DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wb and lamb1

DIOPT Version :10

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:XP_002933140.2 Gene:lamb1 / 100495516 XenbaseID:XB-GENE-1011014 Length:1782 Species:Xenopus tropicalis


Alignment Length:2280 Identity:518/2280 - (22%)
Similarity:800/2280 - (35%) Gaps:760/2280 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   146 SSSFS-----GGLYPPLFN-VVPRA-QISVNATCGQNGAEEYC---KQVGAKPCGICNA----HS 196
            |..||     |..||...: ::.|: |::.::|||....|.:|   .....|.|.||::    :.
 Frog    22 SPDFSHGCAEGSCYPATGDLLIGRSDQLTASSTCGIQKPESFCIVSHLQEEKKCFICDSLDPYNE 86

  Fly   197 SDRAKQRSIQSLISSGSGSGSGSGFEEGWWQSPTLQGGRQFEYVTILLDLKQTFQIFSVWLKSAN 261
            .:..:...|::::::.:.:....     ||||   :.|  .|.|||.|||:..|. |:..:.:..
 Frog    87 QNNTESHRIENVVTTFAPNRLNL-----WWQS---ENG--LENVTIQLDLEAEFH-FTHLIMTFK 140

  Fly   262 SPRPASWILEKSLD-GINFEPWQYFGLSDADCQRRW-NLSGQNGKYVFQNDTEIICSTQFSKPGP 324
            :.|||:.::|:|.| |..::.::||..   ||:..: .:|....|.|    .:|||.:::|...|
 Frog   141 TFRPAAMLIERSSDFGKTWKIYRYFAY---DCETSFPGISTGPMKKV----DDIICDSRYSDIEP 198

  Fly   325 LENG-----VLHASLLKNRPGATDQSPELMKFITTRYIRIRLQGMHSTANQDNSLDWLLDSPSLE 384
            ...|     ||..:...:.|    .|..:...:....:||:...:|:..  ||.||..::   ::
 Frog   199 STEGEVIYRVLDPAFRIDDP----YSLRIKSMLRITNLRIKFLKLHTLG--DNLLDSRVE---IK 254

  Fly   385 KHSFYSLSQLKVSARLDCNGHAN-----RSHESPDDPLM--QCICQHNTCGAQCEQCCPLFQDRP 442
            :..:|::..:.|.....|.|||:     :.:....:.::  :|:|:|||.|..||||...:.|.|
 Frog   255 EKYYYAIYDMVVRGNCFCYGHASECAPVKGYSDNVEGMVHGRCVCRHNTKGLNCEQCLDFYHDLP 319

  Fly   443 Y-----QMGGECEICQCYGHAESCTYDPFL-------DKGICQSCSNNTAGIECEFCEMGFYREL 495
            :     :....|:.|.|..|:..|.:|..:       ..|:|..|.:||.|..||.|:..||:..
 Frog   320 WRPAEGRSSNACKKCNCNEHSTHCHFDMAVYMSTGNTSGGVCDDCQHNTMGRNCEQCKPFFYQHP 384

  Fly   496 DAPLTDP--CLPCSCNPARSTGG--CQ--SD------GGSCNCLEGFQGKNCEECAPGYYG---- 544
            |..:.||  |.||:|:||.|..|  |.  ||      .|.|.|....:|:.|::|..|:|.    
 Frog   385 DKDIRDPNICQPCNCDPAGSQDGGICDRYSDFSVGLIAGQCRCKLNVEGERCDQCKEGFYDLNAE 449

  Fly   545 --DDCKRCECDERGSLGSTGSC---SGVCQCKLNVEGSTCSECAPGYFDLSAENAEGCTSCWCS- 603
              :.|:.|.|:..|::....||   :|.|.||..|.|..|.:|||.::.|| .:.:||..|.|. 
 Frog   450 DPEGCQFCGCNPLGTIPGGNSCDSRNGNCFCKRFVTGRKCDQCAPEFWGLS-NDLDGCRPCDCDH 513

  Fly   604 GVSQ--TCHSAKLQTLAFETLNDWKITDIQRVKPISIPVDAETNRLIFANELDEVEAIYWQASLG 666
            |.|:  .|.....|.               |.:|..|           ..:.:|||:.::..||.
 Frog   514 GGSEDNNCSPESGQC---------------RCRPHMI-----------GRQCNEVESGFYFISLD 552

  Fly   667 Y-------------------------------LGNRLTSYGSRL--------------------- 679
            :                               :|......|:.|                     
 Frog   553 HYTYEAEYANFGPDVRIVERPLPHDRTPSWTGIGFARVPEGAYLEFHINDIPTSMEYDLLIRYEP 617

  Fly   680 QLVLSWD--VIRGDRSGK-PTTGPNVILVGKNGLKIAFGDESLDGL-----------------GI 724
            ||...|:  ||...|.|| ||:       .:.|..:...|.....|                 |:
 Frog   618 QLPEQWEEAVITVIRPGKIPTS-------SRCGNTVPSDDNQSVALPPGSRYITLPRPICFEKGL 675

  Fly   725 NLNVTLTEVGWYHV------PPTVVDIKTRLRRTEGGDYHGESVTRSQFLSVLVSLDAVLIRAAF 783
            |..:.| |:..|.|      |.|::|....|...:..|          ..|:..|.|.|....|:
 Frog   676 NYTIRL-ELPRYSVNSNVENPYTLIDSIVLLPHVKSLD----------IFSMGGSGDDVTTNTAW 729

  Fly   784 HTDQGETSLERAVIYSGGVELGGKSSSQVEQCLCPAGYTGLSCEGCAFGFKRIYENTSDHQILSK 848
            .|.|....||             .|.|.|:..|...      |:...|....:...::       
 Frog   730 QTFQRYRCLE-------------NSQSVVKTPLTDV------CKNFLFTISALLHKSA------- 768

  Fly   849 CIPCPCNGH---SNSCDLQSGNCGDCMHNTFGDRCERCQLGYYGNPLQGTPNDCKRCACPLSEDS 910
             :.|.|:..   |:.||...|.| .|..|..|..|.:|..|.:|    ..||.||.|.|.:...|
 Frog   769 -LECQCDPQGSLSSVCDPNGGQC-QCRPNVIGRNCNKCAPGTFG----FGPNGCKPCECDVRGSS 827

  Fly   911 NNFSPSCQLKSYNYMDLNPQFELIEHAEYICTQCP--EGYTGDHCQVCDDGYFGNPRQPGSSCQR 973
            :   |.|                  |.|  ..|||  .|..|..|.||..||:|.|     ||::
 Frog   828 H---PFC------------------HTE--TGQCPCIHGAFGRQCDVCLPGYWGFP-----SCRQ 864

  Fly   974 CDCAG--GPCNVTTGECITCRGNTEGWHCERCKLGYWGDPAVG----CDPCHC-HTEGSE----S 1027
            |.|.|  ..||..||||..|:.::||:.||||..||:|||.:|    |.||.| ...|||    |
 Frog   865 CQCNGHAEDCNALTGECTNCKDHSEGYSCERCLSGYYGDPRLGSGDHCRPCPCPDGPGSERQFAS 929

  Fly  1028 GLC--DSTDGQ--CLCKPRYAGQKCDECDVGY-ANVEL---RCPSCNC----DPLGSLVQDRCDP 1080
            | |  |.|..|  |.|...|.|.:||.|..|| .|.|.   .|..|:|    |...||.   |..
 Frog   930 G-CYKDPTTLQVVCSCNMGYTGIRCDGCASGYFGNPEEIGGVCQPCHCNNNIDMSDSLA---CHK 990

  Fly  1081 HTGQC-HCKEGVMGAKCHECQDGYFGMNAVAYRMDDLAALRQNSDSDDDEWELVPDTEDPNSEST 1144
            .:|.| .|.....|..|.|||.||:|           .|::|:                      
 Frog   991 QSGLCLKCLYHTEGINCQECQLGYYG-----------NAIQQD---------------------- 1022

  Fly  1145 VACEECHCSSVGS--------LSSDCDKRTGQCACLANVTGRRCDKCRPGHWNLTAGEGCRDCRC 1201
              |..|.|:.:|:        :...|::..|||.||.||.|:.||:|....|||.:|.||..|.|
 Frog  1023 --CRRCVCNYLGTEQENCSGEIDCHCNRTNGQCPCLPNVIGQSCDRCAANTWNLASGTGCEPCAC 1085

  Fly  1202 DPHGSRGHECNPWTGQCDCKIGVGGQHCNECTEGFFGFSTEGCQRCSACRSEGQVCDPHNGRCIC 1266
            |.:.|.|..||.:||||.|..|.||:.|:||.|.|                              
 Frog  1086 DTNRSLGLSCNEFTGQCQCMPGFGGRDCSECQELF------------------------------ 1120

  Fly  1267 PKFTRGLGCGQCVPGTWGWQARLGCRECECDHIGSIGQQCSTGDGQCQCREGYSGRKCDTCAIGY 1331
                            || ...:.||.|:||..|....||:...|.|.|:||..|.:||.||.||
 Frog  1121 ----------------WG-NPDIECRACDCDSRGIQTSQCNRATGHCICKEGVEGVRCDKCARGY 1168

  Fly  1332 FG-YPECRRCGCDAEGSFTQADGSIACDSNGQCPCKSLVVGLKCDTCMQSTFGLSAQNPEGCTRC 1395
            .| :|.|                                                  .|  |.:|
 Frog  1169 SGAFPYC--------------------------------------------------TP--CHKC 1181

  Fly  1396 FCFGRSGECEQSDLSWGHIRMAESRNLSVQQIRPHSVPSSDYEYIVVVQMEGSSFHREDAEIQRM 1460
            |..            |         ::.:|::.                      :|....:.|.
 Frog  1182 FAL------------W---------DIIIQELS----------------------NRTKQLLNRA 1203

  Fly  1461 NDLSLVPKSTGNVSIGAYGQFYHPLYFQLPPQFYGDRTSSYGGFLYFTLITEGAHKPLE--RNIL 1523
            |||    |.:|  .||.|.|                             ..:...:.||  |:||
 Frog  1204 NDL----KISG--VIGPYQQ-----------------------------TVDKVQEKLEEIRSIL 1233

  Fly  1524 GQYPLVQ--------------LHAHSKLLLDFYEYEEFEYSLNVTHRVPL----HESFWKYHHTS 1570
            ...|..|              |.:.....:|..|.:..|..:|.|.::..    .|||.|  ...
 Frog  1234 AHNPAAQPLKNIENLFEEAEKLKSEVSQKVDEVEMKLAEIKINDTEKLDALQADAESFGK--ALK 1296

  Fly  1571 QAVDR------NTLMAALQNIRHIFIRAFAFADFQEVVLQNV-HMDAAIYIKGST-----NLIAK 1623
            :..|:      :.:..|:.:|...|..:.   :.:|:|..:| :.|:.|....:|     |||.:
 Frog  1297 ELGDQLEFMKISNVQGAMDSINKYFQMSL---EAEEMVNASVSNPDSIIEHSAATRQEVENLINE 1358

  Fly  1624 GVERCKCPKRFDGLSCQDPGRSFYRWRNTTIVESVFIEDLIGRAAPCHCNGRSSDCDRETGVCQN 1688
            .:.:.|..:.                     .::..:::|.|       ||:|.|.   :.:.:.
 Frog  1359 NLSQFKKEQE---------------------EQTRLLDELAG-------NGQSLDL---SSLSEK 1392

  Fly  1689 CRGNTGGDHCHQCAEGFYGDPNSPHGCQACPCPETNRNFARGCNVWDGEVSCVCKPGYTGRLCER 1753
            ..||:.|                 ..|:...|...|      |...||:..|    |..|     
 Frog  1393 TCGNSPG-----------------LLCEDSECGGLN------CKTDDGKRKC----GGPG----- 1425

  Fly  1754 CQAGYFGDPMRYPNTTCQPCNCHPDGIQTEGCDVETGRCYCREGVTGLKCDKCQAERHHLVDNGC 1818
            |     |..:...::..:..:.....||....:||             :..|..||         
 Frog  1426 C-----GGLVTVAHSAWKTASSFDTEIQNALAEVE-------------ELSKMVAE--------- 1463

  Fly  1819 KICDNCTLLLLDYMELVGNKLRRGMHNMDLTGIPAPYRKLSEYESAYEKWNGRHWDFSQTKRRLQ 1883
                              :|||..........:      |::..:..||.|..:.|.....::::
 Frog  1464 ------------------SKLRAEEAKQSAQDV------LTKANATKEKVNQSNEDLRNLIKQIR 1504

  Fly  1884 DY---DSADILKLEAHAENLKFQSRKAVATIGKREFAIKSMREDAVTQQHSVGLLRSEILQTLSD 1945
            ::   |.||:..:||.|..:                    ::.|..|....:..|..||.:.:..
 Frog  1505 EFLMQDGADLDSIEAVASEV--------------------LKMDMPTTPEQLQKLTEEIRERVES 1549

  Fly  1946 LHGYGKSAHYLSLPTALKQ-------ARFYLQAIREHDQMVQGIRSTNDCAWKHFYAMGNASDAS 2003
            |.|         :.|.|||       |...|...:|..:....|::|.|...:.....|.|..|:
 Frog  1550 LSG---------VDTILKQSAGDIARAEALLDEAKESSKSAADIKATVDAVKEALMEAGKAQSAA 1605

  Fly  2004 FDESGRLEMLWRDLNQTNHRVVDMRLQVDRVQEVENEAEDVLEHVRNLSIRVGESHQELDEL--- 2065
            .....|.:   .|:..||          |.:..:|:||....|.:.|.:.|:.:....:|:|   
 Frog  1606 EKAIKRAD---DDIKGTN----------DLLTSIESEAAVSEETLNNATKRLVQLENNIDDLMKK 1657

  Fly  2066 ---NQRISDHLDPGYLEQGEGLLRLTVQRQIMLNGHLNQLDG-----YRILLNTTLGVKTEQQRE 2122
               |.:.::.::....|.           :...||....|||     |: .:...:..|.|...|
 Frog  1658 SAANSQTANQVEKSVHEV-----------KANANGAKKVLDGELTNKYK-TVEDLIAKKAEDSEE 1710

  Fly  2123 VRKHWLPKAEKHASHLLARSN---EYARKFQPTRNG-ARIAMLASSAHSNITEAINDARLASILA 2183
            .|:. ..:.:|.|..||.::|   :..:..:.|..| .||....:.....:.|.:. |.|.:|..
 Frog  1711 ARRK-AQELQKEAKGLLEQANKKLDTIKDLEKTYEGNERILEEKAKQLVQLEETVR-ALLQAISQ 1773

  Fly  2184 KERVY 2188
            |..||
 Frog  1774 KAAVY 1778

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 153..398 CDD:459653 61/260 (23%)
EGF_Lam 401..450 CDD:238012 16/60 (27%)
EGF_Lam 505..552 CDD:238012 20/62 (32%)
Laminin_EGF 550..597 CDD:395007 17/49 (35%)
Laminin_B 660..813 CDD:459652 40/230 (17%)
EGF_Lam 851..900 CDD:238012 16/51 (31%)
Laminin_EGF <943..971 CDD:395007 12/29 (41%)
Laminin_EGF 974..1018 CDD:395007 23/49 (47%)
EGF_Lam 1017..1065 CDD:238012 24/60 (40%)
Laminin_EGF 1065..>1105 CDD:395007 16/44 (36%)
EGF_Lam 1150..1197 CDD:238012 20/54 (37%)
Laminin_EGF 1199..1247 CDD:395007 20/47 (43%)
EGF_Lam 1247..1292 CDD:238012 2/44 (5%)
Laminin_EGF 1294..1342 CDD:395007 21/48 (44%)
Laminin_EGF 1340..1392 CDD:395007 1/51 (2%)
Laminin_B 1486..1626 CDD:459652 30/171 (18%)
EGF_Lam 1669..1716 CDD:238012 7/46 (15%)
Laminin_EGF 1718..1767 CDD:395007 10/48 (21%)
EGF_Lam 1772..1819 CDD:238012 7/46 (15%)
YhaN <1907..2141 CDD:443752 49/251 (20%)
SMC_prok_B <2123..>2390 CDD:274008 17/70 (24%)
Laminin_II 2279..2400 CDD:368703
LamG 2399..>2492 CDD:473984
LamG 2586..2753 CDD:238058
Laminin_G_2 2804..2944 CDD:460494
LamG 3018..3167 CDD:238058
LamG 3192..3347 CDD:238058
lamb1XP_002933140.2 Laminin_N 34..268 CDD:459653 61/260 (23%)
EGF_Lam 270..322 CDD:238012 16/51 (31%)
Laminin_EGF 334..384 CDD:395007 16/49 (33%)
Laminin_EGF 397..454 CDD:395007 17/56 (30%)
EGF_Lam 457..507 CDD:238012 18/50 (36%)
EGF_Lam 508..>547 CDD:238012 12/64 (19%)
EGF_Lam 771..816 CDD:214543 16/49 (33%)
Laminin_EGF 819..867 CDD:395007 22/75 (29%)
EGF_Lam 865..909 CDD:238012 22/43 (51%)
EGF_Lam 914..972 CDD:238012 23/58 (40%)
EGF_Lam 973..1024 CDD:238012 19/88 (22%)
EGF_Lam 1025..1081 CDD:238012 20/55 (36%)
Laminin_EGF 1083..1131 CDD:395007 24/94 (26%)
Laminin_EGF 1131..>1170 CDD:395007 18/38 (47%)
PRK03918 <1189..1778 CDD:235175 143/820 (17%)
cc_LAMB1_C 1710..1781 CDD:411971 18/71 (25%)
Blue background indicates that the domain is not in the aligned region.

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