DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wb and Lamb1

DIOPT Version :9

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:NP_032508.3 Gene:Lamb1 / 16777 MGIID:96743 Length:1786 Species:Mus musculus


Alignment Length:2247 Identity:510/2247 - (22%)
Similarity:783/2247 - (34%) Gaps:778/2247 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   151 GGLYPPLFN-VVPRAQ-ISVNATCGQNGAEEYC---KQVGAKPCGICNA----HSSDRAKQRSIQ 206
            |..||...: ::.||| :||.:|||.:..|.||   .....|.|.||::    |.:.......|:
Mouse    33 GSCYPATGDLLIGRAQKLSVTSTCGLHKPEPYCIVSHLQEDKKCFICDSRDPYHETLNPDSHLIE 97

  Fly   207 SLISSGSGSGSGSGFEEG----WWQSPTLQGGRQFEYVTILLDLKQTFQIFSVWLKSANSPRPAS 267
            :::::         |...    ||||   :.|  .|.|||.|||:..|. |:..:.:..:.|||:
Mouse    98 NVVTT---------FAPNRLKIWWQS---ENG--VENVTIQLDLEAEFH-FTHLIMTFKTFRPAA 147

  Fly   268 WILEKSLD-GINFEPWQYFGLSDADCQRRW-NLSGQNGKYVFQNDTEIICSTQFSKPGPLENG-V 329
            .::|:|.| |..:..::||..   ||:..: .:|....|.|    .:|||.:::|...|...| |
Mouse   148 MLIERSSDFGKAWGVYRYFAY---DCESSFPGISTGPMKKV----DDIICDSRYSDIEPSTEGEV 205

  Fly   330 LHASLLKNRPGATDQSPELMKFITTRYIRIRLQGMHSTANQDNSLDWLLDSPSLEKHSFYSLSQL 394
            :..:|..........||.:...:....:||:...:|:..  ||.||..::   :.:..:|::..:
Mouse   206 IFRALDPAFKIEDPYSPRIQNLLKITNLRIKFVKLHTLG--DNLLDSRME---IREKYYYAVYDM 265

  Fly   395 KVSARLDCNGHANRSHESPDDPLMQ---------CICQHNTCGAQCEQCCPLFQDRPY-----QM 445
            .|.....|.|||  |..:|.|.:.:         |:|:|||.|..||.|...:.|.|:     :.
Mouse   266 VVRGNCFCYGHA--SECAPVDGVNEEVEGMVHGHCMCRHNTKGLNCELCMDFYHDLPWRPAEGRN 328

  Fly   446 GGECEICQCYGHAESCTYD--PFL-----DKGICQSCSNNTAGIECEFCEMGFYRELDAPLTDP- 502
            ...|:.|.|..|:.||.:|  .||     ..|:|.:|.:||.|..||.|:..:::..:..:.|| 
Mouse   329 SNACKKCNCNEHSSSCHFDMAVFLATGNVSGGVCDNCQHNTMGRNCEQCKPFYFQHPERDIRDPN 393

  Fly   503 -CLPCSCNPARSTGGCQSDG----------GSCNCLEGFQGKNCEECAPGYY---GDD---CKRC 550
             |.||:|:||.|..|...||          |.|.|....:|:.|:.|..|:|   .:|   ||.|
Mouse   394 LCEPCTCDPAGSENGGICDGYTDFSVGLIAGQCRCKLHVEGERCDVCKEGFYDLSAEDPYGCKSC 458

  Fly   551 ECDERGSLGSTGSC---SGVCQCKLNVEGSTCSECAPGYFDLSAENAEGCTSCWC---SGVSQTC 609
            .|:..|::.....|   :|.|.||..|.|..|.:|.|.::.|| .:.:||..|.|   ..::.:|
Mouse   459 ACNPLGTIPGGNPCDSETGYCYCKRLVTGQRCDQCLPQHWGLS-NDLDGCRPCDCDLGGALNNSC 522

  Fly   610 HSAKLQTLAFETLNDWKITDIQRVKPISIPVDAETNRLIFANELDEVEAIYW------------Q 662
            .....|......:                          ...:.:|||:.|:            :
Mouse   523 SEDSGQCSCLPHM--------------------------IGRQCNEVESGYYFTTLDHYIYEAEE 561

  Fly   663 ASLG---------YLGNRLTSY----------GSRLQLVLS---------------------WD- 686
            |:||         |:.:|:.|:          |:.|:..:.                     |: 
Mouse   562 ANLGPGVIVVERQYIQDRIPSWTGPGFVRVPEGAYLEFFIDNIPYSMEYEILIRYEPQLPDHWEK 626

  Fly   687 -VIRGDRSGK-----------PTTGPNVILVGKNGLKIAFGDESLDGLGINLNVTLTEVGWY--- 736
             ||...|.||           |.....|:.:......:..........|:|..|.| |:..|   
Mouse   627 AVITVQRPGKIPASSRCGNTVPDDDNQVVSLSPGSRYVVLPRPVCFEKGMNYTVRL-ELPQYTAS 690

  Fly   737 ----HVPPTVVD-------IKTRLRRTEGGDYHGESVTRSQFLSVLVSLDAVLIRAAFHTDQGET 790
                ..|.|.:|       .|:....|.||...|| ||.|                |:.|.|...
Mouse   691 GSDVESPYTFIDSLVLMPYCKSLDIFTVGGSGDGE-VTNS----------------AWETFQRYR 738

  Fly   791 SLE--------------RAVIYSGGVELGGKSSSQVEQCLCPAGYTGLSCEGCAFGFKRIYENTS 841
            .||              |.:|:|        .|:.:.|       |||:||              
Mouse   739 CLENSRSVVKTPMTDVCRNIIFS--------ISALIHQ-------TGLACE-------------- 774

  Fly   842 DHQILSKCIPC-PCNGHSNSCDLQSGNCGDCMHNTFGDRCERCQLGYYGNPLQGTPNDCKRCACP 905
                      | |....|:.||...|.| .|..|..|..|.||..|.:|    ..||.||.|.|.
Mouse   775 ----------CDPQGSLSSVCDPNGGQC-QCRPNVVGRTCNRCAPGTFG----FGPNGCKPCDCH 824

  Fly   906 LSEDSNNFSPSCQLKSYNYMDLNPQFELIEHAEYICTQCP--EGYTGDHCQVCDDGYFGNPRQPG 968
            |...::.|                       .:.|..||.  :|.....|..|..||:|.|    
Mouse   825 LQGSASAF-----------------------CDAITGQCHCFQGIYARQCDRCLPGYWGFP---- 862

  Fly   969 SSCQRCDCAGG--PCNVTTGECITCRGNTEGWHCERCKLGYWGDPAVG----CDPCHCHTEGSES 1027
             |||.|.|.|.  .|:..||||::|:..|.|.:||||..||:|||.:|    |.||.| .:|.:|
Mouse   863 -SCQPCQCNGHALDCDTVTGECLSCQDYTTGHNCERCLAGYYGDPIIGSGDHCRPCPC-PDGPDS 925

  Fly  1028 G-----LC--DSTDGQ--CLCKPRYAGQKCDECDVGY----ANVELRCPSCNC-------DPLGS 1072
            |     .|  |....|  |:|.|.|.|.:||:|..|:    ::....|..|.|       ||   
Mouse   926 GRQFARSCYQDPVTLQLACVCDPGYIGSRCDDCASGFFGNPSDFGGSCQPCQCHHNIDTTDP--- 987

  Fly  1073 LVQDRCDPHTGQC-HCKEGVMGAKCHECQDGYFGMNAVAYRMDDLAALRQNSDSDDDEWELVPDT 1136
               :.||..||:| .|.....|..|..||.||:|           .||||:              
Mouse   988 ---EACDKETGRCLKCLYHTEGDHCQLCQYGYYG-----------DALRQD-------------- 1024

  Fly  1137 EDPNSESTVACEECHCSSVGSL-----SSD--CDKRTGQCACLANVTGRRCDKCRPGHWNLTAGE 1194
                      |.:|.|:.:|::     .||  |||.||||:||.||.|:.||:|.|..|.|.:|.
Mouse  1025 ----------CRKCVCNYLGTVKEHCNGSDCHCDKATGQCSCLPNVIGQNCDRCAPNTWQLASGT 1079

  Fly  1195 GCRDCRCDPHGSRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRCSACRSEGQVCDP 1259
            ||..|.|:...|.|..||.:||||.|..|.||:.|:||.|.|:|                   ||
Mouse  1080 GCGPCNCNAAHSFGPSCNEFTGQCQCMPGFGGRTCSECQELFWG-------------------DP 1125

  Fly  1260 HNGRCICPKFTRGLGCGQCVPGTWGWQARLGCRECECDHIGSIGQQCSTGDGQCQCREGYSGRKC 1324
            .                            :.||.|:||..|....||....|||.|.||..|.:|
Mouse  1126 D----------------------------VECRACDCDPRGIETPQCDQSTGQCVCVEGVEGPRC 1162

  Fly  1325 DTCAIGYFG-YPECRRCGCDAEGSFTQADGSIACDSNGQCPCKSLVVGLKCDTCMQSTFGLSAQN 1388
            |.|..||.| :|:|                                                  .
Mouse  1163 DKCTRGYSGVFPDC--------------------------------------------------T 1177

  Fly  1389 PEGCTRCFCFGRSGECEQSDLSWGHIRMAESRNLSVQQIRPHSVPSSDYEYIVVVQMEG-SSFHR 1452
            |  |.:||..            |..| :.|..|      |.|..    .|....:::.| ...:|
Mouse  1178 P--CHQCFAL------------WDAI-IGELTN------RTHKF----LEKAKALKISGVIGPYR 1217

  Fly  1453 E--DAEIQRMND----LSLVPKSTGNVSIGAYGQFYHPLYFQLPPQFYGDRTSSYGGFLYFTLIT 1511
            |  |:..:::|:    |:..|.:....:||        :.|:...:...|.|....  .....:|
Mouse  1218 ETVDSVEKKVNEIKDILAQSPAAEPLKNIG--------ILFEEAEKLTKDVTEKMA--QVEVKLT 1272

  Fly  1512 EGAHKPLERNILGQYPLVQLHAHS--KLLLDFYEYEEFEYSLNVTHRVPLHESFWKYHHTSQAVD 1574
            :.|.:  ..:..|:...:|..|.|  |.:.:..|..||                         :.
Mouse  1273 DTASQ--SNSTAGELGALQAEAESLDKTVKELAEQLEF-------------------------IK 1310

  Fly  1575 RNTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMDAAIYIKGSTNLIAKGVERCKCPKRFDGLSC 1639
            .:.:..||.:|...|               .:.::|...:..||.                    
Mouse  1311 NSDIQGALDSITKYF---------------QMSLEAEKRVNASTT-------------------- 1340

  Fly  1640 QDPGRSFYRWRNTTIVESVF----IEDL-IGRAAPC------------HCNGRSSDCDRETGVCQ 1687
             ||        |:|:.:|..    :||| :.|.:|.            ...|:....|.......
Mouse  1341 -DP--------NSTVEQSALTRDRVEDLMLERESPFKEQQEEQARLLDELAGKLQSLDLSAVAQM 1396

  Fly  1688 NCRGNTGGDHCHQCAEGFYGDPNSPHGCQACPCPETNRNFARGCNVWDGEVSCVCKPGYTGRLCE 1752
            .|....|.|    |:|...|.||                    |...:||..|    |..|    
Mouse  1397 TCGTPPGAD----CSESECGGPN--------------------CRTDEGEKKC----GGPG---- 1429

  Fly  1753 RCQAGYFGDPMRYPNTTCQPCNCHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQAERHHLVDNG 1817
             |     |..:...::..|........:.:...:||             :..|..:|.....|..
Mouse  1430 -C-----GGLVTVAHSAWQKAMDFDRDVLSALAEVE-------------QLSKMVSEAKVRADEA 1475

  Fly  1818 CKICDNCTLLLLDYMELVGNKLRRGMHNMDLTGIPAPYRKLSEYESAYEKWNGRHWDFSQTKRRL 1882
            .:   |...:||   :....|.:....|.||..:....|.....:||                  
Mouse  1476 KQ---NAQDVLL---KTNATKEKVDKSNEDLRNLIKQIRNFLTEDSA------------------ 1516

  Fly  1883 QDYDSA-----DILKLE-----AHAENLKFQSRKAVATIGKREFAIKSMREDAVTQQHSVGLLRS 1937
             |.||.     ::||:|     ...:||....|:.|.|:.:.|         .:.||.:..:.|:
Mouse  1517 -DLDSIEAVANEVLKMEMPSTPQQLQNLTEDIRERVETLSQVE---------VILQQSAADIARA 1571

  Fly  1938 EILQTLSDLHGYGKSAHYLSLPT-----ALKQAR----FYLQAIREHDQMVQGIRSTNDCAWKHF 1993
            |:|  |.:.....|||..:.:..     ||::|.    ...:||::.|:.:||.        ::.
Mouse  1572 ELL--LEEAKRASKSATDVKVTADMVKEALEEAEKAQVAAEKAIKQADEDIQGT--------QNL 1626

  Fly  1994 YAMGNASDASFDESGRLEMLWRDLNQTNHRVVDMRLQVDRVQEVENEAEDVLEHVRNLSIRVGES 2058
            .....:..|:.:|:         |...:.|:..:...|:.::....:.....|::..:...|   
Mouse  1627 LTSIESETAASEET---------LTNASQRISKLERNVEELKRKAAQNSGEAEYIEKVVYSV--- 1679

  Fly  2059 HQELDELNQRISDHLDPGYLEQGEGLLRLTVQRQIMLNGHLNQLDGYRILLNTTLGVKTEQQREV 2123
            .|..|::.:.:...||..|.:                             :.:.:..|||:..:.
Mouse  1680 KQNADDVKKTLDGELDEKYKK-----------------------------VESLIAQKTEESADA 1715

  Fly  2124 RKHWLPKAE---KHASHLLARSN-------EYARKFQ 2150
            |:    |||   ..|..|||::|       :..||::
Mouse  1716 RR----KAELLQNEAKTLLAQANSKLQLLEDLERKYE 1748

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 164..396 CDD:278484 63/246 (26%)
EGF_Lam 401..450 CDD:238012 18/62 (29%)
TNFRSF <407..507 CDD:304602 36/122 (30%)
EGF_Lam 505..552 CDD:238012 21/62 (34%)
Laminin_EGF 550..597 CDD:278482 15/49 (31%)
Laminin_B 660..798 CDD:278481 41/230 (18%)
EGF_Lam 851..900 CDD:238012 17/49 (35%)
Laminin_EGF <943..971 CDD:278482 9/29 (31%)
VSP 953..1414 CDD:146106 148/495 (30%)
Laminin_EGF 974..1018 CDD:278482 22/49 (45%)
EGF_Lam 1017..1065 CDD:238012 19/60 (32%)
Laminin_EGF 1065..>1105 CDD:278482 16/47 (34%)
EGF_Lam 1150..1197 CDD:238012 25/53 (47%)
Laminin_EGF 1199..1247 CDD:278482 20/47 (43%)
EGF_Lam 1247..1292 CDD:238012 2/44 (5%)
Laminin_EGF 1294..1342 CDD:278482 21/48 (44%)
Laminin_EGF 1340..1392 CDD:278482 1/51 (2%)
Laminin_B 1486..1611 CDD:278481 17/126 (13%)
EGF_Lam 1669..1716 CDD:238012 11/58 (19%)
Laminin_EGF 1718..1767 CDD:278482 8/48 (17%)
EGF_Lam 1772..1819 CDD:238012 5/46 (11%)
CrfC <1933..2267 CDD:223771 41/237 (17%)
Laminin_II 2277..2400 CDD:283628
LamG 2399..>2492 CDD:304605
Laminin_G_2 2616..2755 CDD:280389
Laminin_G_2 2804..2944 CDD:280389
Laminin_G_2 3038..3169 CDD:280389
LamG 3192..3347 CDD:238058
Lamb1NP_032508.3 Laminin_N 44..269 CDD:365840 65/251 (26%)
EGF_Lam 271..323 CDD:238012 18/53 (34%)
EGF_Lam 335..387 CDD:238012 17/51 (33%)
Laminin_EGF 398..455 CDD:365839 17/56 (30%)
Laminin_EGF 458..512 CDD:365839 18/54 (33%)
EGF_Lam 509..>548 CDD:238012 7/64 (11%)
EGF_Lam 773..818 CDD:214543 19/73 (26%)
Laminin_EGF 821..869 CDD:365839 18/75 (24%)
EGF_Lam 866..911 CDD:238012 21/44 (48%)
Laminin_EGF 917..973 CDD:365839 17/56 (30%)
Laminin_EGF 976..1025 CDD:365839 21/89 (24%)
Laminin_EGF 1028..1082 CDD:365839 25/53 (47%)
Laminin_EGF 1084..1132 CDD:365839 24/94 (26%)
Laminin_EGF 1132..>1171 CDD:365839 18/38 (47%)
Domain II 1179..1397 51/321 (16%)
SCP-1 <1201..1667 CDD:114219 108/650 (17%)
Domain alpha 1398..1430 14/64 (22%)
Domain I 1431..1786 72/420 (17%)
SMC_prok_B 1456..>1776 CDD:274008 70/395 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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