DRSC/TRiP Functional Genomics Resources

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Protein Alignment wb and LAMC3

DIOPT Version :10

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:XP_011516423.1 Gene:LAMC3 / 10319 HGNCID:6494 Length:1581 Species:Homo sapiens


Alignment Length:1412 Identity:407/1412 - (28%)
Similarity:567/1412 - (40%) Gaps:408/1412 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   127 SGGGAGG---GALRLLKTEDVYSSSFSGGLYPPLFNVVPRAQISVNATCGQNGAEEYCKQVGAKP 188
            :|.|.|.   ||.|..:...|:.::..|.|          ||.|  .||| :..|::|..|||..
Human    18 AGAGMGACYDGAGRPQRCLPVFENAAFGRL----------AQAS--HTCG-SPPEDFCPHVGAAG 69

  Fly   189 CGI----CNAHSSDRAKQRSIQSLISSGSGSGSGSGFEEGWWQSPTLQGGRQF-EYVTILLDLKQ 248
            .|.    |:|....|....|..:...|..        |..|||||::..|.|: ..|.|.|.|.:
Human    70 AGAHCQRCDAADPQRHHNASYLTDFHSQD--------ESTWWQSPSMAFGVQYPTSVNITLRLGK 126

  Fly   249 TFQIFSVWLKSANSPRPASWILEK--SLDGINFEPWQYFGLSDADCQRRWNLSGQNGKYVFQNDT 311
            .::|..|.||...| ||.|:.:.|  ..||    ||:.:....|.||:.:  ....|:|:...:.
Human   127 AYEITYVRLKFHTS-RPESFAIYKRSRADG----PWEPYQFYSASCQKTY--GRPEGQYLRPGED 184

  Fly   312 EII--CSTQFSKPGPLENGVLHASLLKNRPGA--TDQSPELMKFITTRYIRIRLQGMHSTANQDN 372
            |.:  |:::||...||..|.:..|.|:.||.|  .::||.|.:::|:..:.|.|..:::..    
Human   185 ERVAFCTSEFSDISPLSGGNVAFSTLEGRPSAYNFEESPGLQEWVTSTELLISLDRLNTFG---- 245

  Fly   373 SLDWLLDSPSLEKHSFYSLSQLKVSARLDCNGHANRSHESPD-DPLMQCICQHNTCGAQCEQCCP 436
              |.:...|.:.:..:|::|...|..|..|||||  |...|| ...:.|.|||||.|..||:|.|
Human   246 --DDIFKDPKVLQSYYYAVSDFSVGGRCKCNGHA--SECGPDVAGQLACRCQHNTTGTDCERCLP 306

  Fly   437 LFQDRPYQMG-----GECEICQCYGHAESCTYDPFLDK-----GICQSCSNNTAGIECEFCEMGF 491
            .|||||:..|     .||..|.|.|.:|.||:|..|.:     |.|..|.::|||..||.|:..|
Human   307 FFQDRPWARGTAEAAHECLPCNCSGRSEECTFDRELFRSTGHGGRCHHCRDHTAGPHCERCQENF 371

  Fly   492 YRELDAPLTDPCLPCSCNPARSTGGCQSDGGSCNCLEGFQGKNCEECAPGYYG---DDCKRCECD 553
            | ..|..:  ||.||.|..|.|......|.|:|.|.....|..|:.|.||::.   ..|:.|.|:
Human   372 Y-HWDPRM--PCQPCDCQSAGSLHLQCDDTGTCACKPTVTGWKCDRCLPGFHSLSEGGCRPCTCN 433

  Fly   554 ERGSLGSTGSCSGVCQCKLNVEGSTCSECAPGYFDLSAENAEGCTSCWCSGVSQTCHSAKLQTLA 618
            ..|||.:....||.|.||.||||:.|..|.||.|:|...|..||:||:|.|.|:.|.|    |..
Human   434 PAGSLDTCDPRSGRCPCKENVEGNLCDRCRPGTFNLQPHNPAGCSSCFCYGHSKVCAS----TAQ 494

  Fly   619 FET---LND--------WKITDIQRVKPISIPVDAETNRLIFANELDEVEAIYWQASLGYLGNRL 672
            |:.   |:|        |    .:.|.....|.....|.::.:.| ||.|.   .|...:||::.
Human   495 FQVHHILSDFHQGAEGWW----ARSVGGSEHPPQWSPNGVLLSPE-DEEEL---TAPEKFLGDQR 551

  Fly   673 TSYGSRLQLVLSWDVIRGDRSGKPTTGPNVILVGKNGLKIAFGDESLDG---LGINLNVTLTEVG 734
            .|||.  .|:|::.|..||   .|.  |..:.:...||.::....||.|   .|....|.|.   
Human   552 FSYGQ--PLILTFRVPPGD---SPL--PVQLRLEGTGLALSLRHSSLSGPQDAGHPREVELR--- 606

  Fly   735 WYHVPPTVVDIKTRLRRTEGGDYHGESVTRSQFLSVLVSLDAVLIRAA---------FHTDQGET 790
             :|:..|..|:...|     ..:|        |..:|.:|.::.:|.:         |.|:...|
Human   607 -FHLQETSEDVAPPL-----PPFH--------FQRLLANLTSLRLRVSPGPSPAGPVFLTEVRLT 657

  Fly   791 SLERAVIYSGGVELGGKSSSQVEQCLCPAGYTGLSCEGCAFGFKRIYENTSDHQILSKCIPCPCN 855
            |....:         ...:|.||.|.||.||||..||.||.|:||.......:   :.|:||.||
Human   658 SARPGL---------SPPASWVEICSCPTGYTGQFCESCAPGYKREMPQGGPY---ASCVPCTCN 710

  Fly   856 GHSNSCDLQSGNCGDCMHNTFGDRCERCQLGYYGNPLQGTPNDCKRCACPLSEDSNNFSPSCQLK 920
            .| .:||..:|.| .|.|:|.|..||||..|:||||..|..:||:.|.||       ...:|.  
Human   711 QH-GTCDPNTGIC-VCSHHTEGPSCERCLPGFYGNPFAGQADDCQPCPCP-------GQSACT-- 764

  Fly   921 SYNYMDLNPQFELIEHAEYICTQCPEGYTGDHCQVCDDGYFGNP------RQPGSSCQRCDCAG- 978
                       .:.|..|.:||.||.|..|..|:|||||:||:|      .||   |.:|.|:| 
Human   765 -----------TIPESREVVCTHCPPGQRGRRCEVCDDGFFGDPLGLFGHPQP---CHQCQCSGN 815

  Fly   979 ------GPCNVTTGECITCRGNTEGWHCERCKLGYWGD-----PAVGCDPCHCHTEGSESGLCDS 1032
                  |.|:..:|.|:.|..||.|.|||.|:.|::|.     ||..|.||.||.:||.|     
Human   816 VDPNAVGNCDPLSGHCLRCLHNTTGDHCEHCQEGFYGSALAPRPADKCMPCSCHPQGSVS----- 875

  Fly  1033 TDGQCLCKPRYAGQKCDECDVGYANVELRCPSCNCDPLGSLVQDRCDPHTGQCHCKEGVMGAKCH 1097
                                                                             
Human   876 ----------------------------------------------------------------- 875

  Fly  1098 ECQDGYFGMNAVAYRMDDLAALRQNSDSDDDEWELVPDTEDPNSESTVACEECHCSSVGSLSSDC 1162
                                             |.:|                           |
Human   876 ---------------------------------EQMP---------------------------C 880

  Fly  1163 DKRTGQCACLANVTGRRCDKCRPGHWNLTAGEGCRDCRCDPHGSRGHECNPWTGQCDCKIGVGGQ 1227
            |..||||:||.:||.|.|.:|.||.::|..|.|||.|:|.|.||:..:|:|.||||.|:.||.||
Human   881 DPVTGQCSCLPHVTARDCSRCYPGFFDLQPGRGCRSCKCHPLGSQEDQCHPKTGQCTCRPGVTGQ 945

  Fly  1228 HCNECTEGFFGFSTEGCQRCSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPGTWGWQARLGCR 1292
            .|:.|..||||||.:                                               |||
Human   946 ACDRCQLGFFGFSIK-----------------------------------------------GCR 963

  Fly  1293 ECECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGYFGYPECRRCGCDAEGSFTQADGSIAC 1357
            .|.|..:|:...||.. :|.|.||.|:.|.|||.|...:|         ..|:|:..|       
Human   964 ACRCSPLGAASAQCHE-NGTCVCRPGFEGYKCDRCHDNFF---------LTADGTHCQ------- 1011

  Fly  1358 DSNGQCP-CKSLV----VGLKCDTCMQSTF--GLSAQNPEGCTRCFCFGRSGECEQSDLSWGHIR 1415
                ||| |.:||    ..||....:...:  |....:|.|......    ||..:.|:..||..
Human  1012 ----QCPSCYALVKEEAAKLKARLTLTEGWLQGSDCGSPWGPLDILL----GEAPRGDVYQGHHL 1068

  Fly  1416 MAESRNLSVQQIRPHSVPSSDYEYIVVVQMEGS-SFHREDAEIQRMN 1461
            :..:|...::|               ::.:||: ...||  ::||:|
Human  1069 LPGAREAFLEQ---------------MMSLEGAVKAARE--QLQRLN 1098

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 153..398 CDD:459653 71/255 (28%)
EGF_Lam 401..450 CDD:238012 26/54 (48%)
EGF_Lam 505..552 CDD:238012 16/49 (33%)
Laminin_EGF 550..597 CDD:395007 21/46 (46%)
Laminin_B 660..813 CDD:459652 35/164 (21%)
EGF_Lam 851..900 CDD:238012 24/48 (50%)
Laminin_EGF <943..971 CDD:395007 15/33 (45%)
Laminin_EGF 974..1018 CDD:395007 20/55 (36%)
EGF_Lam 1017..1065 CDD:238012 7/47 (15%)
Laminin_EGF 1065..>1105 CDD:395007 0/39 (0%)
EGF_Lam 1150..1197 CDD:238012 18/46 (39%)
Laminin_EGF 1199..1247 CDD:395007 24/47 (51%)
EGF_Lam 1247..1292 CDD:238012 1/44 (2%)
Laminin_EGF 1294..1342 CDD:395007 16/47 (34%)
Laminin_EGF 1340..1392 CDD:395007 13/58 (22%)
Laminin_B 1486..1626 CDD:459652
EGF_Lam 1669..1716 CDD:238012
Laminin_EGF 1718..1767 CDD:395007
EGF_Lam 1772..1819 CDD:238012
YhaN <1907..2141 CDD:443752
SMC_prok_B <2123..>2390 CDD:274008
Laminin_II 2279..2400 CDD:368703
LamG 2399..>2492 CDD:473984
LamG 2586..2753 CDD:238058
Laminin_G_2 2804..2944 CDD:460494
LamG 3018..3167 CDD:238058
LamG 3192..3347 CDD:238058
LAMC3XP_011516423.1 Laminin_N 35..269 CDD:459653 73/267 (27%)
EGF_Lam 270..317 CDD:238012 25/48 (52%)
Laminin_EGF 327..383 CDD:395007 22/58 (38%)
EGF_Lam 382..428 CDD:238012 14/45 (31%)
Laminin_EGF 430..477 CDD:395007 21/46 (46%)
Laminin_B 540..671 CDD:459652 35/166 (21%)
EGF_Lam 706..753 CDD:238012 24/48 (50%)
EGF_Lam 754..802 CDD:238012 21/67 (31%)
Laminin_EGF 810..857 CDD:395007 17/46 (37%)
EGF_Lam 865..915 CDD:238012 27/179 (15%)
EGF_Lam 917..962 CDD:214543 24/91 (26%)
EGF_Lam 964..1011 CDD:238012 18/56 (32%)
Smc <1071..>1499 CDD:440809 9/45 (20%)
Blue background indicates that the domain is not in the aligned region.

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