Protein Alignment wb and LanB1

DIOPT Version :10

• Sequence 1: NP_723870.1
• Gene: wb / 43946
• FlyBaseID: FBgn0261563
• Length: 3375
• Species: Drosophila melanogaster
• Sequence 2: XP_061497163.1
• Gene: LanB1 / 1281797
• VectorBaseID: AGAMI1_014157
• Length: 1790
• Species: Anopheles gambiae
• Alignment Length: 2407
• Identity: 533/2407 - (22%)
• Similarity: 831/2407 - (34%)
• Gaps: 895/2407 - (37%)

  Fly   155 PPLFNVVPRAQ-----------------ISVNATCGQNGAEEYC--KQVGAKPCGICNAH---SS 197
            ||:..|.|..|                 :..::|||....|.||  ..:..|.|.:|:..   .:
Mosquito    43 PPIHRVHPCEQSSCYPATGNLLIGRENRLEASSTCGTVRPERYCIVSHLEEKKCFLCDTRRETEN 107

  Fly   198 DRAKQRSIQSLI---SSGSGSGSGSGFEEGWWQSPTLQGGRQFEYVTILLDLKQTFQ------IF 253
            |..:...|..:|   ..|:       .|:.||||   :.||  |.|||.|||:..|.      :|
Mosquito   108 DPMRNHRIGQIIYKMQPGT-------VEQTWWQS---ENGR--ENVTIQLDLEAEFHFTHLIIVF 160

  Fly   254 SVWLKSANSPRPASWILEKSLD-GINFEPWQYFGLSDADCQRRWNLSGQNGKYVFQNDTEIICST 317
            :.:       |||:.::|:|.| |..:..::||..|   |:.    |..:...|.:|.|::||..
Mosquito   161 ATF-------RPAAMLIERSYDFGKTWHVYKYFAHS---CRE----SFPHAPLVARNITDVICDH 211

  Fly   318 QFSKPGPLENG-VLHASLLKNRPGATDQSPELMKFITTRYIRIRLQGMHSTANQDNSLDWLLDSP 381
            ::|...|.:|| |::..|..|.......:..:...:....:|:....:||..  ||.||   |..
Mosquito   212 RYSGVEPSKNGEVIYRVLPPNMNIENPYAEHVQNMLKMTNLRVNFTKLHSLG--DNLLD---DRD 271

  Fly   382 SLEKHSFYSLSQLKVSARLDCNGHANRS------HESPDDPLMQCICQHNTCGAQCEQCCPLFQD 440
            .:::..:|::|.:.|.....|.|||:|.      ..:.|....:|.|.|||.|..||:|...|.|
Mosquito   272 EIQEKYYYAISNMIVRGSCSCYGHASRCLPLEGVRNTVDMVHGRCECTHNTKGLNCEECEDFFND 336

  Fly   441 RPYQ--MGGE---CEICQCYGHAESCTYDPF-------LDKGICQSCSNNTAGIECEFCEMGFYR 493
            .|::  :|.:   |:.|.|..||.||.:|..       :..|:|.:|.:||.|..||.|...|||
Mosquito   337 LPWKPALGKQTNACKKCNCNNHATSCHFDQAVYEHSGRVSGGVCDNCQHNTQGYHCEECAPFFYR 401

  Fly   494 ELDAPLTDP--CLPCSCNPARS--TGGCQS-----DG---GSCNCLEGFQGKNCEECAPGYYG-- 544
            :.:..:..|  |.||.|:|..|  .|.|.|     :|   |:|:|.....|:.|:.|..|::.
Mosquito   402 DPNEDIQSPYVCKPCDCDPRGSLDDGICDSIADEENGIVAGACHCKRNVNGRRCDHCREGFWNFD 466

  Fly   545 ----DDCKRCECDERGSLGSTGSC---SGVCQCKLNVEGSTCSECAPGYFDLSAENAEGCTSCWC 602
                |.|:.|.|:..|::.::| |   :|.|.||..|.|..|::|.|..:.|| ::.||||.|.|
Mosquito   467 EHNPDGCQPCTCNTLGTVNNSG-CNVYTGECICKRLVTGRDCNQCMPETYGLS-DSLEGCTPCSC 529

  Fly   603 ---SGVSQTCHSAKLQTLAFETLNDWKITDIQRVKP-------------ISIPVDAETNRLIFAN 651
               ..:..:|.               .||...|.:|             ..||.   .:|::.|
Mosquito   530 HPGGSLDNSCD---------------VITGQCRCRPHMQGRDCSEPKQHYFIPT---LHRILEA- 575

  Fly   652 ELDEVEAIYWQASLGYLGNRLTSYGSRLQLVLSWDVIR---GDRSGKPTTGPNVILVGKNGLKIA 713
               ||.:.:.::.    |.:..|.           |:|   .||.. ..|||..|...: |..:.
Mosquito   576 ---EVPSTFCESG----GGQNCSV-----------VVRERANDRDA-DFTGPGFIRASE-GTVLK 620

  Fly   714 FGDESLDGLGINLNVTL-------TEVGWYHVPPTVVDIKTRLRRTEGGDYHGE----------- 760
            |   ::|.:...:|..:       .:..|.:|..||:       |.|..|..|.
Mosquito   621 F---TVDDIPKTMNYDVMVRYQPQMKGDWENVRMTVI-------RPEVYDPEGPCANSHPSYERD 675

  Fly   761 -SVTRSQFLSVLVSLDAVLIRAAFHTDQGET-----SLER---------------AVIYSGGVE- 803
             :.|.|::.:..::|..:.:      :.|:|     |.:|               :::....:|
Mosquito   676 ITTTLSEYETSAIALHDICL------ESGKTYKFIVSFQRHEPYDDNPTAQILIDSIVLIPRIEI 734

  Fly   804 ---LGGKSSSQVEQCLCPAGYTGLSCEGCAFGFKRIYENTSDHQILSKCI---------PCPCN- 855
               :.|...::|..    ..|..|.|....:....|.....:.:.|.|.|         ||.||
Mosquito   735 TPIMQGSHQAEVRH----REYVNLGCNHTYYDVNYILNAPEECKDLLKTISVYINNGAMPCECNP 795

  Fly   856 --GHSNSCDLQSGNCGDCMHNTFGDRCERCQLGYYGNPLQGTPNDCKRCACPLSEDSNNFSPSCQ 918
              ..|..|....|.| .|..|..|.:|:||..|.||    ..|..||.|.|......:|   .|.
Mosquito   796 TGSKSKKCAESGGFC-TCKTNVVGRQCDRCAPGTYG----FGPEGCKACDCNSIGSKDN---DCD 852

  Fly   919 LKSYNYMDLNPQFELIEHAEYICTQC---PEGYTGDHCQVCDDGYFGNPRQPGSSCQRCDCAG-- 978
            |                    |..||   |..| |..|..|..|::..|     :||.|:|.|
Mosquito   853 L--------------------ITGQCNCHPNTY-GRECDQCQPGFWNFP-----NCQICECNGHT 891

  Fly   979 GPCNVTTGECITCRGNTEGWHCERCKLGYWGDP----AVGCDPCHC-------HTEGSESGLCDS 1032
            ..||..||||:.|:..|:||.|:||..||:|:|    ::||.||.|       |:..:|..|..|
Mosquito   892 PTCNSKTGECLHCQDFTQGWKCDRCVDGYYGNPLLGSSIGCRPCRCPDTVASGHSYANECYLHPS 956

  Fly  1033 T-DGQCLCKPRYAGQKCDEC-DVGYANVEL---RCPSCNC----DPLGSLVQDRCDPHTGQC-HC 1087
            | |..|.|:..|:|.:||.| |..|.|.|.   :|.||:|    ||..   ...||..:|:| .|
Mosquito   957 TNDVICSCEEGYSGARCDVCADNYYGNPEKPGGQCQSCDCSNNVDPKR---PGNCDSKSGKCLQC 1018

  Fly  1088 KEGVMGAKCHECQDGYFGMNAVAYRMDDLAALRQNSDSDDDEWELVPDTEDPNSESTVACEECHC 1152
            .....|..|..|:||::|           .||||:                        |..|.|
Mosquito  1019 LYNTEGDHCEYCRDGFYG-----------DALRQD------------------------CRACDC 1048

  Fly  1153 SSVGSLSS--DCDKRTGQCACLANVTGRRCDKCRPGHWNLTAGEGCRDCRCDPHGSRGHECNPWT 1215
            :.:|:..:  .||:.||||.||.||.|:.||:|...||.:.:||||..|.|||.|:...:|||:.
Mosquito  1049 NLLGTNQTIQHCDRYTGQCPCLRNVKGQYCDECIENHWKIASGEGCEACDCDPVGALSEQCNPYD 1113

  Fly  1216 GQCDCKIGVGGQHCNECTEGFFGFSTEGCQRCSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVP 1280
            |||.||.|.||:.||:|...|:|                   ||:
Mosquito  1114 GQCSCKPGFGGRQCNQCEAYFWG-------------------DPN-------------------- 1139

  Fly  1281 GTWGWQARLGCRECECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFGY-PECRRCGCDA 1344
                    :.|:.|||:..||..|||....|:|.|:.|..|.|||.|..||.|. |.|..||
Mosquito  1140 --------VECKPCECNAYGSATQQCDRTTGKCACKSGIGGYKCDQCDRGYLGQAPYCEPCG--- 1193

  Fly  1345 EGSFTQADGSIACDSNGQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGCTRCFCFGRSGECEQSDL 1409
                                                             .||        :..|:
Mosquito  1194 -------------------------------------------------ECF--------DNWDM 1201

  Fly  1410 SWGHIRMAESRNLSVQQIRPHSVPSSDYEYIVVVQMEGSSFHREDAE-IQRMNDLSLVPKSTGNV 1473
            ....:|....|.:                              |:|: |:::.
Mosquito  1202 ILDGLRNETDRTI------------------------------EEAKTIKKLG------------ 1224

  Fly  1474 SIGAYGQFYHPLYFQLPPQFYGDRTSSYGGFLYFTLITEGAHKPLERNILGQYPLVQLHAHSKLL 1538
            :.|||.:.:..:         ..:.:...|.|..|:    :.:.:|. |.|:...::.|....|
Mosquito  1225 ATGAYKKEFDSM---------SKKIAQIEGLLNNTI----SDREIEA-IGGEIDRIRNHLQESL- 1274

  Fly  1539 LDFYEYEEFEYSLNVTHRVPLHESFWKYHHTSQAVDRNTLMAALQNIRHIFIRAFAFADFQEVV- 1602
               :..||.|..|                   |..|.|..:|.:: |.::..||   .|.:::.
Mosquito  1275 ---HNLEESERKL-------------------QETDSNIKLANIE-IVNLGRRA---DDVKQMTN 1313

  Fly  1603 --------LQNVHMDAAIYIK----------GSTNLIAKGVERCKCPKRFDGLSCQDPGRSFYRW 1649
                    ||..:::.|:.:.          |.||:
Mosquito  1314 YLKDNATKLQEGNIEGALNLTRDAWYRVSMLGETNM----------------------------- 1349

  Fly  1650 RNTTIVESVFIEDLIGRAAPCHCNGRSSD-CDRETGVCQNCRGNTGGDHCHQCAEGFYGDPNSPH 1713
             |.|.:                 |.|:.: |.|...:....:.:...:|
Mosquito  1350 -NITAI-----------------NSRAENYCRRAEHLINKNQADVVRNH---------------- 1380

  Fly  1714 GCQACPCPETNR----NFARGCNVWDGEVSCVCKPGYTGRLCERCQAGYFGDPMRYPNTTCQPCN 1774
                    |.|.    .:....|..:|.:     |....|:|:|     .|||
Mosquito  1381 --------ENNEAAFLKYQEELNDLNGNM-----PDLNQRICDR-----HGDP------------ 1415

  Fly  1775 CHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQAERHHLVDNGCKICDNCTLLLLDYMELVGNKL 1839
                      ||...|...|:.|..||:|           :||.
Mosquito  1416 ----------CDEFCGGAGCKNGCGGLRC-----------ENGA--------------------- 1438

  Fly  1840 RRGMHNMDLTGIPAPYRKLSEYESAYEKWNGRHWDFSQTKRRLQDYDSADILKLEAHAENLKFQS 1904
                    ||        |||
Mosquito  1439 --------LT--------LSE-------------------------------------------- 1443

  Fly  1905 RKAVATIGKREFAIKSMREDAVTQQHSVGLLRSEILQTLSDLHGYGKSAHYLSLPTALKQARFYL 1969
             ||:....|.|..||...|           |..:||:::|........:              |.
Mosquito  1444 -KALDFAKKTEQNIKEKEE-----------LADDILRSMSQAKANASES--------------YK 1482

  Fly  1970 QAIREHDQMVQGIRSTNDCAWKHFYAMGNASDASFDESGRLEMLWRDLNQTNHRVVDMRLQVDRV 2034
            :|.|.||:....:..|.|.                            :::.|..||.:...::..
Mosquito  1483 KAKRTHDETQAHLEDTKDL----------------------------IDRANILVVKLTDMIENT 1519

  Fly  2035 QEVENEAEDVLEHVRNLSIRVGESHQELDELNQRISDHLDPGYLEQGEGLLRLTVQRQIMLNGHL 2099
            .....|..:::|.|.:.::::  ..:::|:|.|:|.|.:  .:|...|.::|.|.
Mosquito  1520 TASPGEMRELIEQVMSYTLQL--DPEQIDDLAQKIQDAV--SHLVNVESIIRNTE---------- 1570

  Fly  2100 NQLDGYRILLNTTLGVKTEQQREVRKHWLPKAEKHASHLLARSNEYARKFQPTRNGARIAMLASS 2164
            |.|....:|.:..|..|            .:|||..:.:|
Mosquito  1571 NDLRRVEMLKSDALDKK------------ERAEKVLAGVL------------------------- 1598

  Fly  2165 AHSNITEAINDARLASILAKERVYEAQRTLYPSDGSSMIE-------------RAKHSLHRSKQL 2216
               |||.|::||..|...|::.:.:|...:    .|:.|:             ||..:.:....|
Mosquito  1599 ---NITRALDDADDAQKKARQSIKQANADI----ASAKIDLEEIDKETEEAQKRANSTANAVLAL 1656

  Fly  2217 QQEALKQMHKSNVLKDKLHRQE--QQVEGIK---------STIYDSGLRTNNISGQLQGLSDGSA 2270
            |.. |:|:.|.|: :::|..::  :|.|.:|         :|...:..:|.|.|...|.....||
Mosquito  1657 QSR-LEQLQKDNI-RNELDAKDINKQAEDVKDSANNAHERATQLKNDFKTANESLTAQARRSESA 1719

  Fly  2271 RRQAKDSLEMADR----TGEQMRAELQKAKDMQKSIQNMRNSFSNLEPDWEIKLGMAQENISLTQ 2331
            |.:|::.|..|.:    |..|:.| ||...|:.||.:   ....|||.:.....|.....:...|
Mosquito  1720 RERAQNLLNRASKITVDTTTQLSA-LQSMDDIYKSNE---KEIQNLEAELNDLTGKITFYLQTIQ 1780

  Fly  2332 TN 2333
            ||
Mosquito  1781 TN 1782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wb	NP_723870.1	Laminin_N	153..398	CDD:459653	69/275 (25%)
		EGF_Lam	401..450	CDD:238012	19/59 (32%)
		EGF_Lam	505..552	CDD:238012	19/62 (31%)
		Laminin_EGF	550..597	CDD:395007	17/49 (35%)
		Laminin_B	660..813	CDD:459652	31/198 (16%)
		EGF_Lam	851..900	CDD:238012	18/51 (35%)
		Laminin_EGF	<943..971	CDD:395007	9/30 (30%)
		Laminin_EGF	974..1018	CDD:395007	22/49 (45%)
		EGF_Lam	1017..1065	CDD:238012	21/59 (36%)
		Laminin_EGF	1065..>1105	CDD:395007	14/44 (32%)
		EGF_Lam	1150..1197	CDD:238012	22/48 (46%)
		Laminin_EGF	1199..1247	CDD:395007	21/47 (45%)
		EGF_Lam	1247..1292	CDD:238012	2/44 (5%)
		Laminin_EGF	1294..1342	CDD:395007	23/48 (48%)
		Laminin_EGF	1340..1392	CDD:395007	2/51 (4%)
		Laminin_B	1486..1626	CDD:459652	26/158 (16%)
		EGF_Lam	1669..1716	CDD:238012	5/47 (11%)
		Laminin_EGF	1718..1767	CDD:395007	11/52 (21%)
		EGF_Lam	1772..1819	CDD:238012	10/46 (22%)
		YhaN	<1907..2141	CDD:443752	41/233 (18%)
		SMC_prok_B	<2123..>2390	CDD:274008	53/239 (22%)
		Laminin_II	2279..2400	CDD:368703	16/59 (27%)
		LamG	2399..>2492	CDD:473984
		LamG	2586..2753	CDD:238058
		Laminin_G_2	2804..2944	CDD:460494
		LamG	3018..3167	CDD:238058
		LamG	3192..3347	CDD:238058
LanB1	XP_061497163.1	None