DRSC/TRiP Functional Genomics Resources

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Protein Alignment wb and Lamc1

DIOPT Version :10

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:NP_446418.1 Gene:Lamc1 / 117036 RGDID:621052 Length:1607 Species:Rattus norvegicus


Alignment Length:2225 Identity:498/2225 - (22%)
Similarity:789/2225 - (35%) Gaps:757/2225 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 PPLFNVVPRAQISVNATCGQNGAEEYCKQVG----AKPCGICNAHSSDRAKQRSIQSLISSGSGS 215
            |...|......:....||| ...||||.|.|    .|.|.:|:      |.|..:|         
  Rat    50 PEFVNAAFNVTVVATNTCG-TPPEEYCVQTGVTGVTKSCHLCD------AGQLHLQ--------- 98

  Fly   216 GSGSGF--------EEGWWQSPTLQGGRQF-EYVTILLDLKQTFQIFSVWLKSANSPRPASWILE 271
             .|:.|        :..||||.|:..|.|: ..:.:.|.|.:.|.|..|.||...| ||.|:.:.
  Rat    99 -HGAAFLTDYNNQADTTWWQSQTMLAGVQYPNSINLTLHLGKAFDITYVRLKFHTS-RPESFAIY 161

  Fly   272 KSL--DGINFEPW---QYFGLSDADCQRRWNLSGQNGKYVFQNDTEIICSTQFSKPGPLENGVLH 331
            |..  ||    ||   ||:   ...|:..::.:.:.......::.:.:|:.:||...||..|.:.
  Rat   162 KRTREDG----PWIPYQYY---SGSCENTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGNVA 219

  Fly   332 ASLLKNRPGA--TDQSPELMKFITTRYIRIRLQGMHSTANQDNSL-DWLLDSPSLEKHSFYSLSQ 393
            .|.|:.||.|  .|.||.|.:::|...||:       |.|:.|:. |.:.:.|.:.|..:|::|.
  Rat   220 FSTLEGRPSAYNFDNSPVLQEWVTATDIRV-------TLNRLNTFGDEVFNDPKVLKSYYYAISD 277

  Fly   394 LKVSARLDCNGHANRSHESPDDPLMQCICQHNTCGAQCEQCCPLFQDRPY-----QMGGECEICQ 453
            ..|..|..|||||:...::....|: |.|:|||.|..||:|.|.|.|||:     :...:|..|.
  Rat   278 FAVGGRCKCNGHASECVKNEFGKLV-CNCKHNTYGVDCEKCLPFFNDRPWRRATAESANQCLPCD 341

  Fly   454 CYGHAESCTYDPFLDK-----GICQSCSNNTAGIECEFCEMGFYRELDAPLTDPCLPCSCNPARS 513
            |.|.::.|.:||.|.:     |.|.:|.:||.|.:||.|...|:|   ...|:.|.||.|:|..|
  Rat   342 CNGRSQECYFDPELYRSTGHGGHCTNCRDNTDGAKCERCRENFFR---LGNTEACSPCHCSPVGS 403

  Fly   514 TGGCQSDGGSCNCLEGFQGKNCEECAPGYYG---DDCKRCECDERGSLGSTGSCSGVCQCKLNVE 575
            ........|.|:|..|..|..|:.|.||::.   ..|:.|.||..||.......:|.|.||.|||
  Rat   404 LSTQCDSYGRCSCKPGVMGDKCDRCQPGFHSLTEAGCRPCSCDPSGSTDECNVETGRCVCKDNVE 468

  Fly   576 GSTCSECAPGYFDLSAENAEGCTSCWCSGVSQTCHSAKLQTL-----AFETLND-WKITDIQRVK 634
            |.:|..|.||:|:|.:.|.:|||.|:|.|.|..|.:|...::     .|:...| |::.  ||  
  Rat   469 GFSCERCKPGFFNLESSNPKGCTPCFCFGHSSVCTNAVGYSVYDISSTFQIDEDGWRVE--QR-- 529

  Fly   635 PISIPVDAETNRLIFANELDEVEAI-------YWQASLGYLGNRLTSYGSRLQLVLSWDVIRGDR 692
                  |.....|.::::..::..|       |:.|...:|||::.|||..|.  .|:.|.|.| 
  Rat   530 ------DGSEASLEWSSDRQDIAVISDTYFPRYFVAPAKFLGNQVLSYGQNLS--FSFRVDRRD- 585

  Fly   693 SGKPTTGPNVILVGKNGLKIAFGDESLDGLGINLNVTLTEVGWYHVPPTVVDIKTRLRRTEGGDY 757
                             .:::..|..|:|.|:.::|.|...|  :..|:...:|...|..|..||
  Rat   586 -----------------TRLSAEDLVLEGAGLRVSVPLIAQG--NSYPSETTVKYIFRLHEATDY 631

  Fly   758 HGE-SVTRSQFLSVLVSLDAVLIRAAFHTDQGETSLERAVIYSGGVEL------GGKSSSQVEQC 815
            ... :::..:|..:|.:|.::.||..:.        ||:..|...|.|      .|..::.||.|
  Rat   632 PWRPALSPFEFQKLLNNLTSIKIRGTYS--------ERSAGYLDDVTLQSARPGPGVPATWVESC 688

  Fly   816 LCPAGYTGLSCEGCAFGFKRIYENTSDHQILSKCIPCPCNGHSNSCDLQSGNCGDCMHNTFGDRC 880
            .||.||.|..||.|..|::|   .|......|.|:.|.|||||.:||.::|.| ||..||.|..|
  Rat   689 TCPVGYGGQFCETCLPGYRR---ETPSLGPYSPCVLCTCNGHSETCDPETGVC-DCRDNTAGPHC 749

  Fly   881 ERCQLGYYGNPLQGTPNDCKRCACPLSEDSNNFSPSCQLKSYNYMDLNPQFELIEHAEYICTQCP 945
            |:|..||||:...||.:||:.|.||       ...||.:             :.:..|.:||.||
  Rat   750 EKCSDGYYGDSTLGTSSDCQPCPCP-------GGSSCAI-------------VPKTKEVVCTHCP 794

  Fly   946 EGYTGDHCQVCDDGYFGNP---RQPGSSCQRCDC-------AGGPCNVTTGECITCRGNTEGWHC 1000
            .|..|..|::|||||||:|   ..|...|:.|.|       |.|.||..||||:.|..||.|::|
  Rat   795 TGTAGKRCELCDDGYFGDPLGSNGPVRLCRPCQCNDNIDPNAVGNCNRLTGECLKCIYNTAGFYC 859

  Fly  1001 ERCKLGYWGDPAVGCDPCHCHTEGSESGLCDSTDGQCLCKPRYAGQKCDECDVGYANVELRCPSC 1065
            :|||.|::|:|..                                          .|...:|.:|
  Rat   860 DRCKEGFFGNPLA------------------------------------------PNPADKCKAC 882

  Fly  1066 NCDPLGSLVQDRCDPHTGQCHCKEGVMGAKCHECQDGYFGMNAVAYRMDDLAALRQNSDSDDDEW 1130
            .|:|.|::.|                                                       
  Rat   883 ACNPYGTVQQ------------------------------------------------------- 892

  Fly  1131 ELVPDTEDPNSESTVACEECHCSSVGSLSSDCDKRTGQCACLANVTGRRCDKCRPGHWNLTAGEG 1195
                                        .|.|:..||||.||.:|:||.|..|.||.:||.:|:|
  Rat   893 ----------------------------QSSCNPVTGQCQCLPHVSGRDCGACDPGFYNLQSGQG 929

  Fly  1196 CRDCRCDPHGSRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRCSACRSEGQVCDPH 1260
            |..|.|...||...:|:..||||:|:.|:.||||..|....|||..|                  
  Rat   930 CESCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCETNHFGFGPE------------------ 976

  Fly  1261 NGRCICPKFTRGLGCGQCVPGTWGWQARLGCRECECDHIGSIGQQCSTGDGQCQCREGYSGRKCD 1325
                                         ||:.|:|.|.||:..||. .||:|:||||:.|.:||
  Rat   977 -----------------------------GCKPCDCHHEGSLSLQCK-DDGRCECREGFVGNRCD 1011

  Fly  1326 TCAIGYF---GYPECRRCGCDAEGSFTQADGSIACDSNGQCPCKSLVVGLKCDTCMQSTFGLSAQ 1387
            .|...||   .:|.|:                       :||.                      
  Rat  1012 QCEENYFYNRSWPGCQ-----------------------ECPA---------------------- 1031

  Fly  1388 NPEGCTRCFCFGRSGECEQSDLSWGHIRMAESRNLSVQQIRPHSVPSSDYEYIVVVQMEGSSFHR 1452
                     |:                      .|...::..|.|...:.|.::           
  Rat  1032 ---------CY----------------------RLVKDKVAEHRVKLQELESLI----------- 1054

  Fly  1453 EDAEIQRMNDLSLVPKSTGNVSIGAYGQFYHPLYFQLPPQFYGDRTSSYGGFLYFTLITEGAHKP 1517
                                .::|.                 ||.|.:...|       |...|.
  Rat  1055 --------------------ANLGT-----------------GDETVTDQAF-------EDRLKE 1075

  Fly  1518 LERNILGQYPLVQLHAHSKLLLDFYEYEEFEYSL-NVTHRV--PLHESFWKYHHTSQAVDRNTLM 1579
            .||.:            :.||.:..|.::.:.:| :...||  .||....:.|:....::...::
  Rat  1076 AEREV------------TDLLREAQEVKDVDQNLMDRLQRVNNSLHSQISRLHNIRNTIEETGIL 1128

  Fly  1580 AALQNIRHIFIRAFAFADFQEVVLQNVHMDAAIYIKGSTNLIAKGVERCKCPKRFDGLSCQDPGR 1644
            |.         ||.:..:..|.:::               :.::.:|:.|....  .:|...| .
  Rat  1129 AE---------RARSRVESTEQLIE---------------IASRELEKAKMAAA--NVSITQP-E 1166

  Fly  1645 SFYRWRNTTIVESVFIEDLIGRAAPCHCNGRSSDCDRETGVCQNCRGNTGGDHCHQCAEGFYGDP 1709
            |.....|.|:     :.:...|.|..|    ..:.|....|.:.. ..|..:..:.......|:.
  Rat  1167 STGEPNNMTL-----LAEEARRLAERH----KQEADDIVRVAKTA-NETSAEAYNLLLRTLAGEN 1221

  Fly  1710 NSPHGCQACPCPETNRNFARGCNVWDGEVSCVCKPGYTGRLCERCQAGYFGDPMRYPNTTCQPCN 1774
            .:     |....|.||.:.:..|:                                         
  Rat  1222 QT-----ALEIEELNRKYEQAKNI----------------------------------------- 1240

  Fly  1775 CHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQAERHHL--VDNGCKICDNCTLLLLDYMELVGN 1837
                   ::..:.:..|.:......|.|..:..|....|  ||:             :.:|...|
  Rat  1241 -------SQDLEKQAARVHEEAKRAGDKAVEIYASVAQLTPVDS-------------EALESEAN 1285

  Fly  1838 KLRRGMHNMD-LTGIPAPYRKLSEYESAYEKWNGRHWDFSQTKRRLQ----DYDSADILKLEAHA 1897
            |:::...::| |..     :||.:||...|...|:.   .:.|..|:    :..:||  :|.|.|
  Rat  1286 KIKKEAADLDRLID-----QKLKDYEDLREDMRGKE---HEVKNLLEKGKAEQQTAD--QLLARA 1340

  Fly  1898 ENLKFQSRKAVATIGKREFAIKSMREDAVTQQHSVGLLRSEILQTLSDLHGYGKSAHYLSLPTAL 1962
            :                  |.|::.|:|..:..:.....::||..|.|.     ........||.
  Rat  1341 D------------------AAKALAEEAAKKGRNTLQEANDILNNLKDF-----DRRVNDNKTAA 1382

  Fly  1963 KQARFYLQAIREHDQMVQGIRSTNDCAWKHFYAMGNASDASFDESGRLEMLWRDLNQTNHRVVDM 2027
            ::|...:.||.      :.|...|:...:...|:|||:                        .|.
  Rat  1383 EEALRRIPAIN------RTIAEANEKTREAQLALGNAA------------------------ADA 1417

  Fly  2028 RLQVDRVQEVENEAEDVLEHVRNLSIRVGESHQELDELNQRISDHLDPGYLEQGEGLLRLTVQRQ 2092
            ....::..|.|..|..|.::..:.......:..|:.:|:..:                       
  Rat  1418 TEAKNKAHEAERIASGVQKNATSTKADAERTFSEVTDLDNEV----------------------- 1459

  Fly  2093 IMLNGHLNQLDGYRILLNTTLGVKTEQQREVRKHWLPKAEKHASHLLARSNEYARKFQPTRNGAR 2157
               ||.|.||:                          :||          ||..||.........
  Rat  1460 ---NGMLRQLE--------------------------EAE----------NELKRKQDDADQDMM 1485

  Fly  2158 IAMLASSAHSNITEAINDARLASILAKERVYEAQRTLYPSDGSSMIERAKHSLHRSKQLQQEALK 2222
            :|.:||       :|..:|.|.:..||..|            ||::.:....|   :||.|....
  Rat  1486 MAGMAS-------QAAQEAELNARKAKNSV------------SSLLSQLTDLL---EQLGQLDTV 1528

  Fly  2223 QMHKSNVLKDKLHRQEQQVEGIKSTIYDSGLRTNNISGQLQGLSDGSARRQAKDSLEMADRTGEQ 2287
            .::|.|.::..|::.:.:::     :.|...:.:|:        :..||:|....|:. ||...:
  Rat  1529 DLNKLNEIEGSLNKAKDEMK-----VSDLDRKVSNL--------ENEARKQEAAILDY-DRDIAE 1579

  Fly  2288 MRAELQKAKDMQKSI 2302
            :..::...:|::|::
  Rat  1580 IIKDIHNLEDIKKTL 1594

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 153..398 CDD:459653 72/263 (27%)
EGF_Lam 401..450 CDD:238012 20/53 (38%)
EGF_Lam 505..552 CDD:238012 16/49 (33%)
Laminin_EGF 550..597 CDD:395007 20/46 (43%)
Laminin_B 660..813 CDD:459652 37/159 (23%)
EGF_Lam 851..900 CDD:238012 25/48 (52%)
Laminin_EGF <943..971 CDD:395007 14/30 (47%)
Laminin_EGF 974..1018 CDD:395007 21/50 (42%)
EGF_Lam 1017..1065 CDD:238012 2/47 (4%)
Laminin_EGF 1065..>1105 CDD:395007 5/39 (13%)
EGF_Lam 1150..1197 CDD:238012 19/46 (41%)
Laminin_EGF 1199..1247 CDD:395007 20/47 (43%)
EGF_Lam 1247..1292 CDD:238012 1/44 (2%)
Laminin_EGF 1294..1342 CDD:395007 22/50 (44%)
Laminin_EGF 1340..1392 CDD:395007 2/51 (4%)
Laminin_B 1486..1626 CDD:459652 21/142 (15%)
EGF_Lam 1669..1716 CDD:238012 5/46 (11%)
Laminin_EGF 1718..1767 CDD:395007 4/48 (8%)
EGF_Lam 1772..1819 CDD:238012 7/48 (15%)
YhaN <1907..2141 CDD:443752 33/233 (14%)
SMC_prok_B <2123..>2390 CDD:274008 34/180 (19%)
Laminin_II 2279..2400 CDD:368703 4/24 (17%)
LamG 2399..>2492 CDD:473984
LamG 2586..2753 CDD:238058
Laminin_G_2 2804..2944 CDD:460494
LamG 3018..3167 CDD:238058
LamG 3192..3347 CDD:238058
Lamc1NP_446418.1 LamNT 42..282 CDD:214532 72/263 (27%)
EGF_Lam 283..328 CDD:238012 21/45 (47%)
Laminin_EGF 340..394 CDD:395007 19/56 (34%)
Laminin_EGF 396..443 CDD:395007 14/46 (30%)
Laminin_EGF 443..490 CDD:395007 20/46 (43%)
LamB 552..676 CDD:214597 36/153 (24%)
Laminin_EGF 722..761 CDD:395007 22/39 (56%)
EGF_Lam 770..818 CDD:238012 21/67 (31%)
Laminin_EGF 826..873 CDD:395007 21/88 (24%)
Laminin_EGF 882..930 CDD:395007 23/130 (18%)
EGF_Lam 933..978 CDD:214543 20/91 (22%)
EGF_Lam 980..1027 CDD:238012 21/47 (45%)
SMC_prok_B <1034..1596 CDD:274008 135/892 (15%)
Blue background indicates that the domain is not in the aligned region.

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