DRSC/TRiP Functional Genomics Resources

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Protein Alignment wb and Lamb3

DIOPT Version :10

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:NP_032510.2 Gene:Lamb3 / 16780 MGIID:99915 Length:1168 Species:Mus musculus


Alignment Length:1638 Identity:324/1638 - (19%)
Similarity:516/1638 - (31%) Gaps:603/1638 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   540 PGYYGDDCKRCECDERGSLGSTGSCSG------VCQCKLNVEGSTCSECAPGYFDLSAENAEGCT 598
            ||:.   |.:..|       |.|:|..      :.:.:|....|||....|..:         ||
Mouse    12 PGFL---CAQQAC-------SRGACYPPVGDLLIGRTQLLRASSTCGLTKPETY---------CT 57

  Fly   599 S--------CWC-SGVSQTCHSAKLQTLA--------FETLNDWKITDIQRVKPISIPVDAETNR 646
            .        |.| |.:.:..:|.:::.:|        :::.||        |.|:|:.:|.: .|
Mouse    58 QYGQWQMKCCKCDSRLPRNYNSHRVENVASSSGPMRWWQSQND--------VSPVSLQLDLD-KR 113

  Fly   647 LIFANELDEVEAIYWQASLGYLGNRLTSYGSRLQLVLSWDVIRGDRSGKPTTGPNVILVGKNGLK 711
            :...:.:.:.:.:   ...|.|..|.:.:|.      :|.|.:...:...:|.|.|         
Mouse   114 MQLQDIMMDFKGL---TPAGMLIERSSDFGK------TWRVYQYLATDCASTFPQV--------- 160

  Fly   712 IAFGDESLDGLGINLNVTLTEVGWYH--VPPTVVDIKTR-LRRTEGGDYHGESVTRSQFLSVLVS 773
                                     |  .|....|::.| |.:...|...|..          |.
Mouse   161 -------------------------HQGQPKNWQDVRCRPLSQRPNGHLTGGK----------VQ 190

  Fly   774 LDAVLIRAAFHTDQGETSLERAVIYSGGVELGGKSSSQVE-QCLCPAGYTGLSCEGCAFGFKRIY 837
            |:.:.:.:|....|.:..          .|||..::.:|. ..|.|....|.......|...::.
Mouse   191 LNLMDLASAIPASQSKKI----------QELGDITNLRVNFTKLAPVPQRGSYPPSAYFAVSQLR 245

  Fly   838 ENTSDHQILSKCIPCPCNGHSNSC---------DLQSGNCGDCMHNTFGDRCERCQLGYYGNPLQ 893
            ...|          |.|:||::.|         .:|..|...|.|||.|..|:||...|...|  
Mouse   246 LQGS----------CFCHGHADRCAPNPGGSTTAVQVNNVCVCQHNTAGPNCDRCAPFYNNRP-- 298

  Fly   894 GTPNDCKRCACPLSEDSNNFSPSCQLKSYNYMDLNPQFELIEHAEYICTQCPEGYTGDHCQVCDD 958
                               :.|:                             ||           
Mouse   299 -------------------WRPA-----------------------------EG----------- 304

  Fly   959 GYFGNPRQPGSSCQRCDCAGGPCNVTTGECITCRGNTEGWHCERCKLGYWGDPAVGCDPCHCHTE 1023
                   |....||||||.|                    |.|.|..    ||||     ...::
Mouse   305 -------QDTHECQRCDCNG--------------------HSETCHF----DPAV-----FAASQ 333

  Fly  1024 GSESGLCDSTDGQCLCKPRYAGQKCDECDVGY-------ANVELRCPSCNCDPLGSLVQDRCDPH 1081
            |:..|:||:      |:....|:.|:.|.:.|       |.:...|..|.|||.|::....||..
Mouse   334 GTNGGVCDN------CRDHTEGKNCERCQLHYFRNRRPSAPIHETCIPCECDPDGAVQGAPCDRL 392

  Fly  1082 TGQCHCKEGVMGAKCHECQDGYFGMNAVAYRMDDLAALRQNSDSDDDEWELVPDTEDPNSESTVA 1146
            ||||.|||.|.|.:|..|:.|:.|:...                            :|.     .
Mouse   393 TGQCVCKEYVQGERCDLCKPGFTGLTFA----------------------------NPK-----G 424

  Fly  1147 CEECHCSSVGSLSS-DCDKRTGQCACLANVTGRRCDKCRPGHWNLTAGEGCRDCRCDPHGSRGHE 1210
            |..|.||.:|:... .|::.||:|.||.||.|.:||:|.|.||.|.:|.||..|.|||..|...:
Mouse   425 CHACDCSILGARKDMPCEEETGRCLCLPNVVGPKCDQCAPSHWKLASGLGCEPCACDPRNSLSSQ 489

  Fly  1211 CNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRCSACRSEGQVCDPHNGRCICPKFTRGLGC 1275
            ||.:||||.|:.|.||..|:.                :|.|                        
Mouse   490 CNQFTGQCPCREGFGGLTCSS----------------AAIR------------------------ 514

  Fly  1276 GQCVPGTWGWQARLGCRECECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFG-YPECRR 1339
             ||...|:|..| .|||.|:||..|:.|..|....|:|.||.|::|.:||.|..|:.. ||.|..
Mouse   515 -QCPDQTYGHVA-TGCRACDCDFRGTEGPGCDKASGRCLCRPGFTGPRCDQCQRGHCDRYPVCVA 577

  Fly  1340 CGCDAEGSFTQADGSIACDSNGQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGCTRCFCFGRSGEC 1404
            |    ...|...|..:...:......::...||...|.::. .||::                  
Mouse   578 C----HSCFQAYDTDLQEQARRLHSLRNATEGLWTGTGLED-HGLAS------------------ 619

  Fly  1405 EQSDLSWGHIRMAESRNLSVQQIRPHSVPSSDYEYIVVVQMEGSSFHRED-AEIQRMNDLSLVPK 1468
                      |:.:::: .::|||.              .:||:|...:| |::           
Mouse   620 ----------RLLDAKS-KIEQIRQ--------------ILEGTSVTEQDVAQV----------- 648

  Fly  1469 STGNVSIGAYGQFYHPLYFQLPPQFYGDRTSSYGGFLYFTLITEGAHKPLERNILGQYPLVQLHA 1533
            :.|.:||   .:....|...||.:   :...|:.|.|          ..|:|:.           
Mouse   649 ANGILSI---RRTLQGLPLDLPLE---EEMESFSGDL----------GNLDRSF----------- 686

  Fly  1534 HSKLLLDF-YEYEEFEYSLNVTHRVPLHESFWKYHHTSQAV----DRNTLMAALQNIRHIFIRAF 1593
             |:|||.: .:.|:||...:.............|..:|:|.    |.::|::.|::.|.      
Mouse   687 -SRLLLMYRSKKEQFEKLSSEDPSGAFRMLTMAYEQSSRAAQQVSDSSSLLSQLRDSRR------ 744

  Fly  1594 AFADFQEVVLQNVHMDAAIYIKGSTNLIAKGVERCKCPKRFDGLSCQDPGRSFYRWRNTTIVESV 1658
                    ..:.:...|.....|...|:|..:|....|..                       :.
Mouse   745 --------EAEGLERQAGGGGTGGAQLMALRLEMASLPDL-----------------------TP 778

  Fly  1659 FIEDLIGRAAPCHCNGRSSDCDRETGVCQNCRGNTGGDHCHQC---AEGFYGDPNSPHGCQACPC 1720
            .|..|.||:....|.  ..||..|  :|....|...|.||...   |:|.:      |  .|...
Mouse   779 TINKLCGRSRQTACT--PGDCPGE--LCPQDNGTACGSHCRGALPRAKGAF------H--MAGRV 831

  Fly  1721 PETNRNFARGCNVWDGEVSCVCKPGYTGRLCERCQAGYFGDPMRYPNTTCQPCNCHPDGIQTEGC 1785
            .|..|||..........:          |..|...:....|..|               ::|:  
Mouse   832 AEQLRNFNTQLQQTRQMI----------RAAEEAASRVQADAQR---------------LETQ-- 869

  Fly  1786 DVETGRCYCREGVTGLKCDKCQAERHHLVDNGCKIC----------------DNCTLLLLDYMEL 1834
             |.|.|....|.|...:. ..|..|..|.|......                |:.|:|       
Mouse   870 -VSTSRLLMEEDVQRTRL-LIQQVRGFLTDPDTDAATIQQVSEAVLALWLPTDSATVL------- 925

  Fly  1835 VGNKLRRGMHNMDLTGIPAPYRKLSEYESAYEKWNGRHWDFSQTKRRLQDYDSADILKLEAHAEN 1899
                                 ||:.|.::...:........||||:     |.|...:|:|.|| 
Mouse   926 ---------------------RKMKEIQAIAARLPNVDSVLSQTKQ-----DIARARRLQAEAE- 963

  Fly  1900 LKFQSR-KAVATIGKREFAIKSMREDAVTQQHSVGLLRSEILQTLSD-LHGYGKSAHYLSLPTAL 1962
               |:| :|.|..|:.:..:.::|:..|.            ||...| :.|.|:|...:......
Mouse   964 ---QARSRAHAVEGQVDDVVGNLRQGTVA------------LQEAQDTMQGTGRSLRLIQERVGE 1013

  Fly  1963 KQARFYLQAIREHDQMVQGIRSTNDCAWKHFYAMGNASDASFDESGRLEMLWRDLNQTNHRVVDM 2027
            .|     |.:...:::|:|::......|.                               |:.::
Mouse  1014 VQ-----QVLVPAERLVKGMKEQMSGFWA-------------------------------RMKEL 1042

  Fly  2028 RLQVDRVQEVENEAEDVLEHVRNLSIRVGESHQELDELNQRISDHL--DPGYLEQGEGLLRLTVQ 2090
            |.|....|....:|..:.|.....::...|..:.|.:....:.|.|  .|...|||..:|.:.::
Mouse  1043 RRQAQEEQAQAMQARQLAEGASQQAMNAQEGFKRLKQKYTELKDRLGQSPVLGEQGNRILSIKME 1107

  Fly  2091 RQIMLNGHLNQLD 2103
            .:.:....:..:|
Mouse  1108 AEELFGETMEMMD 1120

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 153..398 CDD:459653
EGF_Lam 401..450 CDD:238012
EGF_Lam 505..552 CDD:238012 3/11 (27%)
Laminin_EGF 550..597 CDD:395007 9/52 (17%)
Laminin_B 660..813 CDD:459652 23/155 (15%)
EGF_Lam 851..900 CDD:238012 17/57 (30%)
Laminin_EGF <943..971 CDD:395007 3/27 (11%)
Laminin_EGF 974..1018 CDD:395007 11/43 (26%)
EGF_Lam 1017..1065 CDD:238012 11/54 (20%)
Laminin_EGF 1065..>1105 CDD:395007 19/39 (49%)
EGF_Lam 1150..1197 CDD:238012 22/47 (47%)
Laminin_EGF 1199..1247 CDD:395007 16/47 (34%)
EGF_Lam 1247..1292 CDD:238012 8/44 (18%)
Laminin_EGF 1294..1342 CDD:395007 20/48 (42%)
Laminin_EGF 1340..1392 CDD:395007 8/51 (16%)
Laminin_B 1486..1626 CDD:459652 25/144 (17%)
EGF_Lam 1669..1716 CDD:238012 12/49 (24%)
Laminin_EGF 1718..1767 CDD:395007 8/48 (17%)
EGF_Lam 1772..1819 CDD:238012 10/46 (22%)
YhaN <1907..2141 CDD:443752 32/200 (16%)
SMC_prok_B <2123..>2390 CDD:274008
Laminin_II 2279..2400 CDD:368703
LamG 2399..>2492 CDD:473984
LamG 2586..2753 CDD:238058
Laminin_G_2 2804..2944 CDD:460494
LamG 3018..3167 CDD:238058
LamG 3192..3347 CDD:238058
Lamb3NP_032510.2 Laminin_N 20..248 CDD:470680 51/315 (16%)
EGF_Lam 249..301 CDD:238012 18/82 (22%)
Laminin_EGF 313..367 CDD:395007 20/88 (23%)
Laminin_EGF 376..425 CDD:395007 21/81 (26%)
Laminin_EGF 428..475 CDD:395007 21/46 (46%)
Laminin_EGF 478..531 CDD:395007 26/94 (28%)
EGF_Lam 530..579 CDD:238012 20/52 (38%)
Domain II 576..781 48/328 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 723..760 7/50 (14%)
Domain alpha 782..812 9/33 (27%)
Domain I 813..1168 74/430 (17%)
SMC_prok_B <830..1161 CDD:274008 68/405 (17%)
cc_LAMB_C 1098..1168 CDD:424069 3/23 (13%)
Blue background indicates that the domain is not in the aligned region.

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