DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wb and LanB2

DIOPT Version :10

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:XP_308240.3 Gene:LanB2 / 1269597 VectorBaseID:AGAMI1_007290 Length:1624 Species:Anopheles gambiae


Alignment Length:2343 Identity:526/2343 - (22%)
Similarity:813/2343 - (34%) Gaps:877/2343 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 PPLFNVVPRAQISVNATCGQNGAEEYCKQVG---AKPCGICNAHSSDRAKQRSIQSLISSGSGSG 216
            |...|...:.|:....|||.....::|.|.|   .|.|.:|:      |.|.|.|.|        
Mosquito    52 PEFENAAYQLQVEATNTCGDETDTDFCVQTGYSNRKSCDVCH------AGQHSPQFL-------- 102

  Fly   217 SGSGFEE----GWWQSPTLQGGRQF-EYVTILLDLKQTFQIFSVWLKSANSPRPASWILEKSL-- 274
              :.|.:    .||||.|:..|.|: ..|.:.|.|.::|.|..:.: ..:||||.|:.:.|.:  
Mosquito   103 --TDFHDPNNPTWWQSETMFEGVQYPNQVNLTLGLGKSFDITYIRI-VFHSPRPESFAIYKRVTP 164

  Fly   275 DGINFEPW---QYFGLSDADCQRRW----NLSGQNGKYVFQNDTEIICSTQFSKPGPLENGVLHA 332
            :|    ||   ||:   .|.|:..:    :||..||    ::::..:|::::|...||.:|.:..
Mosquito   165 NG----PWIPYQYY---SATCRDTYGLPDSLSVMNG----EDESRALCTSEYSDISPLRDGNIAF 218

  Fly   333 SLLKNRPGAT--DQSPELMKFITTRYIRIRLQGMHSTANQDNSLDWLLDSPSLEKHSFYSLSQLK 395
            |.|:.||.|.  |...||.:::|...|||.|..:::..      |.:.....:.|..||:::.:.
Mosquito   219 SSLEGRPSAINFDHHLELQQWVTATDIRITLDRLNTFG------DEVFGDAQVLKSYFYAIADIA 277

  Fly   396 VSARLDCNGHANRSHES---PDDPLMQCICQHNTCGAQCEQCCPLFQDRPYQMG-----GECEIC 452
            |.||..|||||:....|   .......|.|.|.|.|..|::|.|.:.|.|:...     .||:.|
Mosquito   278 VGARCKCNGHASECTTSTALDGQRTRVCKCMHFTDGPDCDRCLPFYNDAPWGRATSKNVHECKPC 342

  Fly   453 QCYGHAESCTYDPFL-----DKGICQSCSNNTAGIECEFCEMGFYRELDAPLTDPCLPCSCNPAR 512
            .|.|::..|.:|..|     ..|.|..|..|..|..||.|:..|:...|.    .|:.|.|:|..
Mosquito   343 NCNGYSTKCFFDRHLYNLTGHGGHCIDCGANRDGPNCERCKENFFMREDG----YCINCGCDPVG 403

  Fly   513 STG-GCQSDGGSCNCLEGFQGKNCEECAPGYYG---DDCKRCECDERGSLGSTGSC---SGVCQC 570
            |.. .|.:: |.|.|..|..|:.|:.|...|:.   ..|:.|.|||||||.:|.||   :|||.|
Mosquito   404 SRSLQCNAE-GRCQCKPGVTGEKCDRCDSNYFNFGPHGCQPCNCDERGSLDNTPSCDPVTGVCSC 467

  Fly   571 KLNVEGSTCSECAPGYFDLSAENAEGCTSCWCSGVSQTCHSAKLQTLAFETLN------DWKITD 629
            |.||||..|.||..|||:|.|||..|||.|:|.|.:..|.||...::...|.|      .|    
Mosquito   468 KENVEGRHCRECRLGYFNLDAENKFGCTPCFCYGHTLECTSASGYSIVSTTSNFNKHKEKW---- 528

  Fly   630 IQRVKPISIPVDAETNRL-----IFANELDEVEAIYWQASLGYLGNRLTSYGS----RLQLVLSW 685
             ..:....:|||.:.|..     :.||   ....:|:.|...:||::..||..    |||||   
Mosquito   529 -TAISDTGVPVDVKYNSHSQSIGVGAN---GHRTVYFLAPDRFLGDQRASYNRLFKFRLQLV--- 586

  Fly   686 DVIRGDRSGKP--TTGP-NVILVGKNGLKIAFGDESLDGLGINLNVTLTEVGWYHVPPTVVDIKT 747
                    |:|  ...| :|:|.|.|.                 :::|.........|:....:.
Mosquito   587 --------GQPRVEVSPYDVVLQGGNS-----------------SISLPIFAQNQRMPSEESHEF 626

  Fly   748 RLRRTEGGDY--HGESVTRSQFLSVLVSLDAVLIRAAFHTDQGETSLERAVIYSGGVELGGKSSS 810
            ..|..|..:|  |..:..|. |:|:|.:|.||.|| |.:.|.||..|:...:.:......|:.::
Mosquito   627 AFRLHENPEYTWHPSNSGRG-FMSILSNLTAVKIR-AIYGDYGEAILDDVELQTAHRGAAGRQAT 689

  Fly   811 QVEQCLCPAGYTGLSCEGCAFGFKRIYENTSDHQILSKCIPCPCNGHSNSCDLQSGNCGDCMHNT 875
            .:|||.||.||.|..||.||.|::   .|.:.......|:||.||.|:..||.::|.| .|.|||
Mosquito   690 WIEQCTCPEGYLGQFCESCAPGYR---HNPARGGPFMPCVPCDCNKHAEICDSETGRC-ICQHNT 750

  Fly   876 FGDRCERCQLGYYGNPLQGTPNDCKRCACPLSEDSNNFSPSCQLKSYNYMDLNPQFELIEHAEYI 940
            .||.|::|..|||||.|.|||.|||||.||     ||  .:|...:.:.:              |
Mosquito   751 AGDTCDQCAKGYYGNALGGTPYDCKRCPCP-----NN--GACMQMAGDTV--------------I 794

  Fly   941 CTQCPEGYTGDHCQVCDDGYFGNPRQPGSS---CQRCDCAG-------GPCNVTTGECITCRGNT 995
            |.:||.||.|..|::|.|||:|:|.....|   ||.|||.|       |.||.|||||:.|..||
Mosquito   795 CLECPVGYFGPRCELCSDGYYGDPTGVYGSVRMCQPCDCNGNVDPNAVGNCNRTTGECLKCIHNT 859

  Fly   996 EGWHCERCKLGYWGDPAV----GCDPCHCHTEGSES-----GLCDSTDGQCLCKPRYAGQKCDEC 1051
            .|.||::|..|::|||..    .|:.|.|:..|:|.     .:||:.:|.|.|||          
Mosquito   860 AGPHCDQCLPGHFGDPLAEPHGSCEECSCYPRGTEQTEKGISICDAINGNCHCKP---------- 914

  Fly  1052 DVGYANVELRCPSCNCDPLGSLVQDRCDPHTGQCHCKEGVMGAKCHECQDGYFGMNAVAYRMDDL 1116
                                                                             
Mosquito   915 ----------------------------------------------------------------- 914

  Fly  1117 AALRQNSDSDDDEWELVPDTEDPNSESTVACEECHCSSVGSLSSDCDKRTGQCACLANVTGRRCD 1181
                                                                     ||.||.|:
Mosquito   915 ---------------------------------------------------------NVIGRTCN 922

  Fly  1182 KCRPGHWNLTAGEGCRDCRCDPHGSRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQR 1246
            :|:.|:||:.:|.||..|.|||.||....|:.::|.|.||.||.|:.|::|...::|||.:    
Mosquito   923 ECKNGYWNIVSGNGCESCNCDPIGSYNASCDTYSGDCFCKPGVVGKKCDKCAPAYYGFSED---- 983

  Fly  1247 CSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPGTWGWQARLGCRECECDHIGSIGQQCSTGDG 1311
                                                       ||..|:||..||.|.||:. .|
Mosquito   984 -------------------------------------------GCHACDCDPSGSKGSQCNQ-YG 1004

  Fly  1312 QCQCREGYSGRKCDTCAIGYFGYPECRRCGCDAEGSFTQADGSIACDSNGQCPCKSLVVGLKCDT 1376
            ||.|.:...||:||.|                .|..:.:..|.:.|.:     |.:||       
Mosquito  1005 QCPCNDNVEGRRCDRC----------------KENKYDRHQGCLDCPA-----CYNLV------- 1041

  Fly  1377 CMQSTFGLSAQNPEGCTRCFCFGRSGECEQSDLSWGHIRMAESRNLSVQQIRPHSVPSSDYEYIV 1441
                                          .|.:..|.......|..:|.|:...:...|.|:  
Mosquito  1042 ------------------------------QDAANDHRAKLAELNQILQDIQSKPIVIDDSEF-- 1074

  Fly  1442 VVQMEGSSFHREDAEIQRMNDLSLVPKSTGNVSIGAYGQFYHPLYFQLPPQFYGDRTSSYGGFLY 1506
                 ....|    .:|...|:.:....:|                            |.||   
Mosquito  1075 -----AGKLH----AVQEKIDILVEDAKSG----------------------------SGGG--- 1099

  Fly  1507 FTLITEGAHKPLERNILGQYPLVQLHAHSKLLLDFYEYEEFEYSLNVTHRVPLHESFWKYHHTSQ 1571
                                                     |.:||...|               
Mosquito  1100 -----------------------------------------EKTLNEILR--------------- 1108

  Fly  1572 AVDRNTLMAALQNIRHIFIRAFAFADFQEVVLQNVHMDAAIYIKGSTNLIAKGVERCKCPKRFDG 1636
                 .|.|.||.::.:...|   ...|||               :.:.|:||            
Mosquito  1109 -----ELEARLQEVQKLLDNA---DQSQEV---------------TNHKISKG------------ 1138

  Fly  1637 LSCQDPGRSFYRWRNTTIVESVFIEDLIGRAAPCHCNGRSSDCDRETGVCQNCRGNTGGDHCHQC 1701
                        ..|.|:                 .||:..|..|:.                  
Mosquito  1139 ------------GYNATL-----------------ANGKIQDARRQL------------------ 1156

  Fly  1702 AEGFYGDPNSPHGCQACPCPETNRNFARGCNVWDGEVSCVCKPGYTGRLCERCQAGYFGDPMRYP 1766
                                             |..:..                          
Mosquito  1157 ---------------------------------DNAIEL-------------------------- 1162

  Fly  1767 NTTCQPCNCHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQAERHHLVDNGCKICDNCTLLLLDY 1831
                         :||||   .|.....:: ::|           ||                  
Mosquito  1163 -------------LQTEG---NTALARAKD-ISG-----------HL------------------ 1181

  Fly  1832 MELVGNKLRRGMHNMDLTGIPAPYRKLSEYESAYEKWNGRHWDFSQTKRRLQDYDSADILKLEAH 1896
                ||:..:      ::||                           .|..:.|  ||..|.||.
Mosquito  1182 ----GNQTNQ------ISGI---------------------------SREARQY--ADRFKAEAD 1207

  Fly  1897 AENLKFQSRKAVATIGKREFAIKSMREDAVTQQHSVGLLRSEILQTLSDLHGYGKSAHYLSLPTA 1961
            | |:| |:::|..   |...|:|. ..||..||.::    ::.|.|              |:.:.
Mosquito  1208 A-NMK-QAQEAHK---KASEALKK-ANDAFNQQANI----TKELDT--------------SISSE 1248

  Fly  1962 LKQARFYLQAIRE-HDQMVQGIRSTNDCAWKHFYAMGNASDASFDESGRLEMLWRDLNQTNHRVV 2025
            :.|||..|..:.: .:|.:...|..||.|...|.|:...:..:.|    ::.:.::.||.|.   
Mosquito  1249 IAQAREKLNTVSKLTEQALTRAREVNDEALTLFAAVNRTAPPNID----IDKIKKEANQYNR--- 1306

  Fly  2026 DMRLQVDRV-QEVENEAEDVLEHVRNLSIRVGESHQELDELNQRISDHLDPGYLEQ--------- 2080
                :.||: :::.|:..|..:.:.|:...:..:...||..:.:..|.:|.  |:|         
Mosquito  1307 ----EADRIAEDLANKMRDHAQLLENVGTNIELAETLLDRASLQKEDAVDA--LKQLKYAKEQAE 1365

  Fly  2081 -----GEGLLRLTVQRQIMLNGHLNQLDGYRILLNTTLGVKTEQQREVRKHWLPKAEK---HASH 2137
                 |:|.|:........|.|..||::            ::.::.|...:.:|..|:   ::..
Mosquito  1366 KAVAEGDGTLQKANYTYQTLAGFKNQVE------------ESSRRAEEALNLVPNIERQIVNSRD 1418

  Fly  2138 LLARSNEYARKFQPTRNGARIAMLASSAHSNITEAINDARLASILAKERVYEAQRTLYPSDGSSM 2202
            ||.|:.|              |:.|:|.::      .|||..:..|:::        |..:.|.:
Mosquito  1419 LLQRAEE--------------ALYAASRNA------EDARKNAQTAQDK--------YAEEASKL 1455

  Fly  2203 IERAKHSLHRSKQLQQEALKQMHKSNVLKDKLHRQEQQVEGIKSTIYDSGLRTNNISGQLQGLSD 2267
            .|..|...:.:|             |..:| ||.:..|:.|   .:..:..|......|::  .|
Mosquito  1456 AENIKKRANATK-------------NTARD-LHHEADQLNG---RLAKTDNRLEEREAQIR--KD 1501

  Fly  2268 GSARRQAKDSLEMADRTGEQMRAELQKAKD----MQKSIQNMRNSFSNLEPDWEIKLGMAQENIS 2328
            .:...:||:.:..|.....:.::::.||..    :...:.|:|....|...|.|.:|..|::.:.
Mosquito  1502 LNLTNEAKEKVGQAQLNSNEAKSQVDKAMREVSLIMSELANLREIDVNSLDDLERRLSAAEKELE 1566

  Fly  2329 LTQTNLRLANVSLSYLEQQAEKEQQVFEVWNNSMAQQLQQLRDQIAKARHAAEAIDVSLESLGPK 2393
            ..|...||:    |.:|.:..:.|.:     .|..::|..||.::|.       |::...||.|.
Mosquito  1567 DAQLTKRLS----SLVEAKNIQNQNI-----RSYQKELADLRLEVAN-------IELIANSLPPG 1615

  Fly  2394 CIR 2396
            |.:
Mosquito  1616 CFK 1618

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 153..398 CDD:459653 70/261 (27%)
EGF_Lam 401..450 CDD:238012 17/56 (30%)
EGF_Lam 505..552 CDD:238012 15/50 (30%)
Laminin_EGF 550..597 CDD:395007 30/49 (61%)
Laminin_B 660..813 CDD:459652 39/161 (24%)
EGF_Lam 851..900 CDD:238012 27/48 (56%)
Laminin_EGF <943..971 CDD:395007 13/30 (43%)
Laminin_EGF 974..1018 CDD:395007 24/54 (44%)
EGF_Lam 1017..1065 CDD:238012 11/52 (21%)
Laminin_EGF 1065..>1105 CDD:395007 0/39 (0%)
EGF_Lam 1150..1197 CDD:238012 11/46 (24%)
Laminin_EGF 1199..1247 CDD:395007 19/47 (40%)
EGF_Lam 1247..1292 CDD:238012 1/44 (2%)
Laminin_EGF 1294..1342 CDD:395007 17/47 (36%)
Laminin_EGF 1340..1392 CDD:395007 6/51 (12%)
Laminin_B 1486..1626 CDD:459652 18/139 (13%)
EGF_Lam 1669..1716 CDD:238012 4/46 (9%)
Laminin_EGF 1718..1767 CDD:395007 1/48 (2%)
EGF_Lam 1772..1819 CDD:238012 8/46 (17%)
YhaN <1907..2141 CDD:443752 49/252 (19%)
SMC_prok_B <2123..>2390 CDD:274008 51/273 (19%)
Laminin_II 2279..2400 CDD:368703 26/122 (21%)
LamG 2399..>2492 CDD:473984
LamG 2586..2753 CDD:238058
Laminin_G_2 2804..2944 CDD:460494
LamG 3018..3167 CDD:238058
LamG 3192..3347 CDD:238058
LanB2XP_308240.3 Laminin_N 50..280 CDD:459653 70/261 (27%)
EGF_Lam 281..328 CDD:238012 16/46 (35%)
Laminin_EGF 342..397 CDD:395007 17/58 (29%)
EGF_Lam 397..441 CDD:214543 13/44 (30%)
Laminin_EGF 444..494 CDD:395007 30/49 (61%)
Laminin_B 560..692 CDD:459652 39/161 (24%)
EGF_Lam 727..769 CDD:238012 23/42 (55%)
Laminin_EGF 831..881 CDD:395007 23/49 (47%)
Laminin_EGF 886..937 CDD:395007 21/182 (12%)
EGF_Lam 940..985 CDD:214543 19/91 (21%)
Laminin_EGF 988..1030 CDD:395007 18/58 (31%)
SMC_prok_B <1046..>1606 CDD:274008 153/995 (15%)
Blue background indicates that the domain is not in the aligned region.

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