Protein Alignment wb and trol

DIOPT Version :10

• Sequence 1: NP_723870.1
• Gene: wb / 43946
• FlyBaseID: FBgn0261563
• Length: 3375
• Species: Drosophila melanogaster
• Sequence 2: XP_061503679.1
• Gene: trol / 1274328
• VectorBaseID: AGAMI1_009733
• Length: 4447
• Species: Anopheles gambiae
• Alignment Length: 3589
• Identity: 718/3589 - (20%)
• Similarity: 1113/3589 - (31%)
• Gaps: 1377/3589 - (38%)

  Fly   399 RLDCNGHANR---SHESPDDPLMQCICQHNTC---------------GAQCEQCCPLFQDRPYQM 445
            |.||..:::.   ||:...:| .|..|::..|               |:..|.|..|..:.|.:.
Mosquito  1339 RQDCADNSDENGCSHKDQCEP-NQFKCRNRKCVLKTWLCDGEQDCGDGSDEENCATLPPNAPCRH 1402

  Fly   446 GG-ECEICQCYGHAESCTYDPFLDKGICQSCSNNTAGIECEFCEMGFYRELDAP----------- 498
            .. :|...||...:..|...|        .|.:.:..:.|.           ||
Mosquito  1403 DEFQCRDGQCIPKSFQCDTHP--------DCQDKSDEVGCM-----------APAVIQPPPPSLS 1448

  Fly   499 -LTDPCLPCSCNPARSTG-----------------GCQSDGGSCNCLEGFQGKNCEECAP---GY 542
             :....|..:|   |:||                 .|.|...     :||....||:..|   |.
Mosquito  1449 IIAGGVLNITC---RATGVPVPLIVWRLNWGHVPEKCTSRND-----QGFGRLTCEDMQPIDSGA 1505

  Fly   543 YGDDCKRCECDERGSLGS-----------TGSCSGVCQCKLNVEGSTCSECAPGYFDLSAENAEG 596
            |       .|:...::|:           |||            |..|.:   |.|:..|.|...
Mosquito  1506 Y-------SCEIINTMGTHFVSPDTIVIVTGS------------GPVCQQ---GTFNSQARNPSD 1548

  Fly   597 CTSCWCSGVSQTCHSAKLQTLAFETLNDWKITDIQRVKPISIPVDAET----------NRLIFAN 651
            |.:|:|.||:.:|:||.|.|.|              :||   ||.:.|          .|.:...
Mosquito  1549 CINCFCFGVTTSCNSADLYTYA--------------LKP---PVSSLTIVGVEGPWSGRRELVVG 1596

  Fly   652 ELDEVEAI--------------------YWQASLGYLGNRLTSYGSRLQLVLSWDVIRGDRSGKP 696
            |.:.....                    |:.....|.||:|.|||..::    :|| ..|.:|:|
Mosquito  1597 EFENHNLTAQRHGVQLRLTNLVPGRRVPYYSLPEEYKGNQLKSYGGSIR----YDV-EYDGTGRP 1656

  Fly   697 TTGPNVILVGKNGLKIAFGDES--LDGLGINLNVTLTEVGWY---HVPPTVVDIKTRLRRTEGGD 756
            ...|:|||.| ||:.:......  ...:..:::|:|....|.   ..|.|..||...|...|
Mosquito  1657 VNAPDVILKG-NGMSLVHWHSGTFYPDIKNHVSVSLLPGNWVRPDRSPATREDIMMALASIE--- 1717

  Fly   757 YHGESVTRSQFLSVL---VSLDAVLIRAAFHTDQGETSLERAVIYSGGVELGGKSSSQVEQCLCP 818
               ..:.|.|::..:   :.|..|::.:|.|.|:|               ||  |:|.||||.||
Mosquito  1718 ---SILIRMQYVDGIERNIELVNVMMDSAAHDDRG---------------LG--SASLVEQCRCP 1762

  Fly   819 AGYTGLSCEGCAFGFKRIYENTSDHQILSKCIPCPCNGHSNSCDLQSGNCGDCMHNTFGDRCERC 883
            |||.|||||.|.:|:.|  :|:...  |.:|:                           .|...|
Mosquito  1763 AGYRGLSCESCDYGYVR--QNSGPW--LGRCV---------------------------KREREC 1796

  Fly   884 QLGYYGNPLQGTPNDCKRCACPLSEDSNNFSPSCQLKSYNYMDLNPQFELIEHAEYICTQCPEGY 948
            |.||||:|.:..|  |..|.||::.:.:. :.||.|.|.:              ..:| ||..||
Mosquito  1797 QPGYYGDPNRDIP--CAPCPCPVAGEKSR-ARSCYLDSRD--------------NVVC-QCDRGY 1843

  Fly   949 TGDHCQVCDDGYFGNPRQPGSSCQRCDCAGGP---CNVTTGECI------TCRGNTEGWHCERCK 1004
            .|:.|..|::||.|||...|       |...|   ||....|.|      .|:...||.:|:||.
Mosquito  1844 AGERCMECEEGYVGNPLGEG-------CFPRPVTNCNALGTERIGSDRRCYCKPGIEGTYCDRCA 1901

  Fly  1005 LGYWGDPAVGCDPCHCHTEGSESGLCDST------------DGQC-------LCKP--------- 1041
            ..::.....||..|.|.   ..:.:|.||            ||:.       ...|
Mosquito  1902 AQHFYMHEKGCVECFCM---GLTNVCSSTTWVRDTIHASFADGRSGFSLISDYTNPSIVANALPV 1963

  Fly  1042 -----------------------RYAGQKCDECDVGYANVELRCP-------SCNCDPLGSLVQD 1076
                                   ::.|.|..... |:.|..||..       |.|..|...|
Mosquito  1964 SNREIVYRNFGASDDTFYWRLPNQFLGNKLTSFG-GHLNYTLRYTPHSSGGISRNSSPDVVL--- 2024

  Fly  1077 RCDPHTGQCHCKEGVMGAKCHECQDGYFGMNAVAYRMDD-LAALRQNSDS---DDDEWELVPDTE 1137
                |:|.        ..|.|.            ||.:. ::....|:.|   .:|||:   :.|
Mosquito  2025 ----HSGN--------KIKLHH------------YRTNSPISPYGSNTHSVSIVEDEWQ---NYE 2062

  Fly  1138 DPNSESTVACEECHCSSVGSLSSDCDKRTGQCACLANVTGRRCDKCRPGHWNLTAGEGCRD---- 1198
            |.|:.:                     |......||||:    |......:|..:.|....
Mosquito  2063 DGNAAT---------------------REYLLMALANVS----DIFIKATYNTVSNEAALSYVSL 2102

  Fly  1199 --CRCDPH--GSRGHECNPW-TGQCDCKIGVGGQHCNECTEGFF----GFSTEGCQRCSACRSEG 1254
              .|..|:  |:|.     | ..||.|..|..|..|.:|..|::    |.....|:.| ||....
Mosquito  2103 DIARDSPYATGARA-----WPVEQCQCPTGHIGLSCEDCAPGYYKGDQGIYLGICEPC-ACNGHS 2161

  Fly  1255 QVCDPHNGRCI-CPKFTRGLGCGQCVPGTWGWQARLGCR-ECECDHIGSIGQQCSTGDGQCQCRE 1317
            ..|||..|.|| |...|.|..|..|.|...| .|.:|.| :|          ..|..|....|||
Mosquito  2162 DECDPQTGACINCRDNTYGNNCELCRPPYVG-NATVGSRYDC----------TLSQPDQSFDCRE 2215

  Fly  1318 GYSGRKCDTCAIGYFGYPECRRCGCDAEGSFTQADGSIACDSNGQCPCKSLVVGLKCDTCMQSTF 1382
                  ||  ..|:.|  .|:| ||:                     ||.||.|.:||.|.:.:|
Mosquito  2216 ------CD--VRGFTG--NCQR-GCE---------------------CKQLVEGRRCDQCREGSF 2248

  Fly  1383 GLSAQNPEGCTRCFCFGRSGECEQSDLSWGHIRMAESRNLSVQQIRPHSVPSSDYEYIVVVQMEG 1447
            ||..|:..||..|||.|.:..|..|:|              .::..|..|.:.| ..|.:...||
Mosquito  2249 GLGTQHETGCVECFCSGVTKSCGSSNL--------------YREELPVIVDAYD-NTITLTDREG 2298

  Fly  1448 SSFHREDAEIQ-RMNDLSLVPKSTGNVSIGAYGQFYHPLYFQLPPQFYGDRTSSYGGFLYFTLIT 1511
            :.....:..|. .:|::|...:..            ...|:.||....|::..|||..|..|...
Mosquito  2299 TLLESRNFAINPSINEISYTFRDR------------ETYYWSLPNLVLGNQVLSYGANLTVTQYV 2351

  Fly  1512 EGAHKPLERNILGQYPLVQLHAHSKLLLDFYEYEEFEYSLNVTHRVPLHESFWKY--HHTSQAVD 1574
            ||. :|     |....::.:.:..||......|::..|:      |||.|..|..  ...|....
Mosquito  2352 EGG-RP-----LADQDIILIGSGMKLAWSREYYDDGTYA------VPLVEHNWIVINRRNSYPAS 2404

  Fly  1575 RNTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMDAAIYIKGSTNLIAKGVERCKCPKRFDGLSC 1639
            |..::..|.|:.||.|||..........|.::.:..||..:  |...|..||.|:||..:.|.||
Mosquito  2405 RGDMLTVLSNLEHILIRATTKESTSVSRLSDITLGTAIPTR--TPYPAVEVEMCRCPPGYRGTSC 2467

  Fly  1640 QDPGRSFYRWRNTTIVESVFIED--LIGRAAPCHCNGRSSD-C---DRETGVCQNCRGNTGGDHC 1698
            :......||        .::...  |:|...||.||..::| |   :|...|| |||....||:|
Mosquito  2468 EQCEDLHYR--------DIYDRSAGLLGACKPCPCNYENADSCQMDNRGVVVC-NCREGYSGDNC 2523

  Fly  1699 HQCAEGFYGDPNSPHGCQACPCPETNRNFARGCNVWDGEVSCVCKPGYTGRLCERCQAGYFGDPM 1763
                     |...|..    |.|..||.        ..:|.|.     ........:.|.|.
Mosquito  2524 ---------DNRLPKR----PRPANNRA--------PTKVDCT-----NNAFVFTSKNGIFN--- 2559

  Fly  1764 RYPNTTCQPCNCHPDGIQTEGCDVETGRCYCRE-----------------------GVTGLKCDK 1805
            :|     |.|:       |||  ||.|..|..:                       .|..:|..:
Mosquito  2560 QY-----QKCD-------TEG--VEIGVMYKSKRSNEELDTRPTVPPRNPVIEVVINVPSIKIVE 2610

  Fly  1806 --------CQAERHHLVD-----------NG----CKICDNCTLLLLDYMELVGN----KLRRGM 1843
                    |.|  ||:|.           ||    ....|..||::.:.....|.    |...|.
Mosquito  2611 IGEDFRADCTA--HHVVSQSPIDVQWTRKNGRLPDSAYTDGGTLVITNIQIKDGGLYVCKASSGT 2673

  Fly  1844 H--------NMDLTGIPAPYRKLSEYESAYEKWNGRHWDFSQTKRRLQDYDSADILKLEAHAENL 1900
            .        |:...|...|...||:             .|......|    ||::|
Mosquito  2674 EVVYKQVTINVSKQGSAKPTVLLSQ-------------PFIDQDEHL----SAEVL--------- 2712

  Fly  1901 KFQSRKAVATIGKREFAIKSMREDAVTQQHSV---GLLRSEILQTLSDLHGY--------GKSAH 1954
                  ..|| |.....|...|.|.....|:|   ||||...|:. .|...|        |:|..
Mosquito  2713 ------CTAT-GYPTPTITWERVDQPLPYHAVTERGLLRFSALRQ-QDAGTYRCVARNDVGESDT 2769

  Fly  1955 YL--------------SLPTALKQARFYLQAIREHDQMVQGIRSTNDCAWKHFYAMGNASDASFD 2005
            .|              |.||.:::...                                |.:|||
Mosquito  2770 LLTVYVRPAVGPTLPPSYPTEMERVEI--------------------------------SPSSFD 2802

  Fly  2006 ----ESGRL--------EMLWRDLNQTNHRVVDMRLQVDRVQEVENEAEDVLEH----------- 2047
                |..||        :::|..|.:.         |:....:|.||.. ::||
Mosquito  2803 GQPGEVIRLICRCSPTAQVVWSKLGER---------QLPSNADVRNEML-IIEHASQENTGRYSC 2857

  Fly  2048 --------VRNLSIRVGESHQELDELNQRISDHLDPGYLEQGEGLLRLTVQRQIMLNGHLNQLDG 2104
                    .:..::.|..:...:...:.:::..::|                   ||.:...|.|
Mosquito  2858 TAYFPNGRTKTSTVDVVIADNNVLPPSNKVAPRVNP-------------------LNKNYVVLQG 2903

  Fly  2105 YRILLNT------------TLGVKTEQQREVRKHWLPKAEKHASHLLARSNEYARKF--QPTRNG 2155
            ....|:.            ||..||.:..                 :.:|....|.|  ||:..|
Mosquito  2904 ADFSLSCEATGTPYPTVKWTLSGKTFESN-----------------VQQSGNVLRIFNAQPSNGG 2951

  Fly  2156 ARIAMLASSAHSNITEAINDARLASILAKERVYEAQRTLYPSDGSSMI--ERAKHSLHRSKQLQQ 2218
            ..|.:.::.      |.::  |..:::..:|..:....:|||:..::.  |..:.|...|..:..
Mosquito  2952 VYICVASNE------EGMD--RAYTVVEIDRREKPVLEIYPSEPQTIKVGESVRLSCRASAGVPY 3008

  Fly  2219 EALKQMHKSNVLKDKL---HRQEQQVEGIKSTIYDSGLRTNNISGQLQGLSDGSARRQAKDSLEM 2280
            .::     :.|.||::   .|.....||: .|:.|:.|..   :|:.:..:|.:|
Mosquito  3009 PSI-----TWVRKDRMPLSSRFTNDAEGV-ITLRDASLED---AGEYECRADNAA---------- 3054

  Fly  2281 ADRTGEQMRAELQKAKDMQKSIQNMRNSFSNLEPDWEIKLGMAQENISLT------------QTN 2333
                |..:         :..:|:.::.....|:|....|:   .||...|            .|.
Mosquito  3055 ----GSAI---------LSTTIEVLQPPIIRLQPSESHKI---TENDEFTIHCSATGKPAPMVTL 3103

  Fly  2334 LRLANVSLSYLEQQAEKEQQVFEVWNNSMAQQLQQLRDQIAKARHAAE--------AIDVSLESL 2390
            |.....|.|:|.||.|..::|....:.:   :|.........|::||.        .:|.....:
Mosquito  3104 LPPPGASRSHLRQQTEGLREVTLYLHQA---ELNDAGTYECTAKNAAGEDSQYLSLQVDPKRGDV 3165

  Fly  2391 GPKCIRSYLPASY-----------------------------GLSTSNKIRMSFALSNHLESSPL 2426
            ||.......|:.|                             .|..:.:.|.:.......:..||
Mosquito  3166 GPHDDDDRPPSYYPPRLPPTRPPGPSSQPIAYTYKAILGEQAHLMCNEEFRSTRTEWRRSDGRPL 3230

  Fly  2427 IHLASSEGRHITLE--------LYK-----------RRVRL---VWNLGGTTATVTHPMVVH--- 2466
            .:.:...|.::|:|        :|.           ..||:   |.:|...:.:...||.|.
Mosquito  3231 PYGSIVRGGNLTIESTGHDAAGMYDCVTFPSPSQPVTIVRIMVEVISLPKISFSPQMPMTVRPGD 3295

  Fly  2467 --------TRDPKYDDAWY---------------------------------HV--EANRTLNLG 2488
                    |.|..|:..|:                                 ||  :...|....
Mosquito  3296 AVDILCNVTSDVAYEVKWHRKDNLPLPPTVQAYGNYLRFSSIAPEDAGRYYCHVRNQFGETEKAA 3360

  Fly  2489 SLVVRRMNNYGELTPPNPVIITGSTDTEHTRFYQSRSDRISLGGFASKDLQF---TPGLNVVVHQ 2550
            .:||    |..||.|..|::        ..|::|:     |||.....|.:.   .|.:||..:
Mosquito  3361 EVVV----NKNELMPEPPIV--------GKRYHQA-----SLGAAIRLDCKLPAGAPYVNVRYN- 3407

  Fly  2551 VEVDNKPLGLWNFVTSEGSCGGSMVGAKESSASSTARHFNGLGYAQLMKTRPRPTRKNLFSVQMT 2615
                      ||                                 :|.:|.| ||.:.:.:.:
Mosquito  3408 ----------WN---------------------------------RLERTLP-PTARIVANGR-- 3426

  Fly  2616 FRTLDENALLFLAVDDKNNRSVSVTLSRGRIMFRIDYGDESKLEINTTKKYNVGQWIKIEAAREF 2680
                 |..|..|..:|.......::...|.:::
Mosquito  3427 -----ELHLFNLEPEDAGTYQCGMSYPDGTVVY-------------------------------- 3454

  Fly  2681 SAKRSTENGMLRVNNDR--PISGAPTLPVNIHLLPDLSKTVYYLGGVPPGFTSGTSKAPGADNPF 2743
                  ::.:|.|..||  ..:|.||....:.........|.:|....|...:||.        |
Mosquito  3455 ------DSIVLTVGRDRLNATTGLPTPAPELCAPSTCGDGVLWLCRASPARCNGTF--------F 3505

  Fly  2744 LGCMKDVQVNGETYDPLESSSYYGVEPSCKNMITKAGFSGNGYLELPSQSLRKRSNTALVFRTLQ 2808
            :.|::        ||....     |....:.|:.:.|.:.:      ::...|.:.|....|...
Mosquito  3506 MCCVQ--------YDRARR-----VGDQERTMVPRLGRADD------TRPTVKDAATVADVRRPP 3551

  Fly  2809 PDCLLLLAAYPPEILGDYDAKDIKGNFSISLVDGQLHVWVNSGRSFIKMSSNSSQMNDGEFHVVH 2873
            |..||     ||                      ..|.:.......:::..:.|.:..||..||.
Mosquito  3552 PHRLL-----PP----------------------THHHFAPESLPVLQLEPSRSMVRPGESLVVD 3589

  Fly  2874 LIK---TGRKLELMVDDELQEIRNLNGNPTVVSLPRDAGGLYIGGAPPHES--YTPLAPTFVNL- 2932
            ...   ||..::....|         |.|...::.::...|||..|...:|  ||.:..|...|
Mosquito  3590 CSSSAGTGVPIKWEKSD---------GTPLPYNIHQEGNRLYIQNAREDDSGTYTCVCFTEDGLR 3645

  Fly  2933 ----------EGAIRDVV--------FNNR--TINF---------------------ND------ 2950
                      |..|.||:        |..|  |:..                     ||
Mosquito  3646 YVSDFQLEVEENTISDVLPRSTSRMEFAERGTTVKLQCNTDLYPTTYQWSRIDGELPNDRDTHGS 3710

  Fly  2951 ALTFANVQIGRNGPLMGSLKGGLYDVLLKTEPMIGKS---------------FTASPEGCKRIGS 3000
            .||..|||....|..:.|.|.|            |:|               |..||.      |
Mosquito  3711 ILTLTNVQASDAGKYVCSAKHG------------GQSANVVITLVVNNVIPFFPQSPR------S 3757

  Fly  3001 YSYEPNAFKFGDDIYSYSQLKLPERHFWQRNFHLSFDFRSFYPNGMLYLSPGSKEKPK-HYVALV 3064
            |.    .||..|::||              .|:....|:....||::..:  |:.:|. .|::|.
Mosquito  3758 YM----EFKSFDNVYS--------------KFYFEVSFKPEKMNGLILYA--SQRRPNLDYISLS 3802

  Fly  3065 LK----------DGQLVLVVRGRRREELQLTAKLNDGEWHRVTISCHDRKVTMSVEIGRTDQKTS 3119
            |:          |||.|:         ||....::.|:||.|.::.......:.|:    ||
Mosquito  3803 LRNGYPQFRFNFDGQQVV---------LQPEKPVHMGQWHTVKVNRVRNNGFLLVD----DQ--- 3851

  Fly  3120 AQMKLPKK-----IGASQLLLVGGLPQ-SPVKVSSDLYVRLEPFKGCLRRVSINNNTQDL----- 3173
            ..:..|.:     :.....|.|||:|| ..|..|:..|  .|.|.||:.|:.:|:....|
Mosquito  3852 TPVNFPDRLKFYGLNLDDHLFVGGVPQFDQVPASAVEY--KEGFVGCISRLKLNDREVQLYEDAL 3914

  Fly  3174 ----------------------------------ARPG------KHS---------NVGQC---- 3185
                                              .|.|      :|.         .||:|
Mosquito  3915 ETVGITTCEPCADDPCKNFGTCLEAQTAQGYSCMCRDGYTGTNCQHEGDGCSDDTCGVGRCEETD 3979

  Fly  3186 ---------FPTVERGSY----------FPGDAYAIYKKNFNVGKYLDLETEFRTSEL-SGILLS 3230
                     ..|.:|..|          |...:||.|.| |...:  .:...|:...| :||:..
Mosquito  3980 TGPECYCPVHKTGDRCQYTEHYTDATLAFKDGSYAAYDK-FQSKR--SIRFRFKPDSLENGIMFY 4041

  Fly  3231 VSD-PNGF-PALSLELHNG--NIIFSCDPGNGAPMRVESSLPTKYALCDNKWHNISALYDGEQI- 3290
            .:: ..|: ..:::.|:||  .|.:|. .|...|:.|.|::|.:    ..:||.:||......|
Mosquito  4042 AAEHEQGYGDFMAVLLNNGFVEIRYSV-AGKMKPLIVRSTVPIE----AGQWHTVSAGRTKAGIG 4101

  Fly  3291 VLRIDQLPAVISVGNQGNAGKVQTRSPLYIGGLPESAPSGSLISRE-----NFKGCIRHVSIRNE 3350
            .|::|.......:.|:.....::|:  :|.||..:..    |:|:|     .|:|||..:.....
Mosquito  4102 YLQVDDEAVNNEMSNRNTPILLKTK--VYAGGYDKRL----LLSQEIGVRRGFEGCIAELETSGN 4160

  Fly  3351 RRDWI-EMEDLRNV 3363
            :.:.| ::.|..||
Mosquito  4161 KLNMIDDIRDSANV 4174

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wb	NP_723870.1	Laminin_N	153..398	CDD:459653
		EGF_Lam	401..450	CDD:238012	13/67 (19%)
		EGF_Lam	505..552	CDD:238012	13/66 (20%)
		Laminin_EGF	550..597	CDD:395007	11/57 (19%)
		Laminin_B	660..813	CDD:459652	41/160 (26%)
		EGF_Lam	851..900	CDD:238012	9/48 (19%)
		Laminin_EGF	<943..971	CDD:395007	13/27 (48%)
		Laminin_EGF	974..1018	CDD:395007	14/52 (27%)
		EGF_Lam	1017..1065	CDD:238012	14/105 (13%)
		Laminin_EGF	1065..>1105	CDD:395007	7/39 (18%)
		EGF_Lam	1150..1197	CDD:238012	8/46 (17%)
		Laminin_EGF	1199..1247	CDD:395007	15/54 (28%)
		EGF_Lam	1247..1292	CDD:238012	18/45 (40%)
		Laminin_EGF	1294..1342	CDD:395007	12/47 (26%)
		Laminin_EGF	1340..1392	CDD:395007	14/51 (27%)
		Laminin_B	1486..1626	CDD:459652	36/141 (26%)
		EGF_Lam	1669..1716	CDD:238012	17/50 (34%)
		Laminin_EGF	1718..1767	CDD:395007	9/48 (19%)
		EGF_Lam	1772..1819	CDD:238012	17/92 (18%)
		YhaN	<1907..2141	CDD:443752	47/301 (16%)
		SMC_prok_B	<2123..>2390	CDD:274008	50/293 (17%)
		Laminin_II	2279..2400	CDD:368703	24/140 (17%)
		LamG	2399..>2492	CDD:473984	24/189 (13%)
		LamG	2586..2753	CDD:238058	24/168 (14%)
		Laminin_G_2	2804..2944	CDD:460494	31/163 (19%)
		LamG	3018..3167	CDD:238058	37/165 (22%)
		LamG	3192..3347	CDD:238058	41/175 (23%)
trol	XP_061503679.1	None