DRSC/TRiP Functional Genomics Resources

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Protein Alignment wb and lam-2

DIOPT Version :10

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:NP_509204.3 Gene:lam-2 / 180980 WormBaseID:WBGene00016913 Length:1633 Species:Caenorhabditis elegans


Alignment Length:2335 Identity:541/2335 - (23%)
Similarity:824/2335 - (35%) Gaps:850/2335 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 PPLFNVVPRAQISVNATCGQNGAEEYCKQVG----AKPCGICNAHSSDRAKQRSIQSLISSGSGS 215
            |...|.....::.|..|||.....::|.|.|    ...|..|:    ||.:..|..:...:....
 Worm    53 PDFVNAAFNLEVQVTNTCGTKRPTKFCVQSGHTGQRSVCETCD----DRHEGFSHPAKYLTDFNV 113

  Fly   216 GSGSGFEEGWWQSPTLQGGRQFEYVT-ILLDLKQTFQIFSVWLKSANSPRPASW-ILEKSLDGIN 278
            |:    .|.||||.|:|.|:|:...| :.|.|.::|.|..|.||.. ||||.|: |.:|:.....
 Worm   114 GN----NETWWQSDTMQEGQQYPTTTNLTLVLGKSFDITYVRLKFI-SPRPESFTIYKKTHTDSE 173

  Fly   279 FEPWQYFGLSDADCQRRWNLSGQNGKYVFQNDTEIICSTQFSKPGPLENGVLHASLLKNRPG--A 341
            :||||::   ...|:..:.|| .....:..|:....|:.:||...|:..|.:..|.|:.||.  |
 Worm   174 WEPWQFY---SGSCRATYGLS-DRAPILPGNEATAQCTKEFSDISPITGGNIAFSTLEGRPSAHA 234

  Fly   342 TDQSPELMKFITTRYIRIRLQGMHSTANQDNSLDWLLDSPSLEKHSFYSLSQLKVSARLDCNGHA 406
            .::|..|.|::|...|||.|..|::..      |.:...|.:.:..:|::|...|..|..|||||
 Worm   235 FEESEVLQKWVTASAIRISLNRMNTFG------DEVFKDPQVLRSYYYAISDFAVGGRCKCNGHA 293

  Fly   407 NR---SHESPDDPLMQCICQHNTCGAQCEQCCPLFQDRPYQMG-----GECEICQCYGHAESCTY 463
            :.   |.....:..:.|.|:|||.||.|.:|.|.:.|||::.|     .||..|.|...:..|.:
 Worm   294 SECVGSSSVDGENRLVCRCEHNTQGADCNECLPFYNDRPWRSGTSVEANECIACNCSQLSNRCYF 358

  Fly   464 DPFLDK-----GICQSCSNNTAGIECEFCEMGFYRELDAPLTDPCLPCSCNPARSTGGCQSDGGS 523
            |..|.:     |.|..|..||.|:.||.|....:|.   |..:.|:.|.||...|......:.|.
 Worm   359 DQQLFEETGHGGHCIDCQGNTQGVHCEQCIANHWRR---PGENYCVACGCNEIGSLSTQCDNEGK 420

  Fly   524 CNCLEGFQGKNCEECAPGYYG---DDCKRCECDERGSLGSTGSC---SGVCQCKLNVEGSTCSEC 582
            |.|..|..|:.|::|..|:|.   :.||.|.|:..|||.:...|   ||.|.|||||||..|.:|
 Worm   421 CQCKPGVTGRFCDQCLDGFYDFSTNGCKNCGCETSGSLNNQPRCDSSSGSCSCKLNVEGRQCDKC 485

  Fly   583 APGYFDLSAENAEGCTSCWCSGVSQTCHSAKLQTLAFETLNDWKITDIQRVKPISIPVDAETNRL 647
            .|||||||.||..|||.|:|.|.|..|::|.    .:..:|...:.|..:.|      .|..||:
 Worm   486 KPGYFDLSTENQFGCTPCFCFGHSSICNTAD----GYFAMNVSSVFDQDKQK------WAGQNRI 540

  Fly   648 IFAN----ELDEVEA--------IYWQASLGYLGNRLTSYGSRLQLVLSWDVIRGDRSGKPTTGP 700
            ...:    |||:..|        :|:.|...:||::.:||...|...|        :..|..|..
 Worm   541 GLQDTQWAELDKAVAVSDTDNSPVYFVAPEQFLGDQRSSYNQDLVFTL--------KVAKHVTNQ 597

  Fly   701 NV---ILVGKNGLKIAFGDESLDGLGINLNVTLTEVGWYHVPPTVVDIKTRLRRTEGGDYHG--E 760
            :|   |:||.:..:              |:.::|..|   .|....:.:|...|.....|.|  .
 Worm   598 DVKDIIIVGADRQE--------------LSTSITAQG---NPFPTTEAQTYRFRVHADPYFGWYP 645

  Fly   761 SVTRSQFLSVLVSLDAVLIRAAF-HTDQGETSLERAVIYSGGVELG----------GKSSSQVEQ 814
            .:....|:.:|.::.|:.||..: :.|.|         |...|.||          .|.::.:|.
 Worm   646 RINELDFIGILSNITAIKIRGTYSYKDIG---------YLSNVNLGTAGVAPSAANPKQATWIEH 701

  Fly   815 CLCPAGYTGLSCEGCAFGFKRIYENTSDHQILSKCIPCPCNGHSNSCDLQSGNCGDCMHNTFGDR 879
            |.|..|:.|..||.|..||:|   .|......:.||.|.|:.|||||:.:||:| .|.|||.||.
 Worm   702 CECLPGFVGQFCESCESGFRR---ETKFGGPFNHCIKCDCHNHSNSCEAESGSC-ICEHNTAGDT 762

  Fly   880 CERCQLGYYGNPLQGTPNDCKRCACPLSEDSNNFSPSCQLKSYNYMDLNPQFELIEHA--EYICT 942
            ||||..||||:.||||..||::|.||      |..| |                |.||  :.|||
 Worm   763 CERCARGYYGDALQGTEEDCQKCPCP------NDGP-C----------------ILHADGDVICT 804

  Fly   943 QCPEGYTGDHCQVCDDGYFGNPRQPGSSCQRCDCAG-------GPCNVTTGECITCRGNTEGWHC 1000
            :||.||||..|..|.|||||||:. |:.|..|.|:|       |.|:..||||..|..||.|::|
 Worm   805 ECPNGYTGRRCDECSDGYFGNPKD-GTECVECACSGNTDPNSIGNCDKITGECKKCIFNTHGFNC 868

  Fly  1001 ERCKLGYWGDPAVGCDPCHCHTEGSESGLCDSTDGQCLCKPRYAGQKCDECDVGYANVELRCPSC 1065
            |.||.|||||                          .|.:|:.                 .|.||
 Worm   869 ENCKPGYWGD--------------------------ALIEPKG-----------------NCQSC 890

  Fly  1066 NCDPLGSLVQDRCDPHTGQCHCKEGVMGAKCHECQDGYFGMNAVAYRMDDLAALRQNSDSDDDEW 1130
            .|...|                                                           
 Worm   891 GCFAAG----------------------------------------------------------- 896

  Fly  1131 ELVPDTEDPNSESTVACEECHCSSVGSLSSDCDKRTGQCACLANVTGRRCDKCRPGHWNLTAGEG 1195
                 |..||::.|:.              :|:::.|||.||.||.|.:||:|..|.:|:|:|.|
 Worm   897 -----TRRPNNDYTLL--------------ECNQQDGQCDCLPNVIGIQCDQCAHGFYNITSGLG 942

  Fly  1196 CRDCRCDPHGSRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRCSACRSEGQVCDPH 1260
            |::|.|||.||.|:.|:..||||.||.||.||.|:.|.:..||||..|||               
 Worm   943 CQECNCDPLGSEGNTCDVNTGQCQCKPGVTGQRCDRCADYHFGFSANGCQ--------------- 992

  Fly  1261 NGRCICPKFTRGLGCGQCVPGTWGWQARLGCRECECDHIGSIGQQCSTGDGQCQCREGYSGRKCD 1325
                                            .|:|::|||..|||....|||.|:|...||:||
 Worm   993 --------------------------------PCDCEYIGSENQQCDVNSGQCLCKENVEGRRCD 1025

  Fly  1326 TCAIGYFGYPECRRCGCDAEGSFTQADGSIACDSNGQCPCKSLVVGLKCDTCMQSTFGLSAQNPE 1390
            .||...:|              .||  |.:.||.              |.|.:||...:..:.  
 Worm  1026 QCAENRYG--------------ITQ--GCLPCDD--------------CYTLIQSRVNVFREK-- 1058

  Fly  1391 GCTRCFCFGRSGECEQSDLSWGHIRMAESRNLSVQQIRPHSVPSSDYEYIVVVQMEGSSFHREDA 1455
                                      .:|.:.::|:|..:..|.:|.::              |.
 Worm  1059 --------------------------VKSLDNTLQEIIENPAPVNDTKF--------------DE 1083

  Fly  1456 EIQRMNDLSLVPKSTGNVSIGAYGQFYHPLYFQLPPQFYGDRTSSYGGFLYFTLITEGAHKPLER 1520
            ::          |.|...:...:             :....:|...||    |:.|:        
 Worm  1084 KV----------KETSRAASEVW-------------EAVKQKTKEGGG----TIKTK-------- 1113

  Fly  1521 NILGQYPLVQLHAHSKLLLDFYEYEEFEYSLNVTHRVPLHESFWKYHHTSQAVDRNTLMAALQNI 1585
                                                             |:|: ::.::|||:.:
 Worm  1114 -------------------------------------------------SKAI-KDEIVAALEKL 1128

  Fly  1586 RHIFIRAFAFADFQEVVLQNVHMDAAIYIKGSTNLIAKGVERCKCPKRFDGLSCQDPGRSFYRWR 1650
                                                                             
 Worm  1129 ----------------------------------------------------------------- 1128

  Fly  1651 NTTIVESVFIEDLIGRAAPCHCNGRSSDCDRETGVCQNCRGNTGGDHCHQCAEGFYGDPNSPHGC 1715
             |:|.|||       ..|....:...:|..|...:.:|.|                         
 Worm  1129 -TSIDESV-------AQAKVGADAAENDMKRWEIIIENAR------------------------- 1160

  Fly  1716 QACPCPETNRNFARGCNVWDGEVSCVCKPGYTGRLCERCQAGYFGDPMRYPNTTCQPCNCHPDGI 1780
                                                                             
 Worm  1161 ----------------------------------------------------------------- 1160

  Fly  1781 QTEGCDVETGRCYCREGVTGLKCDKCQAERHHLVDNGCKICDNCTLLLLDYMELVGNKLRRGMHN 1845
                          ||                 ::|           :|.|:|..|.:..:..:|
 Worm  1161 --------------RE-----------------IEN-----------VLHYLETEGEERAQIAYN 1183

  Fly  1846 MDLTGIPAPYRKLSEYESAYEKWNGRHWDFSQTKRRLQDYDSADILKLEAHAENLKFQSRKAVAT 1910
                              |.:|       :.:..:|:.:..|....:.|.|.             
 Worm  1184 ------------------ASQK-------YGEQSKRMSELASGTREEAEKHL------------- 1210

  Fly  1911 IGKREFAIKSMREDAVTQQHSVGLLRSEILQTLSDLHGYGKSAHYLSLPTA-LKQARFYLQAIRE 1974
              |:...|:.:.|.|:..........|:.:        ||  ...:|...| ||:         :
 Worm  1211 --KQASEIEQLSEQAIANATQANKEASDAI--------YG--GEQISKQIAELKE---------K 1254

  Fly  1975 HDQMVQGIRSTNDCAWKHFYAMGNASDASFDESGRLEMLWRDLNQTNHRVVDMRLQVDRVQEVEN 2039
            .:|:.:.|..|.|.|        .....|.||:..|..    ::.||...|.:. .|| .:|:.|
 Worm  1255 QNQLNESIHRTLDLA--------EEQKKSADEANNLAA----VSLTNVEAVKIP-SVD-PKELRN 1305

  Fly  2040 EAEDVLEHVRNL---SIRVGESHQEL-DELNQRISDHLDPGYLEQGEGLLRLTVQRQIMLNGHLN 2100
            :...|||...||   |::...::.|| ||:|:.::|..:.  |:..:...|  |..|:||     
 Worm  1306 DVAGVLEESENLVDSSVKENSANDELFDEVNRSVADARNE--LQSSQDQQR--VSDQLML----- 1361

  Fly  2101 QLDGYRILLNTTLGVKTEQQREVRKHWLPKAE---KHASHLLARSNEYARKFQPTRNGARIAMLA 2162
                           :.|:.||.....:..|:   |.|...|....|:..|.:.:||.| :|..|
 Worm  1362 ---------------ELEKSRERIVDSVSTADKTLKDAEAALQVLEEFGAKIEKSRNDA-VAEFA 1410

  Fly  2163 SSAHSNITEAINDARLASILAKERVYEAQRTLYPSDGSSMIERAKHSLHRSKQLQQEALKQMHK- 2226
            .      .|.||. ||..|:..:   :.:|...|.|...:|:..|.:        ...|.:.|. 
 Worm  1411 G------VEGINQ-RLDDIIDAQ---DKRRNSLPIDKQFVIDYRKSA--------DVLLNETHAL 1457

  Fly  2227 SNVLKDKLHRQEQQVEGIKSTIYDSGLRTNNISGQLQGLSDGSA-----RRQAKDSLEMADRTGE 2286
            ::..||.:|......:..::..||       |...::.|:|.:.     ::||:|..:||  |..
 Worm  1458 ADRYKDIIHSDVDTRDSTEAVQYD-------IEQLMEELTDSNENLQYYKKQAEDDKQMA--TEA 1513

  Fly  2287 QMRAELQKAKDMQKS---------IQNMRNSFSNLEPDWEIKLGMAQENIS-LTQ--TNLRLANV 2339
            ..:|.|.|...::.:         |:.:.||...:|.....:|...:|.|. |.|  ...:||..
 Worm  1514 VRKATLAKNSAIEANATILAEEDEIKKIINSLDTMEEVNNAELDELEEEIDRLDQLLAQAQLAKE 1578

  Fly  2340 SLSYLEQQAEKEQQVFEVWNNSMAQQ-----LQQLRDQI-AKARHAAEAIDVSLESLGPK 2393
            ..:|.:.:|:::.:|.::.|:....|     |:::||.: .|..:.     ::||..|.|
 Worm  1579 VPTYQQYRADEDVKVAQLKNDISELQKEVLNLEEIRDNLPTKCFNV-----INLEQEGQK 1633

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 153..398 CDD:459653 71/250 (28%)
EGF_Lam 401..450 CDD:238012 21/56 (38%)
EGF_Lam 505..552 CDD:238012 16/49 (33%)
Laminin_EGF 550..597 CDD:395007 27/49 (55%)
Laminin_B 660..813 CDD:459652 34/168 (20%)
EGF_Lam 851..900 CDD:238012 29/48 (60%)
Laminin_EGF <943..971 CDD:395007 16/27 (59%)
Laminin_EGF 974..1018 CDD:395007 22/50 (44%)
EGF_Lam 1017..1065 CDD:238012 3/47 (6%)
Laminin_EGF 1065..>1105 CDD:395007 3/39 (8%)
EGF_Lam 1150..1197 CDD:238012 17/46 (37%)
Laminin_EGF 1199..1247 CDD:395007 27/47 (57%)
EGF_Lam 1247..1292 CDD:238012 0/44 (0%)
Laminin_EGF 1294..1342 CDD:395007 20/47 (43%)
Laminin_EGF 1340..1392 CDD:395007 9/51 (18%)
Laminin_B 1486..1626 CDD:459652 10/139 (7%)
EGF_Lam 1669..1716 CDD:238012 4/46 (9%)
Laminin_EGF 1718..1767 CDD:395007 0/48 (0%)
EGF_Lam 1772..1819 CDD:238012 3/46 (7%)
YhaN <1907..2141 CDD:443752 52/241 (22%)
SMC_prok_B <2123..>2390 CDD:274008 63/293 (22%)
Laminin_II 2279..2400 CDD:368703 30/133 (23%)
LamG 2399..>2492 CDD:473984
LamG 2586..2753 CDD:238058
Laminin_G_2 2804..2944 CDD:460494
LamG 3018..3167 CDD:238058
LamG 3192..3347 CDD:238058
lam-2NP_509204.3 LamNT 45..285 CDD:214532 71/250 (28%)
EGF_Lam 286..337 CDD:238012 20/50 (40%)
Laminin_EGF 347..405 CDD:395007 18/60 (30%)
EGF_Lam 403..447 CDD:214543 13/43 (30%)
LamB 560..684 CDD:214597 33/157 (21%)
EGF_Lam 736..783 CDD:238012 29/47 (62%)
EGF_Lam 785..833 CDD:238012 28/71 (39%)
Laminin_EGF 835..890 CDD:395007 25/97 (26%)
EGF_Lam 889..944 CDD:238012 25/132 (19%)
EGF_Lam 946..991 CDD:214543 24/44 (55%)
EGF_Lam 993..1041 CDD:238012 23/63 (37%)
Smc <1087..>1617 CDD:440809 143/934 (15%)
Blue background indicates that the domain is not in the aligned region.

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