DRSC/TRiP Functional Genomics Resources

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Protein Alignment wb and Lamc1

DIOPT Version :9

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:NP_446418.1 Gene:Lamc1 / 117036 RGDID:621052 Length:1607 Species:Rattus norvegicus


Alignment Length:2225 Identity:498/2225 - (22%)
Similarity:789/2225 - (35%) Gaps:757/2225 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 PPLFNVVPRAQISVNATCGQNGAEEYCKQVG----AKPCGICNAHSSDRAKQRSIQSLISSGSGS 215
            |...|......:....||| ...||||.|.|    .|.|.:|:      |.|..:|         
  Rat    50 PEFVNAAFNVTVVATNTCG-TPPEEYCVQTGVTGVTKSCHLCD------AGQLHLQ--------- 98

  Fly   216 GSGSGF--------EEGWWQSPTLQGGRQF-EYVTILLDLKQTFQIFSVWLKSANSPRPASWILE 271
             .|:.|        :..||||.|:..|.|: ..:.:.|.|.:.|.|..|.||...| ||.|:.:.
  Rat    99 -HGAAFLTDYNNQADTTWWQSQTMLAGVQYPNSINLTLHLGKAFDITYVRLKFHTS-RPESFAIY 161

  Fly   272 KSL--DGINFEPW---QYFGLSDADCQRRWNLSGQNGKYVFQNDTEIICSTQFSKPGPLENGVLH 331
            |..  ||    ||   ||:   ...|:..::.:.:.......::.:.:|:.:||...||..|.:.
  Rat   162 KRTREDG----PWIPYQYY---SGSCENTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGNVA 219

  Fly   332 ASLLKNRPGA--TDQSPELMKFITTRYIRIRLQGMHSTANQDNSL-DWLLDSPSLEKHSFYSLSQ 393
            .|.|:.||.|  .|.||.|.:::|...||:       |.|:.|:. |.:.:.|.:.|..:|::|.
  Rat   220 FSTLEGRPSAYNFDNSPVLQEWVTATDIRV-------TLNRLNTFGDEVFNDPKVLKSYYYAISD 277

  Fly   394 LKVSARLDCNGHANRSHESPDDPLMQCICQHNTCGAQCEQCCPLFQDRPY-----QMGGECEICQ 453
            ..|..|..|||||:...::....|: |.|:|||.|..||:|.|.|.|||:     :...:|..|.
  Rat   278 FAVGGRCKCNGHASECVKNEFGKLV-CNCKHNTYGVDCEKCLPFFNDRPWRRATAESANQCLPCD 341

  Fly   454 CYGHAESCTYDPFLDK-----GICQSCSNNTAGIECEFCEMGFYRELDAPLTDPCLPCSCNPARS 513
            |.|.::.|.:||.|.:     |.|.:|.:||.|.:||.|...|:|   ...|:.|.||.|:|..|
  Rat   342 CNGRSQECYFDPELYRSTGHGGHCTNCRDNTDGAKCERCRENFFR---LGNTEACSPCHCSPVGS 403

  Fly   514 TGGCQSDGGSCNCLEGFQGKNCEECAPGYYG---DDCKRCECDERGSLGSTGSCSGVCQCKLNVE 575
            ........|.|:|..|..|..|:.|.||::.   ..|:.|.||..||.......:|.|.||.|||
  Rat   404 LSTQCDSYGRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPCSCDPSGSTDECNVETGRCVCKDNVE 468

  Fly   576 GSTCSECAPGYFDLSAENAEGCTSCWCSGVSQTCHSAKLQTL-----AFETLND-WKITDIQRVK 634
            |.:|..|.||:|:|.:.|.:|||.|:|.|.|..|.:|...::     .|:...| |::.  ||  
  Rat   469 GFSCERCKPGFFNLESSNPKGCTPCFCFGHSSVCTNAVGYSVYDISSTFQIDEDGWRVE--QR-- 529

  Fly   635 PISIPVDAETNRLIFANELDEVEAI-------YWQASLGYLGNRLTSYGSRLQLVLSWDVIRGDR 692
                  |.....|.::::..::..|       |:.|...:|||::.|||..|.  .|:.|.|.| 
  Rat   530 ------DGSEASLEWSSDRQDIAVISDTYFPRYFVAPAKFLGNQVLSYGQNLS--FSFRVDRRD- 585

  Fly   693 SGKPTTGPNVILVGKNGLKIAFGDESLDGLGINLNVTLTEVGWYHVPPTVVDIKTRLRRTEGGDY 757
                             .:::..|..|:|.|:.::|.|...|  :..|:...:|...|..|..||
  Rat   586 -----------------TRLSAEDLVLEGAGLRVSVPLIAQG--NSYPSETTVKYIFRLHEATDY 631

  Fly   758 HGE-SVTRSQFLSVLVSLDAVLIRAAFHTDQGETSLERAVIYSGGVEL------GGKSSSQVEQC 815
            ... :::..:|..:|.:|.::.||..:.        ||:..|...|.|      .|..::.||.|
  Rat   632 PWRPALSPFEFQKLLNNLTSIKIRGTYS--------ERSAGYLDDVTLQSARPGPGVPATWVESC 688

  Fly   816 LCPAGYTGLSCEGCAFGFKRIYENTSDHQILSKCIPCPCNGHSNSCDLQSGNCGDCMHNTFGDRC 880
            .||.||.|..||.|..|::|   .|......|.|:.|.|||||.:||.::|.| ||..||.|..|
  Rat   689 TCPVGYGGQFCETCLPGYRR---ETPSLGPYSPCVLCTCNGHSETCDPETGVC-DCRDNTAGPHC 749

  Fly   881 ERCQLGYYGNPLQGTPNDCKRCACPLSEDSNNFSPSCQLKSYNYMDLNPQFELIEHAEYICTQCP 945
            |:|..||||:...||.:||:.|.||       ...||.:             :.:..|.:||.||
  Rat   750 EKCSDGYYGDSTLGTSSDCQPCPCP-------GGSSCAI-------------VPKTKEVVCTHCP 794

  Fly   946 EGYTGDHCQVCDDGYFGNP---RQPGSSCQRCDC-------AGGPCNVTTGECITCRGNTEGWHC 1000
            .|..|..|::|||||||:|   ..|...|:.|.|       |.|.||..||||:.|..||.|::|
  Rat   795 TGTAGKRCELCDDGYFGDPLGSNGPVRLCRPCQCNDNIDPNAVGNCNRLTGECLKCIYNTAGFYC 859

  Fly  1001 ERCKLGYWGDPAVGCDPCHCHTEGSESGLCDSTDGQCLCKPRYAGQKCDECDVGYANVELRCPSC 1065
            :|||.|::|:|..                                          .|...:|.:|
  Rat   860 DRCKEGFFGNPLA------------------------------------------PNPADKCKAC 882

  Fly  1066 NCDPLGSLVQDRCDPHTGQCHCKEGVMGAKCHECQDGYFGMNAVAYRMDDLAALRQNSDSDDDEW 1130
            .|:|.|::.|                                                       
  Rat   883 ACNPYGTVQQ------------------------------------------------------- 892

  Fly  1131 ELVPDTEDPNSESTVACEECHCSSVGSLSSDCDKRTGQCACLANVTGRRCDKCRPGHWNLTAGEG 1195
                                        .|.|:..||||.||.:|:||.|..|.||.:||.:|:|
  Rat   893 ----------------------------QSSCNPVTGQCQCLPHVSGRDCGACDPGFYNLQSGQG 929

  Fly  1196 CRDCRCDPHGSRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRCSACRSEGQVCDPH 1260
            |..|.|...||...:|:..||||:|:.|:.||||..|....|||..|                  
  Rat   930 CESCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCETNHFGFGPE------------------ 976

  Fly  1261 NGRCICPKFTRGLGCGQCVPGTWGWQARLGCRECECDHIGSIGQQCSTGDGQCQCREGYSGRKCD 1325
                                         ||:.|:|.|.||:..||. .||:|:||||:.|.:||
  Rat   977 -----------------------------GCKPCDCHHEGSLSLQCK-DDGRCECREGFVGNRCD 1011

  Fly  1326 TCAIGYF---GYPECRRCGCDAEGSFTQADGSIACDSNGQCPCKSLVVGLKCDTCMQSTFGLSAQ 1387
            .|...||   .:|.|:                       :||.                      
  Rat  1012 QCEENYFYNRSWPGCQ-----------------------ECPA---------------------- 1031

  Fly  1388 NPEGCTRCFCFGRSGECEQSDLSWGHIRMAESRNLSVQQIRPHSVPSSDYEYIVVVQMEGSSFHR 1452
                     |:                      .|...::..|.|...:.|.::           
  Rat  1032 ---------CY----------------------RLVKDKVAEHRVKLQELESLI----------- 1054

  Fly  1453 EDAEIQRMNDLSLVPKSTGNVSIGAYGQFYHPLYFQLPPQFYGDRTSSYGGFLYFTLITEGAHKP 1517
                                .::|.                 ||.|.:...|       |...|.
  Rat  1055 --------------------ANLGT-----------------GDETVTDQAF-------EDRLKE 1075

  Fly  1518 LERNILGQYPLVQLHAHSKLLLDFYEYEEFEYSL-NVTHRV--PLHESFWKYHHTSQAVDRNTLM 1579
            .||.:            :.||.:..|.::.:.:| :...||  .||....:.|:....::...::
  Rat  1076 AEREV------------TDLLREAQEVKDVDQNLMDRLQRVNNSLHSQISRLHNIRNTIEETGIL 1128

  Fly  1580 AALQNIRHIFIRAFAFADFQEVVLQNVHMDAAIYIKGSTNLIAKGVERCKCPKRFDGLSCQDPGR 1644
            |.         ||.:..:..|.:::               :.::.:|:.|....  .:|...| .
  Rat  1129 AE---------RARSRVESTEQLIE---------------IASRELEKAKMAAA--NVSITQP-E 1166

  Fly  1645 SFYRWRNTTIVESVFIEDLIGRAAPCHCNGRSSDCDRETGVCQNCRGNTGGDHCHQCAEGFYGDP 1709
            |.....|.|:     :.:...|.|..|    ..:.|....|.:.. ..|..:..:.......|:.
  Rat  1167 STGEPNNMTL-----LAEEARRLAERH----KQEADDIVRVAKTA-NETSAEAYNLLLRTLAGEN 1221

  Fly  1710 NSPHGCQACPCPETNRNFARGCNVWDGEVSCVCKPGYTGRLCERCQAGYFGDPMRYPNTTCQPCN 1774
            .:     |....|.||.:.:..|:                                         
  Rat  1222 QT-----ALEIEELNRKYEQAKNI----------------------------------------- 1240

  Fly  1775 CHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQAERHHL--VDNGCKICDNCTLLLLDYMELVGN 1837
                   ::..:.:..|.:......|.|..:..|....|  ||:             :.:|...|
  Rat  1241 -------SQDLEKQAARVHEEAKRAGDKAVEIYASVAQLTPVDS-------------EALESEAN 1285

  Fly  1838 KLRRGMHNMD-LTGIPAPYRKLSEYESAYEKWNGRHWDFSQTKRRLQ----DYDSADILKLEAHA 1897
            |:::...::| |..     :||.:||...|...|:.   .:.|..|:    :..:||  :|.|.|
  Rat  1286 KIKKEAADLDRLID-----QKLKDYEDLREDMRGKE---HEVKNLLEKGKAEQQTAD--QLLARA 1340

  Fly  1898 ENLKFQSRKAVATIGKREFAIKSMREDAVTQQHSVGLLRSEILQTLSDLHGYGKSAHYLSLPTAL 1962
            :                  |.|::.|:|..:..:.....::||..|.|.     ........||.
  Rat  1341 D------------------AAKALAEEAAKKGRNTLQEANDILNNLKDF-----DRRVNDNKTAA 1382

  Fly  1963 KQARFYLQAIREHDQMVQGIRSTNDCAWKHFYAMGNASDASFDESGRLEMLWRDLNQTNHRVVDM 2027
            ::|...:.||.      :.|...|:...:...|:|||:                        .|.
  Rat  1383 EEALRRIPAIN------RTIAEANEKTREAQLALGNAA------------------------ADA 1417

  Fly  2028 RLQVDRVQEVENEAEDVLEHVRNLSIRVGESHQELDELNQRISDHLDPGYLEQGEGLLRLTVQRQ 2092
            ....::..|.|..|..|.::..:.......:..|:.:|:..:                       
  Rat  1418 TEAKNKAHEAERIASGVQKNATSTKADAERTFSEVTDLDNEV----------------------- 1459

  Fly  2093 IMLNGHLNQLDGYRILLNTTLGVKTEQQREVRKHWLPKAEKHASHLLARSNEYARKFQPTRNGAR 2157
               ||.|.||:                          :||          ||..||.........
  Rat  1460 ---NGMLRQLE--------------------------EAE----------NELKRKQDDADQDMM 1485

  Fly  2158 IAMLASSAHSNITEAINDARLASILAKERVYEAQRTLYPSDGSSMIERAKHSLHRSKQLQQEALK 2222
            :|.:||       :|..:|.|.:..||..|            ||::.:....|   :||.|....
  Rat  1486 MAGMAS-------QAAQEAELNARKAKNSV------------SSLLSQLTDLL---EQLGQLDTV 1528

  Fly  2223 QMHKSNVLKDKLHRQEQQVEGIKSTIYDSGLRTNNISGQLQGLSDGSARRQAKDSLEMADRTGEQ 2287
            .::|.|.::..|::.:.:::     :.|...:.:|:        :..||:|....|:. ||...:
  Rat  1529 DLNKLNEIEGSLNKAKDEMK-----VSDLDRKVSNL--------ENEARKQEAAILDY-DRDIAE 1579

  Fly  2288 MRAELQKAKDMQKSI 2302
            :..::...:|::|::
  Rat  1580 IIKDIHNLEDIKKTL 1594

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 164..396 CDD:278484 69/252 (27%)
EGF_Lam 401..450 CDD:238012 20/53 (38%)
TNFRSF <407..507 CDD:304602 37/109 (34%)
EGF_Lam 505..552 CDD:238012 16/49 (33%)
Laminin_EGF 550..597 CDD:278482 20/46 (43%)
Laminin_B 660..798 CDD:278481 33/138 (24%)
EGF_Lam 851..900 CDD:238012 25/48 (52%)
Laminin_EGF <943..971 CDD:278482 14/30 (47%)
VSP 953..1414 CDD:146106 106/473 (22%)
Laminin_EGF 974..1018 CDD:278482 21/50 (42%)
EGF_Lam 1017..1065 CDD:238012 2/47 (4%)
Laminin_EGF 1065..>1105 CDD:278482 5/39 (13%)
EGF_Lam 1150..1197 CDD:238012 19/46 (41%)
Laminin_EGF 1199..1247 CDD:278482 20/47 (43%)
EGF_Lam 1247..1292 CDD:238012 1/44 (2%)
Laminin_EGF 1294..1342 CDD:278482 22/50 (44%)
Laminin_EGF 1340..1392 CDD:278482 2/51 (4%)
Laminin_B 1486..1611 CDD:278481 21/127 (17%)
EGF_Lam 1669..1716 CDD:238012 5/46 (11%)
Laminin_EGF 1718..1767 CDD:278482 4/48 (8%)
EGF_Lam 1772..1819 CDD:238012 7/48 (15%)
CrfC <1933..2267 CDD:223771 53/333 (16%)
Laminin_II 2277..2400 CDD:283628 5/26 (19%)
LamG 2399..>2492 CDD:304605
Laminin_G_2 2616..2755 CDD:280389
Laminin_G_2 2804..2944 CDD:280389
Laminin_G_2 3038..3169 CDD:280389
LamG 3192..3347 CDD:238058
Lamc1NP_446418.1 LamNT 42..282 CDD:214532 72/263 (27%)
EGF_Lam 283..328 CDD:238012 21/45 (47%)
Laminin_EGF 340..394 CDD:278482 19/56 (34%)
Laminin_EGF 396..443 CDD:278482 14/46 (30%)
Laminin_EGF 443..490 CDD:278482 20/46 (43%)
LamB 552..676 CDD:214597 36/153 (24%)
Laminin_EGF 722..761 CDD:278482 22/39 (56%)
EGF_Lam 770..818 CDD:238012 21/67 (31%)
Laminin_EGF 826..873 CDD:278482 21/88 (24%)
Laminin_EGF 882..930 CDD:278482 23/130 (18%)
EGF_Lam 933..978 CDD:214543 20/91 (22%)
EGF_Lam 980..1027 CDD:238012 21/47 (45%)
FlgN <1048..1121 CDD:298847 19/139 (14%)
MA 1089..1300 CDD:214599 42/318 (13%)
Tropomyosin 1355..1586 CDD:278679 59/363 (16%)
Prefoldin 1416..1551 CDD:298833 36/223 (16%)
SPX <1518..1588 CDD:271919 15/86 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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