Protein Alignment wb and Ntn1

DIOPT Version :10

• Sequence 1: NP_723870.1
• Gene: wb / 43946
• FlyBaseID: FBgn0261563
• Length: 3375
• Species: Drosophila melanogaster
• Sequence 2: NP_032770.2
• Gene: Ntn1 / 18208
• MGIID: 105088
• Length: 604
• Species: Mus musculus
• Alignment Length: 593
• Identity: 164/593 - (27%)
• Similarity: 244/593 - (41%)
• Gaps: 138/593 - (23%)

  Fly   155 PPLFNVVPRAQISVNATCGQNGAEEYC-----KQVGAKPCGICNAHSSDRAKQRSIQSLISSGSG 214
            |...|......:.|::|||:..| .||     .:...:.|.:||  |||..|......|....:.
Mouse    53 PDFVNAAFGKDVRVSSTCGRPPA-RYCVVSERGEERLRSCHLCN--SSDPKKAHPPAFLTDLNNP 114

  Fly   215 SGSGSGFEEGWWQSPTLQGGRQFEY-VTILLDLKQTFQIFSVWLKSANSPRPASWILEKSLD-GI 277
            .....      |||   :...||.: ||:.|.|.:.|::..|.|:.. ||||.|..:.||:| |.
Mouse   115 HNLTC------WQS---ENYLQFPHNVTLTLSLGKKFEVTYVSLQFC-SPRPESMAIYKSMDYGR 169

  Fly   278 NFEPWQYFGLSDADCQRRWNLSGQNGKYVFQNDTEIICSTQFSKPGPLENGVLHASLLKNRPGA- 341
            .:.|:|::   ...|::.:| .........||:.|.:|:...:...||..|::..|.|..||.|
Mouse   170 TWVPFQFY---STQCRKMYN-RPHRAPITKQNEQEAVCTDSHTDMRPLSGGLIAFSTLDGRPSAH 230

  Fly   342 -TDQSPELMKFITTRYIRIRLQGMHSTANQDNSLDWLLDSPSLEKHS-FYSLSQLKVSARLDCNG 404
             .|.||.|..::|...||:....:|:..:::.      |...|.:.| :|::|.|:|..|..|||
Mouse   231 DFDNSPVLQDWVTATDIRVAFSRLHTFGDENE------DDSELARDSYYYAVSDLQVGGRCKCNG 289

  Fly   405 HANRSHESPDDPLMQCICQHNTCGAQCEQCCPLFQDRPYQM-----GGECEICQCYGHAESCTYD 464
            ||.|.....||.|: |.|:|||.|.:|::|.|...|||:|.     ..||..|.|..||..|.::
Mouse   290 HAARCVRDRDDSLV-CDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFN 353

  Fly   465 PFLDK-------GICQSCSNNTAGIECEFCEMGFYRELDAPLT--DPCLPCSCNPARSTGGCQSD 520
            ..|.|       |:|.:|.:||||..|.:|:.||||::..|:|  ..|..|.|:|.
Mouse   354 MELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGFYRDMGKPITHRKACKACDCHPV--------- 409

  Fly   521 GGSCNCLEGFQGKNCEECAPGYYGDDCKRCECDERGSLGSTGSCSGVCQCKLNVEGSTCSECAPG 585
                    |..||.|.:                          .:|.|.||..|.|.||:.||.|
Mouse   410 --------GAAGKTCNQ--------------------------TTGQCPCKDGVTGITCNRCAKG 440

  Fly   586 YFDLSAENAEGCTSCWCSGVSQTCHSAKLQTLAFETLNDWKITDIQRVKPISIPVDAETNRLIFA 650
            |    .::......|                                   |.|||...|......
Mouse   441 Y----QQSRSPIAPC-----------------------------------IKIPVAPPTTAASSV 466

  Fly   651 NELDEVEAIYWQASLGYLGNRLTSYGSRLQLVLSWDVIRGDRSG---KPTTGPNVILVGKNGL-K 711
            .|.::.:: |.:||.|.|...:..| .|....:...:::.|::|   |.|.  |:|.|.|.|. :
Mouse   467 EEPEDCDS-YCKASKGKLKMNMKKY-CRKDYAVQIHILKADKAGDWWKFTV--NIISVYKQGTSR 527

  Fly   712 IAFGDESL 719
            |..||:||
Mouse   528 IRRGDQSL 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wb	NP_723870.1	Laminin_N	153..398	CDD:459653	69/252 (27%)
		EGF_Lam	401..450	CDD:238012	23/53 (43%)
		EGF_Lam	505..552	CDD:238012	7/46 (15%)
		Laminin_EGF	550..597	CDD:395007	12/46 (26%)
		Laminin_B	660..813	CDD:459652	21/64 (33%)
		EGF_Lam	851..900	CDD:238012
		Laminin_EGF	<943..971	CDD:395007
		Laminin_EGF	974..1018	CDD:395007
		EGF_Lam	1017..1065	CDD:238012
		Laminin_EGF	1065..>1105	CDD:395007
		EGF_Lam	1150..1197	CDD:238012
		Laminin_EGF	1199..1247	CDD:395007
		EGF_Lam	1247..1292	CDD:238012
		Laminin_EGF	1294..1342	CDD:395007
		Laminin_EGF	1340..1392	CDD:395007
		Laminin_B	1486..1626	CDD:459652
		EGF_Lam	1669..1716	CDD:238012
		Laminin_EGF	1718..1767	CDD:395007
		EGF_Lam	1772..1819	CDD:238012
		YhaN	<1907..2141	CDD:443752
		SMC_prok_B	<2123..>2390	CDD:274008
		Laminin_II	2279..2400	CDD:368703
		LamG	2399..>2492	CDD:473984
		LamG	2586..2753	CDD:238058
		Laminin_G_2	2804..2944	CDD:460494
		LamG	3018..3167	CDD:238058
		LamG	3192..3347	CDD:238058
Ntn1	NP_032770.2	LamNT	46..283	CDD:214532	69/252 (27%)
		EGF_Lam	284..329	CDD:238012	22/45 (49%)
		Laminin_EGF	341..401	CDD:395007	22/59 (37%)
		Laminin_EGF	404..>441	CDD:395007	17/79 (22%)
		NTR_netrin-1_like	487..601	CDD:239634	16/52 (31%)
		Cell attachment site. /evidence=ECO:0000255	530..532		0/1 (0%)