DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wb and Agrn

DIOPT Version :9

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:XP_006538554.1 Gene:Agrn / 11603 MGIID:87961 Length:2057 Species:Mus musculus


Alignment Length:2205 Identity:434/2205 - (19%)
Similarity:651/2205 - (29%) Gaps:892/2205 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   459 ESCTYD---------PFLDKGICQSCSNNTAGIECEFCEMGFYRELDAPLTDP----CLPCSCN- 509
            |.|..|         |.:...:|:       |:.|     ||....:..:.||    |: |..| 
Mouse   152 EFCVEDKPGIHFTAAPSMPPDVCR-------GMLC-----GFGAVCEPSVEDPGRASCV-CKKNV 203

  Fly   510 -PARSTGGCQSDGGSCNCLEGFQGKNCEECAPGYYGDDC--KRCECDE--------RGSLGSTGS 563
             ||.....|.||..:                   |.::|  :|.:|::        :|..||...
Mouse   204 CPAMVAPVCGSDAST-------------------YSNECELQRAQCNQQRRIRLLRQGPCGSRDP 249

  Fly   564 CSGVCQCKLNVEGSTCSECAPGYFDLSAENAEGCT-SCWCSGVSQTCHSAKLQTLAFETLNDWKI 627
            |:.| .|..   ||||           ..:|:|.| ||.|   ..||..|...|:......|:  
Mouse   250 CANV-TCSF---GSTC-----------VPSADGQTASCLC---PTTCFGAPDGTVCGSDGVDY-- 294

  Fly   628 TDIQRVKPISIPVDAETNRLIFANELDEVEAIY---------WQASLGYLGNRLTSYGSRLQLVL 683
                       |.:.:..|...||:    |.|:         .|.|:..| |.:.....|     
Mouse   295 -----------PSECQLLRHACANQ----EHIFKKFDGPCDPCQGSMSDL-NHICRVNPR----- 338

  Fly   684 SWDVIRGDRSGKPTTGPNVILVGKN----GLKIAFGDESLDGLGINLNVTLTEVGWYHVPPTVVD 744
                         |..|.::|..:|    ...|. ||   ||:....:..::.:|   ....::.
Mouse   339 -------------TRHPEMLLRPENCPAQHTPIC-GD---DGVTYENDCVMSRIG---AARGLLL 383

  Fly   745 IKTRLRRTEGGDYHGESVTRSQFLSVLV--------SLDAVLIRAAFHTDQGETSLERAVIYSGG 801
            .|.|..:.:..|...|:   .||.||.:        |.|.|....|:          |.|....|
Mouse   384 QKVRSGQCQTRDQCPET---CQFNSVCLSRRGRPHCSCDRVTCDGAY----------RPVCAQDG 435

  Fly   802 VELGGKSSSQVEQC----------LCPAGYTGLSCEG--CAFGFKRIYENTSDHQILSKCIPCPC 854
            .........|..:|          ..|...|...|.|  ||||.....:|       .|.: |.|
Mouse   436 HTYDNDCWRQQAECRQQQTIPPKHQGPCDQTPSPCRGAQCAFGATCTVKN-------GKAV-CEC 492

  Fly   855 N----------------GHSNSCDLQSGNC-----------GDCMHNTFGDRCERCQLGYYGNPL 892
            .                .:.:.|:|:|..|           |.|      |||.:|:.|......
Mouse   493 QRVCSGGYDPVCGSDGVTYGSVCELESMACTLGREIRVARRGPC------DRCGQCRFGSLCEVE 551

  Fly   893 QGTPNDCKRCACPLSEDSNNFSPSCQLKSYNYMDLNPQFELIEHAEYICTQCPEGY--TGDHCQV 955
            .|      ||.|| ||...:..|.|....:.|..   :.||..||   ||.....|  :..|||.
Mouse   552 TG------RCVCP-SECVESAQPVCGSDGHTYAS---ECELHVHA---CTHQISLYVASAGHCQT 603

  Fly   956 CDDGY--FGNPRQPGSS-CQRCD-------CAG------GPCNVTTGECITCRGNTEGWHCERCK 1004
            |.:..  ||.....|.. |.||:       |..      ..|.:....|      .:....|..:
Mouse   604 CGETVCTFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYLSACELREAAC------QQQVQIEEAR 662

  Fly  1005 LGYWGDPAVGCDPCHCHTEGSESG--------LC---------DSTDGQCLCKPRYAGQKCDECD 1052
            .|       .|:|..|.:.||.||        ||         ||.||.|:            ||
Mouse   663 AG-------PCEPAECGSGGSGSGEDNACEQELCRQHGGVWDEDSEDGPCV------------CD 708

  Fly  1053 VGYANVELRCPSCNCDPLGSLVQDRCDPHTGQCHCKEGVMGAKCHECQDGYFGMNAVAYRMDDLA 1117
            ....:| |:.|.|..|.:         .::.:||.|:    |:|...|:.|..... |.|...||
Mouse   709 FSCQSV-LKSPVCGSDGV---------TYSTECHLKK----ARCEARQELYVAAQG-ACRGPTLA 758

  Fly  1118 ALRQNSDSDDDEWELVPDTEDPNSESTVAC-----------------EECHCSSVGSLSSDCDKR 1165
                         .|:|......:::...|                 ..|||:..||.|..||..
Mouse   759 -------------PLLPMASPHCAQTPYGCCQDNVTAAQGVGLAGCPSTCHCNPHGSYSGTCDPV 810

  Fly  1166 TGQCACLANVTGRRCDKCRPGHWN----LTAG-EGCRDCRCDPHGSRGHECNPWTGQCDCKIGVG 1225
            ||||:|...|.|.|||:|.||.||    :|.| .||..|.|||.|:...:|...||.|.|:.||.
Mouse   811 TGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGHSGCTPCSCDPRGAVRDDCEQMTGLCSCRPGVA 875

  Fly  1226 GQHCNECTEGFFGFSTEGCQRCSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPGTWGWQARLG 1290
            |..|.:|.:|               ::.|.                 ||| :..|.|     .:.
Mouse   876 GPKCGQCPDG---------------QALGH-----------------LGC-EADPTT-----PVT 902

  Fly  1291 CRECECDHIGSIGQQC--STGDGQCQCREGYSGRKCDTCAIGYFGYPECRRCGCDAEGSFTQADG 1353
            |.|..|:    .|..|  ..|..||.|       ...||       ||              |:.
Mouse   903 CVEMHCE----FGASCVEEAGFAQCVC-------PTLTC-------PE--------------ANS 935

  Fly  1354 SIACDSNG-----QCPCKSLVVGLKCDTCMQSTFGLSAQNPEGCTRCFCFGRSGECEQS---DLS 1410
            :..|.|:|     :|..|::....:.|..:||.                    |.|.:|   .:|
Mouse   936 TKVCGSDGVTYGNECQLKTIACRQRLDISIQSL--------------------GPCRESVAPGVS 980

  Fly  1411 WGHIRMAESRN-LSVQQIRPHS----------------VPSSDYEYI------------------ 1440
            .....|...|: ||.....|||                :|:|....:                  
Mouse   981 PTSASMTTPRHILSRTLASPHSSLPLSPSTTAHDWPTPLPTSPQTVVGTPRSTAATPSDVASLAT 1045

  Fly  1441 VVVQMEGSSFHREDAEIQRMNDLS------LVPKSTGNVSIGAYGQFYHPLYFQLPPQFYGDRTS 1499
            .:.:..||:....|.|:....:.|      |.| ..|:|.: .:|          ||.   :|.|
Mouse  1046 AIFRESGSTNGSGDEELSGDEEASGGGSGGLEP-PVGSVVV-THG----------PPI---ERAS 1095

  Fly  1500 SYGGFLYF-------TLITEGAHKPLERNILGQYPLVQLHAHSKLLLDFYEYEEFEYSLNVTHRV 1557
            .|...|..       :|.:||::.|..:...|           .|.|:..|.:|..|:..:..  
Mouse  1096 CYNSPLGCCSDGKTPSLDSEGSNCPATKAFQG-----------VLELEGVEGQELFYTPEMAD-- 1147

  Fly  1558 PLHESFWKYHHTSQAVD-------RNT------------------LMAALQNIRHIFIRAFAFAD 1597
            |..|.|.:   |:::::       ||:                  |:.|:.::......||...|
Mouse  1148 PKSELFGE---TARSIESTLDDLFRNSDVKKDFWSIRLRELGPGKLVRAIVDVHFDPTTAFQAPD 1209

  Fly  1598 FQEVVLQNVHMDA--AIYIK------------------------GSTNLIAKG----VERCKC-- 1630
            ..:.:||.:.:..  |:.::                        |:|..:|..    |.|...  
Mouse  1210 VGQALLQQIQVSRPWALAVRRPLREHVRFLDFDWFPTFFTGAATGTTAAVATARATTVSRLSASS 1274

  Fly  1631 --PKRFDGLSCQDPGRS---FYRWRNTTIVESVFIEDLIG--------RAAPCHCNGRSSDCDRE 1682
              |:.:...:.:..||:   ....|..|...|:......|        .:.||...|...|.|..
Mouse  1275 VTPRVYPSYTSRPVGRTTAPLTTRRPPTTTASIDRPRTPGPQRPPKSCDSQPCLHGGTCQDLDSG 1339

  Fly  1683 TGVCQNCRGNTGGDHCHQC-----------------------------------AEG-------- 1704
            .|...:|.....|..|.:.                                   .||        
Mouse  1340 KGFSCSCTAGRAGTVCEKVQLPSVPAFKGHSFLAFPTLRAYHTLRLALEFRALETEGLLLYNGNA 1404

  Fly  1705 ----------------FYGDPNSPHGCQACPCP---------ETNRNFARGCNVWDGEV------ 1738
                            |..|..|.........|         |.:|::.:|....|||.      
Mouse  1405 RGKDFLALALLDGHVQFRFDTGSGPAVLTSLVPVEPGRWHRLELSRHWRQGTLSVDGEAPVVGES 1469

  Fly  1739 -------------------------------------SCV------------------------- 1741
                                                 .|:                         
Mouse  1470 PSGTDGLNLDTKLYVGGLPEEQVATVLDRTSVGIGLKGCIRMLDINNQQLELSDWQRAVVQSSGV 1534

  Fly  1742 -------CKPG--YTGRLCE---------RCQAGYFGDPMRYPNTTCQPCNCH---PDGIQTEGC 1785
                   |.|.  :.|.||:         :|..|.||.........|||..||   |..:.:.| 
Mouse  1535 GECGDHPCSPNPCHGGALCQALEAGVFLCQCPPGRFGPTCADEKNPCQPNPCHGSAPCHVLSRG- 1598

  Fly  1786 DVETGRCYCREGVTGLKCD---KCQAERHHLVD-NGCKICDNCTLLLLDYMELVGNKLRRGMHNM 1846
               ..:|.|..|.:|..|:   :....|..|.| ||           ..|:||      :|:|..
Mouse  1599 ---GAKCACPLGRSGSFCETVLENAGSRPFLADFNG-----------FSYLEL------KGLHTF 1643

  Fly  1847 DLTGIPAPYRKLSEYESAYEK------------WNGRHWDFSQTKRRLQDYDSADILKLEAHAEN 1899
            :        |.|.| :.|.|.            :||:..|           ...|.:.|..|..:
Mouse  1644 E--------RDLGE-KMALEMVFLARGPSGLLLYNGQKTD-----------GKGDFVSLALHNRH 1688

  Fly  1900 LKFQ--SRKAVATIGKRE----------FAIKSMREDAVTQQHSVGLL-----RSEILQTLSDLH 1947
            |:|:  ..|..|.|..:|          |..::.|:.|:.......:|     ..::..|:.:| 
Mouse  1689 LEFRYDLGKGAAIIRSKEPIALGTWVRVFLERNGRKGALQVGDGPRVLGESPKSRKVPHTMLNL- 1752

  Fly  1948 GYGKSAHYL-SLPTALKQAR-----------FYLQAIREHDQMVQG--IRST------------- 1985
               |...|: ..|...|.||           ..|.::|.|..:.|.  :|:.             
Mouse  1753 ---KEPLYVGGAPDFSKLARGAAVASGFDGAIQLVSLRGHQLLTQEHVLRAVDVAPFAGHPCTQA 1814

  Fly  1986 --NDCAWKHFYAMGNAS----DASFD------------ESGRLEMLWRDLNQTNHRVVDMRLQVD 2032
              |.|       :...|    :|:::            |.|.:|....||...   ..|.|..::
Mouse  1815 VDNPC-------LNGGSCIPREATYECLCPGGFSGLHCEKGIVEKSVGDLETL---AFDGRTYIE 1869

  Fly  2033 RVQEV-ENEAEDVLEHVRNLSIRVGESHQELDELNQRISDHLDPGY-LEQGEGLL--------RL 2087
            .:..| |:|..:.:.....|..|...|.:.|.      |:|.:... .|..:||:        |.
Mouse  1870 YLNAVTESELTNEIPAPETLDSRALFSEKALQ------SNHFELSLRTEATQGLVLWIGKVGERA 1928

  Fly  2088 TVQRQIMLNGHLN---QLDGYRILLNTTLGVKTEQQREVRKHWLPKAEKHASHLLARSNE 2144
            ......:::|||.   .|....::|.:|:.|.|.:...||.|     .:|....|...||
Mouse  1929 DYMALAIVDGHLQLSYDLGSQPVVLRSTVKVNTNRWLRVRAH-----REHREGSLQVGNE 1983

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 164..396 CDD:278484
EGF_Lam 401..450 CDD:238012
TNFRSF <407..507 CDD:304602 12/60 (20%)
EGF_Lam 505..552 CDD:238012 10/50 (20%)
Laminin_EGF 550..597 CDD:278482 12/54 (22%)
Laminin_B 660..798 CDD:278481 29/158 (18%)
EGF_Lam 851..900 CDD:238012 14/75 (19%)
Laminin_EGF <943..971 CDD:278482 8/32 (25%)
VSP 953..1414 CDD:146106 124/525 (24%)
Laminin_EGF 974..1018 CDD:278482 7/56 (13%)
EGF_Lam 1017..1065 CDD:238012 18/64 (28%)
Laminin_EGF 1065..>1105 CDD:278482 9/39 (23%)
EGF_Lam 1150..1197 CDD:238012 26/51 (51%)
Laminin_EGF 1199..1247 CDD:278482 16/47 (34%)
EGF_Lam 1247..1292 CDD:238012 6/44 (14%)
Laminin_EGF 1294..1342 CDD:278482 11/49 (22%)
Laminin_EGF 1340..1392 CDD:278482 9/56 (16%)
Laminin_B 1486..1611 CDD:278481 29/158 (18%)
EGF_Lam 1669..1716 CDD:238012 14/105 (13%)
Laminin_EGF 1718..1767 CDD:278482 17/143 (12%)
EGF_Lam 1772..1819 CDD:238012 15/53 (28%)
CrfC <1933..2267 CDD:223771 53/275 (19%)
Laminin_II 2277..2400 CDD:283628
LamG 2399..>2492 CDD:304605
Laminin_G_2 2616..2755 CDD:280389
Laminin_G_2 2804..2944 CDD:280389
Laminin_G_2 3038..3169 CDD:280389
LamG 3192..3347 CDD:238058
AgrnXP_006538554.1 NtA 46..148 CDD:367356
KAZAL 198..244 CDD:197624 12/65 (18%)
KAZAL 274..319 CDD:197624 12/64 (19%)
Kazal_1 351..391 CDD:333798 8/46 (17%)
KAZAL_FS 423..463 CDD:238052 6/49 (12%)
KAZAL 491..536 CDD:197624 6/44 (14%)
KAZAL 556..601 CDD:197624 14/51 (27%)
KAZAL 621..666 CDD:197624 8/57 (14%)
KAZAL 706..752 CDD:197624 14/72 (19%)
EGF_Lam 795..835 CDD:238012 22/39 (56%)
Laminin_EGF 849..>885 CDD:365839 15/35 (43%)
KAZAL 924..971 CDD:197624 15/94 (16%)
SEA 1121..1245 CDD:214554 20/139 (14%)
EGF 1322..1352 CDD:333761 7/29 (24%)
Laminin_G_1 1389..1520 CDD:333802 13/130 (10%)
Laminin_G_1 1657..1792 CDD:333802 27/149 (18%)
EGF_CA 1814..1846 CDD:238011 4/38 (11%)
Laminin_G_1 1910..2040 CDD:333802 19/79 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.