Protein Alignment wb and Ntng2

DIOPT Version :10

• Sequence 1: NP_723870.1
• Gene: wb / 43946
• FlyBaseID: FBgn0261563
• Length: 3375
• Species: Drosophila melanogaster
• Sequence 2: NP_598008.1
• Gene: Ntng2 / 171171
• MGIID: 2159341
• Length: 589
• Species: Mus musculus
• Alignment Length: 536
• Identity: 126/536 - (23%)
• Similarity: 197/536 - (36%)
• Gaps: 162/536 - (30%)

  Fly   171 TCGQNGAEEYCKQVGAKPC-GICNAHSSDRAKQRSIQSLISSGSGSGSGSGFEEGWWQ---SP-- 229
            ||| :..|.:|.......| ..|:|.:.|.|..   ..|:......|..:.::...|.   ||
Mouse    60 TCG-DPPERFCSHENPYLCSNECDASNPDLAHP---PRLMFDREDEGLATYWQSVTWSRYPSPLE 120

  Fly   230 ---TLQGGRQFEYVTILLDLKQTFQIFSVWLKSANSPRPASWILEKSLD-GINFEPWQYFGLSDA 290
               ||...:..|...   |:..||:.          .||...:|||||| |..::|:|::.   .
Mouse   121 ANITLSWNKSVELTD---DVVVTFEY----------GRPTVMVLEKSLDNGRTWQPYQFYA---E 169

  Fly   291 DCQRRWNLSGQNGKYVFQNDT-EIICSTQFSK---------------------PGP-LENGVLHA 332
            ||...:.:|.:..:.:..:.. .::|:.::|:                     .|| |.|
Mouse   170 DCMEAFGMSARRARDMSPSSAHRVLCTEEYSRWAGSKKEKHVRFEVRDRFAIFAGPDLRN----- 229

  Fly   333 SLLKNRPGATDQSPELMKFITTRYIRIRL--QGMHSTANQDNSLDWLLDSPSLEKHSFYSLSQLK 395
              :.|.....:.:..|.:|.|...:|:||  ..:..|         .:...:|.|: ||::|.::
Mouse   230 --MDNLYTRMESAKGLKEFFTFTDLRMRLLRPALGGT---------YVQRENLYKY-FYAISNIE 282

  Fly   396 VSARLDCNGHANRSHESPDDPLMQCICQHNTCGAQCEQCCPLFQDRPYQMGG------------- 447
            |..|..||.|||..  :..:..:||.|:|||.|..|.:|...|:.|.::.|.
Mouse   283 VIGRCKCNLHANLC--TVREGSLQCECEHNTTGPDCGRCKKNFRTRAWRAGSYLPLPHGSPNACA 345

  Fly   448 ---------------------------------------------------------------EC 449
                                                                           |.
Mouse   346 AAGSAFGSQTKPPTMAPLGDSSFWPQVSSSAEAVAISVAVPSQAKDSTLFELKPRSPQVIPIEEF 410

  Fly   450 EICQCYGHAESCTYDPFLDKGICQSCSNNTAGIECEFCEMGFYRELDAPLTDP--CLPCSCNPAR 512
            :.|:||||:..|:|..||:...|.||.:||.|..|:.|.:|:||...|.|.|.  |:.|:||...
Mouse   411 QDCECYGHSNRCSYIDFLNVVTCVSCKHNTRGQHCQHCRLGYYRNGSAELDDENVCIECNCNQIG 475

  Fly   513 STGGCQSDGGSCNCLEGFQGKNCEECAP-GYYGDDCKRCECDERGSLGSTGSCSGVCQCKLNVEG 576
            |.....::.|.|.|.||..|..|::|.| .|:...|....||:...|...|   |.||     :.
Mouse   476 SVHDRCNETGFCECREGAVGPKCDDCLPTHYWRQGCYPNVCDDDQLLCQNG---GTCQ-----QN 532

  Fly   577 STCSECAPGYFDLSAE 592
            ..|: |.|||..:..|
Mouse   533 QRCA-CPPGYTGIRCE 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wb	NP_723870.1	Laminin_N	153..398	CDD:459653	55/261 (21%)
		EGF_Lam	401..450	CDD:238012	18/124 (15%)
		EGF_Lam	505..552	CDD:238012	15/47 (32%)
		Laminin_EGF	550..597	CDD:395007	13/43 (30%)
		Laminin_B	660..813	CDD:459652
		EGF_Lam	851..900	CDD:238012
		Laminin_EGF	<943..971	CDD:395007
		Laminin_EGF	974..1018	CDD:395007
		EGF_Lam	1017..1065	CDD:238012
		Laminin_EGF	1065..>1105	CDD:395007
		EGF_Lam	1150..1197	CDD:238012
		Laminin_EGF	1199..1247	CDD:395007
		EGF_Lam	1247..1292	CDD:238012
		Laminin_EGF	1294..1342	CDD:395007
		Laminin_EGF	1340..1392	CDD:395007
		Laminin_B	1486..1626	CDD:459652
		EGF_Lam	1669..1716	CDD:238012
		Laminin_EGF	1718..1767	CDD:395007
		EGF_Lam	1772..1819	CDD:238012
		YhaN	<1907..2141	CDD:443752
		SMC_prok_B	<2123..>2390	CDD:274008
		Laminin_II	2279..2400	CDD:368703
		LamG	2399..>2492	CDD:473984
		LamG	2586..2753	CDD:238058
		Laminin_G_2	2804..2944	CDD:460494
		LamG	3018..3167	CDD:238058
		LamG	3192..3347	CDD:238058
Ntng2	NP_598008.1	Laminin_N	60..285	CDD:459653	55/261 (21%)
		NGL discriminant loop I. /evidence=ECO:0000250	69..88		4/18 (22%)
		NGL discriminant loop II. /evidence=ECO:0000250	201..203		0/1 (0%)
		NGL discriminant loop III. /evidence=ECO:0000250	264..267		1/11 (9%)
		EGF_Lam	286..332	CDD:238012	17/47 (36%)
		EGF_Lam	413..461	CDD:238012	21/47 (45%)
		Laminin_EGF	469..516	CDD:395007	15/46 (33%)
		EGF_CA	<523..547	CDD:238011	9/32 (28%)