DRSC/TRiP Functional Genomics Resources

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Protein Alignment wb and unc-6

DIOPT Version :10

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:NP_509165.1 Gene:unc-6 / 180961 WormBaseID:WBGene00006746 Length:612 Species:Caenorhabditis elegans


Alignment Length:669 Identity:163/669 - (24%)
Similarity:252/669 - (37%) Gaps:177/669 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 PPLFNVVPRAQISVNATCGQNGAEEYC--KQ----VGAKPCGICNAHSSDRAKQRSIQSLISSGS 213
            |...|......:..:.|||.|..::||  |:    :..:.|..|:|.:..::...|:.:.::|  
 Worm    49 PEFINAAFGKPVIASDTCGTNRPDKYCTVKEGPDGIIREQCDTCDARNHFQSHPASLLTDLNS-- 111

  Fly   214 GSGSGSGFEEGWWQSPTLQGGRQFEYVTILLDLKQTFQIFSVWLKSANSPRPASWILEKSLD-GI 277
                 .|....|..:|:|..    :.|::.|.|.:.|::..|.:... |..|.|..|.||.| |.
 Worm   112 -----IGNMTCWVSTPSLSP----QNVSLTLSLGKKFELTYVSMHFC-SRLPDSMALYKSADFGK 166

  Fly   278 NFEPWQYFGLSDADCQRRWNLSGQNG--KYVFQNDTEIICSTQFSKPGPLENGVLHASLLKNRPG 340
            .:.|:|::   .::|:|   :.|::.  .....|:.|.:|:..... ||..|.|.. ..|:|||.
 Worm   167 TWTPFQFY---SSECRR---IFGRDPDVSITKSNEQEAVCTASHIM-GPGGNRVAF-PFLENRPS 223

  Fly   341 AT--DQSPELMKFITTRYIRI----------RLQGMHSTANQ-DNSLDWLLDSPSLEKHSFYSLS 392
            |.  :.||.|..::|...|::          .|.|:.:..|. .|..|     ..:::..|||:.
 Worm   224 AQNFENSPVLQDWVTATDIKVVFSRLSPDQAELYGLSNDVNSYGNETD-----DEVKQRYFYSMG 283

  Fly   393 QLKVSARLDCNGHANRSHESPDDPLMQCI----------CQHNTCGAQCEQCCPLFQDRPY---- 443
            :|.|..|..|||||:|           ||          |:|||.|.:||.|.|...|||:    
 Worm   284 ELAVGGRCKCNGHASR-----------CIFDKMGRYTCDCKHNTAGTECEMCKPFHYDRPWGRAT 337

  Fly   444 -QMGGECEICQCYGHAESCTYDPFLDK-------GICQSCSNNTAGIECEFCEMGFYRELDAPLT 500
             .....|..|.|..||:.|.:|..|.:       |:|.:|.:||||..|..|:.||.|:...|:|
 Worm   338 ANSANSCVACNCNQHAKRCRFDAELFRLSGNRSGGVCLNCRHNTAGRNCHLCKPGFVRDTSLPMT 402

  Fly   501 --DPCLPCSCNPARSTG-GCQSDGGSCNCLEGFQGKNCEECAPGYYGDDCKRCECDERGSLGSTG 562
              ..|..|.|:|..|.| .|....|.|.|..|..|..|..||.||                  ..
 Worm   403 HRKACKSCGCHPVGSLGKSCNQSSGQCVCKPGVTGTTCNRCAKGY------------------QQ 449

  Fly   563 SCSGVCQC-----KLNVEGSTCSECAPGYFDLSAENAEGCTSC-----------WCSGVSQTCHS 611
            |.|.|..|     |.:..||:.|           |..:.|:.|           :|    :..|:
 Worm   450 SRSTVTPCIKIPTKADFIGSSHS-----------EEQDQCSKCRIVPKRLNQKKFC----KRDHA 499

  Fly   612 AKLQTLAFETLNDWKITDIQRVKPISIPVDAETNRLIFANELDEVEAIYWQASLGYLGNRLTSYG 676
            .::..::.|.::.|        ....|.|::...|  ....:...|...|.:..|.:        
 Worm   500 VQMVVVSREMVDGW--------AKYKIVVESVFKR--GTENMQRGETSLWISPQGVI-------- 546

  Fly   677 SRLQLVLSWDVIRGDRSGKPTTGPNVILVGKNGLKIAFGDESLDGLGINLNVTLTEVGWYHVPPT 741
                          .:..|...|...:|:|||.     .|...|||.:|....|.|  |..    
 Worm   547 --------------CKCPKLRVGRRYLLLGKND-----SDHERDGLMVNPQTVLVE--WED---- 586

  Fly   742 VVDIKTRLRRTEGGDYHGE 760
              ||..::.|....|..|:
 Worm   587 --DIMDKVLRFSKKDKLGQ 603

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 153..398 CDD:459653 63/264 (24%)
EGF_Lam 401..450 CDD:238012 20/63 (32%)
EGF_Lam 505..552 CDD:238012 16/47 (34%)
Laminin_EGF 550..597 CDD:395007 9/51 (18%)
Laminin_B 660..813 CDD:459652 21/101 (21%)
EGF_Lam 851..900 CDD:238012
Laminin_EGF <943..971 CDD:395007
Laminin_EGF 974..1018 CDD:395007
EGF_Lam 1017..1065 CDD:238012
Laminin_EGF 1065..>1105 CDD:395007
EGF_Lam 1150..1197 CDD:238012
Laminin_EGF 1199..1247 CDD:395007
EGF_Lam 1247..1292 CDD:238012
Laminin_EGF 1294..1342 CDD:395007
Laminin_EGF 1340..1392 CDD:395007
Laminin_B 1486..1626 CDD:459652
EGF_Lam 1669..1716 CDD:238012
Laminin_EGF 1718..1767 CDD:395007
EGF_Lam 1772..1819 CDD:238012
YhaN <1907..2141 CDD:443752
SMC_prok_B <2123..>2390 CDD:274008
Laminin_II 2279..2400 CDD:368703
LamG 2399..>2492 CDD:473984
LamG 2586..2753 CDD:238058
Laminin_G_2 2804..2944 CDD:460494
LamG 3018..3167 CDD:238058
LamG 3192..3347 CDD:238058
unc-6NP_509165.1 LamNT 41..289 CDD:214532 63/264 (24%)
EGF_Lam 290..333 CDD:238012 20/53 (38%)
Laminin_EGF 347..400 CDD:395007 19/52 (37%)
Laminin_EGF 410..453 CDD:395007 17/60 (28%)
NTR_netrin-1_like 490..604 CDD:239634 29/163 (18%)
Blue background indicates that the domain is not in the aligned region.

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