DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wb and lam-2

DIOPT Version :9

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:NP_509204.3 Gene:lam-2 / 180980 WormBaseID:WBGene00016913 Length:1633 Species:Caenorhabditis elegans


Alignment Length:2335 Identity:541/2335 - (23%)
Similarity:824/2335 - (35%) Gaps:850/2335 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 PPLFNVVPRAQISVNATCGQNGAEEYCKQVG----AKPCGICNAHSSDRAKQRSIQSLISSGSGS 215
            |...|.....::.|..|||.....::|.|.|    ...|..|:    ||.:..|..:...:....
 Worm    53 PDFVNAAFNLEVQVTNTCGTKRPTKFCVQSGHTGQRSVCETCD----DRHEGFSHPAKYLTDFNV 113

  Fly   216 GSGSGFEEGWWQSPTLQGGRQFEYVT-ILLDLKQTFQIFSVWLKSANSPRPASW-ILEKSLDGIN 278
            |:    .|.||||.|:|.|:|:...| :.|.|.::|.|..|.||.. ||||.|: |.:|:.....
 Worm   114 GN----NETWWQSDTMQEGQQYPTTTNLTLVLGKSFDITYVRLKFI-SPRPESFTIYKKTHTDSE 173

  Fly   279 FEPWQYFGLSDADCQRRWNLSGQNGKYVFQNDTEIICSTQFSKPGPLENGVLHASLLKNRPG--A 341
            :||||::   ...|:..:.|| .....:..|:....|:.:||...|:..|.:..|.|:.||.  |
 Worm   174 WEPWQFY---SGSCRATYGLS-DRAPILPGNEATAQCTKEFSDISPITGGNIAFSTLEGRPSAHA 234

  Fly   342 TDQSPELMKFITTRYIRIRLQGMHSTANQDNSLDWLLDSPSLEKHSFYSLSQLKVSARLDCNGHA 406
            .::|..|.|::|...|||.|..|::..      |.:...|.:.:..:|::|...|..|..|||||
 Worm   235 FEESEVLQKWVTASAIRISLNRMNTFG------DEVFKDPQVLRSYYYAISDFAVGGRCKCNGHA 293

  Fly   407 NR---SHESPDDPLMQCICQHNTCGAQCEQCCPLFQDRPYQMG-----GECEICQCYGHAESCTY 463
            :.   |.....:..:.|.|:|||.||.|.:|.|.:.|||::.|     .||..|.|...:..|.:
 Worm   294 SECVGSSSVDGENRLVCRCEHNTQGADCNECLPFYNDRPWRSGTSVEANECIACNCSQLSNRCYF 358

  Fly   464 DPFLDK-----GICQSCSNNTAGIECEFCEMGFYRELDAPLTDPCLPCSCNPARSTGGCQSDGGS 523
            |..|.:     |.|..|..||.|:.||.|....:|.   |..:.|:.|.||...|......:.|.
 Worm   359 DQQLFEETGHGGHCIDCQGNTQGVHCEQCIANHWRR---PGENYCVACGCNEIGSLSTQCDNEGK 420

  Fly   524 CNCLEGFQGKNCEECAPGYYG---DDCKRCECDERGSLGSTGSC---SGVCQCKLNVEGSTCSEC 582
            |.|..|..|:.|::|..|:|.   :.||.|.|:..|||.:...|   ||.|.|||||||..|.:|
 Worm   421 CQCKPGVTGRFCDQCLDGFYDFSTNGCKNCGCETSGSLNNQPRCDSSSGSCSCKLNVEGRQCDKC 485

  Fly   583 APGYFDLSAENAEGCTSCWCSGVSQTCHSAKLQTLAFETLNDWKITDIQRVKPISIPVDAETNRL 647
            .|||||||.||..|||.|:|.|.|..|::|.    .:..:|...:.|..:.|      .|..||:
 Worm   486 KPGYFDLSTENQFGCTPCFCFGHSSICNTAD----GYFAMNVSSVFDQDKQK------WAGQNRI 540

  Fly   648 IFAN----ELDEVEA--------IYWQASLGYLGNRLTSYGSRLQLVLSWDVIRGDRSGKPTTGP 700
            ...:    |||:..|        :|:.|...:||::.:||...|...|        :..|..|..
 Worm   541 GLQDTQWAELDKAVAVSDTDNSPVYFVAPEQFLGDQRSSYNQDLVFTL--------KVAKHVTNQ 597

  Fly   701 NV---ILVGKNGLKIAFGDESLDGLGINLNVTLTEVGWYHVPPTVVDIKTRLRRTEGGDYHG--E 760
            :|   |:||.:..:              |:.::|..|   .|....:.:|...|.....|.|  .
 Worm   598 DVKDIIIVGADRQE--------------LSTSITAQG---NPFPTTEAQTYRFRVHADPYFGWYP 645

  Fly   761 SVTRSQFLSVLVSLDAVLIRAAF-HTDQGETSLERAVIYSGGVELG----------GKSSSQVEQ 814
            .:....|:.:|.::.|:.||..: :.|.|         |...|.||          .|.::.:|.
 Worm   646 RINELDFIGILSNITAIKIRGTYSYKDIG---------YLSNVNLGTAGVAPSAANPKQATWIEH 701

  Fly   815 CLCPAGYTGLSCEGCAFGFKRIYENTSDHQILSKCIPCPCNGHSNSCDLQSGNCGDCMHNTFGDR 879
            |.|..|:.|..||.|..||:|   .|......:.||.|.|:.|||||:.:||:| .|.|||.||.
 Worm   702 CECLPGFVGQFCESCESGFRR---ETKFGGPFNHCIKCDCHNHSNSCEAESGSC-ICEHNTAGDT 762

  Fly   880 CERCQLGYYGNPLQGTPNDCKRCACPLSEDSNNFSPSCQLKSYNYMDLNPQFELIEHA--EYICT 942
            ||||..||||:.||||..||::|.||      |..| |                |.||  :.|||
 Worm   763 CERCARGYYGDALQGTEEDCQKCPCP------NDGP-C----------------ILHADGDVICT 804

  Fly   943 QCPEGYTGDHCQVCDDGYFGNPRQPGSSCQRCDCAG-------GPCNVTTGECITCRGNTEGWHC 1000
            :||.||||..|..|.|||||||:. |:.|..|.|:|       |.|:..||||..|..||.|::|
 Worm   805 ECPNGYTGRRCDECSDGYFGNPKD-GTECVECACSGNTDPNSIGNCDKITGECKKCIFNTHGFNC 868

  Fly  1001 ERCKLGYWGDPAVGCDPCHCHTEGSESGLCDSTDGQCLCKPRYAGQKCDECDVGYANVELRCPSC 1065
            |.||.|||||                          .|.:|:.                 .|.||
 Worm   869 ENCKPGYWGD--------------------------ALIEPKG-----------------NCQSC 890

  Fly  1066 NCDPLGSLVQDRCDPHTGQCHCKEGVMGAKCHECQDGYFGMNAVAYRMDDLAALRQNSDSDDDEW 1130
            .|...|                                                           
 Worm   891 GCFAAG----------------------------------------------------------- 896

  Fly  1131 ELVPDTEDPNSESTVACEECHCSSVGSLSSDCDKRTGQCACLANVTGRRCDKCRPGHWNLTAGEG 1195
                 |..||::.|:.              :|:::.|||.||.||.|.:||:|..|.:|:|:|.|
 Worm   897 -----TRRPNNDYTLL--------------ECNQQDGQCDCLPNVIGIQCDQCAHGFYNITSGLG 942

  Fly  1196 CRDCRCDPHGSRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRCSACRSEGQVCDPH 1260
            |::|.|||.||.|:.|:..||||.||.||.||.|:.|.:..||||..|||               
 Worm   943 CQECNCDPLGSEGNTCDVNTGQCQCKPGVTGQRCDRCADYHFGFSANGCQ--------------- 992

  Fly  1261 NGRCICPKFTRGLGCGQCVPGTWGWQARLGCRECECDHIGSIGQQCSTGDGQCQCREGYSGRKCD 1325
                                            .|:|::|||..|||....|||.|:|...||:||
 Worm   993 --------------------------------PCDCEYIGSENQQCDVNSGQCLCKENVEGRRCD 1025

  Fly  1326 TCAIGYFGYPECRRCGCDAEGSFTQADGSIACDSNGQCPCKSLVVGLKCDTCMQSTFGLSAQNPE 1390
            .||...:|              .||  |.:.||.              |.|.:||...:..:.  
 Worm  1026 QCAENRYG--------------ITQ--GCLPCDD--------------CYTLIQSRVNVFREK-- 1058

  Fly  1391 GCTRCFCFGRSGECEQSDLSWGHIRMAESRNLSVQQIRPHSVPSSDYEYIVVVQMEGSSFHREDA 1455
                                      .:|.:.::|:|..:..|.:|.::              |.
 Worm  1059 --------------------------VKSLDNTLQEIIENPAPVNDTKF--------------DE 1083

  Fly  1456 EIQRMNDLSLVPKSTGNVSIGAYGQFYHPLYFQLPPQFYGDRTSSYGGFLYFTLITEGAHKPLER 1520
            ::          |.|...:...:             :....:|...||    |:.|:        
 Worm  1084 KV----------KETSRAASEVW-------------EAVKQKTKEGGG----TIKTK-------- 1113

  Fly  1521 NILGQYPLVQLHAHSKLLLDFYEYEEFEYSLNVTHRVPLHESFWKYHHTSQAVDRNTLMAALQNI 1585
                                                             |:|: ::.::|||:.:
 Worm  1114 -------------------------------------------------SKAI-KDEIVAALEKL 1128

  Fly  1586 RHIFIRAFAFADFQEVVLQNVHMDAAIYIKGSTNLIAKGVERCKCPKRFDGLSCQDPGRSFYRWR 1650
                                                                             
 Worm  1129 ----------------------------------------------------------------- 1128

  Fly  1651 NTTIVESVFIEDLIGRAAPCHCNGRSSDCDRETGVCQNCRGNTGGDHCHQCAEGFYGDPNSPHGC 1715
             |:|.|||       ..|....:...:|..|...:.:|.|                         
 Worm  1129 -TSIDESV-------AQAKVGADAAENDMKRWEIIIENAR------------------------- 1160

  Fly  1716 QACPCPETNRNFARGCNVWDGEVSCVCKPGYTGRLCERCQAGYFGDPMRYPNTTCQPCNCHPDGI 1780
                                                                             
 Worm  1161 ----------------------------------------------------------------- 1160

  Fly  1781 QTEGCDVETGRCYCREGVTGLKCDKCQAERHHLVDNGCKICDNCTLLLLDYMELVGNKLRRGMHN 1845
                          ||                 ::|           :|.|:|..|.:..:..:|
 Worm  1161 --------------RE-----------------IEN-----------VLHYLETEGEERAQIAYN 1183

  Fly  1846 MDLTGIPAPYRKLSEYESAYEKWNGRHWDFSQTKRRLQDYDSADILKLEAHAENLKFQSRKAVAT 1910
                              |.:|       :.:..:|:.:..|....:.|.|.             
 Worm  1184 ------------------ASQK-------YGEQSKRMSELASGTREEAEKHL------------- 1210

  Fly  1911 IGKREFAIKSMREDAVTQQHSVGLLRSEILQTLSDLHGYGKSAHYLSLPTA-LKQARFYLQAIRE 1974
              |:...|:.:.|.|:..........|:.:        ||  ...:|...| ||:         :
 Worm  1211 --KQASEIEQLSEQAIANATQANKEASDAI--------YG--GEQISKQIAELKE---------K 1254

  Fly  1975 HDQMVQGIRSTNDCAWKHFYAMGNASDASFDESGRLEMLWRDLNQTNHRVVDMRLQVDRVQEVEN 2039
            .:|:.:.|..|.|.|        .....|.||:..|..    ::.||...|.:. .|| .:|:.|
 Worm  1255 QNQLNESIHRTLDLA--------EEQKKSADEANNLAA----VSLTNVEAVKIP-SVD-PKELRN 1305

  Fly  2040 EAEDVLEHVRNL---SIRVGESHQEL-DELNQRISDHLDPGYLEQGEGLLRLTVQRQIMLNGHLN 2100
            :...|||...||   |::...::.|| ||:|:.::|..:.  |:..:...|  |..|:||     
 Worm  1306 DVAGVLEESENLVDSSVKENSANDELFDEVNRSVADARNE--LQSSQDQQR--VSDQLML----- 1361

  Fly  2101 QLDGYRILLNTTLGVKTEQQREVRKHWLPKAE---KHASHLLARSNEYARKFQPTRNGARIAMLA 2162
                           :.|:.||.....:..|:   |.|...|....|:..|.:.:||.| :|..|
 Worm  1362 ---------------ELEKSRERIVDSVSTADKTLKDAEAALQVLEEFGAKIEKSRNDA-VAEFA 1410

  Fly  2163 SSAHSNITEAINDARLASILAKERVYEAQRTLYPSDGSSMIERAKHSLHRSKQLQQEALKQMHK- 2226
            .      .|.||. ||..|:..:   :.:|...|.|...:|:..|.:        ...|.:.|. 
 Worm  1411 G------VEGINQ-RLDDIIDAQ---DKRRNSLPIDKQFVIDYRKSA--------DVLLNETHAL 1457

  Fly  2227 SNVLKDKLHRQEQQVEGIKSTIYDSGLRTNNISGQLQGLSDGSA-----RRQAKDSLEMADRTGE 2286
            ::..||.:|......:..::..||       |...::.|:|.:.     ::||:|..:||  |..
 Worm  1458 ADRYKDIIHSDVDTRDSTEAVQYD-------IEQLMEELTDSNENLQYYKKQAEDDKQMA--TEA 1513

  Fly  2287 QMRAELQKAKDMQKS---------IQNMRNSFSNLEPDWEIKLGMAQENIS-LTQ--TNLRLANV 2339
            ..:|.|.|...::.:         |:.:.||...:|.....:|...:|.|. |.|  ...:||..
 Worm  1514 VRKATLAKNSAIEANATILAEEDEIKKIINSLDTMEEVNNAELDELEEEIDRLDQLLAQAQLAKE 1578

  Fly  2340 SLSYLEQQAEKEQQVFEVWNNSMAQQ-----LQQLRDQI-AKARHAAEAIDVSLESLGPK 2393
            ..:|.:.:|:::.:|.::.|:....|     |:::||.: .|..:.     ::||..|.|
 Worm  1579 VPTYQQYRADEDVKVAQLKNDISELQKEVLNLEEIRDNLPTKCFNV-----INLEQEGQK 1633

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 164..396 CDD:278484 68/239 (28%)
EGF_Lam 401..450 CDD:238012 21/56 (38%)
TNFRSF <407..507 CDD:304602 34/112 (30%)
EGF_Lam 505..552 CDD:238012 16/49 (33%)
Laminin_EGF 550..597 CDD:278482 27/49 (55%)
Laminin_B 660..798 CDD:278481 29/143 (20%)
EGF_Lam 851..900 CDD:238012 29/48 (60%)
Laminin_EGF <943..971 CDD:278482 16/27 (59%)
VSP 953..1414 CDD:146106 118/467 (25%)
Laminin_EGF 974..1018 CDD:278482 22/50 (44%)
EGF_Lam 1017..1065 CDD:238012 3/47 (6%)
Laminin_EGF 1065..>1105 CDD:278482 3/39 (8%)
EGF_Lam 1150..1197 CDD:238012 17/46 (37%)
Laminin_EGF 1199..1247 CDD:278482 27/47 (57%)
EGF_Lam 1247..1292 CDD:238012 0/44 (0%)
Laminin_EGF 1294..1342 CDD:278482 20/47 (43%)
Laminin_EGF 1340..1392 CDD:278482 9/51 (18%)
Laminin_B 1486..1611 CDD:278481 10/124 (8%)
EGF_Lam 1669..1716 CDD:238012 4/46 (9%)
Laminin_EGF 1718..1767 CDD:278482 0/48 (0%)
EGF_Lam 1772..1819 CDD:238012 3/46 (7%)
CrfC <1933..2267 CDD:223771 75/342 (22%)
Laminin_II 2277..2400 CDD:283628 30/135 (22%)
LamG 2399..>2492 CDD:304605
Laminin_G_2 2616..2755 CDD:280389
Laminin_G_2 2804..2944 CDD:280389
Laminin_G_2 3038..3169 CDD:280389
LamG 3192..3347 CDD:238058
lam-2NP_509204.3 LamNT 45..285 CDD:214532 71/250 (28%)
EGF_Lam 286..337 CDD:238012 20/50 (40%)
Laminin_EGF 347..405 CDD:278482 18/60 (30%)
EGF_Lam 403..447 CDD:214543 13/43 (30%)
LamB 560..684 CDD:214597 33/157 (21%)
EGF_Lam 736..783 CDD:238012 29/47 (62%)
EGF_Lam 785..833 CDD:238012 28/71 (39%)
Laminin_EGF 835..890 CDD:278482 25/97 (26%)
EGF_Lam 889..944 CDD:238012 25/132 (19%)
EGF_Lam 946..991 CDD:214543 24/44 (55%)
EGF_Lam 993..1041 CDD:238012 23/63 (37%)
MA 1048..1262 CDD:214599 56/604 (9%)
CM_2 1109..>1165 CDD:294459 19/307 (6%)
MCP_signal 1179..1358 CDD:304920 49/255 (19%)
MA 1190..1424 CDD:214599 69/313 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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