTGIPAPYRKLSEYESAYEKW-NGRHWDFSQTKR---RLQDYD 1886
            ....|:.|.| :|.:.  ....:|.|.|..:..:..|:|..|. :...:|...|::   .::...
Mouse   114 FPGGDFTEQV-SKTKE--PEQTVTQILAELKSSAPAEAANPKTASASLYDTDCTRKLISEMKTVS 175

  Fly  1887 SADILKLEAHAENLKFQSRKAVATIGKREFAIKSMREDAVTQQHSV--GLLRSEILQTLSDLHGY 1949
            ::|.|..|..:|.|            ..|||          :.|.|  ||.:.|....|     :
Mouse   176 ASDDLLGEIESELL------------SAEFA----------EGHQVPNGLNKGEQALAL-----F 213

  Fly  1950 GKSAH--YLSLPTALKQARFYLQAIREHDQMVQGIRSTNDCAWKHFYAMGNASDASFDESGRLEM 2012
            .|..|  ||.....:||   .::..:.|.:::..|.|..|...:.............:...:||:
Mouse   214 EKCVHSRYLQQELTVKQ---LIKENKNHQELILNICSEKDSLREELRKRTETEKQHMNTIKQLEL 275

  Fly  2013 LWRDLN---------------------QTNHRVVDMRL----------------QVDRVQEVENE 2040
            ...:||                     |..|:.:..|:                .|.:....|.|
Mouse   276 RIEELNKEIKASKDQLVAQDVTAKNAIQQIHKEMAQRMDQANKKCEEARQEKEAMVMKYVRGEKE 340

  Fly  2041 AEDVLEHVRNLSIRVGESHQELDELNQRISD-HLDPGYLEQ----GEGLLRLTVQRQIMLNGHLN 2100
            |.|:.:....|..::.::.:||::...:|.. ..:.|.|:|    .||.....::....|...:|
Mouse   341 ALDLRKEKETLERKLRDASKELEKNTNKIKQLSQEKGRLQQLYESKEGETTRLIREIEKLKEEMN 405

  Fly  2101 ---------------QLDGYR----ILLNTT--LGVKTEQQREVRKHWLPKAEKHASHLLARSNE 2144
                           ::|.::    .|..||  |....|:..::|::.....:.:......:|||
Mouse   406 SQVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEAEQIRQNCQDMIKTYQESEEIKSNE 470

  Fly  2145 YARKFQPTRNGARIAMLASS-----AHSNITEAINDAR---------LASILAKERVYEAQRTLY 2195
            ...|.:.|:......|...|     .|:.|.| :.|.:         |.::..|.:..|.:|...
Mouse   471 LDAKLRVTKGELEKQMQEKSDQLEMHHAKIKE-LEDLKRTFKEGMDELRTLRTKAKCLEDERLRT 534

  Fly  2196 PSDGSSMIERAKHSLHRSKQLQQEALKQMHKSNVLKDKLHRQEQQVEGIKSTIYDSGLRTNNISG 2260
            ..:    :.:.:..::|.|...|..|.::..::.|.::|...:|::|.:|..:..    .|::..
Mouse   535 EDE----LSKYREIINRQKSEIQNLLDKVKITDQLHEQLQSGKQEIEHLKEEMES----LNSLIN 591

  Fly  2261 QLQGLSDGSARRQAKDSLEMADRTGEQMRAELQ-KAKDMQKSIQNMRNSFSNLEPDWEIKLGMAQ 2324
            .||...:||.:|:::..|.....|.:  .|:|| ::..:|..:.|:..:.|.|:...: ::|.|.
Mouse   592 DLQKDIEGSRKRESELLLFTEKLTSK--NAQLQSESSALQSQVDNLSCTESQLQSQCQ-QMGQAN 653

  Fly  2325 ENIS---LTQTNLRLANVSLSYLEQQAEKEQQVFEVWNNSMAQQLQQLRDQIA--KARHAAEAID 2384
            .|:.   |.:..||...|.    ..|||......||  .:::.|:::|:|::.  :.:||:...|
Mouse   654 RNLESKLLKEEELRKEEVQ----TLQAELSAAQTEV--KALSTQVEELKDELVTQRRKHASNVKD 712

  Fly  2385 VS 2386
            :|
Mouse   713 LS 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wb	NP_723870.1	Laminin_N	164..396	CDD:278484
		EGF_Lam	401..450	CDD:238012
		TNFRSF	<407..507	CDD:304602
		EGF_Lam	505..552	CDD:238012
		Laminin_EGF	550..597	CDD:278482
		Laminin_B	660..798	CDD:278481
		EGF_Lam	851..900	CDD:238012
		Laminin_EGF	<943..971	CDD:278482
		VSP	953..1414	CDD:146106
		Laminin_EGF	974..1018	CDD:278482
		EGF_Lam	1017..1065	CDD:238012
		Laminin_EGF	1065..>1105	CDD:278482
		EGF_Lam	1150..1197	CDD:238012
		Laminin_EGF	1199..1247	CDD:278482
		EGF_Lam	1247..1292	CDD:238012
		Laminin_EGF	1294..1342	CDD:278482
		Laminin_EGF	1340..1392	CDD:278482
		Laminin_B	1486..1611	CDD:278481
		EGF_Lam	1669..1716	CDD:238012
		Laminin_EGF	1718..1767	CDD:278482
		EGF_Lam	1772..1819	CDD:238012	11/49 (22%)
		CrfC	<1933..2267	CDD:223771	71/412 (17%)
		Laminin_II	2277..2400	CDD:283628	28/116 (24%)
		LamG	2399..>2492	CDD:304605
		Laminin_G_2	2616..2755	CDD:280389
		Laminin_G_2	2804..2944	CDD:280389
		Laminin_G_2	3038..3169	CDD:280389
		LamG	3192..3347	CDD:238058
Ccdc186	NP_739563.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		138/717 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	97..118		3/20 (15%)
		Taxilin	315..645	CDD:286771	62/340 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	701..769		4/14 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1836
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900