Protein Alignment wb and ntn1

DIOPT Version :10

• Sequence 1: NP_723870.1
• Gene: wb / 43946
• FlyBaseID: FBgn0261563
• Length: 3375
• Species: Drosophila melanogaster
• Sequence 2: XP_031750355.1
• Gene: ntn1 / 100493770
• XenbaseID: XB-GENE-989335
• Length: 602
• Species: Xenopus tropicalis
• Alignment Length: 597
• Identity: 163/597 - (27%)
• Similarity: 248/597 - (41%)
• Gaps: 146/597 - (24%)

  Fly   155 PPLFNVVPRAQISVNATCGQNGAEEYC--KQVGA---KPCGICNAHSSDRAKQRSIQSLISSGSG 214
            |...|.....::.|:.|||: ....||  .:.|.   :.|.|||.....||...|..:.:::...
 Frog    51 PDFVNSAFGKEVRVSGTCGK-PPSRYCVVTEKGEDRFRNCHICNTSDPKRAHPPSFLTDLNNPHN 114

  Fly   215 SGSGSGFEEGWWQSPTLQGGRQFEY---VTILLDLKQTFQIFSVWLKSANSPRPASWILEKSLD- 275
            ...        |||.     ...:|   ||:.|.|.:.|::..|.|:.. ||||.|..:.||:|
 Frog   115 LTC--------WQSE-----NYIQYPQNVTLTLSLGKKFEVTYVSLQFC-SPRPESMAIFKSMDY 165

  Fly   276 GINFEPWQYFGLSDADCQRRWNLSGQNGKYVF--QNDTEIICSTQFSKPGPLENGVLHASLLKNR 338
            |.::.|:|::   ...|::.:|   :..|.:.  ||:.|.||:...:...||..|::..|.|..|
 Frog   166 GKSWVPFQFY---STQCRKMYN---KPNKAIITKQNEQEAICTDSHTDMHPLSGGLIAFSTLDGR 224

  Fly   339 PGA--TDQSPELMKFITTRYIRIRLQGMHSTANQDNSLDWLLDSPSLEKHS-FYSLSQLKVSARL 400
            |.|  .|.||.|..::|...|::....:|:..:::.      |...|.:.| ||::|.|:|..|.
 Frog   225 PSAHDFDNSPVLQDWVTATDIKVVFSRLHTFGDENE------DDSELARDSYFYAVSDLQVGGRC 283

  Fly   401 DCNGHANRSHESPDDPLMQCICQHNTCGAQCEQCCPLFQDRPYQM-----GGECEICQCYGHAES 460
            .|||||:|..:..||.|: |.|:|||.|.:|::|.|...|||:|.     ..||..|.|..||..
 Frog   284 KCNGHASRCVKDRDDNLV-CDCKHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARR 347

  Fly   461 CTYDPFLDK-------GICQSCSNNTAGIECEFCEMGFYRELDAPLT--DPCLPCSCNPARSTGG 516
            |.::..|.|       |:|.:|.:||||..|.:|:.|:||::..|:|  ..|..|.|:|.
 Frog   348 CRFNMELFKLSGRRSGGVCLNCRHNTAGRHCHYCKEGYYRDMTKPITHRKACKACDCHPV----- 407

  Fly   517 CQSDGGSCNCLEGFQGKNCEECAPGYYGDDCKRCECDERGSLGSTGSCSGVCQCKLNVEGSTCSE 581
                        |..||.|.:                          .:|.|.||..|.|.||:.
 Frog   408 ------------GAAGKTCNQ--------------------------TTGQCPCKDGVTGITCNR 434

  Fly   582 CAPGYFDLSAENAEGCTSCWCSGVSQTCHSAKLQTLAFETLNDWKITDIQRVKPISIPVDAETNR 646
            ||.||    .::......|                                   |.|||...|..
 Frog   435 CAKGY----QQSRSPIAPC-----------------------------------IKIPVVPPTTA 460

  Fly   647 LIFANELDEVEAIYWQASLGYLGNRLTSYGSRLQLVLSWDVIRGDRSG---KPTTGPNVILVGKN 708
            .....|..:.:| |.:||.|.|...:..| .:....:...:::.|::|   |.|.  |||.|.|.
 Frog   461 ASSMEEPADCDA-YCKASKGKLKINMKKY-CKKDYAVQIHILKADKAGDWWKFTV--NVISVYKQ 521

  Fly   709 GL-KIAFGDESL 719
            |. :|..||::|
 Frog   522 GTNRIRRGDQNL 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wb	NP_723870.1	Laminin_N	153..398	CDD:459653	69/256 (27%)
		EGF_Lam	401..450	CDD:238012	23/53 (43%)
		EGF_Lam	505..552	CDD:238012	7/46 (15%)
		Laminin_EGF	550..597	CDD:395007	12/46 (26%)
		Laminin_B	660..813	CDD:459652	20/64 (31%)
		EGF_Lam	851..900	CDD:238012
		Laminin_EGF	<943..971	CDD:395007
		Laminin_EGF	974..1018	CDD:395007
		EGF_Lam	1017..1065	CDD:238012
		Laminin_EGF	1065..>1105	CDD:395007
		EGF_Lam	1150..1197	CDD:238012
		Laminin_EGF	1199..1247	CDD:395007
		EGF_Lam	1247..1292	CDD:238012
		Laminin_EGF	1294..1342	CDD:395007
		Laminin_EGF	1340..1392	CDD:395007
		Laminin_B	1486..1626	CDD:459652
		EGF_Lam	1669..1716	CDD:238012
		Laminin_EGF	1718..1767	CDD:395007
		EGF_Lam	1772..1819	CDD:238012
		YhaN	<1907..2141	CDD:443752
		SMC_prok_B	<2123..>2390	CDD:274008
		Laminin_II	2279..2400	CDD:368703
		LamG	2399..>2492	CDD:473984
		LamG	2586..2753	CDD:238058
		Laminin_G_2	2804..2944	CDD:460494
		LamG	3018..3167	CDD:238058
		LamG	3192..3347	CDD:238058
ntn1	XP_031750355.1	LamNT	44..281	CDD:214532	69/256 (27%)
		EGF_Lam	282..327	CDD:238012	22/45 (49%)
		Laminin_EGF	339..399	CDD:395007	21/59 (36%)
		Laminin_EGF	402..>439	CDD:395007	17/79 (22%)
		NTR_netrin-1_like	485..599	CDD:239634	15/52 (29%)