Protein Alignment wb and ntng2

DIOPT Version :10

• Sequence 1: NP_723870.1
• Gene: wb / 43946
• FlyBaseID: FBgn0261563
• Length: 3375
• Species: Drosophila melanogaster
• Sequence 2: XP_004916725.1
• Gene: ntng2 / 100489740
• XenbaseID: XB-GENE-6032766
• Length: 659
• Species: Xenopus tropicalis
• Alignment Length: 635
• Identity: 130/635 - (20%)
• Similarity: 202/635 - (31%)
• Gaps: 250/635 - (39%)

  Fly   171 TCGQNGAEEYCKQVGAKPCG-ICNAHSSDRAKQRSIQSLISSGSGSGSGSGFE---EG---WWQS 228
            ||| |..|.:|.......|. .|:|.:.|.|...|:.              |:   ||   :|||
 Frog    60 TCG-NPPERFCTHENPYLCSDECDASNPDLAHPPSLM--------------FDKEKEGLATYWQS 109

  Fly   229 PTLQGGRQFEYVTILLDLKQTFQIFSVWLKSANSPRPASWILEKSLD-GINFEPWQYFGLSDADC 292
            .|.:...:.....|.|...::.::....:.:....||.:.:|||||| |..:.|:||:.   .||
 Frog   110 VTWKRYPEPLVANITLSWNKSLELTDDIVVTFEYGRPTAMMLEKSLDYGRTWHPYQYYA---DDC 171

  Fly   293 QRRWNLSGQNGK-YVFQNDTEIICSTQFSK---------------------PGP----LENGVLH 331
            ...:.:..:..: ....:...::|:.::|:                     .||    :||..|.
 Frog   172 MEAFGMPPRKVRDLAASSANRVLCTEEYSRWAGSKKEKDVRFEVRDRFAIFAGPDLRKMENLYLR 236

  Fly   332 ASLLKNRPGATDQSPELMKFITTRYIRIRL--QGMHSTANQDNSLDWLLDSPSLEKHSFYSLSQL 394
            ....|.          |..|.|...:|:||  ..:..|         .:...:|.|: ||::|..
 Frog   237 MESAKG----------LKDFFTLTDLRLRLLRPALGGT---------YVQRENLYKY-FYAISNF 281

  Fly   395 KVSARLDCNGHANRSHESPDDPLMQCICQHNTCGAQCEQCCPLFQDRPYQMGG------------ 447
            :|.||..||.|||..:..  |..:||.|:|||.|..|.:|...|:.:.::.|.
 Frog   282 EVVARCKCNLHANACNFR--DGALQCECEHNTTGQDCGRCKKNFRSKSWRSGSYTPTPNGSPNAC 344

  Fly   448 -----------------------------------------------------------ECEI-- 451
                                                                       |..:
 Frog   345 AAAGTAFGTVDPILERTDLPIIPEYTENKRVVQMSLTPPVLDQKPKLPEKIQAAPPVLRELAVTP 409

  Fly   452 ----------------------------------------------------------------- 451
                                                                             
 Frog   410 ASGKKQTKTVPSPVNRQMTTTPASSKKQTKTAAPSISRELPLPPASGKKHTKTAAPKSSIPLEPS 474

  Fly   452 --------------CQCYGHAESCTYDPFLDKGICQSCSNNTAGIECEFCEMGFYRELDAPLTDP 502
                          |:||||:..|:|..||:...|.||.:||.|..|:.|.:|:||.:.|.|.|.
 Frog   475 TVKVSETLGKSVTDCECYGHSNRCSYIDFLNVVTCVSCKHNTRGQHCQHCRLGYYRNVSAELDDE 539

  Fly   503 --CLPCSCNPARSTGGCQSDGGSCNCLEGFQGKNCEECAPGY-YGDDCKRCECDERGSLGSTGSC 564
              |:.|:||...|.....::.|.|.|.:|.....|:||.||| :...|:...|||...:...|
 Frog   540 NVCIECNCNQLGSLHDRCNETGYCECRKGSISPKCDECLPGYHWRQGCQPNVCDEELLICQNG-- 602

  Fly   565 SGVCQCKLNVEGSTCSECAPGYFDLSAENAEG--CTSCWCSGVSQTCHSA 612
             |.|.     :|..|. |..|:        :|  |....|....:.|.|:
 Frog   603 -GTCH-----QGQRCI-CPTGF--------KGALCQDVKCDSSHRNCDSS 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wb	NP_723870.1	Laminin_N	153..398	CDD:459653	56/262 (21%)
		EGF_Lam	401..450	CDD:238012	18/119 (15%)
		EGF_Lam	505..552	CDD:238012	15/47 (32%)
		Laminin_EGF	550..597	CDD:395007	11/48 (23%)
		Laminin_B	660..813	CDD:459652
		EGF_Lam	851..900	CDD:238012
		Laminin_EGF	<943..971	CDD:395007
		Laminin_EGF	974..1018	CDD:395007
		EGF_Lam	1017..1065	CDD:238012
		Laminin_EGF	1065..>1105	CDD:395007
		EGF_Lam	1150..1197	CDD:238012
		Laminin_EGF	1199..1247	CDD:395007
		EGF_Lam	1247..1292	CDD:238012
		Laminin_EGF	1294..1342	CDD:395007
		Laminin_EGF	1340..1392	CDD:395007
		Laminin_B	1486..1626	CDD:459652
		EGF_Lam	1669..1716	CDD:238012
		Laminin_EGF	1718..1767	CDD:395007
		EGF_Lam	1772..1819	CDD:238012
		YhaN	<1907..2141	CDD:443752
		SMC_prok_B	<2123..>2390	CDD:274008
		Laminin_II	2279..2400	CDD:368703
		LamG	2399..>2492	CDD:473984
		LamG	2586..2753	CDD:238058
		Laminin_G_2	2804..2944	CDD:460494
		LamG	3018..3167	CDD:238058
		LamG	3192..3347	CDD:238058
ntng2	XP_004916725.1	Laminin_N	60..283	CDD:470680	55/260 (21%)
		EGF_Lam	286..>323	CDD:238012	16/38 (42%)
		EGF_Lam	489..531	CDD:238012	19/41 (46%)
		Laminin_EGF	545..592	CDD:395007	15/46 (33%)